Routing in the Space Internet: A contact graph routing tutorial

A Space Internet is possible, as long as the delay and disruption challenges imposed by the space environment are properly tackled. Because these conditions are not well addressed by terrestrial Internet, more capable Delay-Tolerant Networking (DTN) protocols and algorithms are being developed. In particular, the principles and techniques for routing among ground elements and spacecraft in near-Earth orbit and deep-space are enacted in the Contact Graph Routing (CGR) framework. CGR blends a set of non-trivial algorithm adaptations, space operations concepts, time-dynamic scheduling, and specific graph models. The complexity of that framework suggests a need for a focused discussion to facilitate its direct and correct apprehension. To this end, we present an in-depth tutorial that collects and organizes first-hand experience on researching, developing, implementing, and standardizing CGR. Content is laid out in a structure that considers the planning, route search and management, and forwarding phases bridging ground and space domains. We rely on intuitive graphical examples, supporting code material, and references to flight-grade CGR implementations details where pertinent. We hope this tutorial will serve as a valuable resource for engineers and that researchers can also apply the insights presented here to topics in DTN research.Fil: Fraire, Juan Andres. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Universitat Saarland; AlemaniaFil: De Jonckère, Olivier. Technische Universität Dresden; AlemaniaFil: Burleigh, Scott C.. California Institute of Technology; Estados Unido

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

SummaryObjectiveThe role of inflammation in structural and symptomatic osteoarthritis (OA) remains unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for attracting monocytes to sites of injury. We investigated the role of CCL2 and its receptor CCR2 in experimental OA.DesignOA was induced in 10 weeks old male wild type (WT), Ccl2−/− and Ccr2−/− mice, by destabilisation of the medial meniscus (DMM). RNA was extracted from whole joints at 6 h and 7 days post-surgery and examined by reverse transcription polymerase chain reaction (RT-PCR). Gene expression changes between naïve and DMM-operated mice were compared. Chondropathy scores, from mice at 8, 12, 16 and 20 weeks post DMM were calculated using modified Osteoarthritis Research Society International (OARSI) grading systems. Changes in hind paw weight distribution, as a measure of pain, were assessed by Linton incapacitance.ResultsAbsence of CCL2 strongly suppressed (>90%) selective inflammatory response genes in the joint 6 h post DMM, including arginase 1, prostaglandin synthase 2, nitric oxide synthase 2 and inhibin A. IL6, MMP3 and tissue inhibitor of metalloproteinase 1 were also significantly suppressed. Similar trends were also observed in the absence of CCR2. A lower average chondropathy score was observed in both Ccl2−/− and Ccr2−/− mice at 12, 16 and 20 weeks post DMM compared with WT mice, but this was only statistically significant at 20 weeks in Ccr2−/− mice. Pain-related behaviour in Ccl2−/− and Ccr2−/− mice post DMM was delayed in onset.ConclusionThe CCL2/CCR2 axis plays an important role in the development of pain in murine OA, but contributes little to cartilage damage

Detached white dwarf main-sequence star binaries

We considered the formation of detached white dwarf main-sequence star (WDMS) binaries through seven evolutionary channels subdivided according to the evolutionary process that gives rise to the formation of the white dwarf or its helium-star progenitor: dynamically stable Roche-lobe overflow (Algol-type evolution), dynamically unstable Roche-lobe overflow (common-envelope evolution), or stellar winds (single star evolution). We examine the sensitivity of the population to changes in the amount of mass lost from the system during stable Roche-lobe overflow, the common-envelope ejection efficiency, and the initial mass ratio or initial secondary mass distribution. In the case of a flat initial mass ratio distribution, the local space density of WDMS binaries is of the order of 10^{-3}/pc^3. This number decreases to 10^{-4}/pc^3 when the initial mass ratio distribution is approximately proportional to the inverse of the initial mass ratio. More than 75% of the WDMS binary population stems from wide systems in which both components evolve as if they were single stars. The remaining part of the population is dominated by systems in which the white dwarf is formed in a common-envelope phase. The birthrate of WDMS binaries forming through a common-envelope phase is about 10 times larger than the birthrate of WDMS binaries forming through a stable Roche-lobe overflow phase. The ratio of the number of helium white dwarf systems to the number of carbon/oxygen or oxygen/neon/magnesium white dwarf systems derived from large samples of observed WDMS binaries by, e.g., future planet-search missions such as SuperWASP, COROT, and Kepler may furthermore constrain the common-envelope ejection efficiency.Comment: 22 pages, accepted for publication in A&

From Connectivity to Advanced Internet Services: A Comprehensive Review of Small Satellites Communications and Networks

Recently the availability of innovative and affordable COTS (Commercial Off The Shelf) technological solutions and the ever improving results of microelectronics and microsystems technologies have enabled the design of ever smaller yet ever more powerful satellites. The emergence of very capable small satellites heralds an era of new opportunities in the commercial space market. Initially applied only to scientific missions, earth observation and remote sensing, small satellites are now being deployed to support telecommunications services. This review paper examines the operational features of small satellites that contribute to their success. An overview of recent advances and development trends in the field of small satellites is provided, with a special focus on telecommunication aspects such as the use of higher frequency bands, optical communications, new protocols, and advanced architectures

Born Again Protoplanetary Disk Around Mira B

The Mira AB system is a nearby (~107 pc) example of a wind accreting binary star system. In this class of system, the wind from a mass-losing red giant star (Mira A) is accreted onto a companion (Mira B), as indicated by an accretion shock signature in spectra at ultraviolet and X-ray wavelengths. Using novel imaging techniques, we report the detection of emission at mid-infrared wavelengths between 9.7 and 18.3 $\mu$m from the vicinity of Mira B but with a peak at a radial position about 10 AU closer to the primary Mira A. We interpret the mid-infrared emission as the edge of an optically-thick accretion disk heated by Mira A. The discovery of this new class of accretion disk fed by M-giant mass loss implies a potential population of young planetary systems in white-dwarf binaries which has been little explored, despite being relatively common in the solar neighborhood.Comment: Accepted for Ap

An NGS-based phylogeny of Orthotricheae (Orthotrichaceae, Bryophyta) with the proposal of the new genus Rehubryum from Zealandia

Phylogenomic data increase the possibilities of resolving the evolutionary and systematic relationships among taxa. This is especially valuable in groups with few and homoplasious morphological characters, in which systematic and taxonomical delimitations have been traditionally difficult. Such is the case of several lineages within Bryophyta, like Orthotrichaceae, the second most diverse family of mosses. Members of tribe Orthotricheae are common in temperate and cold regions, as well as in high tropical mountains. In extratropical areas, they represent one of the main components of epiphytic communities, both in dry and oceanic or hyperoceanic conditions. The epiphytic environment is considered a hostile one for plant development, mainly due to its low capacity of moisture retention. Thus, the diversification of the Orthotrichaceae in this environment could be seen as striking. Over the last two decades, great taxonomic and systematic progresses have led to a rearrangement at the generic level in this tribe, providing a new framework to link environment to patterns of diversification. Here, we use nuclear loci targeted with the GoFlag 408 enrichment probe set to generate a well-sampled phylogeny with well-supported suprageneric taxa and increasing the phylogenetic resolution within the two recognized subtribes. Specifically, we show that several genera with Ulota-like morphology jointly constitute an independent lineage. Within this lineage, the recently described Atlantichella from Macaronesia and Western Europe appears as the sister group of Ulota bellii from Zealandia. This latter species is here segregated in the new genus Rehubryum. Assessment of the ecological and biogeographical affinities of the species within the phylogenetic framework suggests that niche adaptation (including climate and substrate) may be a key evolutionary driver that shaped the high diversification of Orthotrichea

What is Life Worth? A Rough Guide to Valuation

In this speculative article, the aim is to elaborate a definition of life that is not biological, and a valuation of it that is not commodified. This is undertaken by the development of an understanding of death as a process which is embedded in the life of a community. The idea is that we can best understand what life is worth by first understanding what death means

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.

BACKGROUND: Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. RESULTS: We show here, using 1 million exon mouse arrays (Exon 1.0 Affymetrix) and quantitative polymerase chain reaction (QPCR) validation to analyse microdissected hypothalamic tissue from Gpr54 and Kiss1 knockout mice, the extent of transcriptional regulation in the hypothalamus. The sensitivity to detect important transcript differences in microdissected RNA was confirmed by the observation of counter-regulation of Kiss1 expression in Gpr54 knockouts and confirmed by immunohistochemistry (IHC). Since Gpr54 and Kiss1 knockout animals are effectively pre-pubertal with low testosterone (T) levels, we also determined which of the validated transcripts were T-responsive and which varied according to genotype alone. We observed four types of transcriptional regulation (i) genotype only dependent regulation, (ii) T only dependent regulation, (iii) genotype and T-dependent regulation with interaction between these variables, (iv) genotype and T-dependent regulation with no interaction between these variables. The results implicate for the first time several transcription factors (e.g. Npas4, Esr2), proteases (Klk1b22), and the orphan 10-transmembrane transporter TMEM144 in the biology of GPR54/kisspeptin function in the hypothalamus. We show for the neuronal activity regulated transcription factor NPAS4, that distinct protein over-expression is seen in the hypothalamus and hippocampus in Gpr54 knockout mice. This links for the first time the hypothalamic-gonadal axis with this important regulator of inhibitory synapse formation. Similarly we confirm TMEM144 up-regulation in the hypothalamus by RNA in situ hybridization and western blot. CONCLUSIONS: Taken together, global transcriptional profiling shows that loss of GPR54 and kisspeptin are not fully equivalent in the mouse hypothalamus.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets