The large-scale energetic ion layer in the high latitude Jovian magnetosphere as revealed by Ulysses/HI-SCALE cross-field intensity-gradient measurements

Ulysses investigated the high latitude Jovian magnetosphere for a second time after Pioneer 11 mission and gave us the opportunity to search the structure and the dynamics of this giant magnetosphere above the magnetodisc. Kivelson(1976) and Kennel & Coroniti(1979) reported that Pioneer 11 observed energetic particle intensities at high latitudes at the same level with those measured in the plasma sheet and inferred that they were not consistent with the magnetodisc model. Ulysses observations supported the idea about a large-scale layer of energetic ions and electrons in the outer high latitude Jovian magnetosphere (Cowley et al.1996; Anagnostopoulos et al. 2001). This study perform a number of further tests for the existence of the large scale layer of energetic ions in the outer high latitude Jovian magnetosphere by studying appropriate cross-B field anisotropies in order to monitor the ion northward/southward intensity gradients. In particular, we examined Ulysses/HI-SCALE observations of energetic ions with large gyro-radius (0.5-1.6MeV protons and >2.5MeV heavy(Z>5) ions) in order to compare instant intensity changes with remote sensing intensity gradients. Our analysis confirms the existence of an energetic particle layer in the north hemisphere, during the inbound trajectory of Ulysses traveling at moderate latitudes, and in the south high-latitude duskside magnetosphere, during the outbound segment of the spacecraft trajectory. Our Ulysses/HI-SCALE data analysis also provides evidence for the detection of an energetic proton magnetopause boundary layer during the outbound trajectory of the spacecraft. During Ulysses flyby of Jupiter the almost permanent appearance of alternative northward and southward intensity gradients suggests that the high latitude layer appeared to be a third major area of energetic particles, which coexisted with the radiation belts and the magnetodisc.Comment: 37 pages, 11 figures, 1 tabl

An Australian longitudinal pilot study examining health determinants of cardiac outcomes 12 months post percutaneous coronary intervention

Background Percutaneous coronary intervention (PCI) is a very common revascularisation procedure for coronary artery disease (CAD). The purpose of this study was to evaluate cardiac outcomes, health related quality of life (HRQoL), resilience and adherence behaviours in patients who have undergone a PCI at two time points (6 and 12 months) following their procedure. Methods A longitudinal pilot study was conducted to observe the cardiac outcomes across a cohort of patients who had undergone a percutaneous coronary intervention (PCI). Participants who had undergone PCI 6 months prior were invited. Those participants who met the inclusion criteria and provided consent then completed a telephone survey (time point 1). These participants were then contacted 6 months later (i.e. 12 months post-intervention, time point 2) and the measures were repeated. Results All patients (n = 51) were recorded as being alive at time point 1. The multiple model indicated that controlling for other factors, gender was significantly associated with a linear combination of outcome measures (p = 0.004). The effect was moderate in magnitude (partial-η2 = 0.303), where males performed significantly better than females 6 months after the PCI procedure physically and with mood. Follow-up univariate ANOVAs indicated that gender differences were grounded in the scale measuring depression (PHQ9) (p = 0.005) and the physical component score of the short form measuring HRQoL (SF12-PCS) (p = 0.003). Thirteen patients were lost to follow-up between time points 1 and 2. One patient was confirmed to have passed away. The pattern of correlations between outcome measures at time point 2 revealed statistically significant negative correlation between the PHQ instrument and the resilience scale (CD-RISC) (r = -0.611; p < 0.001); and the physical component score of the SF-12 instrument (r = -0.437; p = 0.054). Conclusions Men were performing better than women in the 6 months post-PCI, particularly in the areas of mood (depression) and physical health. This pilot results indicate gender-sensitive practices are recommended particularly up to 6 months post-PCI. Any gender differences observed at 6 month appear to disappear at 12 months post-PCI. Further research into the management of mood particularly for women post-PCI is warranted. A more detailed inquiry related to access/attendance to secondary prevention is also warranted

Powerful Winds from Low-Mass Stars: V374 Peg

The rapid rotation (P=0.44 d) of the M dwarf V374Peg (M4) along with its intense magnetic field point toward magneto-centrifugal acceleration of a coronal wind. In this work, we investigate the structure of the wind of V374Peg by means of 3D magnetohydrodynamical (MHD) numerical simulations. For the first time, an observationally derived surface magnetic field map is implemented in MHD models of stellar winds for a low mass star. We show that the wind of V374Peg deviates greatly from a low-velocity, low-mass-loss rate solar-type wind. We find general scaling relations for the terminal velocities, mass-loss rates, and spin-down times of highly magnetized M dwarfs. In particular, for V374Peg, our models show that terminal velocities across a range of stellar latitudes reach ~(1500-2300) n_{12}^{-1/2} km/s, where n_{12} is the coronal wind base density in units of 10^{12} cm^{-3}, while the mass-loss rates are about 4 x 10^{-10} n_{12}^{1/2} Msun/yr. We also evaluate the angular-momentum loss of V374Peg, which presents a rotational braking timescale ~28 n_{12}^{-1/2} Myr. Compared to observationally derived values from period distributions of stars in open clusters, this suggests that V374Peg may have low coronal base densities (< 10^{11} cm^{-3}). We show that the wind ram pressure of V374Peg is about 5 orders of magnitude larger than for the solar wind. Nevertheless, a small planetary magnetic field intensity (~ 0.1G) is able to shield a planet orbiting at 1 AU against the erosive effects of the stellar wind. However, planets orbiting inside the habitable zone of V374Peg, where the wind ram pressure is higher, might be facing a more significant atmospheric erosion. In that case, higher planetary magnetic fields of, at least, about half the magnetic field intensity of Jupiter, are required to protect the planet's atmosphere.Comment: 13 pages, 5 figures, 1 table. MNRAS in pres

Response of Jupiter's auroras to conditions in the interplanetary medium as measured by the Hubble Space Telescope and Juno

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the interplanetary conditions. We show that for ∼1-3 days following compression region onset the planet's main emission brightened. A duskside poleward region also brightened during compressions, as well as during shallow rarefaction conditions at the start of the program. The power emitted from the noon active region did not exhibit dependence on any interplanetary parameter, though the morphology typically differed between rarefactions and compressions. The auroras equatorward of the main emission brightened over ∼10 days following an interval of increased volcanic activity on Io. These results show that the dependence of Jupiter's magnetosphere and auroras on the interplanetary conditions are more diverse than previously thought

Interaction of Saturn's magnetosphere and its moons: 2. Shape of the Enceladus plume

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95207/1/jgra20314.pd

Presence of depression and anxiety before and after coronary artery bypass graft surgery and their relationship to age

<p>Abstract</p> <p>Background</p> <p>Scientific literature on depression and anxiety in patients with coronary heart disease (CHD) consistently reports data of elevated anxiety and depression scores indicating clinically relevant quantities of these psychopathological conditions. Depression is considered to be a risk factor for the development of CHD and deteriorates the outcome after cardiac rehabilitation efforts. The aim of our study was to evaluate the presence of clinically relevant anxiety and depression in patients before and after coronary artery bypass grafting (CABG). Additionally we evaluated their relationship to age because of the increasing number of elderly patients undergoing CABG surgery.</p> <p>Methods</p> <p>One hundred and forty-two consecutive patients who underwent CABG in our hospital were asked to fill in the "Hospital Anxiety and Depression Scale – German Version (HADS)" to measure depression and anxiety scores two days before and ten days after CABG surgery. Differences between these pre- and post-surgical scores were then calculated as means for changes, and the amount of elevated scores were appraised. In order to investigate the relationship between age and anxiety and depression, respectively, Spearman correlations between age and the difference scores were calculated. In addition, ANOVA procedures with the factor "age group" and McNemar tests were calculated. Therefore the sample was divided into four equally sized age groups.</p> <p>Results</p> <p>25.8% of the patients were clinically depressed before and 17.5% after surgery; 34.0% of the patients were clinically anxious before and 24.7% after surgery. This overall change is not significant. We found a significant negative correlation between age and the difference between the two time points for anxiety (Spearman rho = -.218; p = 0.03), but not for depression (Spearman rho = -.128; p = 0.21). ANOVA and McNemar-Tests revealed that anxiety scores and the number of patients high in anxiety declined statistically meaningful only in the youngest patient group. Such a relationship could not be found for depression.</p> <p>Conclusion</p> <p>Our data show a relationship between age and anxiety. Younger patients are more anxious before CABG surgery than older ones and show a decline in symptoms while elderly patients show hardly any change.</p

