Comparative wood anatomy of tree native species of Schinopsis (Anacardiaceae)

Schinopsis, género endémico de Sudamérica, incluye ocho especies que habitan en los bosques xerófilos chaqueños de Argentina, Bolivia, Paraguay y Brasil. Son cuatro las especies nativas de Argentina, dos de gran importancia económica. El objetivo del trabajo es comparar anatómicamente el xilema de: S. lorentzii (Griseb.) Engl., S. balansae Engl. y Schinopsis marginata Engl. Se trabajó con 5 árboles por especie. Se usó la terminología del Comité de Nomenclatura de IAWA y Tortorelli en las descripciones. Se utilizaron los índices de vulnerabilidad y mesomorfía propuestos por Carlquist para determinar el tipo de comportamiento. Se analizó comparativamente los rasgos anatómicos relevantes. Se analizaron estadísticamente cinco variables cuantitativas: frecuencia de poros/mm2 (Fv); diámetro tangencial (Vd) y longitud de los elementos vasculares (VI); altura del radio (Rh). El leño homogéneo, presenta diferencias en las variables cuantitativas como frecuencia, diámetro y longitud de vaso. El rasgo anatómico predominante es la presencia de canales secretores de tanino radiales y vasos del duramen ocluidos por tilosis. Los leños de S. lorentzii y S. marginata mostraron gran afinidad y rasgos mesofiticos con tendencia a xerofíticos; mientras que S. balansae presenta signos mesofíticos.Schinopsis, endemic genus of South America, includes eight species that inhabit the Chaco dry forests of Argentina, Bolivia, Paraguay and Brazil. Four species are native to Argentina; two of great economic importance. The aim of this work is to perform comparative wood anatomy of S. lorentzii, S. balansae and S. marginata. It worked with 5 trees of each species. The terminology of IAWA Committee on Nomenclature and Tortorelli were used in wood descriptions. Vulnerability and mesomorphy index proposed by Carlquist, to determine the type of behavior, were used. Relevant anatomical features were comparatively analyzed. Five variables were statistically analyzed: vessel frequency/ mm2 (Fv); tangential vessel diameter (Vd); length of vascular elements (VI) and ray height (Rh). The anatomy of wood is homogeneous, with significant differences in the variables: frequency, diameter and vessel length. Secretory radial tannin channels and tilosis occluding vessel, are predominant anatomical features. Wood anatomy of S. lorentzii and S. marginata showed high affinity and mesophitic to xeric trait; while S. balansae presents mesophitic signs.Fil: Gimenez, Ana Maria Isabel. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Forestales. Instituto de Silvicultura y Manejo de Bosques; ArgentinaFil: Calatayu, Federico. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Forestales; ArgentinaFil: Diaz Zirpolo, Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Figueroa, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez, Damian. Fondo para la Investigación Científica y Tecnológica; Argentin

Dilatonic ghost condensate as dark energy

We explore a dark energy model with a ghost scalar field in the context of the runaway dilaton scenario in low-energy effective string theory. We address the problem of vacuum stability by implementing higher-order derivative terms and show that a cosmologically viable model of ``phantomized'' dark energy can be constructed without violating the stability of quantum fluctuations. We also analytically derive the condition under which cosmological scaling solutions exist starting from a general Lagrangian including the phantom type scalar field. We apply this method to the case where the dilaton is coupled to non-relativistic dark matter and find that the system tends to become quantum mechanically unstable when a constant coupling is always present. Nevertheless, it is possible to obtain a viable cosmological solution in which the energy density of the dilaton eventually approaches the present value of dark energy provided that the coupling rapidly grows during the transition to the scalar field dominated era.Comment: 26 pages, 6 figure

Role of targeted therapies in rheumatic patients on COVID-19 outcomes: results from the COVIDSER study

Objectives: To analyse the effect of targeted therapies, either biological (b) disease-modifying antirheumatic drugs (DMARDs), targeted synthetic (ts) DMARDs and other factors (demographics, comorbidities or COVID-19 symptoms) on the risk of COVID-19 related hospitalisation in patients with inflammatory rheumatic diseases. Methods: The COVIDSER study is an observational cohort including 7782 patients with inflammatory rheumatic diseases. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Antirheumatic medication taken immediately prior to infection, demographic characteristics, rheumatic disease diagnosis, comorbidities and COVID-19 symptoms were analysed. Results: A total of 426 cases of symptomatic COVID-19 from 1 March 2020 to 13 April 2021 were included in the analyses: 106 (24.9%) were hospitalised and 19 (4.4%) died. In multivariate-adjusted models, bDMARDs and tsDMARDs in combination were not associated with hospitalisation compared with conventional synthetic DMARDs (OR 0.55, 95% CI 0.24 to 1.25 of b/tsDMARDs, p=0.15). Tumour necrosis factor inhibitors (TNF-i) were associated with a reduced likelihood of hospitalisation (OR 0.32, 95% CI 0.12 to 0.82, p=0.018), whereas rituximab showed a tendency to an increased risk of hospitalisation (OR 4.85, 95% CI 0.86 to 27.2). Glucocorticoid use was not associated with hospitalisation (OR 1.69, 95% CI 0.81 to 3.55). A mix of sociodemographic factors, comorbidities and COVID-19 symptoms contribute to patients' hospitalisation. Conclusions: The use of targeted therapies as a group is not associated with COVID-19 severity, except for rituximab, which shows a trend towards an increased risk of hospitalisation, while TNF-i was associated with decreased odds of hospitalisation in patients with rheumatic disease. Other factors like age, male gender, comorbidities and COVID-19 symptoms do play a role.This Project has been financed by Bristol-Myers Squibb, Galapagos Biopharma Spain SLU, Gebro Pharma, Roche Farma and Sanofi Aventis

Effectiveness of rotavirus vaccination in Spain

With the aim of determining rotavirus vaccine effectiveness (RVVE) in Spain, from Oct-2008/Jun-2009, 467 consecutive children below 2 years old with acute gastroenteritis (AGE) were recruited using a pediatric research network (ReGALIP-www.regalip.org) that includes primary, emergency and hospital care settings. Of 467 enrolled children, 32.3% were rotavirus positive and 35.0% had received at least one dose of any rotavirus vaccine. RRVE to prevent any episode of rotavirus AGE was 91.5% (95% CI: 83.7%-95.6%). RVVE to prevent hospitalization by rotavirus AGE was 95.6% (85.6-98.6%). No differences in RVVE were found regarding the vaccine used. Rotavirus vaccines have showed an outstanding effectiveness in Spain

A decentralized approach to model national and global food and land use systems

The achievement of several sustainable development goals and the Paris Climate Agreement depends on rapid progress towards sustainable food and land systems in all countries. We have built a flexible, collaborative modeling framework to foster the development of national pathways by local research teams and their integration up to global scale. Local researchers independently customize national models to explore mid-century pathways of the food and land use system transformation in collaboration with stakeholders. An online platform connects the national models, iteratively balances global exports and imports, and aggregates results to the global level. Our results show that actions toward greater sustainability in countries could sum up to 1 Mha net forest gain per year, 950 Mha net gain in the land where natural processes predominate, and an increased CO2 sink of 3.7 GtCO2e yr−1 over the period 2020-2050 compared to current trends, while average food consumption per capita remains above the adequate food requirements in all countries. We show examples of how the global linkage impacts national results and how different assumptions in national pathways impact global results. This modeling setup acknowledges the broad heterogeneity of socio-ecological contexts and the fact that people who live in these different contexts should be empowered to design the future they want. But it also demonstrates to local decision-makers the interconnectedness of our food and land use system and the urgent need for more collaboration to converge local and global priorities.Fil: Mosnier, Aline. Sustainable Development Solutions Network; FranciaFil: Javalera Rincon, Valeria. International Institute For Applied Systems Analysis, Laxenburg; AustriaFil: Jones, Sarah K. Alliance of Bioversity International; FranciaFil: Andrew, Robbie. Center for International Climate Research; NoruegaFil: Bai, Zhaohai. Chinese Academy of Sciences; República de ChinaFil: Baker, Justin. North Carolina State University; Estados UnidosFil: Basnet, Shyam. Stockholm Resilience Centre; SueciaFil: Boer, Rizaldi. Bogor Agricultural University; IndonesiaFil: Chavarro, John. Geo-agro-environmental Sciences And Resources Research Center; ColombiaFil: Costa, Wanderson. Centro de Previsao de Tempo e Estudos Climáticos. Instituto Nacional de Pesquisas Espaciais; BrasilFil: Daloz, Anne Sophie. Center for International Climate Research; NoruegaFil: DeClerck, Fabrice A.. Alliance of Bioversity International; Francia. Stockholm Resilience Centre; SueciaFil: Diaz, Maria. Sustainable Development Solutions Network; FranciaFil: Douzal, Clara. Sustainable Development Solutions Network; FranciaFil: Howe Fan, Andrew Chiah. Sunway University; MalasiaFil: Fetzer, Ingo. Stockholm Resilience Centre; SueciaFil: Frank, Federico. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; ArgentinaFil: Gonzalez Abraham, Charlotte E.. University of California at San Diego; Estados UnidosFil: Habiburrachman, A. H. F.. Universitas Indonesia; IndonesiaFil: Immanuel, Gito. Stockholm Resilience Centre; SueciaFil: Harrison, Paula A.. Centre for Ecology & Hydrology; Reino UnidoFil: Imanirareba, Dative. Uganda Martyrs University; UgandaFil: Jha, Chandan. Indian Institute Of Management Ahmedabad; IndiaFil: Monjeau, Jorge Adrian. Fundación Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vittis, Yiorgos. International Institute For Applied Systems Analysis; AustriaFil: Wade, Chris. North Carolina State University; Estados UnidosFil: Winarni, Nurul L.. Universitas Indonesia; IndonesiaFil: Woldeyes, Firew Bekele. Ethiopian Development Research Institute; EtiopíaFil: Wu, Grace C.. University of California; Estados UnidosFil: Zerriffi, Hisham. University of British Columbia; Canad

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Sex differences in brain atrophy in dementia with Lewy bodies

Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.Peer reviewe