Leave the Dishes in the Sink: Adventures of an Activist in Conservative Utah

Alison Thorne provides a small-town Utah perspective on the progressive social movements that in the mid to late twentieth century dramatically affected American society. A born activist, Thorne has fought for women\u27s rights, educational reform in public schools and universities, the environment, peace, and the war on poverty. Her efforts have been all the more challenging because of the conservative social and cultural environment in which she has undertaken them. Yet, Thorne, who has deep personal and familial roots in the politically conservative and predominantly Mormon culture of Utah and much of the West, has worked well with people with varied political and social perspectives and agendas. She has been able to establish effective coalitions in contexts that seem inherently hostile. She demonstrated this through her election to the local school board and through her appointment by both Republican and Democratic governors, eventually as chair, to the statewide Governor\u27s Committee on the Status of Women. Alison Thorne\u27s background prepared her to challenge restrictive social contexts, see the broader picture, and encourage progressive change. Educated in the field of consumption economics, which studies those aspects of consumption that operate outside the market system, especially government services and unpaid household production, primarily by women, she received a Ph.D. in economics after graduate study at the University of Chicago and Iowa State, a first for a woman at the latter. Moving with her husband after he was hired at Utah State University, she soon discovered that her education and abilities were undervalued and that tight nepotism rules kept her out of an academic position. She devoted herself to research and writing about alternatives to the narrow definitions of a housewife\u27s role and duties prevalent in the 1940s and 1950s. Both her scholarly work and her personal inclinations prepared her for the emergence of the second wave of feminism in the 1960s. Her participation in the fight for the Equal Rights Amendment honed her skills as an activist, which she applied to multiple other causes. But Alison Thorne\u27s style has never been mere protest of injustice; she has always been fully engaged with her communities, directly working for social change and betterment. Rather than be discouraged by initial rejection, she found ways to contribute to education on the USU campus, eventually achieved academic standing, and helped create women\u27s studies programs and a women\u27s center. She met other challenges in her city and state similarly, by taking her gloves off, reaching out to others, building coalitions, and getting to work.https://digitalcommons.usu.edu/usupress_pubs/1018/thumbnail.jp

Leave the Dishes in the Sink: Adventures of an Activist in Conservative Utah

Alison Thorne provides a small-town Utah perspective on the progressive social movements that in the mid to late twentieth century dramatically affected American society. A born activist, Thorne has fought for women's rights, educational reform in public schools and universities, the environment, peace, and the war on poverty. Her efforts have been all the more challenging because of the conservative social and cultural environment in which she has undertaken them. Yet, Thorne, who has deep personal and familial roots in the politically conservative and predominantly Mormon culture of Utah and much of the West, has worked well with people with varied political and social perspectives and agendas. She has been able to establish effective coalitions in contexts that seem inherently hostile. She demonstrated this through her election to the local school board and through her appointment by both Republican and Democratic governors, eventually as chair, to the statewide Governor's Committee on the Status of Women. Alison Thorne's background prepared her to challenge restrictive social contexts, see the broader picture, and encourage progressive change. Educated in the field of consumption economics, which studies those aspects of consumption that operate outside the market system, especially government services and unpaid household production, primarily by women, she received a Ph.D. in economics after graduate study at the University of Chicago and Iowa State, a first for a woman at the latter. Moving with her husband after he was hired at Utah State University, she soon discovered that her education and abilities were undervalued and that tight nepotism rules kept her out of an academic position. She devoted herself to research and writing about alternatives to the narrow definitions of a housewife's role and duties prevalent in the 1940s and 1950s. Both her scholarly work and her personal inclinations prepared her for the emergence of the second wave of feminism in the 1960s. Her participation in the fight for the Equal Rights Amendment honed her skills as an activist, which she applied to multiple other causes. But Alison Thorne's style has never been mere protest of injustice; she has always been fully engaged with her communities, directly working for social change and betterment. Rather than be discouraged by initial rejection, she found ways to contribute to education on the USU campus, eventually achieved academic standing, and helped create women's studies programs and a women's center. She met other challenges in her city and state similarly, by taking her gloves off, reaching out to others, building coalitions, and getting to work

Visible and Invisible Women in Land-Grant Colleges, 1890-1940

The role and status of women in land-grant colleges has not really been studied. As many of these institutions have approached their centennials and have reflected on their past achievements, the lack of research about women faculty, women students, women staff, and faculty wives has been astounding. In part, our misperceptions or ignorance concerning women in this institutional setting is understandable. Like many women in other historical milieus, women at land-grant institutions have been invisible. Because they were rarely administrators, because they composed such a small part of the faculty, and often because of the discipline in which they taught, their contributions have been obscured. They left few clear traces of their roles and achievements in the institutional records. This Lecture is an attempt to redress that balance and reclaim the details of women\u27s experiences with land-grant institution

