40 research outputs found
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017 : A systematic analysis for the global burden of disease study
- Author
- Abate Degu
- Abate Degu
- Abbasi Naghmeh
- Abbasi Naghmeh
- Abbastabar Hedayat
- Abbastabar Hedayat
- Abd-Allah Foad
- Abd-Allah Foad
- Abdel-Rahman Omar
- Abdel-Rahman Omar
- Abdelalim Ahmed
- Abdelalim Ahmed
- Abdoli Amir
- Abdoli Amir
- Abdollahpour Ibrahim
- Abdollahpour Ibrahim
- Abdulle Abdishakur SM
- Abdulle Abdishakur SM
- Abebe Nebiyu Dereje
- Abebe Nebiyu Dereje
- Abraha Haftom Niguse
- Abraha Haftom Niguse
- Abu-Raddad Laith Jamal
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abualhasan Ahmed
- Adedeji Isaac Akinkunmi
- Adedeji Isaac Akinkunmi
- Advani Shailesh M
- Advani Shailesh M
- Afarideh Mohsen
- Afarideh Mohsen
- Afshari Mahdi
- Afshari Mahdi
- Aghaali Mohammad
- Aghaali Mohammad
- Agius Dominic
- Agius Dominic
- Agrawal Sutapa
- Agrawal Sutapa
- Ahmadi Ayat
- Ahmadi Ayat
- Ahmadian Elham
- Ahmadian Elham
- Ahmadpour Ehsan
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Ahmed Muktar Beshir
- Akbari Mohammad Esmaeil
- Akbari Mohammad Esmaeil
- Akinyemiju Tomi
- Akinyemiju Tomi
- Al-Aly Ziyad
- Al-Aly Ziyad
- AlAbdulKader Assim M
- AlAbdulKader Assim M
- Alahdab Fares
- Alahdab Fares
- Alam Tahiya
- Alam Tahiya
- Alamene Genet Melak
- Alamene Genet Melak
- Alemnew Birhan Tamene T
- Alemnew Birhan Tamene T
- Alene Kefyalew Addis
- Alene Kefyalew Addis
- Alinia Cyrus
- Alinia Cyrus
- Alipour Vahid
- Alipour Vahid
- Aljunid Syed Mohamed
- Aljunid Syed Mohamed
- Almadi Majid Abdulrahman Hamad
- Almadi Majid Abdulrahman Hamad
- Almasi-Hashiani Amir
- Almasi-Hashiani Amir
- Alsharif Ubai
- Alsharif Ubai
- Alsowaidi Shirina
- Alsowaidi Shirina
- Alvis-Guzman Nelson
- Alvis-Guzman Nelson
- Amini Erfan
- Amini Erfan
- Amini Saeed
- Amini Saeed
- Amoako Yaw Ampem
- Amoako Yaw Ampem
- Anbari Zohreh
- Anbari Zohreh
- Anber Nahla Hamed
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Andrei Catalina Liliana
- Anjomshoa Mina
- Anjomshoa Mina
- Ansari Fereshteh
- Ansari Fereshteh
- Ansariadi Ansariadi
- Ansariadi Ansariadi
- Appiah Seth Christopher Yaw
- Appiah Seth Christopher Yaw
- Arab-Zozani Morteza
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabloo Jalal
- Arefi Zohreh
- Arefi Zohreh
- Aremu Olatunde
- Aremu Olatunde
- Areri Habtamu Abera
- Areri Habtamu Abera
- Artaman Al
- Artaman Al
- Asayesh Hamid
- Asayesh Hamid
- Asfaw Ephrem Tsegay
- Asfaw Ephrem Tsegay
- Ashagre Alebachew Fasil
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- Assadi Reza
- Assadi Reza
- Ataeinia Bahar
- Ataeinia Bahar
- Atalay Hagos Tasew
- Atalay Hagos Tasew
- Ataro Zerihun
- Ataro Zerihun
- Atique Suleman
- Atique Suleman
- Ausloos Marcel
- Ausloos Marcel
- Avila-Burgos Leticia
- Avila-Burgos Leticia
- Avokpaho Euripide FGA
- Avokpaho Euripide FGA
- Awasthi Ashish
- Awasthi Ashish
- Awoke Nefsu
- Awoke Nefsu
- Ayala Quintanilla Beatriz Paulina
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayanore Martin Amogre
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- Bakeshei Fatemeh Allah
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- Balouchi Abbas
- Battista Robert J
- Battista Robert J
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- Bicer Burcu Kucuk
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- Bijani Ali
- Bin Sayeed Muhammad Shahdaat
- Bin Sayeed Muhammad Shahdaat
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- Bjørge Tone
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- Bleyer Archie
- Bogale Kassawmar Angaw
- Bogale Kassawmar Angaw
- Bojia Hunduma Amensisa
- Bojia Hunduma Amensisa
- Borzì Antonio M
- Borzì Antonio M
- Bosetti Cristina
- Bosetti Cristina
- Bou-Orm Ibrahim R
- Bou-Orm Ibrahim R
- Brenner Hermann
- Brenner Hermann
- Brewer Jerry D
- Brewer Jerry D
- Briko Andrey Nikolaevich
- Briko Andrey Nikolaevich
- Briko Nikolay Ivanovich
- Briko Nikolay Ivanovich
- Bustamante-Teixeira Maria Teresa
- Bustamante-Teixeira Maria Teresa
- Butt Zahid A
- Butt Zahid A
- Bärnighausen Till Winfried
- Bärnighausen Till Winfried
- Carreras Giulia
- Carreras Giulia
- Carrero Juan J
- Carrero Juan J
- Carvalho Félix
- Carvalho Félix
- Castro Clara
- Castro Clara
- Castro Franz
- Castro Franz
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- Catalá-López Ferrán
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- Cerin Ester
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- Chaiah Yazan
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- Chattu Vijay Kumar
- Chaturvedi Pankaj
- Chaturvedi Pankaj
- Chauhan Neelima Singh
- Chauhan Neelima Singh
- Chehrazi Mohammad
- Chehrazi Mohammad
- Chiang Peggy Pei-Chia
- Chiang Peggy Pei-Chia
- Chichiabellu Tesfaye Yitna
- Chichiabellu Tesfaye Yitna
- Chido-Amajuoyi Onyema Greg
- Chido-Amajuoyi Onyema Greg
- Chimed-Ochir Odgerel
