151 research outputs found
The geometry of the limit of N=2 minimal models
We consider the limit of two-dimensional N=(2,2) superconformal minimal
models when the central charge approaches c=3. Starting from a geometric
description as non-linear sigma models, we show that one can obtain two
different limit theories. One is the free theory of two bosons and two
fermions, the other one is a continuous orbifold thereof. We substantiate this
claim by detailed conformal field theory computations.Comment: 35 pages, 3 figures; v2 minor corrections, version to be published in
J. Phys.
A Large Area Detector proposed for the Large Observatory for X-ray Timing (LOFT)
The Large Observatory for X-ray Timing (LOFT) is one of the four candidate
ESA M3 missions considered for launch in the 2022 time-frame. It is
specifically designed to perform fast X-ray timing and probe the status of the
matter near black holes and neutron stars. The LOFT scientific payload is
composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD
is a 10 m2-class pointed instrument with 20 times the collecting area of the
best past timing missions (such as RXTE) over the 2-30 keV range, which holds
the capability to revolutionize studies of X-ray variability down to the
millisecond time scales. Its ground-breaking characteristic is a low mass per
unit surface, enabling an effective area of ~10 m^2 (@10 keV) at a reasonable
weight. The development of such large but light experiment, with low mass and
power per unit area, is now made possible by the recent advancements in the
field of large-area silicon detectors - able to time tag an X-ray photon with
an accuracy <10 {\mu}s and an energy resolution of ~260 eV at 6 keV - and
capillary-plate X-ray collimators. In this paper, we will summarize the
characteristics of the LAD instrument and give an overview of its capabilities.Comment: Proceedings of SPIE, Vo. 8443, Paper No. 8443-8
Design, construction, and test of the Gas Pixel Detectors for the IXPE mission
Due to be launched in late 2021, the Imaging X-Ray Polarimetry Explorer
(IXPE) is a NASA Small Explorer mission designed to perform polarization
measurements in the 2-8 keV band, complemented with imaging, spectroscopy and
timing capabilities. At the heart of the focal plane is a set of three
polarization-sensitive Gas Pixel Detectors (GPD), each based on a custom ASIC
acting as a charge-collecting anode. In this paper we shall review the design,
manufacturing, and test of the IXPE focal-plane detectors, with particular
emphasis on the connection between the science drivers, the performance metrics
and the operational aspects. We shall present a thorough characterization of
the GPDs in terms of effective noise, trigger efficiency, dead time, uniformity
of response, and spectral and polarimetric performance. In addition, we shall
discuss in detail a number of instrumental effects that are relevant for
high-level science analysis -- particularly as far as the response to
unpolarized radiation and the stability in time are concerned.Comment: To be published in Astroparticle Physic
Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer
The Large Observatory for x-ray timing
The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a WideField Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study
The Large Observatory For X-ray Timing: LOFT
LOFT, the Large Observatory for X-ray Timing, is a new space mission concept devoted to observations of Galactic and extra-Galactic sources in the X-ray domain with the main goals of probing gravity theory in the very strong field environment of black holes and other compact objects, and investigating the state of matter at supra-nuclear densities in neutron stars. The instruments on-board LOFT, the Large area detector and the Wide Field Monitor combine for the first time an unprecedented large effective area (~10 m2 at 8 keV) sensitive to X-ray photons mainly in the 2-30 keV energy range and a spectral resolution approaching that of CCD-based telescopes (down to 200 eV at 6 keV). LOFT is currently competing for a launch of opportunity in 2022 together with the other M3 mission candidates of the ESA Cosmic Vision Progra
The LOFT mission concept: a status update
The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, >8m2 effective area, 2-30 keV, 240 eV spectral resolution, 1 degree collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g., GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the current technical and programmatic status of the mission
Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study
Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care
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