Thematic analysis of influencers on continuing professional learning of tenure track engineering faculty as assistant professors at an RU/VH institution

“Although the need for lifelong learning of professionals is stressed through university education, the patent differences between learning as a student, within a controlled framework focusing on accessible outcomes, and learning as a professional have not been clarified” (Webster-Wright, 2009, p. 708). Assistant professors are entry level professionals in academia who been prepared through their extensive education process to be lifelong learners and yet it is unknown how these assistant professors are engaging, or being engaged by others, in continuing their professional learning (CPL) for short-term and long-term success in academia as a career. This study aimed to understand who and/or what influenced tenure-track engineering faculty’s continuing professional learning early in their career. An exploratory qualitative thematic analysis was conducted using responses to semi-structured interviews from 13 tenure-track engineering faculty members at a Carnegie classified as Research Universities (very high research activity) institution about their professional development experiences when they were assistant professors. A stratified purposeful criterion sampling strategy was employed to maximize the diversity in background and experiences participants brought to the study. The results that emerged from the data was that the influencers of CPL were (1) institutional impacts on learning, (2) self-directed learning, (3) socially constructed learning, and (4) mentored learning. The findings identified within the themes was that (1) no one dominant pathway existed in the continuing professional learning of tenure-track engineering faculty as assistant professors; and (2) the four influencers – institution impacts on learning, self-directed learning, socially constructed learning, and mentored learning – can be combined in multiple ways to construct the continuing professional learning experience for an individual faculty member. A series of metaphorical equations were constructed to model the collective continuing professional learning of an individual faculty member including the detailed contribution of the individual influencers. Additionally, a framework for constructing CPL environments was proposed as an adaptation of Bransford’s How People Learn (HPL) framework. The researcher acknowledges this was an exploratory qualitative research study with a small, specialized sample size (N=13) so these findings are not generalizable to the larger population of faculty, engineering faculty, or professionals

Lateglacial and early postglacial environments in part of the Grampian highlands of Scotland

The pollen diagrams were divided into individual pollen assemblage zones which enabled the vegetational record at each site to be assessed independently. Correlations between the profiles showed that at the five sites outside the presumed maximal extent of Loch Lomond Readvance ice, the basal deposits were of Lateglacial age with pollen spectra indicati ng a milder Interstadial followed by a harsher Stadial phase. The overlying sediments were found to be Postglacial in age. At the sites within the mapped Loch Lomond Readvance limits, only Postglacial deposits were present. The combined results of pollen analyses, sedimentological and geomorphological studies suggest the following history of landscape evolution.The Late Devensian ice-sheet, which probably reached its greatest extent 17,000 to 18,000 radiocarbon years ago, had virtually disappeared from the Grampian Highlands by ca. 13,000 B. P. The early Lateglacial pollen spectra at all the sites reflect an initial period of colonisation by open-habitat taxa on freshly-exposed substrates following ice-sheet decay. After this early phase of vegetational development, the plant cover of that area of the Grampians to the north and west of the Ben Nevis-Lochnagar watershed was dominated by Empetrum heaths, while grassland with juniper, dwarf birch, willow and occasional copses of tree birch characterised the southern and eastern slopes. Only in the extreme south of the study area did tree birch become established in significant numbers during the Interstadial. At ca. 11,000 B. P., declining temperatures heralded the onset of colder Stadial conditions with the recrudescence of glacier ice of the Loch Lomond Readvance, and the break-up of existing plant communities through increasingly widespread solifluxion. Open-habitat and chionophilous vegetation proliferated, environmental conditions became increasingly more severe, and a tundra landscape developed. This phase was relatively short-lived however, for rapid climatic amelioration at about 10,000 B. P. saw the final disappearance of glacier ice from Scotland, the cessation of solifluxion, and the initiation of a plant succession which culminated in the establishment of climax forest over much of the area. At that time, mixed woodland covered the southern and eastern Grampian slopes, while to the north and west of the Highland watershed, the landscape was one of coniferous forest.The purpose of the investigation is to present a geographical interpretation of the past environment of part of the Grampian Highlands between ca. 13,000 and 7000 B. P. The study is based principally on pollen analysis, but also draws widely on the results of sedimentological and geomorphologieal investigations. Six sites were selected for analysis, five of which are situated out¬ side the presumed limits of the Loch Lomond Beadvance, while the sixth site is located within those mapped limits. Detailed pollen analyses were carried out on all the profiles, and at three of the sites, organic carbon content, particle size and alkali cation percentages were also determined. Radiocarbon dates on critical horizons were obtained from two of the sites

Assessing the Pedagogical Impact of the VaNTH Engineering Research Center on Faculty and Postdoctoral Professionals

From 1999 to 2007, the Vanderbilt-Northwestern-Texas-Harvard/MIT (VaNTH) Engineering Research Center focused on improving bioengineering education through the applications of learning science, learning technology, and assessment and evaluation within the domain of bioengineering. This paper discusses results from a survey to explore the impact of the VaNTH experience on participating faculty and postdoctoral professionals. The results note that respondents differed in their familiarity with and applications of dimensions of the “How People Learn” framework and in their operationalization of effective instruction after their participation in VaNTH. Implications for teaching and learning with the context of a Center model are discussed along with next steps for exploring the experiences of faculty and professionals engaged in the VaNTH ERC

