A one-way ANOVA test for functional data with graphical interpretation

A new functional ANOVA test, with a graphical interpretation of the result, is presented. The test is an extension of the global envelope test introduced by Myllymaki et al. (2017, Global envelope tests for spatial processes, J. R. Statist. Soc. B 79, 381--404, doi: 10.1111/rssb.12172). The graphical interpretation is realized by a global envelope which is drawn jointly for all samples of functions. If a mean function computed from the empirical data is out of the given envelope, the null hypothesis is rejected with the predetermined significance level $\alpha$. The advantages of the proposed one-way functional ANOVA are that it identifies the domains of the functions which are responsible for the potential rejection. We introduce two versions of this test: the first gives a graphical interpretation of the test results in the original space of the functions and the second immediately offers a post-hoc test by identifying the significant pair-wise differences between groups. The proposed tests rely on discretization of the functions, therefore the tests are also applicable in the multidimensional ANOVA problem. In the empirical part of the article, we demonstrate the use of the method by analyzing fiscal decentralization in European countries. The aim of the empirical analysis is to capture differences between the levels of government expenditure decentralization ratio among different groups of European countries. The idea behind, based on the existing literature, is straightforward: countries with a longer European integration history are supposed to decentralize more of their government expenditure. We use the government expenditure centralization ratios of 29 European Union and EFTA countries in period from 1995 to 2016 sorted into three groups according to the presumed level of European economic and political integration.Comment: arXiv admin note: text overlap with arXiv:1506.0164

CanopyShotNoise - An individual-based tree canopy modelling framework for projecting remote-sensing data and ecological sensitivity analysis

Very few spatially explicit tree models have so far been constructed with a view to project remote-sensing data directly. To fill this gap, we introduced the prototype of the CanopyShotNoise model, an individual-based model specifically designed for projecting airborne laser scanning (ALS) data. Given the nature of ALS data, the model focuses on the dynamics of individual-tree canopies in forest ecosystems, that is, spatial tree interaction and resulting growth, birth and death processes. In this study, CanopyShotNoise was used to analyse the long-term effects of the processes crown plasticity (C) and superorganism formation (S) on spatial tree canopy patterns that are likely to play an important role in ongoing climate change. We designed a replicated computer experiment involving the four scenarios C0S0, C1S0, C0S1 and C1S1 where 0 and 1 imply that the preceding process was switched off and on, respectively. We hypothesized that C and S are antagonistic processes, specifically that C would lead to increasing regularity of tree locations and S would result in clustering. Our simulation results confirmed that in the long run intertree distances decreased and canopy gap size increased when superorganisms were encouraged to form. At the same time, the overlap and packing of tree crowns increased. The long-term effect of crown plasticity increased the regularity of tree locations; however, this effect was much weaker than that of superorganism formation. As a result, gap patterns remained more or less unaffected by crown plasticity. In scenario C1S1, both processes interestingly interacted in such a way that crown plasticity even increased the effect of superorganism formation. Our simulation results are likely to prove helpful in recognizing patterns of facilitation with ongoing climate change

