Vladimir Jankélévitch: Filosofía de la vida y filosofía de la música

[ES] Filosofía y estética de la música en Vladimir Jankélévitch

İnsan kolorektal adenokarsinom hücrelerindeki Ca2+ sinyal iletimi üzerine ekonazolün etkisi

Introduction: Econazole, an azole compound widely used as an antifungal drug, is currently investigated for additional therapeutic effects. In fact, the antitumoral properties of econazole have been recently demonstrated, both in vivo and at the cellular level. However, the precise mechanism of action behind its effects is still unclear. Aim: To examine the effect of econazole on intracellular Ca2+ signaling pathways in a human adenocarcinoma cell line. Methods: [Ca2+]i was measured in Fura 2-loaded HT29 cells by fluorescence. Fluorescence was recorded from 1ml aliquots of magnetically stirred HT29 cells using a Cary Eclipse Spectrophotometer (Varian Ltd., Madrid, Spain) with excitation wavelengths of 340 and 380 nm and emission at 510 nm. Results: We have demonstrated that econazole has a dual effect on Ca2+ homeostasis. It caused a dose-dependent increase in [Ca2+]i. Both mobilization from thapsigargin-sensitive stores and extracellular Ca2+ influx contributed to the effect. A phospholipase C-dependent pathway proved to be activated by econazole. In addition, econazole greatly inhibited a physiological activation of store-operated Ca2+ entry. Conclusion: This study provides further molecular mechanism of econazole suggesting that this drug may modify the physiology of human adenocarcinoma HT29 cell line.Junta de Castilla y Leon (BU001A09), M.E.C. (fellowship C. Carrillo

Efecto antitumoral del ácido oleico; mecanismos de acción: revisión científica

Introduction: The beneficial effects of oleic acid in cancer processes can no longer be doubted, but little is known about the mechanisms of action behind this phenomenon. Aim: The aim of the present review is to clarify whether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Aim: The aim of the present review is to clarify whether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Methods:We searched electronic databases and biblio - graphies of selected articles were inspected for further reference. We focused our research on two cellular transformations characterizing cancer development: proliferation and cell death or apoptosis. Results: Numerous studies have reported an inhibition in cell proliferation induced by oleic acid in different tumor cell lines. Herein, oleic acid could suppress the over-expression of HER2 (erbB-2), a well-characterized oncogene which plays a key role in the etiology, invasive progression and metastasis in several human cancers. In addition, oleic acid could play a role in intracellular calcium signaling pathways linked to the proliferation event. Regarding cell death, oleic acid has been shown to induce apoptosis in carcinoma cells. The mechanisms behind the apoptotic event induced by oleic acid could be related to an increase in intracellular ROS production or caspase 3 activity. Several unsaturated fatty acids have been reported to induce apoptosis through a release of calcium from intracellular stores. However, evidence regarding such a role in oleic acid is lacking. Conclusions:Oleic acid plays a role in the activation of different intracellular pathways involved in carcinoma cell development. Such a role could be the root of its antitumoral effects reported in clinical studies

Papel del ácido oleico en el sistema inmune: mecanismos de acción: revisión científica

Introduction:Although n-3 polyunsaturated fatty acids have been widely described as antiinflammatory fats, little is known about the role of oleic acid in immune system. Aim: The aim of the present review is to join all the reports available in order to analyze where exactly the knowledge concerning this topic is and what the causes of the controversial data could be. Methods: We searched electronic databases and bibliographies of selected articles were inspected for further reference. Results:Diets rich in oleic acid have beneficial effects in inflammatory-related diseases. In addition, a wide range of studies evaluate the effect of oleic acid in different cellular functions thus reporting a potential mechanism for the biological effect of such a fat. However, some controversial data can be found in literature, maybe related to the kind of study or even the dose of the reagent added. Conclusion:In conclusion, oleic acid could be reported as an anti-inflammatory fatty acid playing a role in the activation of different pathways of immune competent cells

Puesta en marcha de un sistema de evaluación formativa multidisciplinar aplicado a asignaturas de Ingeniería Química y Nutrición en el Grado en Ciencia y Tecnología de los Alimentos

Ponencia presentada en: VIII Jornadas de Innovación Docente de la UBU, Burgos, 5 de abril de 2016, organizadas por el Instituto de Formación e Innovación Educativa-IFIE de la Universidad de Burgo

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Vladimir Jankélécitch: el instante y la música como no-lugar

Vladimir Jankélévitch’s reflection about the time includes an original theory on the instant that seeks her roots in musical experience. In the meeting point between Bergsonism and Impressionism, Debussy’s work is going to turn into his dearest philosophical reference and into the best metaphor of the ineffability and silence. Music is going to be the expression of a plentiful temporality that invites to the hope and has a real action in the world. Opposite to the anguish of the interval and the finite condition there are an eternal moment of enigmatic and infinitesimal nature, a Presque-rien between the being and the non-being of whom the music is the best ambassador.La reflexión sobre el tiempo de Vladimir Jankélévitch argumenta una original teoría del instante enraizada en la experiencia musical. En el punto de encuentro entre bergsonismo e impresionismo, la obra de Debussy va a convertirse en su más querida referencia filosófica, en la mejor metáfora de la inefabilidad y el silencio. La música va a ser la expresión de una temporalidad plenificada que invita a la esperanza y que actúa realmente en el mundo. Frente a la angustia del intervalo y de la finitud hay un momento eterno de naturaleza enigmática e infinitesimal, un Presque-rien entre el ser y el no-ser del que la música es la mejor embajadora

La recepción del pensamiento estético de Vladimir Jankélévitch

Most of the studies that treat the aesthetic thought of Vladimir Jankélévitch have been written in France and in Italy. These works show us the obsessions of the author, his philosophy of the intangible and his unconditional love for the music.La mayor parte de los estudios que tratan el pensamiento estético de Vladimir Jankélévitch se han escrito en Francia y en Italia. Estos trabajos nos muestran las obsesiones del autor, su filosofía de lo intangible y su amor incondicional por la música

Poner fin al hambre, lograr la seguridad alimentaria y la mejora de la nutrición y promover la agricultura sostenible

Obra financiada por el Ayuntamiento de Burgo