- Chimed-Ochir Odgerel
- Choi Jee-Young J
- Choi Jee-Young J
- Christopher Devasahayam J
- Christopher Devasahayam J
- Chu Dinh-Toi
- Chu Dinh-Toi
- Constantin Maria-Magdalena
- Constantin Maria-Magdalena
- Costa Vera M
- Costa Vera M
- Crocetti Emanuele
- Crocetti Emanuele
- Crowe Christopher Stephen
- Crowe Christopher Stephen
- Curado Maria Paula
- Curado Maria Paula
- Dahlawi Saad MA
- Dahlawi Saad MA
- Damiani Giovanni
- Damiani Giovanni
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- Darwesh Aso Mohammad
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- Daryani Ahmad
- das Neves José
- das Neves José
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- Denova-Gutiérrez Edgar
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- Derakhshani Afshin
- Deribe Kalkidan Solomon
- Deribe Kalkidan Solomon
- Desai Rupak
- Desai Rupak
- Desalegn Beruk Berhanu
- Desalegn Beruk Berhanu
- Desta Melaku
- Desta Melaku
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- Dey Subhojit
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- Dharmaratne Samath Dhamminda
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- Dhimal Meghnath
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- Diaz Daniel
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- Dinberu Mesfin Tadese Tadese
- Djalalinia Shirin
- Djalalinia Shirin
- Doku David Teye
- Doku David Teye
- Drake Thomas M
- Drake Thomas M
- Dubey Manisha
- Dubey Manisha
- Dubljanin Eleonora
- Dubljanin Eleonora
- Duken Eyasu Ejeta
- Duken Eyasu Ejeta
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- Ebrahimi Hedyeh
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- Effiong Andem
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- Eftekhari Aziz
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- El Razek Hassan Magdy Abd
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- El Sayed Iman
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- El-Jaafary Shaimaa I
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- El-Khatib Ziad
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- Elemineh Demelash Abewa
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- Elkout Hajer
- Ellenbogen Richard G
- Ellenbogen Richard G
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- Emamian Mohammad Hassan
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- Fischer Florian
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- Fisher James L
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- Force Lisa M
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- Guimaraes Andre Luiz Sena
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- Henry Nathaniel J
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- Muhammed Oumer Sada S
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- Musa Jonah
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- Nixon Molly R
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- Nojomi Marzieh
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- Oh In-Hwan
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- Olagunju Tinuke O
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- Omonisi Abidemi E
- Omonisi Abidemi E
- Onwujekwe Obinna E
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- Oommen Anu Mary
- Oommen Anu Mary
- Oren Eyal
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- Ortega-Altamirano Doris DV
- Ortega-Altamirano Doris DV
- Ota Erika
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- Otstavnov Stanislav S
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- P A Mahesh
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- Padubidri Jagadish Rao
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- Pakpour Amir H
- Pakpour Amir H
- Pana Adrian
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- Parsian Hadi
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- Pashaei Tahereh
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- Patel Shanti
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- Patil Snehal T
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- Pennini Alyssa
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- Pereira David M
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- Pourjafar Hadi
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- Rahimi Mahdi
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- Rahman Muhammad Aziz
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- Rajati Fatemeh
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- Rana Saleem M
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- Raoofi Samira
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- Rath Goura Kishor
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- Rawaf David Laith
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- Rawaf Salman
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- Reiner Robert C
