Innovating for sustainability: a systematic review of the body of knowledge

publication-status: PublishedThis systematic review identifies activities that firms should be doing to adapt their innovation systems to drive sustainable outcomes. Firms can innovate toward sustainability through a series of small incremental steps or through more radical, disruptive transformations. We call these different contexts “Operational Optimization” and “Systems Building.” A third context, “Organizational Transformation,” is transitional.Network for Business Sustainabilit

Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2

A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alphav beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin. It has been shown to be an informative tool ligand in pre-clinical imaging studies for selective labelling of the αvβ6 integrin in a number of disease models. In a radioligand- binding assay using a radiolabelled form of the peptide ([3H]A20FMDV2), its high affinity (KD:0.22nmol/l) and selectivity (at least 85-fold) for αvβ6 over the other members of the RGD integrin family was confirmed. [3H]A20FMDV2 αvβ6 binding could be fully reversed only in the presence of EDTA, whereas a partial reversal was observed in the presence of excess concentrations of an RGD-mimetic small molecule (SC-68448) or unlabelled A20FMDV2. Using flow cytometry on bronchial epithelial cells, the ligand-induced internalization of αvβ6 by A20FMDV2 and LAP1 was shown to be fast (t1/2:1.5and 3.1 min, respectively), concentration-dependent (EC50:values 1.1 and 3.6nmol/l, respectively) and was followed by a moderately slow return of integrin to the surface. The results of the radioligand-binding studies suggest that the binding of A20FMDV2 to the RGD-binding site on αvβ6 is required to maintain its engagement with the hypothesised A20FMDV2 synergy site on the integrin. In addition, there is evidence from flow cytometric studies that the RGD-ligand engagement of αvβ6 post-internalization plays a role in delaying recycling of the integrin to the cell surface. This mechanism may act as a homeostatic control of membrane αvβ6 following RGD ligand engagement

Antibiotic stories:A mixed-methods, multi-country analysis of household antibiotic use in Malawi, Uganda and Zimbabwe

Background As concerns about the prevalence of infections that are resistant to available antibiotics increase, attention has turned toward the use of these medicines both within and outside of formal healthcare settings. Much of what is known about use beyond formal settings is informed by survey-based research. Few studies to date have used comparative, mixed-methods approaches to render visible patterns of use within and between settings as well as wider points of context shaping these patterns. Design This article analyses findings from mixed-methods anthropological studies of antibiotic use in a range of rural and urban settings in Zimbabwe, Malawi and Uganda between 2018 and 2020. All used a ‘drug bag’ survey tool to capture the frequency and types of antibiotics used among 1811 households. We then undertook observations and interviews in residential settings, with health providers and key stakeholders to better understand the stories behind the most-used antibiotics. Results The most self-reported ‘frequently used’ antibiotics across settings were amoxicillin, cotrimoxazole and metronidazole. The stories behind their use varied between settings, reflecting differences in the configuration of health systems and antibiotic supplies. At the same time, these stories reveal cross-cutting features and omissions of contemporary global health programming that shape the contours of antibiotic (over)use at national and local levels. Conclusions Our findings challenge the predominant focus of stewardship frameworks on the practices of antibiotic end users. We suggest future interventions could consider systems—rather than individuals—as stewards of antibiotics, reducing the need to rely on these medicines to fix other issues of inequity, productivity and security

What do introduction sections tell us about the intent of scholarly work: A contribution on contributions

This paper presents empirical examination of the semantics of contribution claims in the introduction sections of journal articles, a significantly under-examined area of scholarly activity, which underpins the methodical act of communicating the value of research to an audience. The paper presents a systematic review of 538 papers in three leading industrial marketing journals, Industrial Marketing Management, the Journal of Business & Industrial Marketing and the Journal of Business-to-Business Marketing and uses a phased approach to categorize contribution claims made by authors in their introductions and abstracts. The paper identifies four main categories of contribution, defined as incremental, revelatory, replicatory and consolidatory, with sub-categorizations within them, and reports on the proportionality of these strategies in the sample while capturing the semantic games played by authors in pursuit of these claims. Specific findings are of interest to industrial marketers, but the conceptual framework and systematic methods presented in the paper are transferable to any discipline or body of work, and therefore have broader disciplinary appeal. Findings are also of interest to authors, reviewers and editors for coalescing fragmented understanding of contribution strategies into a coherent framework for action

Missed, not missing: Phylogenomic evidence for the existence of Avian FoxP3

The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing view is that FoxP3 is absent in birds and that avian Tregs rely on alternative developmental and suppressive pathways. Prompted by the automated annotation of foxp3 in the ground tit (Parus humilis) genome, we have questioned this assumption. Our analysis of all available avian genomes has revealed that the foxp3 locus is missing, incomplete or of poor quality in the relevant genomic assemblies for nearly all avian species. Nevertheless, in two species, the peregrine falcon (Falco peregrinus) and the saker falcon (F. cherrug), there is compelling evidence for the existence of exons showing synteny with foxp3 in the ground tit. A broader phylogenomic analysis has shown that FoxP3 sequences from these three species are similar to crocodilian sequences, the closest living relatives of birds. In both birds and crocodilians, we have also identified a highly proline-enriched region at the N terminus of FoxP3, a region previously identified only in mammals

Colonial lives of the carceral archipelago: rethinking the neoliberal security state