Report of the President, Bowdoin College 1914-1915

https://digitalcommons.bowdoin.edu/presidents-reports/1023/thumbnail.jp

Twist1 Directly Regulates Genes That Promote Cell Proliferation and Migration in Developing Heart Valves

Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells. In the developing heart, Twist1 is highly expressed in endocardial cushion (ECC) valve mesenchymal cells and is down regulated during valve differentiation and remodeling. Previous studies demonstrated that Twist1 promotes cell proliferation, migration, and expression of primitive extracellular matrix (ECM) molecules in ECC mesenchymal cells. Furthermore, Twist1 expression is induced in human pediatric and adult diseased heart valves. However, the Twist1 downstream target genes that mediate increased cell proliferation and migration during early heart valve development remain largely unknown. Candidate gene and global gene profiling approaches were used to identify transcriptional targets of Twist1 during heart valve development. Candidate target genes were analyzed for evolutionarily conserved regions (ECRs) containing E-box consensus sequences that are potential Twist1 binding sites. ECRs containing conserved E-box sequences were identified for Twist1 responsive genes Tbx20, Cdh11, Sema3C, Rab39b, and Gadd45a. Twist1 binding to these sequences in vivo was determined by chromatin immunoprecipitation (ChIP) assays, and binding was detected in ECCs but not late stage remodeling valves. In addition identified Twist1 target genes are highly expressed in ECCs and have reduced expression during heart valve remodeling in vivo, which is consistent with the expression pattern of Twist1. Together these analyses identify multiple new genes involved in cell proliferation and migration that are differentially expressed in the developing heart valves, are responsive to Twist1 transcriptional function, and contain Twist1-responsive regulatory sequences

The impact of preoperative anxiety and education level on long-term mortality after cardiac surgery

<p>Abstract</p> <p>Background</p> <p>Psychosocial factors have shown independent predictive value in the development of cardiovascular diseases. Although there is strong evidence to support the role of psychosocial factors in cardiovascular mortality, there is a scarcity of knowledge about how these factors are related. Therefore, we investigated the relationship between depression, anxiety, education, social isolation and mortality 7.5 years after cardiac surgery.</p> <p>Methods</p> <p>After informed consent, 180 patients undergoing cardiac surgery between July 2000 and May 2001 were prospectively enrolled and followed for ten years. During the follow-up period, the patients were contacted annually by mail. Anxiety (Spielberger State-Trait Anxiety Inventory, STAI-S/STAI-T), depression (Beck Depression Inventory, BDI) and the number and reason for rehospitalizations were assessed each year. Those patients who did not respond were contacted by telephone, and national registries were searched for deaths.</p> <p>Results</p> <p>During a median follow-up of 7.6 years (25^th to 75^th percentile, 7.4 to 8.1 years), the mortality rate was 23.6% (95% confidence interval [CI] 17.3-29.9; 42 deaths). In a Cox regression model, the risk factors associated with an increased risk of mortality were a higher EUROSCORE (points; Adjusted Hazard Ratio (AHR):1.30, 95%CI:1.07-1.58)), a higher preoperative STAI-T score (points; AHR:1.06, 95%CI 1.02-1.09), lower education level (school years; AHR:0.86, 95%CI:0.74-0.98), and the occurrence of major adverse cardiac and cerebral events during follow up (AHR:7.24, 95%CI:2.65-19.7). In the postdischarge model, the same risk factors remained.</p> <p>Conclusions</p> <p>Our results suggest that the assessment of psychosocial factors, particularly anxiety and education may help identify patients at an increased risk for long-term mortality after cardiac surgery.</p