Disentangling phonological well-formedness and attestedness

Disentangling the roles of phonological well-formedness and lexical attestedness in phonotactic processing has proven challenging. In this study, we present results from a passive listening ERP study showing that English speakers exhibit distinct neural responses to CCVC nonce words according to the phonological well-formedness and attestedness (in English) of the onset cluster. Clusters with poor sonority sequencing evoked an N400 effect compared to those without poor sonority sequencing, regardless of whether the well-formed clusters were attested in English. In contrast, unattested clusters, regardless of whether they were well-formed or ill-formed in terms of sonority sequencing, evoked a late positivity compared to attested clusters. The results suggest that listeners first perform a phonological analysis on potential words before submitting them to a lexical search

Cognitive load elevates discrimination thresholds of duration, intensity, and f0 for a synthesized vowel

Dual-tasking negatively impacts on speech perception by raising cognitive load (CL). Previous research has shown that CL increases reliance on lexical knowledge and decreases reliance on phonetic detail. Less is known about the effect of CL on the perception of acoustic dimensions below the phonetic level. This study tested the effect of CL on the ability to discriminate differences in duration, intensity, and fundamental frequency of a synthesized vowel. A psychophysical adaptive procedure was used to obtain just noticeable differences (JNDs) on each dimension under load and no load. Load was imposed by N-back tasks at two levels of difficulty (one-back, two-back) and under two types of load (images, nonwords). Compared to a control condition with no CL, all N-back conditions increased JNDs across the three dimensions. JNDs were also higher under two-back than one-back load. Nonword load was marginally more detrimental than image load for intensity and fundamental frequency discrimination. Overall, the decreased auditory acuity demonstrates that the effect of CL on the listening experience can be traced to distortions in the perception of core auditory dimensions

Focus perception in Japanese: Effects of lexical accent and focus location.

This study explored the contexts in which native Japanese listeners have difficulty identifying prosodic focus. Using a 4AFC identification task, we compared native Japanese listeners' focus identification accuracy in different lexical accent × focus location conditions using resynthesised speech stimuli, which varied only in fundamental frequency. Experiment 1 compared the identification accuracy in lexical accent × focus location conditions using both natural and resynthesised stimuli. The results showed that focus identification rates were similar with the two stimulus types, thus establishing the reliability of the resynthesised stimuli. Experiment 2 explored these conditions further using only resynthesised stimuli. Narrow foci bearing the lexical pitch accent were always more correctly identified than unaccented ones, whereas the identification rate for final focus was the lowest among all focus locations. From these results, we argue that the difficulty of focus perception in Japanese is attributed to (i) the blocking of PFC by unaccented words, and (ii) similarity in F0 contours between lexical pitch accent and narrow focus, including in particular the similarity between downstep and PFC. Focus perception is therefore contingent on other concurrent communicative functions which may sometimes take precedence in a +PFC language

Phonetic categorization and discrimination of voice onset time under divided attention

Event durations are perceived to be shorter under divided attention. “Time shrinkage” is thought to be due to rapid attentional switches between tasks, leading to a loss of input samples, and hence, an under-estimation of duration. However, few studies have considered whether this phenomenon applies to durations relevant to time-based phonetic categorization. In this study, participants categorized auditory stimuli varying in voice onset time (VOT) as /ɡ/ or /k/. They did so under focused attention (auditory task alone) or while performing a low-level visual task at the same time (divided attention). Under divided attention, there was increased response imprecision but no bias toward hearing /ɡ/, the shorter-VOT sound. It is concluded that sample loss under divided attention does not apply to the perception of phonetic contrasts within the VOT range

Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001-2009

Background: This study examined the use of low doses of antipsychotic medications (300mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates. Methods: Information on hospitalized patients with schizophrenia, aged 55 years or older, was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001-2009). Data on 1,452 patients in eight Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India, and Malaysia were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure. Results: The prescription frequency for low doses of antipsychotic medications was 40.9% in the pooled sample. Multiple logistic regression analysis of the whole sample showed that patients on low doses of antipsychotic medications were more likely to be female, have an older age, a shorter length of illness, and less positive symptoms. Of patients in the six countries and territories that participated in all the surveys between 2001 and 2009, those in Japan were less likely to receive low doses of antipsychotics. Conclusion: Low doses of antipsychotic medications were only applied in less than half of older Asian patients with schizophreni

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

The psychological science accelerator’s COVID-19 rapid-response dataset

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data