Integration of magnetic residuals,derivates and located euler deconvolution for structural and geologic mapping of parts of the precambrian gneisses of Ago-Iwoye, Southwestern Nigeria

Ground based magnetic survey conducted between longitude 06O 55I 51IIN –06O 55I 54IIN and latitude 03O 52I 06IIE –03O 52I 4.8IIE (Olabisi Onabanjo University) remarkably revealed a consistent subsurface NW -SE structural azimuth of localized discontinuities within the shallowly buried heterogeneous basement rocks, which at exposed locations are composed of strongly foliated granite gneiss and migmatite-gneiss with veins and veinlets principally orientated in NNW –SSE direction.Magnetic survey of the area was preceded by site inspection to avoid metallic objects interferences. Field procedure in the area involved Cartesian gridding, base station establishment, data acquisition at gridded points, and repeated bihourly diurnal checksat the base station. At the processing stage, diurnal variation effect was aptly removed before subjection to Kriging (gridding). The gridded data was then prepared as input for Forward Fourier Filter Transform (FFT), which upon definition and implementation enabled Butterworth filtering of isolated ringing effects, reduction to the equator (RTE) for geomagnetic correction, and the use of Gaussian and Upward Continuation filtering for regional magnetic intensity trend determination. Removal of the regional magnetic intensity (RMI) from the total magnetic intensity (TMI) resulted in the derivation of the residual anomaly. Enhancement filters adopted for better resolution of the residual magnetic gradient include analytical signal (AS), tilt-angle derivative (TDR), vertical derivative deconvolution (VDD), and the first vertical derivatives (FVD).TMI and RMI values range between 32925nT –33050nT and 32935nT –333050nT respectively, while the residual gradient ranges between 15nT/m and10nT/m; AS ranges between 0.28nT/m and4.1nT/m; and TDR ranges from-1.4nT/m to 1.4nT/m. Source depth calculation estimated from power spectrum analysis and Euler deconvolution ranges between 1m and15m. Composite overlay of magnetic maps revealed jointed and faulted zones within the area; exhibiting a NW-SE principal azimuth of Liberian orogenic impress, which are in consistence with the foliation direction of the jagged foliated bedrock with an estimated maximum overburden of about 15m.The structural significance of this area as a prospective hydro-geological centre, and as an undesirable spot for high-rise building has been accurately evaluated from research findings. Application of integrated geophysical approach, complemented by detailed geological studies may furnish greater information about the subsurface structural architecture.Keywords:Gneisses; Ground Magnetic Surveying;RTE;Structural discontinuities;TDR.1INTRODUCTIONStructuralmapping is an integral part of geologic surveys. It involves measurements, analyses, interpretation and recognition of geometrical features (structures) generated by rock deformations [1]. These structures often serve as fountains of environmental challenges or unparalleled opportunities depending on their modesof occurrences, which in most cases are imminently controlled by the dynamic interplay of differential stress distributions within the earth interior. In line with the principle of uniformitarianism, a broad understanding about Earth’s paleo processes and internal workingsare deductible from the various deformation types for diverse applications. Deductible inferences from brittle deformationsinclude the kinematics of crustal blocks, orientation of principal axes of regional and local stresses, and geometry. Deeper insights indeep seated stresses, regional movements and block motions are obtainable from ductile deformations

Application of Radiometric Surveys to Delineate between Sedimentary Terrain and Basement Complex: A case study of Sagamu and Abeokuta, South Western Nigeria

NaI (TI) detector crystal coupled to a Canberra series 10 plus multichannel analyser (MCA) was used to analyse the soil samples collected from Sagamu (Sedimentary terrain) and Abeokuta (Basement complex) in South Western Nigeria. The use of the soil samples is to determine the activity concentrations due to radium, thorium and potassium so as to delineate between the two terrains using radiometric survey. From the result of the activity concentrations of these radionuclide, the mean value of the activity concentrations of 40k (72±48) in sedimentary terrain is higher than in 226Ra (35± 20) and 232Thorium (43 ±26) respectively. In the basement complex, the average value of the activity concentration of 40k (80 ±46) was also higher in 226Ra (44±18) and 232Thorium (53 ± 25) respectively. The relatively high value recorded 40k radionuclide may be attributed to the perceived variations in the environment resulting from past activities. The results shows that the activity concentration of the radionuclides is higher in basement complex than in sedimentary terrain thus, delineate between the two terrains since it is well know that in basement complex, granites contain high concentrations of uranium, thorium and potassium. Keywords: key words: Activity concentrations, Basement complex, Radiometric survey, Sedimentary terrain, Soil sample

National Security Risks? Uncertainty, Austerity and Other Logics of Risk in the UK government’s National Security Strategy

Risk scholars within Security studies have argued that the concept of security has gone through a fundamental transformation away from a threat-based conceptualisation of defence, urgency and exceptionality to one of preparedness, precautions and prevention of future risks, some of which are calculable, others of which are not. This article explores whether and how the concept of security is changing due to this ‘rise of risk’, through a hermeneutically grounded conceptual and discourse analysis of the United Kingdom government’s national security strategy (NSS) from 1998 to 2011. We ask how risk-security language is employed in the NSS; what factors motivate such discursive shifts; and what, if any, consequences of these shifts can be discerned in UK national security practices. Our aim is twofold: to better understand shifts in the security understandings and policies of UK authorities; and to contribute to the conceptual debate on the significance of the rise of risk as a component of the concept of security

The First Post-Kepler Brightness Dips of KIC 8462852

We present a photometric detection of the first brightness dips of the unique variable star KIC 8462852 since the end of the Kepler space mission in 2013 May. Our regular photometric surveillance started in October 2015, and a sequence of dipping began in 2017 May continuing on through the end of 2017, when the star was no longer visible from Earth. We distinguish four main 1-2.5% dips, named "Elsie," "Celeste," "Skara Brae," and "Angkor", which persist on timescales from several days to weeks. Our main results so far are: (i) there are no apparent changes of the stellar spectrum or polarization during the dips; (ii) the multiband photometry of the dips shows differential reddening favoring non-grey extinction. Therefore, our data are inconsistent with dip models that invoke optically thick material, but rather they are in-line with predictions for an occulter consisting primarily of ordinary dust, where much of the material must be optically thin with a size scale <<1um, and may also be consistent with models invoking variations intrinsic to the stellar photosphere. Notably, our data do not place constraints on the color of the longer-term "secular" dimming, which may be caused by independent processes, or probe different regimes of a single process

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery