Variabilidad genética de la yuca cultivada por pequeños agricultores de la región caribe de Colombia

Usando la técnica de marcadores moleculares, tipo microsatélites, se evaluó la variabilidad genética de 717 genotipos de yuca Manihot esculenta Crantz colectados en fincas de pequeños agricultores de la región Caribe de Colombia, en los departamentos de Atlántico, Magdalena, Córdoba y Sucre. Mediante el Análisis de Correspondencia Múltiple (ACM) se establecieron seis grupos genéticamente diferentes, con un Gst bajo (0.18), lo cual indica que la variabilidad no se debe a diferencias entre los grupos sino a diferencias dentro de cada grupo. La diversidad genética encontrada fue alta (HT: 0.61692).Using molecular microsatellites analysis, the genetic diversity of 717 cassava genotypes from small formers in the Caribbean region of Colombia was assessed. Six genetically distinct groups was established, with a low Gst (0.18), indicating that the variability was not due to differences between groups but within each group. The genetic diversity was high (Ht: 0.61692)

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase inhibitors that grouped into 59 structural clusters and showed activity against T. brucei, the causative agent of HAT. We herein report the results of further investigation of one of these clusters consisting of substituted isatin derivatives, focusing on establishing structure-activity and -property relationship scope. We also describe their in vitro absorption, distribution, metabolism, and excretion (ADME) properties. For one isatin, NEU-4391, which offered the best activity-property profile, pharmacokinetic parameters were measured in mice

Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis

Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases has meant that existing therapeutics have serious shortcomings in terms of safety, efficacy, and administration, and better therapeutics are needed. We now report a series of 3,5-disubstituted-7-azaindoles identified as growth inhibitors of Trypanosoma brucei, the parasite that causes HAT, through a high-throughput screen. We describe the hit-to-lead optimization of this series and the development and preclinical investigation of 29d, a potent antitrypanosomal compound with promising pharmacokinetic (PK) parameters. This compound was ultimately not progressed beyond in vivo PK studies due to its inability to penetrate the blood-brain barrier (BBB), critical for stage 2 HAT treatments

PERFIL BIOQUIMICO DE PACIENTES CON DIABETES MELLITUS TIPO 2 QUE PERTENECEN AL GRUPO DE AUTOAYUDA EN UN PRIMER NIVEL DE ATENCIÓN MEDICA

Describir el perfil bioquímico de los pacientes del grupo de autoayuda en Diabetes Mellitus tipo 2. (DM 2). Estudio transversal con todos los pacientes pertenecientes al grupo de autoayuda en DM 2  (n = 50) y de los cuales se obtuvieron los datos séricos de glucosa, colesterol y triglicéridos de los últimos seis meses, así como el número de mediciones realizadas. La edad promedio fue 57.8 años, predominó el sexo femenino con el 92%. El 66% cumplió con el ejercicio y el 18% no asistía a pláticas programadas. El 50% presento obesidad (IMC > 30); se encontró una media de 152.6 mg/dl., 211.5 mg/dl. y 183.96 mg/dl para glicemia central, colesterol y triglicéridos respectivamente. Aun perteneciendo a un grupo de autoayuda, los niveles séricos se mantienen por arriba de lo recomendado, lo que sugiere una mayor interrelación entre el paciente y los equipos de salud y  mayor participación, así como una adecuada difusión y promoción de estos grupos. Abstract To describe the biochemical profile in patients of the group of self-help in Diabetes Mellitus type 2. A cross sectional study in the total patients belonged to the group of self-help (n=50). Were obtained data of glucose, cholesterol and triglycerides of last the six months, as well as the number of measurements made them. The age average were 57.8 years, female with 92% predominated. 66% it completes the exercise and 18% did not attend programmed talks. 50% I present obesity (BMI > 30); an average of 152.6 mg/dl., 211.5 mg/dl. and 183.96 mg/dl for central glycaemia, cholesterol and triglycerides respectively. Even belonging to a group of self-help, the serum levels stay by above of the recommended, that suggests a interrelation between the patient and the equipment of health and bigger participation, as well as a suitable diffusion and promotion of these groups. Palabras clave: Grupos de autoayuda, Diabetes Mellitus tipo 2, Medicina de familia, Perfil bioquímic

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio