215 research outputs found
Design and Synthesis of Novel Hyperforin Analogues - Fascinating skeletal rearrangements of polycyclic polyprenylated acylphloroglucinols core
Get PDFAn Unusual Michael-Induced Skeletal Rearrangement of a Bicyclo[3.3.1]nonane Framework of Phloroglucinols to a Novel Bioactive Bicyclo[3.3.0]octane
Get PDFA novel skeletal rearrangement of bicyclo[3.3.1]nonane-2,4,9-trione (16) to an unprecedented highly functionalized bicyclo[3.3.0]octane system (17), induced by an intramolecular Michael addition, is presented. This novel framework was found to be similarly active to hyperforin (1), against PC-3 cell lines. A mechanistic study was examined in detail, proposing a number of cascade transformations. Also, reactivity of the Δ7,10-double bond was examined under several conditions to explain the above results
Catalytic Asymmetric Aldehyde Prenylation and Application in the Total Synthesis of (‒)-Rosiridol and (‒)-Bifurcadiol
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ChemInform Abstract: Stereoselective Synthesis of Sugar-Amino Acid Conjugates. A Novel Class of Amino Sugars.
No full textChemInform Abstract: A General Synthetic Route Towards Bastadins. Part 2. Synthesis of the Western Part of Bastadins 4-16, and Fully Functionalized Macrocycle of Bastadin 12.
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