Cuidado informal al adulto mayor encamado en un área de salud

Introduction: the informal care of a dependent person often supposes a significant source of stress affecting the life of informal caregivers.Objective: to diagnose the present-day status of informal care of old people confined to bed in the health area of Manuel Piti Fajardo Polyclinic, Guane municipality in Pinar del Río province from July 2015 to October 2016.Methods: observational, descriptive and cross sectional study was conducted, the target group was constituted by 79 informal caregivers of old patients confined to bed and the sample included 35 of them who met the inclusion criteria, using theoretical, empirical and statistical (descriptive statistics) methods in the analysis.Results: the present-day trends in the development of this subject matter were identified, along with the diagnosis of the initial status, determining the regularities that make possible the transformation of its insufficiencies.Conclusions: the results indicate that there is a need for multidisciplinary actions aimed at improving the informal care process, designing and generating interventions that articulate the activity of caregivers, family, basic working team and the community.Introducción: el cuidado informal a una persona dependiente supone con frecuencia notable fuente de estrés que afecta la vida del cuidador informal.Objetivo: diagnosticar el estado actual del cuidado informal al adulto mayor encamado en el área de salud del Policlínico Manuel Piti Fajardo de Guane en Pinar del Río, durante el período de julio 2015 a octubre 2016.Métodos: se realizó un estudio observacional, descriptivo y transversal, constituido por una población de 79 cuidadores informales de adultos mayores encamados y una muestra de 35 de estos, que cumplieron con los criterios de inclusión, utilizando en el análisis métodos teóricos, empíricos y estadísticos (estadística descriptiva).Resultados: se identificaron tendencias actuales en el desarrollo del objeto, se realizó el diagnóstico del estado inicial, determinando regularidades que posibilitan la transformación de sus insuficienciasConclusiones: los resultados indican que existe la necesidad de actuaciones multidisciplinarias encaminadas a perfeccionar el proceso de cuidado informal, diseñando y generando intervenciones que articulen la actividad del cuidador, la familia, el grupo básico de trabajo y la comunidad

Cuidado informal al adulto mayor encamado en un área de salud

Introducción: el cuidado informal a una persona dependiente supone con frecuencia notable fuente de estrés que afecta la vida del cuidador informal. Objetivo: diagnosticar el estado actual del cuidado informal al adulto mayor encamado en el área de salud del Policlínico Manuel Piti Fajardo de Guane en Pinar del Río, durante el período de julio 2015 a octubre 2016. Métodos: se realizó un estudio observacional, descriptivo y transversal, constituido por una población de 79 cuidadores informales de adultos mayores encamados y una muestra de 35 de estos, que cumplieron con los criterios de inclusión, utilizando en el análisis métodos teóricos, empíricos y estadísticos (estadística descriptiva). Resultados: se identificaron tendencias actuales en el desarrollo del objeto, se realizó el diagnóstico del estado inicial, determinando regularidades que posibilitan la transformación de sus insuficiencias Conclusiones: los resultados indican que existe la necesidad de actuaciones multidisciplinarias encaminadas a perfeccionar el proceso de cuidado informal, diseñando y generando intervenciones que articulen la actividad del cuidador, la familia, el grupo básico de trabajo y la comunidad

Fertility in Cebú × brown Swiss cows treated with prostaglandins, progesterone and eCG

Objective: To evaluate the application of 1 or 2 doses of prostaglandin F2? (PGF2?), the use of progestogen on different days of the estrous cycle, and the use of eCG in estrus and fertility synchronization of Zebu × Brown Swiss cows. Design / Methodology / Approach: The study was based on three protocols. Protocol 1 consisted of two treatments: PGI) 26 cows were injected with a single dose of 25 mg PGF2?, and 10 cows with two doses of 25 mg PGF2? with a 14 day interval. Protocol 2 consisted of two treatments: NG14) 11 cows were implanted with 3 mg Norgestomet on day 7 of the estrous cycle, and NG7) 11 animals received the same dose on day 14. In protocol 3, all the cows were implanted with 3 mg Norgestomet for 9 days, 48 h before removing the implant, 25 mg PGF2? was applied. Once the implant was removed, the cows were distributed into two treatments. Norgestomet (n=11) without eCG and Norgestomet + eCG (500 IU) (n=11).    Results: The application of PGF2? on two occasions had no influence (p> 0.05) on the percentages of estrus or pregnancies. NG7 achieved estrus synchronization in 81.8% of the cows between 24 and 36 h, compared with 45.4% of NG14; however, the pregnancy rate was lower (p<0.05). The application of eCG synchronized 90.9% estrus between 24 and 36 h, compared with 36.4% in the group where no eCG was applied. Study limitations / implications: The use of transrectal ultrasound is required to evaluate the ovarian structures present at the time of initiating an estrus synchronization protocol. Findings / conclusions: Cows that present corpus luteum do not require more than one injection of PGF2?, the percentage of pregnancy increases when Norgestomet is implanted on day 14 of the estrous cycle, in addition the application of eCG increases the percentage of synchronization of heat of the 24 to 36 h after withdrawal of progestogenObjective: To evaluate the application of one or two doses of prostaglandin F2?(PGF2?), the application of a progestogen on different days of the estrous cycle and theusage of eCG in the estrus synchronization and fertility of Zebu × Brown Swiss cows.Design / methodology / approach: The study was based on three protocols. The firstconsisted of two treatments: PGI) 26 cows were injected with a single 25 mg dose ofPGF2? and 10 cows with two 25 mg doses of PGF2? at a 14-day interval. Protocol 2consisted of two treatments: NG14) 11 cows were implanted with 3 mg of Norgestometon day 7 of their estrous cycle and NG7) 11 animals received the same dose on day 14.In protocol 3 all cows were implanted with 3 mg of Norgestomet for 9 days, 48 h beforeremoving the implant, 25 mg of PGF2? was applied. Once the implants were removed,they were distributed into two treatments. Norgestomet (n = 11) without eCG andNorgestomet + eCG (500 IU) (n = 11). Results: The application of PGF2? at two times had no influence (p > 0.05) in theestrous percentages and conception. The NG7 achieved estrous synchronization in 81.8% of the cows, in between 24 and 36 h, compared to 45.4 % of the NG14; however, theconception rate was lower (p ? 0.05). The eCG application synchronized 90.9 % ofestrous between 24 and 36 h, compared with 36.4 % of the group with no eCGapplication.Study limitations / implications: Transrectal ultrasounds are required to assess theovarian structures present at the time of the estrus onset in a synchronization protocol.Findings / conclusions: Cows that present corpus luteum do not require more thanone injection of PGF2?, the pregnancy percentage increases when Norgestomet isimplanted on day 14 of the estrous cycle, in addition the application of eCG increasesthe synchronization percentage of the heat between 24 to 36 h after the progestogenwithdrawal

Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

[EN] Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.European funds (European Regional Development Fund, ERDF); Spanish Ministerio de Economı´a y Competitividad; Junta de Andalucí

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Measurement of B-c(2S)(+) and B-c*(2S)(+) cross section ratios in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of the W gamma Production Cross Section in Proton-Proton Collisions at root s=13 TeV and Constraints on Effective Field Theory Coefficients

A fiducial cross section for W gamma production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb(-1) of data collected using the CMS detector at the LHC. The W -> e nu and mu nu decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Peer reviewe