128 research outputs found
Contribution of ocean, fossil fuel, land biosphere, and biomass burning carbon fluxes to seasonal and interannual variability in atmospheric CO2
Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 113 (2008): G01010, doi:10.1029/2007JG000408.Seasonal and interannual variability in atmospheric carbon dioxide (CO2) concentrations was simulated using fluxes from fossil fuel, ocean and terrestrial biogeochemical models, and a tracer transport model with time-varying winds. The atmospheric CO2 variability resulting from these surface fluxes was compared to observations from 89 GLOBALVIEW monitoring stations. At northern hemisphere stations, the model simulations captured most of the observed seasonal cycle in atmospheric CO2, with the land tracer accounting for the majority of the signal. The ocean tracer was 3â6 months out of phase with the observed cycle at these stations and had a seasonal amplitude only âŒ10% on average of observed. Model and observed interannual CO2 growth anomalies were only moderately well correlated in the northern hemisphere (R ⌠0.4â0.8), and more poorly correlated in the southern hemisphere (R < 0.6). Land dominated the interannual variability (IAV) in the northern hemisphere, and biomass burning in particular accounted for much of the strong positive CO2 growth anomaly observed during the 1997â1998 El Niño event. The signals in atmospheric CO2 from the terrestrial biosphere extended throughout the southern hemisphere, but oceanic fluxes also exerted a strong influence there, accounting for roughly half of the IAV at many extratropical stations. However, the modeled ocean tracer was generally uncorrelated with observations in either hemisphere from 1979â2004, except during the weak El Niño/post-Pinatubo period of the early 1990s. During that time, model results suggested that the ocean may have accounted for 20â25% of the observed slowdown in the atmospheric CO2 growth rate.We acknowledge the support of NASA
grant NNG05GG30G and NSF grant ATM0628472
The effects of CO2, climate and land-use on terrestrial carbon balance, 1920-1992: An analysis with four process-based ecosystem models
The concurrent effects of increasing atmospheric CO2 concentration, climate variability, and cropland establishment and abandonment on terrestrial carbon storage between 1920 and 1992 were assessed using a standard simulation protocol with four process-based terrestrial biosphere models. Over the long-term(1920â1992), the simulations yielded a time history of terrestrial uptake that is consistent (within the uncertainty) with a long-term analysis based on ice core and atmospheric CO2 data. Up to 1958, three of four analyses indicated a net release of carbon from terrestrial ecosystems to the atmosphere caused by cropland establishment. After 1958, all analyses indicate a net uptake of carbon by terrestrial ecosystems, primarily because of the physiological effects of rapidly rising atmospheric CO2. During the 1980s the simulations indicate that terrestrial ecosystems stored between 0.3 and 1.5 Pg C yrâ1, which is within the uncertainty of analysis based on CO2 and O2 budgets. Three of the four models indicated (in accordance with O2 evidence) that the tropics were approximately neutral while a net sink existed in ecosystems north of the tropics. Although all of the models agree that the long-term effect of climate on carbon storage has been small relative to the effects of increasing atmospheric CO2 and land use, the models disagree as to whether climate variability and change in the twentieth century has promoted carbon storage or release. Simulated interannual variability from 1958 generally reproduced the El Niño/Southern Oscillation (ENSO)-scale variability in the atmospheric CO2 increase, but there were substantial differences in the magnitude of interannual variability simulated by the models. The analysis of the ability of the models to simulate the changing amplitude of the seasonal cycle of atmospheric CO2 suggested that the observed trend may be a consequence of CO2 effects, climate variability, land use changes, or a combination of these effects. The next steps for improving the process-based simulation of historical terrestrial carbon include (1) the transfer of insight gained from stand-level process studies to improve the sensitivity of simulated carbon storage responses to changes in CO2 and climate, (2) improvements in the data sets used to drive the models so that they incorporate the timing, extent, and types of major disturbances, (3) the enhancement of the models so that they consider major crop types and management schemes, (4) development of data sets that identify the spatial extent of major crop types and management schemes through time, and (5) the consideration of the effects of anthropogenic nitrogen deposition. The evaluation of the performance of the models in the context of a more complete consideration of the factors influencing historical terrestrial carbon dynamics is important for reducing uncertainties in representing the role of terrestrial ecosystems in future projections of the Earth system
