*Feminist ecclesiology and a liberating counterhistory: reimagining church for the 21st century

The purpose of this dissertation is to prompt ecclesial imagination for the sake of envisioning and reshaping contemporary ecclesiology and church practice in more liberative forms. The thesis is that non-dominant theologies and historical narratives are sources that prompt ecclesial imagination and can potentially reshape ecclesiology and church practice. *Feminist Ecclesiology and a Liberating Counterhistory analyzes and interprets two such non-dominant sources in two case studies: *feminist ecclesiological writing on the church from the 1968 to 2020, and the archeological evidence of ancient Iron Age I Hebrew highland settlements, which pre-date biblical narratives and support a counter-narrative to conquest, namely a non-militaristic response to empire and societal collapse. This dissertation utilizes the term *feminist to indicate the full range of white feminist, womanist, mujerista, Latin American, African, and Asian women’s ecclesiologies. The asterisk is meant to disrupt the totalizing tendency of the generic term feminist to imply only white feminist perspectives. The review of literature and textual analysis of *feminist ecclesiological discourses reveal four prominent conceptual themes, identified as four marks of the *feminist church: holistic, incarnate, utopic, and apostolic. The study of the highland settlements focuses on archeological findings, such as Iron Age I pottery, building foundations, and other material artifacts. A *feminist analysis of the settlements uncovers a liberative counterhistory that contrasts with genocidal and militaristic narrations of the origins of the Hebrew people in Canaan, such as found in Joshua 1-11. Although the two case studies are drawn across great expanses of time and in different cultural settings, a close look reveals important resonances that make them a congruent pairing, albeit unexpected. Individually, they have much to offer towards ecclesial imagination. Interpreted together, the two cases are grounded in the depths of historical tradition, and offer nuanced critiques and imagination for the present, while simultaneously reaching towards an alternative future. The dissertation concludes with integrative insights that demonstrate how the highland settlement evidence can augment the *feminist marks of the church. Building upon these discoveries, the final chapter offers five principles of practice, suggesting ways that the cases and their integrative interpretation can prompt ecclesial imagination and practices for the future church

Information-sharing in health and social care: Lessons from a socio-technical initiative

Advances in information technology have led to new and innovative approaches in data-sharing, analysis, interpretation, and the potential for real-time responses to changes in health and social care status. However, health and social care information is not only complex but often socially and personally sensitive in ways that do not apply in other domains. This requires adoption of a tailored interdisciplinary (social, ethical, legal, technical and data science) and intersectoral (health and social care, academic and commercial institutions and citizens) approach to technology development. The authors present some important lessons to date from ongoing development of an innovative infrastructure for sharing health and social care data. Data is essential for delivering direct care, service planning and improvement, and research ethically, lawfully, safely and efficiently. The article exemplifies, with the help of a region-wide health and social care information-sharing initiative, the importance and need for strategic planning and collaborative decision-making within each of these dimensions. It thus contributes to improved understanding of the scope, opportunities, benefits, limitations and practicalities of information-sharing in health and social care. The article is therefore relevant for all stakeholders, including patients, practitioners from across care settings, commissioners, managers, technologists, academics, innovators, designers and governance teams

A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: The GRACE Genetics Study

Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS).status: publishe

Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group

CCG-2961 incorporated 3 new agents, idarubicin, fludarabine and interleukin-2, into a phase 3 AML trial using intensive-timing remission induction/consolidation and related donor marrow transplantation or high-dose cytarabine intensifi-cation. Among 901 patients under age 21 years, 5-year survival was 52%, and event-free survival was 42%. Survival improved from 44% between 1996 and 1998 to 58% between 2000 and 2002 (P = .005), and treatment-related mortality declined from 19% to 12% (P = .025). Partial replacement of daunomycin with idarubicin in the 5-drug induction combination achieved a remission rate of 88%, similar to historical controls. Postremission survival was 56% in patients randomized to either 5-drug reinduction or fludarabine/cytarabine/idarubicin. For patients with or without a related donor, respective 5-year disease-free survival was 61% and 50% (P = .021); respective survival was 68% and 62% (P = .425). Donor availability conferred no benefit on those with inv(16) or t(8;21) cytogenetics. After cytarabine intensification, patients randomized to interleukin-2 or none experienced similar outcomes. Factors predictive of inferior survival were age more than 16 years, non-white ethnicity, absence of related donor, obesity, white blood cell count more than 100 000 × 109/L, −7/7q−, −5/5q−, and/or complex karyotype. No new agent improved outcomes; experience may have contributed to better results time