Differences Between Familial and Sporadic Celiac Disease

Background It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study. Methods Altogether 1064 patients were analyzed for celiac disease-associated serology, predisposing HLA-DQ, and non-HLA genotypes. Medical data were collected from patient records and supplementary interviews. Current symptoms and quality of life were further evaluated with the Gastrointestinal Symptom Rating Scale (GSRS), the Psychological General Well-Being questionnaire (PGWB), and Short Form 36 (SF-36) questionnaires. Results Familial and sporadic groups differed (P <0.001) in the reason for diagnosis and clinical presentation at diagnosis, familial patients being more often screen-detected (26% vs. 2%,P <0.001) and having less often gastrointestinal (49% vs. 69%) and severe symptoms (47% vs. 65%). The groups were comparable in terms of histological damage, frequency of malabsorption, comorbidities, childhood diagnoses, and short-term treatment response. At the time of the study, familial cases reported fewer symptoms (21% vs. 30%,P = 0.004) and lower prevalence of all (78% vs. 86%,P = 0.007), neurological (10% vs. 15%,P = 0.013), and dermatological (9% vs. 17%,P = 0.001) comorbidities. Dietary adherence and GSRS scores were comparable, but familial cases had better quality of life according to PGWB and SF-36. High-risk genotype HLA-DQ2.5/DQ2.5 was more frequent among familial cases, and four non-HLA SNPs were associated with familial celiac disease. Conclusions Despite the greater proportion of high-risk genotypes, familial cases had milder symptoms at presentation than did sporadic cases. Worse experience of symptoms and poorer quality of life in sporadic disease indicate a need for intensified support.Peer reviewe

Влияние состава водной бронировки заряда из сплава тротила с гексогеном на выход и качество детонационного наноалмаза и алмазной шихты при детонационном синтезе

Приведены факторы детонационного синтеза, определяющие выход детонационных наноалмазов, алмазной шихты и их качество. Описано влияние такого важного фактора, как состав бронировки (оболочки) заряда взрывчатого вещества. Рассмотрены три различных варианта подрыва заряда взрывчатого вещества – газовый, водный, ледяной, их преимущества и недостатки. Показано влияние состава смесей водных растворов различных веществ (органических и неорганических) на результат детонационного синтеза.Наведено фактори детонаційного синтезу, що визначають вихід детонаційних наноалмазів, алмазної шихти та їх якість. Описано вплив такого важливого чинника, як склад бронювання (оболонки) заряду вибухової речовини. Розглянуто три різні варіанти підриву заряду вибухової речовини – газовий, водний, крижаний, їх переваги і недоліки. Показано вплив складу сумішей водних розчинів різних речовин (органічних і неорганічних) на результат детонаційного синтезу.This paper presents the factors of detonation synthesis, determining detonation nanodiamonds and the diamond blend yield and their quality We describe the effect of such an important factor as the composition of armor protection (shell) of the explosive charge. We consider three different ways of undermining an explosive charge – gas, water, ice, their advantages and disadvantages. We also shows the influence of the aqueous solutions composition of various mixtures of substances (organic and inorganic) on detonation synthesis result in details

Metabolic alterations in preneoplastic development revealed by untargeted metabolomic analysis

Metabolic rewiring is a critical hallmark of tumorigenesis and is essential for the development of cancer. Although many key features of metabolic alteration that are crucial for tumor cell survival, proliferation and progression have been identified, these are obtained from studies with established tumors and cancer cell lines. However, information on the essential metabolic changes that occur during pre-neoplastic cell (PNC) development that enables its progression to full blown tumor is still lacking. Here, we present an untargeted metabolomics analysis of human oncogene HRAS(G12V) induced PNC development, using a transgenic inducible zebrafish larval skin development model. By comparison with normal sibling controls, we identified six metabolic pathways that are significantly altered during PNC development in the skin. Amongst these altered pathways are pyrimidine, purine and amino acid metabolism that are common to the cancer metabolic changes that support rapid cell proliferation and growth. Our data also suggest alterations in post transcriptional modification of RNAs that might play a role in PNC development. Our study provides a proof of principle work flow for identifying metabolic alterations during PNC development driven by an oncogenic mutation. In the future, this approach could be combined with transcriptomic or proteomic approaches to establish the detailed interaction between signaling networks and cellular metabolic pathways that occur at the onset of tumor progression

Indexing, browsing and searching of digital video

Video is a communications medium that normally brings together moving pictures with a synchronised audio track into a discrete piece or pieces of information. The size of a “piece ” of video can variously be referred to as a frame, a shot, a scene, a clip, a programme or an episode, and these are distinguished by their lengths and by their composition. We shall return to the definition of each of these in section 4 this chapter. In modern society, video is ver