Long-term follow-up and treatment of congenital alveolar proteinosis
<p>Abstract</p> <p>Background</p> <p>Clinical presentation, diagnosis, management and outcome of molecularly defined congenital pulmonary alveolar proteinosis (PAP) due to mutations in the GM-CSF receptor are not well known.</p> <p>Case presentation</p> <p>A 2 1/2 years old girl was diagnosed as having alveolar proteinosis. Whole lung lavages were performed with a new catheter balloon technique, feasible in small sized airways. Because of some interstitial inflammation in the lung biopsy and to further improve the condition, empirical therapy with systemic steroids and azathioprin, and inhaled and subcutaneous GMCSF, were used. Based on clinical measures, total protein and lipid recovered by whole lung lavages, all these treatments were without benefit. Conversely, severe respiratory viral infections and an invasive aspergillosis with aspergilloma formation occurred. Recently the novel homozygous stop mutation p.Ser25X of the GMCSF receptor alpha chain was identified in the patient. This mutation leads to a lack of functional GMCSF receptor and a reduced response to GMCSF stimulation of CD11b expression of mononuclear cells of the patient. Subsequently a very intense treatment with monthly lavages was initiated, resulting for the first time in complete resolution of partial respiratory insufficiency and a significant improvement of the overall somato-psychosocial condition of the child.</p> <p>Conclusions</p> <p>The long term management from early childhood into young adolescence of severe alveolar proteinosis due to GMCSF receptor deficiency requires a dedicated specialized team to perform technically demanding whole lung lavages and cope with complications.</p
Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients
<p>Abstract</p> <p>Background</p> <p>Patients with Adult Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid. No information is available on their turnover.</p> <p>Objectives</p> <p>To analyze disaturated-phosphatidylcholine and surfactant protein-B turnover in patients with ARDS/ALI and in human adults with normal lungs (controls).</p> <p>Methods</p> <p><sup>2</sup>H<sub>2</sub>O as precursor of disaturated-phosphatidylcholine-palmitate and 1<sup>13</sup>C-Leucine as precursor of surfactant protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls. Disaturated-phosphatidylcholine and surfactant protein-B were isolated from serial tracheal aspirates, and their fractional synthetic rate was derived from the <sup>2</sup>H and <sup>13</sup>C enrichment curves, obtained by gas chromatography mass spectrometry. Disaturated-phosphatidylcholine, surfactant protein-B, and protein concentrations in tracheal aspirates were also measured.</p> <p>Results</p> <p>1) Surfactant protein-B turned over at faster rate than disaturated-phosphatidylcholine both in ARDS/ALI patients and in controls. 2) In patients with ARDS/ALI the fractional synthesis rate of disaturated-phosphatidylcholine was 3.1 times higher than in controls (p < 0.01), while the fractional synthesis rate of surfactant protein-B was not different. 3) In ARDS/ALI patients the concentrations of disaturated-phosphatidylcholine and surfactant protein-B in tracheal aspirates were markedly and significantly reduced (17% and 40% of the control values respectively).</p> <p>Conclusions</p> <p>1) Disaturated-phosphatidylcholine and surfactant protein-B have a different turnover both in healthy and diseased lungs. 2) In ARDS/ALI the synthesis of these two surfactant components may be differently regulated.</p
Current systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system
A globally integrated carbon observation and analysis system is needed to
improve the fundamental understanding of the global carbon cycle, to improve
our ability to project future changes, and to verify the effectiveness of
policies aiming to reduce greenhouse gas emissions and increase carbon
sequestration. Building an integrated carbon observation system requires
transformational advances from the existing sparse, exploratory framework
towards a dense, robust, and sustained system in all components:
anthropogenic emissions, the atmosphere, the ocean, and the terrestrial
biosphere. The paper is addressed to scientists, policymakers, and funding
agencies who need to have a global picture of the current state of the
(diverse) carbon observations. We identify the current state of carbon
observations, and the needs and notional requirements for a global integrated
carbon observation system that can be built in the next decade. A key
conclusion is the substantial expansion of the ground-based observation
networks required to reach the high spatial resolution for CO<sub>2</sub> and
CH<sub>4</sub> fluxes, and for carbon stocks for addressing policy-relevant
objectives, and attributing flux changes to underlying processes in each
region. In order to establish flux and stock diagnostics over areas such as
the southern oceans, tropical forests, and the Arctic, in situ observations
will have to be complemented with remote-sensing measurements. Remote sensing
offers the advantage of dense spatial coverage and frequent revisit. A key
challenge is to bring remote-sensing measurements to a level of long-term
consistency and accuracy so that they can be efficiently combined in models
to reduce uncertainties, in synergy with ground-based data. Bringing tight
observational constraints on fossil fuel and land use change emissions will
be the biggest challenge for deployment of a policy-relevant integrated
carbon observation system. This will require in situ and remotely sensed data
at much higher resolution and density than currently achieved for natural
fluxes, although over a small land area (cities, industrial sites, power
plants), as well as the inclusion of fossil fuel CO<sub>2</sub> proxy measurements
such as radiocarbon in CO<sub>2</sub> and carbon-fuel combustion tracers.
Additionally, a policy-relevant carbon monitoring system should also provide
mechanisms for reconciling regional top-down (atmosphere-based) and bottom-up
(surface-based) flux estimates across the range of spatial and temporal
scales relevant to mitigation policies. In addition, uncertainties for each
observation data-stream should be assessed. The success of the system will
rely on long-term commitments to monitoring, on improved international
collaboration to fill gaps in the current observations, on sustained efforts
to improve access to the different data streams and make databases
interoperable, and on the calibration of each component of the system to
agreed-upon international scales
Is the northern high-latitude land-based CO2 sink weakening?
Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 25 (2011): GB3018, doi:10.1029/2010GB003813.Studies indicate that, historically, terrestrial ecosystems of the northern high-latitude region may have been responsible for up to 60% of the global net land-based sink for atmospheric CO2. However, these regions have recently experienced remarkable modification of the major driving forces of the carbon cycle, including surface air temperature warming that is significantly greater than the global average and associated increases in the frequency and severity of disturbances. Whether Arctic tundra and boreal forest ecosystems will continue to sequester atmospheric CO2 in the face of these dramatic changes is unknown. Here we show the results of model simulations that estimate a 41 Tg C yrâ1 sink in the boreal land regions from 1997 to 2006, which represents a 73% reduction in the strength of the sink estimated for previous decades in the late 20th century. Our results suggest that CO2 uptake by the region in previous decades may not be as strong as previously estimated. The recent decline in sink strength is the combined result of (1) weakening sinks due to warming-induced increases in soil organic matter decomposition and (2) strengthening sources from pyrogenic CO2 emissions as a result of the substantial area of boreal forest burned in wildfires across the region in recent years. Such changes create positive feedbacks to the climate system that accelerate global warming, putting further pressure on emission reductions to achieve atmospheric stabilization targets.This study was supported through grants
provided as part of the Arctic System Science Program (NSF OPPâ
0531047), the North American Carbon Program (NASA NNG05GD25G),
and the Bonanza Creek LongâTerm Ecological Program (funded jointly by
NSF grant DEBâ0423442 and USDA Forest Service, Pacific Northwest
Research Station grant PNW01âJV11261952â231)
The N3RO trial: a randomised controlled trial of docosahexaenoic acid to reduce bronchopulmonary dysplasia in preterm infants <â29Â weeksâ gestation