Returning Students in Engineering Education: Making a Case for “Experience Capital”

Students returning to college are not generally studied, where most of the research on non-traditional students is focused on individuals returning to earn their undergraduate degree. There are, however, many students returning to receive graduate degrees as they pursue new directions in life by interest or economic necessity. Undergraduate students with experience have clear educational related goals, practical approaches to problem-solving, and high learning motivation.Returning graduate students are expected to model similar behaviors. These individuals bring a lifetime of personal and professional expertise, which we identify as “experience capital.”A review of the literature reveals that capital has been pondered since early western philosophers considered the concept of social capital in terms of „community governance‟. Others credit Dewey with the first use of the term „social capital‟. Since then, development of other capitals include human, cultural, and symbolic. Human capital is viewed as knowledge, skills, and attributes; cultural capital as an indicator of class position acquired by family and education ; and symbolic as the prestige, recognition, and fame. Today, social capital is viewed as the networks,relationships, and connections of influence and support. Experience capital is the partial union of social, human, cultural, and symbolic capital, which individuals develop from their persona land professional experiences as they progress through life.This is an exploratory study capturing the perceptions of “experience capital” of individuals with several years of professional experience in their discipline returning for a doctoral degree in engineering education. The research question this study addresses is: what “experience capital”do returning students bring to an engineering education doctoral program? The participants will be interviewed; open coding will be used to identify common themes. The results of this qualitative study will position the experiences of the participants at the partial union of social,human, cultural, and symbolic capital, in a space called experience capital

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist

© 2020 by the Society of Nuclear Medicine and Molecular Imaging. Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in autoimmune diseases, and during stem cell-based repair processes after stroke and myocardial infarction. Previously reported PET imaging agents targeting CXCR4 suffer from either high nonspecific uptake or bind only to the human form of the receptor. The objective of this study was to develop a high-stability 64Cu-labeled small-molecule PET agent for imaging both human and murine CXCR4 chemokine receptors. Methods: Synthesis, radiochemistry, stability and radioligand binding assays were performed for the novel tracer 64Cu-CuCB-bicyclam. In vivo dynamic PET studies were performed on mice bearing U87 (CXCR4 low-expressing) and U87.CXCR4 (human-CXCR4 high-expressing) tumors. Biodistribution and receptor blocking studies were performed on CD1-IGS immunocompetent mice. CXCR4 expression on tumor and liver disaggregates was confirmed using a combination of immunohistochemistry, quantitative polymerase chain reaction, and Western blot. Results:64Cu-CuCB-bicyclam has a high affinity for both the human and the murine variants of the CXCR4 receptor (half-maximal inhibitory concentration, 8 nM [human]/2 nM [murine]) and can be obtained from the parent chelator that has low affinity. In vitro and in vivo studies demonstrate specific uptake in CXCR4-expressing cells that can be blocked by more than 90% using a higher-affinity antagonist, with limited uptake in non-CXCR4-expressing organs and high in vivo stability. The tracer was also able to selectively displace the CXCR4 antagonists AMD3100 and AMD3465 from the liver. Conclusion: The tetraazamacrocyclic small molecule 64Cu-CuCB-bicyclam has been shown to be an imaging agent for the CXCR4 receptor that is likely to be applicable across a range of species. It has high affinity and stability and is suitable for preclinical research in immunocompetent murine models

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic

Abstract Background Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 drugs on multiple occasions. It is puzzling that these strains have retained fitness and transmissibility despite the potential fitness cost associated with drug resistance mutations. Methods We conducted Illumina sequencing of 211 Beijing genotype M. tuberculosis isolates to facilitate the detection of genomic features that may promote acquisition of drug resistance and restore fitness in highly resistant atypical Beijing forms. Phylogenetic and comparative genomic analysis was done to determine changes that are unique to the resistant strains that also transmit well. Minimum inhibitory concentration (MIC) determination for streptomycin and bedaquiline was done for a limited number of isolates to demonstrate a difference in MIC between isolates with and without certain variants. Results Phylogenetic analysis confirmed that two clades of atypical Beijing strains have independently developed resistance to virtually all the potent drugs included in standard (pre-bedaquiline) drug-resistant TB treatment regimens. We show that undetected drug resistance in a progenitor strain was likely instrumental in this resistance acquisition. In this cohort, ethionamide (ethA A381P) resistance would be missed in first-line drug-susceptible isolates, and streptomycin (gidB L79S) resistance may be missed due to an MIC close to the critical concentration. Subsequent inadequate treatment historically led to amplification of resistance and facilitated spread of the strains. Bedaquiline resistance was found in a small number of isolates, despite lack of exposure to the drug. The highly resistant clades also carry inhA promoter mutations, which arose after ethA and katG mutations. In these isolates, inhA promoter mutations do not alter drug resistance, suggesting a possible alternative role. Conclusion The presence of the ethA mutation in otherwise susceptible isolates from ethionamide-naïve patients demonstrates that known exposure is not an adequate indicator of drug susceptibility. Similarly, it is demonstrated that bedaquiline resistance can occur without exposure to the drug. Inappropriate treatment regimens, due to missed resistance, leads to amplification of resistance, and transmission. We put these results into the context of current WHO treatment regimens, underscoring the risks of treatment without knowledge of the full drug resistance profile

Comparative Genomics of the Apicomplexan Parasites Toxoplasma gondii and Neospora caninum: Coccidia Differing in Host Range and Transmission Strategy

Toxoplasma gondii is a zoonotic protozoan parasite which infects nearly one third of the human population and is found in an extraordinary range of vertebrate hosts. Its epidemiology depends heavily on horizontal transmission, especially between rodents and its definitive host, the cat. Neospora caninum is a recently discovered close relative of Toxoplasma, whose definitive host is the dog. Both species are tissue-dwelling Coccidia and members of the phylum Apicomplexa; they share many common features, but Neospora neither infects humans nor shares the same wide host range as Toxoplasma, rather it shows a striking preference for highly efficient vertical transmission in cattle. These species therefore provide a remarkable opportunity to investigate mechanisms of host restriction, transmission strategies, virulence and zoonotic potential. We sequenced the genome of N. caninum and transcriptomes of the invasive stage of both species, undertaking an extensive comparative genomics and transcriptomics analysis. We estimate that these organisms diverged from their common ancestor around 28 million years ago and find that both genomes and gene expression are remarkably conserved. However, in N. caninum we identified an unexpected expansion of surface antigen gene families and the divergence of secreted virulence factors, including rhoptry kinases. Specifically we show that the rhoptry kinase ROP18 is pseudogenised in N. caninum and that, as a possible consequence, Neospora is unable to phosphorylate host immunity-related GTPases, as Toxoplasma does. This defense strategy is thought to be key to virulence in Toxoplasma. We conclude that the ecological niches occupied by these species are influenced by a relatively small number of gene products which operate at the host-parasite interface and that the dominance of vertical transmission in N. caninum may be associated with the evolution of reduced virulence in this species

Without Apology: Writings on Abortion in Canada

Until the late 1960s, the authorities on abortion were for the most part men—politicians, clergy, lawyers, physicians, all of whom had an interest in regulating women’s bodies. Even today, when we hear women speak publicly about abortion, the voices are usually those of the leaders of women’s and abortion rights organizations, women who hold political office, and, on occasion, female physicians. We also hear quite frequently from spokeswomen for anti-abortion groups. Rarely, however, do we hear the voices of ordinary women—women whose lives have been in some way touched by abortion. Their thoughts typically owe more to human circumstance than to ideology, and without them, we run the risk of thinking and talking about the issue of abortion only in the abstract. Without Apology seeks to address this issue by gathering the voices of activists, feminists, and scholars as well as abortion providers and clinic support staff alongside the stories of women whose experience with abortion is more personal. With the particular aim of moving beyond the polarizing rhetoric that has characterized the issue of abortion and reproductive justice for so long, Without Apology is an engrossing and arresting account that will promote both reflection and discussion.Canada Council for the Arts Government of Canada Canada Book Fund (CFB) Government of Alberta, Alberta Media Fun

EFSA Panel on Biological Hazards (BIOHAZ); Scientific Opinion on public health risks represented by certain composite products containing food of animal origin

This Opinion reviews the factors that affect microbial survival and growth in composite products, and in foods in general. It concludes that the main factors to be considered are: water activity, pH, temperature and duration of storage, processing, and intensity and duration of other non-thermal physical processes applied. Prevalence and concentration of the pathogens in food are important to determine the risk for consumers. The opinion presents a review of the quantitative microbiology models and databases that can be used to provide quantitative estimations of the impact of the above factors on the survival and growth of the main bacterial pathogens. In composite products, migration and diffusion of moisture and substances among the ingredients may change their physico-chemical parameters, particularly at the interfaces. Therefore, the assessment of the risk posed by composite products needs to consider the combinations of parameters most permissive to survival and growth of pathogens. Two complementary approaches are proposed for the identification and profiling of microbiological hazards in different specific composite products. The first one is based on past outbreaks and prevalence of hazards in the products and leads to the conclusion that the most frequent hazard-composite product combinations are Salmonella in cakes and bakery products. The second one consists in decision tools based on the impact on the pathogens of food composition and food processing. Categorisation of the risk for composite products requires information on their composition, processing and further handling, which can largely differ for foods belonging to the same category. Further conditions may influence the risk and should be verified, i.e. hygienic conditions during preparation of the composite products and their ingredients, shelf-life conditions, and reliability of cooking by consumers to inactivate pathogens. The decision tools developed apply to all composite products considered by the mandate, as well as to all other foods. © European Food Safety Authority, 201