Mass incarceration, police brutality, and border controls are part and parcel of the everyday experiences of marginalized and racialized communities across the world. Recent scholarship in international relations, sociology, and geography has examined the prevalence of these coercive practices through the prism of “disciplinary,” “penal,” or “authoritarian” neoliberalism. In this collective discussion, we argue that although this literature has brought to the fore neoliberalism's reliance on state violence, it has yet to interrogate how these carceral measures are linked to previous forms of global racial ordering. To rectify this moment of “colonial unknowing,” the collective discussion draws on decolonial approaches, Indigenous studies, and theories of racial capitalism. It demonstrates that “new” and “neoliberal” forms of domestic control must be situated within the global longue durée of racialized and colonial accumulation by dispossession. By mapping contemporary modes of policing, incarceration, migration control, and surveillance onto earlier forms of racial–colonial subjugation, we argue that countering the violence of neoliberalism requires more than nostalgic appeals for a return to Keynesianism. What is needed is abolition—not just of the carceral archipelago, but of the very system of racial capitalism that produces and depends on these global vectors of organized violence and abandonment. L'incarcération de masse, la brutalité policière et les contrôles aux frontières constituent une partie intégrante des expériences quotidiennes des communautés marginalisées et racialisées du monde entier. Des études récentes en relations internationales, en sociologie et en géographie ont examiné la prévalence de ces pratiques coercitives par le prisme du néolibéralisme « disciplinaire », « pénal » ou « autoritaire ». Dans cet article, nous soutenons que bien que cette littérature ait mis en évidence la dépendance du néolibéralisme à la violence étatique, elle ne s'est pas encore interrogée sur le lien entre ces mesures carcérales et les formes précédentes d'ordre racial mondial. Cet article s'appuie sur le féminisme noir, les approches décoloniales, les études indigènes et les théories de capitalisme racial pour rectifier cette « ignorance coloniale » marquante. Il démontre que les formes « nouvelles » et « néolibérales » de contrôle national doivent se situer dans la longue durée globale de l'accumulation racialisée et coloniale par dépossession. Nous associons les modes contemporains de maintien de l'ordre, d'incarcération, de contrôle migratoire et de surveillance à des formes antérieures d'assujettissement racial/colonial pour soutenir que contrer la violence du néolibéralisme exige davantage que des appels nostalgiques au retour du keynésianisme. Ce qu'il faut, c'est une abolition : non seulement de l'archipel carcéral, mais aussi du système de capitalisme racial en lui-même qui produit et dépend de ces vecteurs globaux de violence organisée et d'abandon. El encarcelamiento masivo, la brutalidad policial y los controles fronterizos forman parte de las experiencias cotidianas de las comunidades marginadas y racializadas de todo el mundo. Estudios recientes en RI, Sociología y Geografía han examinado la prevalencia de estas prácticas coercitivas a través del prisma del neoliberalismo “disciplinario,” “penal” o “autoritario.” En este artículo, sostenemos que, si bien esta literatura puso en primer plano la dependencia del neoliberalismo de la violencia estatal, aún tiene que cuestionar la manera en que estas medidas carcelarias se vinculan a formas anteriores de ordenamiento racial global. Para rectificar este momento de “desconocimiento colonial,” el artículo recurre al feminismo negro, a los abordajes descoloniales, a los estudios indígenas y a las teorías del capitalismo racial. Demuestra que las formas “nuevas” y “neoliberales” de control interno se deben situar dentro de la longue durée global de la acumulación por desposesión racializada y colonial. Al trazar un mapa de los modos contemporáneos de vigilancia policial, encarcelamiento, control de la migración y vigilancia sobre las formas anteriores de subyugación racial-colonial, sostenemos que contrarrestar la violencia del neoliberalismo requiere algo más que apelaciones nostálgicas de retorno al keynesianismo. Lo que se necesita es la abolición, no solo del archipiélago carcelario, sino también del propio sistema de capitalismo racial que produce y depende de estos vectores globales de violencia y abandono organizados

Educational Pr0gram in Pasture Management for the Cedar Vale Community

Agricultural Educatio

Breathing patterns and aerosol delivery: impact of regular human patterns, and sine and square waveforms on rate of delivery

In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns to those obtained with matching sine and square waveforms. Regular human breathing patterns with tidal volumes (VT) of approximately 40, approximately 200, approximately 500, and approximately 800 mL were selected. Sine and square waveforms that matched the VT, peak inspiratory flow rate (PIF), breathing frequency (f), and inspiratory duty cycle (t(i)/t(tot)) of the human breathing patterns were created with a breathing simulator. The rate of delivery of nebulized technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTC-DTPA) from two different jet nebulizer brands was determined. The rate of delivery was defined as the amount of the 99mTC-DTPA deposited during 30 sec of nebulization on a filter placed between the nebulizer and the breathing simulator. The rate of delivery of 99mTC-DTPA with the human breathing pattern was similar to that measured with the matching sine or square waveforms for either nebulizer. The configuration of the breath (PIF, VT, f, t(i)/t(tot)) did, however, influence the rate of delivery. In conclusion, the shape of the waveform, in other words, one resulting from a human breathing pattern, or a matching sine or square waveform, did not influence the rate of 99mTC-DTPA delivery from a nebulizer in vitro