Ovarian damage from chemotherapy and current approaches to its protection

BACKGROUND: Anti-cancer therapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicle reserve is extremely sensitive to the effects of chemotherapy and radiotherapy. While oocyte, embryo and ovarian cortex cryopreservation can help some women with cancer-induced infertility achieve pregnancy, the development of effective methods to protect ovarian function during chemotherapy would be a significant advantage.OBJECTIVE AND RATIONALE: This paper critically discusses the different damaging effects of the most common chemotherapeutic compounds on the ovary, in particular, the ovarian follicles and the molecular pathways that lead to that damage. The mechanisms through which fertility-protective agents might prevent chemotherapy drug-induced follicle loss are then reviewed.SEARCH METHODS: Articles published in English were searched on PubMed up to March 2019 using the following terms: ovary, fertility preservation, chemotherapy, follicle death, adjuvant therapy, cyclophosphamide, cisplatin, doxorubicin. Inclusion and exclusion criteria were applied to the analysis of the protective agents.OUTCOMES: Recent studies reveal how chemotherapeutic drugs can affect the different cellular components of the ovary, causing rapid depletion of the ovarian follicular reserve. The three most commonly used drugs, cyclophosphamide, cisplatin and doxorubicin, cause premature ovarian insufficiency by inducing death and/or accelerated activation of primordial follicles and increased atresia of growing follicles. They also cause an increase in damage to blood vessels and the stromal compartment and increment inflammation. In the past 20 years, many compounds have been investigated as potential protective agents to counteract these adverse effects. The interactions of recently described fertility-protective agents with these damage pathways are discussed.WIDER IMPLICATIONS: Understanding the mechanisms underlying the action of chemotherapy compounds on the various components of the ovary is essential for the development of efficient and targeted pharmacological therapies that could protect and prolong female fertility. While there are increasing preclinical investigations of potential fertility preserving adjuvants, there remains a lack of approaches that are being developed and tested clinically

Fetal cyclophosphamide exposure induces testicular cancer and reduced spermatogenesis and ovarian follicle numbers in mice

<div><p>Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cyclophosphamide (CP) is currently used to treat breast cancer in pregnant women, and the effects of fetal exposure to this drug manifested in the offspring must be better understood to offer such patients suitable counseling. The present study was designed to determine whether fetal exposure to CP induces testicular cancer and/or gonadal toxicity in 129 and in 129.MOLF congenic (L1) mice. Exposure to CP on embryonic days 10.5 and 11.5 dramatically increased TGCT incidence to 28% in offspring of 129 mice (control value, 2%) and to 80% in the male offspring of L1 (control value 33%). These increases are similar to those observed in both lines of mice by radiation. <i>In utero</i> exposure to CP also significantly reduced testis weights at 4 weeks of age to ∼70% of control and induced atrophic seminiferous tubules in ∼30% of the testes. When the <i>in utero</i> CP-exposed 129 mice reached adulthood, there were significant reductions in testicular and epididymal sperm counts to 62% and 70%, respectively, of controls. In female offspring, CP caused the loss of 77% of primordial follicles and increased follicle growth activation. The results indicate that i) DNA damage is a common mechanism leading to induction of testicular cancer, ii) increased induction of testis cancer by external agents is proportional to the spontaneous incidence due to inherent genetic susceptibility, and iii) children exposed to radiation or DNA damaging chemotherapeutic agents <i>in utero</i> may have increased risks of developing testis cancer and having reduced spermatogenic potential or diminished reproductive lifespan.</p></div

Use of ovary culture techniques in reproductive toxicology

Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. Acknowledgements The author's studies in this field are supported by MRC grants G1002118 (NS and RAA) and G110357 (RAA), MR/L010011/1 (PAF), the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 212885 (PAF) and the Wellcome Trust (080388 to PAF). AS was funded by a BBSRC CASE Studentship co-funded by AstraZeneca.Peer reviewedPublisher PD

Association of processed red meat and prostate cancer stage in Mexican-Americans: A population based case-control study

Objective: The objective of this study is to investigate the association between processed and unprocessed red meat consumption and prostate cancer (PCa) stage in a homogenous Mexican-American population. Methods: This population-based case-control study had a total of 582 participants (287 cases with histologically confirmed adenocarcinoma of the prostate gland and 295 age and ethnicity-matched controls) that were all residing in the Southeast region of Texas from 1998 to 2006. All questionnaire information was collected using a validated data collection instrument. Statistical Analysis: Descriptive analyses included Student\u27s t-test and Pearson\u27s Chi-square tests. Odds ratios and 95% confidence intervals were calculated to quantify the association between nutritional factors and PCa stage. A multivariable model was used for unconditional logistic regression. Results: After adjusting for relevant covariates, those who consume high amounts of processed red meat have a non-significant increased odds of being diagnosed with localized PCa (OR = 1.60 95% CI: 0.85 - 3.03) and total PCa (OR = 1.43 95% CI: 0.81 - 2.52) but not for advanced PCa (OR = 0.91 95% CI: 1.37 - 2.23). Interestingly, high consumption of carbohydrates shows a significant reduction in the odds of being diagnosed with total PCa and advanced PCa (OR = 0.43 95% CI: 0.24 - 0.77; OR = 0.27 95% CI: 0.10 - 0.71, respectively). However, consuming high amounts of energy from protein and fat was shown to increase the odds of being diagnosed with advanced PCa (OR = 4.62 95% CI: 1.69 - 12.59; OR = 2.61 95% CI: 1.04 - 6.58, respectively). Conclusion: Mexican-Americans who consume high amounts of energy from protein and fat had increased odds of being diagnosed with advanced PCa, while high amounts of carbohydrates reduced the odds of being diagnosed with total and advanced PCa