A post-graduate study in Process Design: An Innovative Model in the Netherlands

Applied Science

Computer vision classification of barley flour based on spatial pyramid partition ensemble

Imaging sensors are largely employed in the food processing industry for quality control. Flour from malting barley varieties is a valuable ingredient in the food industry, but its use is restricted due to quality aspects such as color variations and the presence of husk fragments. On the other hand, naked varieties present superior quality with better visual appearance and nutritional composition for human consumption. Computer Vision Systems (CVS) can provide an automatic and precise classification of samples, but identification of grain and flour characteristics require more specialized methods. In this paper, we propose CVS combined with the Spatial Pyramid Partition ensemble (SPPe) technique to distinguish between naked and malting types of twenty-two flour varieties using image features and machine learning. SPPe leverages the analysis of patterns from different spatial regions, providing more reliable classification. Support Vector Machine (SVM), k-Nearest Neighbors (k-NN), J48 decision tree, and Random Forest (RF) were compared for samples' classification. Machine learning algorithms embedded in the CVS were induced based on 55 image features. The results ranged from 75.00% (k-NN) to 100.00% (J48) accuracy, showing that sample assessment by CVS with SPPe was highly accurate, representing a potential technique for automatic barley flour classification1913CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ420562/2018-

Integrating process design and control: An application of optimal control to chemical processes

In this paper, the optimal design of process systems generically used in chemical industries is studied. The closely coupled nature of optimal design specification of the equipment, the determination of the optimal process parameters in steady-state, moreover, some issues of the application of optimal control is shown. The solution of the overall optimization problem including (i) optimal design of the equipment and (ii) specification of its optimal control strategy can be found relying on two different design concepts, namely, on the conventionally used sequential or, on the newly emerged simultaneous design approaches. This paper gives the theoretical background of the ideas and presents a comparative summary of the approaches. The two approaches are contrasted to each other in which the effects of the interaction of optimal process design and optimal control is highlighted. A new simultaneous optimization procedure providing economic and operability benefits over the traditional stand-alone approach is proposed. The applicability of the idea is demonstrated by means of a design study carried out for optimal design of a coaxial heat exchanger and a reactive distillation column for the synthesis of ethyl tert butyl ether (ETBE), relying on the benefits of the utilization of optimal control

Sur7 Promotes Plasma Membrane Organization and Is Needed for Resistance to Stressful Conditions and to the Invasive Growth and Virulence of Candida albicans

The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion of virulence factors, morphogenesis, and cell wall synthesis. Difficulties in studying hydrophobic membranes have limited the understanding of how plasma membrane organization contributes to its function and to the actions of antifungal drugs. Therefore, the role of the recently discovered plasma membrane subdomains termed the membrane compartment containing Can1 (MCC) was analyzed by assessing the virulence of a sur7Δ mutant. Sur7 is an integral membrane protein component of the MCC that is needed for proper localization of actin, morphogenesis, cell wall synthesis, and responding to cell wall stress. MCC domains are stable 300-nm-sized punctate patches that associate with a complex of cytoplasmic proteins known as an eisosome. Analysis of virulence-related properties of a sur7Δ mutant revealed defects in intraphagosomal growth in macrophages that correlate with increased sensitivity to oxidation and copper. The sur7Δ mutant was also strongly defective in pathogenesis in a mouse model of systemic candidiasis. The mutant cells showed a decreased ability to initiate an infection and greatly diminished invasive growth into kidney tissues. These studies on Sur7 demonstrate that the plasma membrane MCC domains are critical for virulence and represent an important new target for the development of novel therapeutic strategies

Noncommutative Induced Gauge Theory

We consider an external gauge potential minimally coupled to a renormalisable scalar theory on 4-dimensional Moyal space and compute in position space the one-loop Yang-Mills-type effective theory generated from the integration over the scalar field. We find that the gauge invariant effective action involves, beyond the expected noncommutative version of the pure Yang-Mills action, additional terms that may be interpreted as the gauge theory counterpart of the harmonic oscillator term, which for the noncommutative $\phi^4$-theory on Moyal space ensures renormalisability. The expression of a possible candidate for a renormalisable action for a gauge theory defined on Moyal space is conjectured and discussed.Comment: 20 pages, 6 figure

Vacuum configurations for renormalizable non-commutative scalar models

In this paper we find non-trivial vacuum states for the renormalizable non-commutative $\phi^4$ model. An associated linear sigma model is then considered. We further investigate the corresponding spontaneous symmetry breaking.Comment: 17 page

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Importance:Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders. Objectives:To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma. Design, Settings, and Participants:A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma. Exposures:Genetic variants associated with primary open-angle glaucoma. Main Outcomes and Measures:Presence of primary open-angle glaucoma. Genome-wide significance was defined as P < 5 × 10-8 in the discovery stage and in the meta-analysis of combined discovery and validation data. Results:A total of 2320 individuals with primary open-angle glaucoma (mean [interquartile range] age, 64.6 [56-74] years; 1055 [45.5%] women) and 2121 individuals without primary open-angle glaucoma (mean [interquartile range] age, 63.4 [55-71] years; 1025 [48.3%] women) were included in the discovery GWAS. The GWAS discovery meta-analysis demonstrated association of variants at amyloid-β A4 precursor protein-binding family B member 2 (APBB2; chromosome 4, rs59892895T>C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P < .001). Each copy of the rs59892895*C risk allele was associated with increased risk of primary open-angle glaucoma when all data were included in a meta-analysis (OR, 1.19 [95% CI, 1.14-1.25]; P = 4 × 10-13). The rs59892895*C risk allele was present at appreciable frequency only in African ancestry populations. In contrast, the rs59892895*C risk allele had a frequency of less than 0.1% in individuals of European or Asian ancestry. Conclusions and Relevance:In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry. If validated in additional populations this finding may have implications for risk assessment and therapeutic strategies

Flux-splitting schemes for parabolic problems

To solve numerically boundary value problems for parabolic equations with mixed derivatives, the construction of difference schemes with prescribed quality faces essential difficulties. In parabolic problems, some possibilities are associated with the transition to a new formulation of the problem, where the fluxes (derivatives with respect to a spatial direction) are treated as unknown quantities. In this case, the original problem is rewritten in the form of a boundary value problem for the system of equations in the fluxes. This work deals with studying schemes with weights for parabolic equations written in the flux coordinates. Unconditionally stable flux locally one-dimensional schemes of the first and second order of approximation in time are constructed for parabolic equations without mixed derivatives. A peculiarity of the system of equations written in flux variables for equations with mixed derivatives is that there do exist coupled terms with time derivatives

A single center case series of immune checkpoint inhibitor-induced type 1 diabetes mellitus, patterns of disease onset and long-term clinical outcome

BackgroundType 1 diabetes mellitus (T1DM) is a rare, but serious immune-related adverse event (irAE) of immune checkpoint inhibitors (ICIs). Our goal was to characterize treatment outcomes associated with ICI-induced T1DM through analysis of clinical, immunological and proteomic data.MethodsThis was a single-center case series of patients with solid tumors who received ICIs and subsequently had a new diagnosis of T1DM. ICD codes and C-peptide levels were used to identify patients for chart review to confirm ICI-induced T1DM. Baseline blood specimens were studied for proteomic and immunophenotypic changes.ResultsBetween 2011 and 2023, 18 of 3744 patients treated at Huntsman Cancer Institute with ICIs were confirmed to have ICI-induced T1DM (0.48%). Eleven of the 18 patients received anti-PD1 monotherapy, 4 received anti-PD1 plus chemotherapy or targeted therapy, and 3 received ipilimumab plus nivolumab. The mean time to onset was 218 days (range 22-418 days). Patients had sudden elevated serum glucose within 2-3 weeks prior to diagnosis. Sixteen (89%) presented with diabetic ketoacidosis. Three of 12 patients had positive T1DM-associated autoantibodies. All patients with T1DM became insulin-dependent through follow-up. At median follow-up of 21.9 months (range 8.4-82.4), no patients in the melanoma group had progressed or died from disease. In the melanoma group, best responses were 2 complete response and 2 partial response while on active treatment; none in the adjuvant group had disease recurrence. Proteomic analysis of baseline blood suggested low inflammatory (IL-6, OSMR) markers and high metabolic (GLO1, DXCR) markers in ICI-induced T1DM cohort.ConclusionsOur case series demonstrates rapid onset and irreversibility of ICI-induced T1DM. Melanoma patients with ICI-induced T1DM display excellent clinical response and survival. Limited proteomic data also suggested a unique proteomic profile. Our study helps clinicians to understand the unique clinical presentation and long-term outcomes of this rare irAE for best clinical management