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- Rezaei Nima
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- Rezapour Aziz
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- Sahebkar Amirhossein
- Salahshoor Mohammad Reza
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- Salehi Farkhonde
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- Salimzadeh Hamideh
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- Samy Abdallah M
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- Sepanlou Sadaf G
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- Sepehrimanesh Masood
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- Silva Diego Augusto Santos
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- Singh Ambrish
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- Stathopoulou Vasiliki
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- Tsadik Afewerki Gebremeskel
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- Ullah Irfan
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- Varona Pérez Patricia
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- Veisani Yousef
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- Vos Theo
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- Yeshaneh Alex
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- Yimer Ebrahim M
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- Yisma Engida
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- Yonemoto Naohiro
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- Younis Mustafa Z
- Younis Mustafa Z
- Yousefi Bahman
- Yousefi Bahman
- Yousefifard Mahmoud
- Yousefifard Mahmoud
- Yu Chuanhua
- Yu Chuanhua
- Zabeh Erfan
- Zabeh Erfan
- Zadnik Vesna
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- Zaidi Zoubida
- Zaidi Zoubida
- Zaki Leila
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- Zamani Mohammad
- Zamani Mohammad
- Zandian Hamed
- Zandian Hamed
- Zangeneh Alireza
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- Zendehdel Kazem
- Zendehdel Kazem
- Zenebe Zerihun Menlkalew
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- Zewale Taye Abuhay
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- Ziapour Arash
- Ziapour Arash
- Zodpey Sanjay
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-Adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs). Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care. © 2019 American Medical Association. All rights reserved.Peer reviewe
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
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- Adams Charles Q.
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- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
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- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
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- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
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- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
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- Fennell Stephen
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- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
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- Finley Maria C.
- Finn Robert
- Fischer Heather
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- Fitzgerald Mike
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- Flanagan J.
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- Flint Mark
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- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
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- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
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- Furey Terrence S.
- Furuhashi Mie
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- Gabisi Abdul M.
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- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
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- Garnett Jane
- Garza Melissa
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- Gatland Leigh
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- Gooderham April
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- Grant Michael
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- Griffith Jeffrey K.
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- Griffiths Ed
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- Gui Qi
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- Hamilton Matt
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
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- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
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- Heyen Joshua
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- Hildebrand Carl E.
