18 research outputs found
Systems medicine and integrated care to combat chronic noncommunicable diseases
We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems
Agroforesterie et services écosystémiques en zone tropicale
Respectueux de lâenvironnement et garantissant une sĂ©curitĂ© alimentaire soutenue par la diversification des productions et des revenus quâils procurent, les systĂšmes agroforestiers apparaissent comme un modĂšle prometteur dâagriculture durable dans les pays du Sud les plus vulnĂ©rables aux changements globaux. Cependant, ces systĂšmes agroforestiers ne peuvent ĂȘtre optimisĂ©s quâĂ condition de mieux comprendre et de mieux maĂźtriser les facteurs de leurs productions. Lâouvrage prĂ©sente un ensemble de connaissances rĂ©centes sur les mĂ©canismes biophysiques et socio-Ă©conomiques qui sous-tendent le fonctionnement et la dynamique des systĂšmes agroforestiers. Il concerne, dâune part les systĂšmes agroforestiers Ă base de cultures pĂ©rennes, telles que cacaoyers et cafĂ©iers, de rĂ©gions tropicales humides en AmĂ©rique du Sud, en Afrique de lâEst et du Centre, dâautre part les parcs arborĂ©s et arbustifs Ă base de cultures vivriĂšres, principalement de cĂ©rĂ©ales, de la rĂ©gion semi-aride subsaharienne dâAfrique de lâOuest. Il synthĂ©tise les derniĂšres avancĂ©es acquises grĂące Ă plusieurs projets associant le Cirad, lâIRD et leurs partenaires du Sud qui ont Ă©tĂ© conduits entre 2012 et 2016 dans ces rĂ©gions. Lâensemble de ces projets sâarticulent autour des dynamiques des systĂšmes agroforestiers et des compromis entre les services de production et les autres services socio-Ă©cosystĂ©miques que ces systĂšmes fournissent
Influence of additives and water vapour on the transformation of transition aluminas into alpha alumina
International audienceAddition of magnesium cations to gamma (and delta) alumina enhances its rate of transformation into alpha alumina, whereas addition of zirconium cations inhibits it. The effect of adding both magnesium and zirconium cations at various concentrations from 0.5 to 5% to aluminium ions has been studied. The kinetic curves of transformation into alpha alumina at 1373 K are reported. The effects observed are in agreement with the D.T.A. measurements. Changes in surface area accompanying the phase transformation have also been measured. A synergy effect may occur between magnesium and zirconium behaviours, since maximum stabilization of the surface area is found with a particular co-doped product (Mg2+(1%)-Zrsup>4+(0.5%)). In the case of pure alumina, the influence of water vapour in the range 1-20 torr has also been investigated with the same methods. The results show that water vapour enhances the rate of transformation into alpha
Systems Medicine and Integrated Care to Combat Chronic Noncommunicable Diseases
We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems
Carbon allocation in fruit trees: from theory to modelling
International audienceCarbon allocation within a plant depends on complex rules linking source organs (mainly shoots) and sink organs (mainly roots and fruits). The complexity of these rules comes from both regulations and interactions between various plant processes involving carbon. This paper presents these regulations and interactions, and analyses how agricultural management can influence them. Ecophysiological models of carbon production and allocation are good tools for such analyses. The fundamental bases of these models are first presented, focusing on their underlying processes and concepts. Different approaches are used for modelling carbon economy. They are classified as empirical, teleonomic, driven by sourceâsink relationships, or based on transport and chemical/biochemical conversion concepts. These four approaches are presented with a particular emphasis on the regulations and interactions between organs and between processes. The role of plant architecture in carbon partitioning is also discussed and the interest of coupling plant architecture models with carbon allocatio
Lâinfluence de la PEP sur le dĂ©bit sanguin rĂ©gional est diffĂ©rente selon que lâabdomen est fermĂ© ou ouvert : Un modĂšle expĂ©rimental chez le lapin
Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies
Chronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing)
MACVIA-LR, Reference site of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) in Languedoc Roussillon
International audienc