Morphological alterations of exogenous surfactant inhibited by meconium can be prevented by dextran
BACKGROUND: Surfactant dysfunction due to inhibition is involved in the pathophysiology of meconium aspiration syndrome. Dextran addition has been shown to reverse exogenous surfactant inactivation by meconium, but the precise mechanisms and the morphological correlate of this effect are yet unknown. Morphological surfactant analysis by transmission electron microscopy (TEM) and stereology allows the differentiation of active (large aggregates = LA) and inactive (small aggregates = SA) subtypes. METHODS: To determine the in vitro effects of meconium and dextran addition on the morphology of a modified porcine natural surfactant (Curosurf), Curosurf samples were either incubated alone or together with meconium or with meconium and dextran, fixed and processed for TEM. Volume fractions of surfactant subtypes [lamellar body-like forms (LBL), multilamellar vesicles (MV), unilamellar vesicles (UV)] were determined stereologically. RESULTS: All preparations contained LBL and MV (corresponding to LA) as well as UV (corresponding to SA). The volume fraction of UV increased with addition of meconium and decreased with further addition of dextran. Correspondingly, the UV/(LBL+MV) ratio (resembling the SA/LA ratio) increased when meconium was added and decreased when dextran was added to the surfactant-meconium mixture. CONCLUSION: Meconium causes alterations in the ultrastructural composition of Curosurf that can be visualized and analyzed by TEM and stereology. These alterations resemble an increase in the SA/LA ratio and are paralleled by an increase in minimum surface tension. Dextran prevents these effects and may therefore be a useful additive to exogenous surfactant preparations to preserve their structural and functional integrity, thereby improving their resistance to inactivation
Theory of Chemical Kinetics and Charge Transfer based on Nonequilibrium Thermodynamics
Classical theories of chemical kinetics assume independent reactions in
dilute solutions, whose rates are determined by mean concentrations. In
condensed matter, strong interactions alter chemical activities and create
inhomogeneities that can dramatically affect the reaction rate. The extreme
case is that of a reaction coupled to a phase transformation, whose kinetics
must depend on the order parameter -- and its gradients, at phase boundaries.
This Account presents a general theory of chemical kinetics based on
nonequilibrium thermodynamics. The reaction rate is a nonlinear function of the
thermodynamic driving force (free energy of reaction) expressed in terms of
variational chemical potentials. The Cahn-Hilliard and Allen-Cahn equations are
unified and extended via a master equation for non-equilibrium chemical
thermodynamics. For electrochemistry, both Marcus and Butler-Volmer kinetics
are generalized for concentrated solutions and ionic solids. The theory is
applied to intercalation dynamics in the phase separating Li-ion battery
material LiFePO.Comment: research account, 17 two-column pages, 12 figs, 78 refs - some typos
corrected Accounts of Chemical Research (2013
Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants
© 2017 The Author(s). Background: Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact upon the validity of data for benchmarking purposes. Method: Data from all VLGA or VLBW infants admitted in the 3 Networks between 2008 and 2011 were used. Two-thirds of each network cohort was randomly selected to develop prediction models for mortality and composite adverse outcome (CAO: mortality or cerebral injuries, chronic lung disease, severe retinopathy or necrotizing enterocolitis) and the remaining for internal validation. Areas under the ROC curves (AUC) of the models were compared. Results: VLBW cohort (24,335 infants) had twice more SGA infants (20.4% vs. 9.3%) than the VLGA cohort (29,180 infants) and had a higher rate of CAO (36.5% vs. 32.6%). The two models had equal prediction power for mortality and CAO (AUC 0.83), and similarly for all other cross-cohort validations (AUC 0.81-0.85). Neither model performed well for the extremes of birth weight for gestation (<1500 g and â„32 weeks, AUC 0.50-0.65; â„1500 g and <32 weeks, AUC 0.60-0.62). Conclusion: There was no difference in prediction power for adverse outcome between cohorting VLGA or VLBW despite substantial bias in SGA population. Either cohorting practises are suitable for international benchmarking
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