Cuidados de enfermería en la promoción de la salud y estilo de vida del adulto del A.H La Legua_Catacaos_Piura, 2022

El problema de investigación es ¿Existe relación entre el cuidado de enfermería en la promoción de la salud y estilo de vida del adulto del A? ¿H La Legua _Catacaos_ Piura, 2022? tuvo como objetivo general: Determinar la relación entre los cuidados de enfermería en la promoción de la salud y estilo de vida del adulto del A.H La Legua _Catacaos_ Piura, 2022, tuvo una metodología cuantitativa, descriptiva correlacional. La muestra de estudio estuvo conformada de 354 adultos. Aplicando dos instrumentos sobre cuidados de enfermería y estilos de vida, a través de la entrevista. Los resultados obtenidos se procesaron en SSPS, para expresar los resultados en tablas y gráficos estadísticos, y establecer la relación de las variables por medio de la prueba del Chi cuadrado, obteniéndose de ello un nivel de confiabilidad al 95% con un índice de significancia de p<0.05. Llegando a los siguientes resultados y conclusiones: más de la mitad de adultos refieren un cuidado de enfermería en promoción de la salud es adecuado y un porcentaje considerable un cuidado de enfermería inadecuado. La mayoría tiene un estilo de vida no saludable, y un porcentaje significativo saludable. Al realizar la prueba de Chi cuadrado entre el cuidado de enfermería y los estilos de vida se encontró que si existe relación estadísticamente significativa

Forecasting Urban Expansion in the Seven Lakes Area in San Pablo City, Laguna, the Philippines Using the Land Transformation Model

Managing urban growth is essential to the conservation of the Seven Lakes ecosystem in San Pablo City, Laguna province in the Philippines. This study simulates potential conversion of agricultural lands to built-up areas using the land transformation model (LTM), which integrates geographical information systems (GIS) and an artificial neural network (ANN). Historical drivers of the expansion of built-up areas are identified and validated through the application of LTM to land cover maps from 1988 to 2015. Identified drivers include distance to roads, distance to trails, distance to the Seven Lakes, distance to existing built-up areas, slopes and population density per barangay. Results from the percent correct matrix (PCM) were 79.88 per cent for the 1988–2003 runs and 66.42 per cent for the 2003–2015 runs, while the Kappa statistic for both time periods was higher than 0.60, which indicates high levels of agreement. Forecasted scenarios were business-as-usual (BAU) growth, doubled growth and strict law implementation protecting the vicinity around the Seven Lakes and other natural areas. In the BAU scenario, urban expansion spread out along the road networks. The doubled growth scenario showed that further expansion will likely extend around the proximity of the lakes, which may adversely affect the livelihoods of the local fishing communities. As such, it was recommended that preventive measures, such as strict implementation of buffer zones coupled with regular monitoring, be taken to manage land use in the surrounding lake areas

A supply chain framework for characterizing indirect vulnerability

Purpose Climate vulnerability assessments are often operationalized by the analysis of indicators defined by the spatial boundaries of the community under study. These, however, sometimes fail to capture interdependency among communities for basic resources. This paper aims to propose a framework for characterizing vulnerability caused by interdependency by adapting a supply chain lens. Design/methodology/approach The paper proposes a definition for “indirect vulnerability” that recognizes the transboundary and teleconnected nature of vulnerability arising from resource networks among cities and communities. A conceptual framework using a supply chain approach is presented for climate hazards in particular. This approach is then demonstrated through a rapid appraisal of the rice, energy and water supply chains and the waste management chains of Metro Manila. Findings The application of the supply chain lens to assessing the indirect vulnerability of Metro Manila brings to fore issues extending beyond the decision-making boundaries of local government units. Addressing these will require vertical government coordination and horizontal inter-sectoral collaboration. Thus, this supply chain-based indirect vulnerability assessment can be complementary to traditional vulnerability assessments in providing a larger systems perspective. Originality/value Innovative tools are needed to make community vulnerability assessments both holistic and tractable. Existing methods in the private sector can be adapted rather than reinventing the wheel. This supply chain framework can be a useful decision support and planning tool across governance levels to comprehensively address vulnerability

Global human footprint on the linkage between biodiversity and ecosystem functioning in reef fishes

Copyright: © 2011 Mora et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Difficulties in scaling up theoretical and experimental results have raised controversy over the consequences of biodiversity loss for the functioning of natural ecosystems. Using a global survey of reef fish assemblages, we show that in contrast to previous theoretical and experimental studies, ecosystem functioning (as measured by standing biomass) scales in a non-saturating manner with biodiversity (as measured by species and functional richness) in this ecosystem. Our field study also shows a significant and negative interaction between human population density and biodiversity on ecosystem functioning (i.e., for the same human density there were larger reductions in standing biomass at more diverse reefs). Human effects were found to be related to fishing, coastal development, and land use stressors, and currently affect over 75% of the world's coral reefs. Our results indicate that the consequences of biodiversity loss in coral reefs have been considerably underestimated based on existing knowledge and that reef fish assemblages, particularly the most diverse, are greatly vulnerable to the expansion and intensity of anthropogenic stressors in coastal areas

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk outcome pairs, and new data on risk exposure levels and risk outcome associations. Methods: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings: In 2017,34.1 million (95% uncertainty interval [UI] 33.3-35.0) deaths and 121 billion (144-1.28) DALYs were attributable to GBD risk factors. Globally, 61.0% (59.6-62.4) of deaths and 48.3% (46.3-50.2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10.4 million (9.39-11.5) deaths and 218 million (198-237) DALYs, followed by smoking (7.10 million [6.83-7.37] deaths and 182 million [173-193] DALYs), high fasting plasma glucose (6.53 million [5.23-8.23] deaths and 171 million [144-201] DALYs), high body-mass index (BMI; 4.72 million [2.99-6.70] deaths and 148 million [98.6-202] DALYs), and short gestation for birthweight (1.43 million [1.36-1.51] deaths and 139 million [131-147] DALYs). In total, risk-attributable DALYs declined by 4.9% (3.3-6.5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23.5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18.6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning

A supply chain framework for characterizing indirect vulnerability

Purpose: Climate vulnerability assessments are often operationalized by the analysis of indicators defined by the spatial boundaries of the community under study. These, however, sometimes fail to capture interdependency among communities for basic resources. This paper aims to propose a framework for characterizing vulnerability caused by interdependency by adapting a supply chain lens. Design/methodology/approach: The paper proposes a definition for "indirect vulnerability" that recognizes the transboundary and teleconnected nature of vulnerability arising from resource networks among cities and communities. A conceptual framework using a supply chain approach is presented for climate hazards in particular. This approach is then demonstrated through a rapid appraisal of the rice, energy and water supply chains and the waste management chains of Metro Manila. Findings: The application of the supply chain lens to assessing the indirect vulnerability of Metro Manila brings to fore issues extending beyond the decision-making boundaries of local government units. Addressing these will require vertical government coordination and horizontal inter-sectoral collaboration. Thus, this supply chain-based indirect vulnerability assessment can be complementary to traditional vulnerability assessments in providing a larger systems perspective. Originality/value: Innovative tools are needed to make community vulnerability assessments both holistic and tractable. Existing methods in the private sector can be adapted rather than reinventing the wheel. This supply chain framework can be a useful decision support and planning tool across governance levels to comprehensively address vulnerability.This paper was supported by a grant from the Ateneo de Manila University (ADMU) University Research Council (URC) for the project #URC-14-0

Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model

HFpEF is a major and global disease with limited treatment options and novel therapeutics are eagerly awaited. A potential treatment option may be Nicotinamide N-methyltransferase (NNMT) inhibition. This study aimed to investigate the cardiac protective effects of the NNMT enzyme inhibitor AMO-NAM in a HFpEF mouse model. Aged (18–22 months old) female mice developed a cardiometabolic HFpEF phenotype using a multiple hit strategy with high-fat diet (HFD) and angiotensin II (AngII) infusion. NNMT inhibitor 4-amino-6-methoxynicotinamide (AMO-NAM) was added to HFD and mice were treated for four weeks. Cardiac function was assessed by echocardiography, molecular (RT-qPCR; O-link, LC-MS assay) and histological analyses (Masson staining; macrophage staining) were performed to evaluate AMO-NAMs drug-specific effects. We observed significant increases in 1-MNA (+121.6 %), the product of the reaction catalysed by NNMT, and its downstream metabolites levels, 2PY (+274.7 %), and 4PY (+296.4 %) in the left ventricle (LV) of the HFpEF model. Treatment with the AMO-NAM did not affect NAD levels in the HFpEF model but markedly decreased 1-MNA (-77.1 %), 2PY (-66.2 %), and 4PY (-71.1 %) levels. NNMT inhibition led to notable improvements in cardiac function, evidenced by enhanced global longitudinal strain and reversed peak longitudinal strain rate alongside significant reductions in LV hypertrophy and fibrosis. This was accompanied by decreased pro-inflammatory and pro-fibrotic gene expression in plasma and LV tissue and reduced macrophage infiltration in LV and visceral adipose tissue, highlighting the anti-inflammatory and anti-fibrotic effects of NNMT inhibition. Targeting the NNMT is cardioprotective and holds promise for treating HFpEF patients with an unfavorable cardiometabolic phenotype.</p

Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine response

Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation

Cell proliferation and neuroinflammation in the adult hypothalamus may contribute to the pathogenesis of obesity. We tested whether the intertwining of these two processes plays a role in the metabolic changes caused by 3 weeks of a high-saturated fat diet (HFD) consumption. Compared with chow-fed mice, HFD-fed mice had a rapid increase in body weight and fat mass and specifically showed an increased number of microglia in the arcuate nucleus (ARC) of the hypothalamus. Microglia expansion required the adequate presence of fats and carbohydrates in the diet because feeding mice a very high-fat, very low-carbohydrate diet did not affect cell proliferation. Blocking HFD-induced cell proliferation by central delivery of the antimitotic drug arabinofuranosyl cytidine (AraC) blunted food intake, body weight gain, and adiposity. AraC treatment completely prevented the increase in number of activated microglia in the ARC, the expression of the proinflammatory cytokine tumor necrosis factor-? in microglia, and the recruitment of the nuclear factor-?B pathway while restoring hypothalamic leptin sensitivity. Central blockade of cell proliferation also normalized circulating levels of the cytokines leptin and interleukin 1? and decreased peritoneal proinflammatory CD86 immunoreactive macrophage number. These findings suggest that inhibition of diet-dependent microglia expansion hinders body weight gain while preventing central and peripheral inflammatory responses due to caloric overload.Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes

How maternal morbidities impact women’s quality of life during pregnancy and postpartum in sub-Saharan Africa and South Asia:A qualitative study

Maternal morbidities present a major burden to the health and well-being of childbearing women. However, their impacts on women’s functional health are not well understood. This work aims to describe how maternal morbidities affect women’s quality of life (QoL) in pregnancy and the postpartum period . This qualitative study involved 118 pregnant and 135 postpartum women at six study sites in Kenya, Ghana, Zambia, Pakistan, and India. Data were collected between December 2023 and June 2024. Participants were selected via purposive sampling, with consideration of age, trimester, and time since delivery. A total of 23 focus group discussions with pregnant and late postpartum (≥6 months) participants and 48 in-depth interviews with early postpartum (≤6 weeks) participants were conducted using semi-structured guides. Data were analyzed using a collaborative, inductive, thematic approach. Four overarching themes were identified and were cross-cutting irrespective of continent or country: (1) physical and emotional challenges pose a barrier to daily activities; (2) lack of social support detracts from women’s QoL; (3) receipt of social support mitigates adverse impacts of maternal morbidities on QoL; and (4) economic challenges exacerbate declines in women’s QoL during pregnancy and postpartum. Physical and emotional morbidities related to childbearing severely limited women’s ability to complete daily tasks and adversely impacted their perceived QoL. Social and financial support from the baby’s father, family and/or in-laws, community members, and healthcare providers are important to mitigate the impacts of pregnancy and postpartum challenges on women’s health and well-being.</p