127 research outputs found
Numerical investigations of discrete scale invariance in fractals and multifractal measures
Fractals and multifractals and their associated scaling laws provide a
quantification of the complexity of a variety of scale invariant complex
systems. Here, we focus on lattice multifractals which exhibit complex
exponents associated with observable log-periodicity. We perform detailed
numerical analyses of lattice multifractals and explain the origin of three
different scaling regions found in the moments. A novel numerical approach is
proposed to extract the log-frequencies. In the non-lattice case, there is no
visible log-periodicity, {\em{i.e.}}, no preferred scaling ratio since the set
of complex exponents spread irregularly within the complex plane. A non-lattice
multifractal can be approximated by a sequence of lattice multifractals so that
the sets of complex exponents of the lattice sequence converge to the set of
complex exponents of the non-lattice one. An algorithm for the construction of
the lattice sequence is proposed explicitly.Comment: 31 Elsart pages including 12 eps figure
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyper laxity and Urticarial Neutrophilic Dermatosis
Peer reviewe
Data-Adaptive Wavelets and Multi-Scale Singular Spectrum Analysis
Using multi-scale ideas from wavelet analysis, we extend singular-spectrum
analysis (SSA) to the study of nonstationary time series of length whose
intermittency can give rise to the divergence of their variance. SSA relies on
the construction of the lag-covariance matrix C on M lagged copies of the time
series over a fixed window width W to detect the regular part of the
variability in that window in terms of the minimal number of oscillatory
components; here W = M Dt, with Dt the time step. The proposed multi-scale SSA
is a local SSA analysis within a moving window of width M <= W <= N.
Multi-scale SSA varies W, while keeping a fixed W/M ratio, and uses the
eigenvectors of the corresponding lag-covariance matrix C_M as a data-adaptive
wavelets; successive eigenvectors of C_M correspond approximately to successive
derivatives of the first mother wavelet in standard wavelet analysis.
Multi-scale SSA thus solves objectively the delicate problem of optimizing the
analyzing wavelet in the time-frequency domain, by a suitable localization of
the signal's covariance matrix. We present several examples of application to
synthetic signals with fractal or power-law behavior which mimic selected
features of certain climatic and geophysical time series. A real application is
to the Southern Oscillation index (SOI) monthly values for 1933-1996. Our
methodology highlights an abrupt periodicity shift in the SOI near 1960. This
abrupt shift between 4 and 3 years supports the Devil's staircase scenario for
the El Nino/Southern Oscillation phenomenon.Comment: 24 pages, 19 figure
Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and KLIPPEL TRENAUNAY SYNDROME (KTS): the TOTEM trial, a phase 1/2 multicentre, open-label, single-arm study
Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
International audienc
Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities.
PURPOSE: Hypomelanosis of Ito (HI) is a skin marker of somatic mosaicism. Mosaic MTOR pathogenic variants have been reported in HI with brain overgrowth. We sought to delineate further the pigmentary skin phenotype and clinical spectrum of neurodevelopmental manifestations of MTOR-related HI. METHODS: From two cohorts totaling 71 patients with pigmentary mosaicism, we identified 14 patients with Blaschko-linear and one with flag-like pigmentation abnormalities, psychomotor impairment or seizures, and a postzygotic MTOR variant in skin. Patient records, including brain magnetic resonance image (MRI) were reviewed. Immunostaining (nâ=â3) for melanocyte markers and ultrastructural studies (nâ=â2) were performed on skin biopsies. RESULTS: MTOR variants were present in skin, but absent from blood in half of cases. In a patient (p.[Glu2419Lys] variant), phosphorylation of p70S6K was constitutively increased. In hypopigmented skin of two patients, we found a decrease in stage 4 melanosomes in melanocytes and keratinocytes. Most patients (80%) had macrocephaly or (hemi)megalencephaly on MRI. CONCLUSION: MTOR-related HI is a recognizable neurocutaneous phenotype of patterned dyspigmentation, epilepsy, intellectual deficiency, and brain overgrowth, and a distinct subtype of hypomelanosis related to somatic mosaicism. Hypopigmentation may be due to a defect in melanogenesis, through mTORC1 activation, similar to hypochromic patches in tuberous sclerosis complex
Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing
Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation
Purpose
By incorporating major developments in genetics, ophthalmology, dermatology, and neuroimaging, to revise the diagnostic criteria for neurofibromatosis type 1 (NF1) and to establish diagnostic criteria for Legius syndrome (LGSS).
Methods
We used a multistep process, beginning with a Delphi method involving global experts and subsequently involving non-NF experts, patients, and foundations/patient advocacy groups.
Results
We reached consensus on the minimal clinical and genetic criteria for diagnosing and differentiating NF1 and LGSS, which have phenotypic overlap in young patients with pigmentary findings. Criteria for the mosaic forms of these conditions are also recommended.
Conclusion
The revised criteria for NF1 incorporate new clinical features and genetic testing, whereas the criteria for LGSS were created to differentiate the two conditions. It is likely that continued refinement of these new criteria will be necessary as investigators (1) study the diagnostic properties of the revised criteria, (2) reconsider criteria not included in this process, and (3) identify new clinical and other features of these conditions. For this reason, we propose an initiative to update periodically the diagnostic criteria for NF1 and LGSS
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
The Extra-cutaneous Localizations of the Neutrophilic Disease
International audienceIn 1991, Vignon-Pennamen and Wallach proposed a unifying and prescient concept of âneutrophilic diseaseâ (ND) in the light of clinical observations: (1) numerous reports of clinicopathological symptoms overlapping the typical forms of ND, including subcorneal pustular dermatosis (SPD; Sneddon-Wilkinson disease); Sweetâs syndrome (SwS); pyoderma gangrenosum (PG) and erythema elevatum diutinum (EED); (2) extracutaneous manifestations of neutrophilic disease; (3) non fortuitous association with systemic diseases and (4) usual therapeutic response to corticosteroid and/or dapsone [1]. In their article, they reviewed and argued the rare cases of various organ involvement suspected to be related to ND and previously reported, generally one or two observations for each organ, including bones, liver, lymph nodes, spleen, lung and kidney. Almost a quarter century later, a large number of extracutaneous manifestations of ND have been reported and allow a clarification on the risk of organ involvement depending on type of neutrophilic diseases, mostly Sweet syndrome and pyoderma gangrenosum, and their treatment (Table 16.1)
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