- Hillier LaDeana
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- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
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- Holden Jane
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- Honan Tracy
- Hood Leroy
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- Howden Philip
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- Huckle Elizabeth
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- Huynh Sandy
- Hyde David
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
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- Ishizaki Hinako
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- Itoh Takehiko
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- Iwatate Mariko
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- Izumiyama Tomohiro
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
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- Jareborg Niclas
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- Jeffery Grant
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- Jia Jia
- Jia Jia
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- Jones Steven
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- Kosiura Anna
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- Krawczyk Marie-Claude
- Kremitzki Colin
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- Kube Michael
- Kubischta Duane
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- Nguyen Ngoc Bich
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- O\u27Leary Sinead
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- Perrin William
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- Zeng Yixin
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- Zhang Haiqing
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- Zhang Yilin
- Zhang Ying
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- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The stoma that appeared from nowhere
- Publication venue
- 'BMJ'
- Publication date
- 20/01/2012
- Field of study
A Case for Dynamic Pipeline Scaling
- Publication venue
- Publication date
- 01/01/2002
- Field of study
Energy consumption can be reduced by scaling down frequency when peak performance is not needed. A lower frequency permits slower circuits, and hence a lower supply voltage. Energy reduction comes from voltage reduction, a technique called Dynamic Voltage Scaling (DVS). This paper makes the case that the useful frequency range of DVS is limited because there is a lower bound on voltage. Lowering frequency permits voltage reduction until the lowest voltage is reached. Beyond that point, lowering frequency further does not save energy because voltage is constant. However, there is still opportunity for energy reduction outside the influence of DVS. If frequency is lowered enough, pairs of pipeline stages can be merged to form a shallower pipeline. The shallow pipeline has better instructions-per-cycle (IPC) than the deep pipeline. Since energy also depends on IPC, energy is reduced for a given frequency. Accordingly, we propose Dynamic Pipeline Scaling (DPS). A DPS-enabled deep pipeline can merge adjacent pairs of stages by making the intermediate latches transparent and disabling corresponding feedback paths. Thus, a DPS-enabled pipeline has a deep mode for higher frequencies within the influence of DVS, and a shallow mode for lower frequencies. Shallow mode extends the frequency range for which energy reduction is possible. For frequencies outside the influence of DVS, a DPS-enabled deep pipeline consumes from 23 % to 40 % less energy than a rigid deep pipeline
A case for dynamic pipeline scaling
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- 01/01/2004
- Field of study
Herpes simplex virus 1 protein UL37 interacts with viral glycoprotein gK and membrane protein UL20 and functions in cytoplasmic virion envelopment
- Author
- Publication venue
- LSU Digital Commons
- Publication date
- 01/01/2014
- Field of study
We have shown that glycoprotein K (gK) and its interacting partner, the UL20 protein, play crucial roles in virion envelopment. Specifically, virions lacking either gK or UL20 fail to acquire an envelope, thus causing accumulation of capsids in the cytoplasm of infected cells. The herpes simplex virus 1 (HSV-1) UL37 protein has also been implicated in cytoplasmic virion envelopment. To further investigate the role of UL37 in virion envelopment, the recombinant virus DC480 was constructed by insertion of a 12-amino-acid protein C (protC) epitope tag within the UL37 amino acid sequence immediately after amino acid 480. The DC480 mutant virus expressed full-size UL37 as detected by the anti-protC antibody in Western immunoblots, accumulated unenveloped capsids in the cytoplasm of infected cells, and produced very small plaques on African green monkey kidney (Vero) cells that were similar in size to those produced by the UL20-null and UL37-null viruses. The DC480 virus replicated nearly 4 log less efficiently than the parental wild-type virus when grown on Vero cells. However, DC480 mutant virus titers increased nearly 20-fold when the virus was grown on FRT cells engineered to express the UL20 gene in comparison to the titers on Vero cells, while the UL37-null virus replicated approximately 20-fold less efficiently than the DC480 virus on FRT cells. Coimmunoprecipitation experiments and proximity ligation assays showed that gK and UL20 interact with the UL37 protein in infected cells. Collectively, these results indicate that UL37 interacts with the gK-UL20 protein complex to facilitate cytoplasmic virion envelopment. © 2014, American Society for Microbiology
Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels
- Author
- Publication venue
- 'The Endocrine Society'
- Publication date
- Field of study
Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo
- Author
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study