Complexity of modular neuromuscular control increases and variability decreases during human locomotor development

When does modular control of locomotion emerge during human development? One view is that modularity is not innate, being learnt over several months of experience. Alternatively, the basic motor modules are present at birth, but are subsequently reconfigured due to changing brain-body-environment interactions. One problem in identifying modular structures in stepping infants is the presence of noise. Here, using both simulated and experimental muscle activity data from stepping neonates, infants, preschoolers, and adults, we dissect the influence of noise, and identify modular structures in all individuals, including neonates. Complexity of modularity increases from the neonatal stage to adulthood at multiple levels of the motor infrastructure, from the intrinsic rhythmicity measured at the level of individual muscles activities, to the level of muscle synergies and of bilateral intermuscular network connectivity. Low complexity and high variability of neuromuscular signals attest neonatal immaturity, but they also involve potential benefits for learning locomotor tasks

R&D Paths of Pixel Detectors for Vertex Tracking and Radiation Imaging

This report reviews current trends in the R&D of semiconductor pixellated sensors for vertex tracking and radiation imaging. It identifies requirements of future HEP experiments at colliders, needed technological breakthroughs and highlights the relation to radiation detection and imaging applications in other fields of science.Comment: 17 pages, 2 figures, submitted to the European Strategy Preparatory Grou

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells

The Sox6 transcription factor plays critical roles in various cell types, including erythroid cells. Sox6-deficient mice are anemic due to impaired red cell maturation and show inappropriate globin gene expression in definitive erythrocytes. To identify new Sox6 target genes in erythroid cells, we used the known repressive double Sox6 consensus within the εy-globin promoter to perform a bioinformatic genome-wide search for similar, evolutionarily conserved motifs located within genes whose expression changes during erythropoiesis. We found a highly conserved Sox6 consensus within the Sox6 human gene promoter itself. This sequence is bound by Sox6 in vitro and in vivo, and mediates transcriptional repression in transient transfections in human erythroleukemic K562 cells and in primary erythroblasts. The binding of a lentiviral transduced Sox6FLAG protein to the endogenous Sox6 promoter is accompanied, in erythroid cells, by strong downregulation of the endogenous Sox6 transcript and by decreased in vivo chromatin accessibility of this region to the PstI restriction enzyme. These observations suggest that the negative Sox6 autoregulation, mediated by the double Sox6 binding site within its own promoter, may be relevant to control the Sox6 transcriptional downregulation that we observe in human erythroid cultures and in mouse bone marrow cells in late erythroid maturation

Electronic Imaging & the Visual Arts. EVA 2014 Florence

Information Technologies of interest for Culture Heritage are presented: multimedia systems, data-bases, data protection, access to digital content, Virtual Galleries. Particular reference is reserved to digital images (Electronic Imaging & the Visual Arts), regarding Cultural Institutions (Museums, Libraries, Palace - Monuments, Archaeological Sites). The International Conference includes the following Sessions: Strategic Issues; EC Projects and Related Networks & Initiatives; 2D - 3D Technologies and Applications; Virtual Galleries - Museums and Related Initiatives; Access to the Culture Information. Three Workshops regard: International Cooperation; Innovation and Enterprise; e.Culture Cloud. Sono presentate le tematiche relative alle Tecnologie dell\u27Informazione per i Beni Culturali: sistemi multimediali, archivi, protezione dei dati, accesso ai contenuti digitali, Gallerie Virtuali. Particolare rilievo \ue8 riservato alle immagini digitali (Electronic Imaging & the Visual Arts), che riguardano le Itituzioni Culturali (Musei, Biblioteche, Palazzi - Monumenti, Siti Archeologici). La Conferenza Internazionale \ue8 articolata nelle seguenti Sessioni: Attivit\ue0 di interesse generale strategico; Progetti Europei e relative Strutture ed Iniziative; Tecnologie ed Applicazioni 2D - 3D; Gallerie Virtuali - Musei Digitali e relative Iniziative; Accesso alle informazioni relative ai Beni Culturali. Tre Workshops riguardano: la Collaborazione Internazionale; l\u27Innovazione e l\u27Impresa; il Sistema Cloud per la Cultura ("e.Culture Cloud")

Electronic Imaging & the Visual Arts. EVA 2013 Florence

Important Information Technology topics are presented: multimedia systems, data-bases, protection of data, access to the content. Particular reference is reserved to digital images (2D, 3D) regarding Cultural Institutions (Museums, Libraries, Palace – Monuments, Archaeological Sites). The main parts of the Conference Proceedings regard: Strategic Issues, EC Projects and Related Networks & Initiatives, International Forum on “Culture & Technology”, 2D – 3D Technologies & Applications, Virtual Galleries – Museums and Related Initiatives, Access to the Culture Information. Three Workshops are related to: International Cooperation, Innovation and Enterprise, Creative Industries and Cultural Tourism

Electronic Imaging & the Visual Arts. EVA 2017 Florence : Florence (10-11 May 2017)

The Publication is following the yearly Editions of EVA FLORENCE. The State of Art is presented regarding the Application of Technologies (in particular of digital type) to Cultural Heritage. The more recent results of the Researches in the considered Area are presented. Information Technologies of interest for Culture Heritage are presented: multimedia systems, data-bases, data protection, access to digital content, Virtual Galleries. Particular reference is reserved to digital images (Electronic Imaging & the Visual Arts), regarding Cultural Institutions (Museums, Libraries, Palace - Monuments, Archaeological Sites). The International Conference includes the following Sessions: Strategic Issues; New Sciences and Culture Developments and Applications; New Technical Developments & Applications; Museums - Virtual Galleries and Related Initiatives; Art and Humanities Ecosystem & Applications; Access to the Culture Information. Two Workshops regard: Innovation and Enterprise; the Cloud Systems connected to the Culture (eCulture Cloud) in the Smart Cities context. The more recent results of the Researches at national and international are reported in the Area of Technologies and Culture Heritage, also with experimental demonstrations of developed Activities. La Pubblicazione prosegue le edizioni annuali di EVA FLORENCE. Presenta lo stato dell’arte a livello nazionale ed internazionale sulla applicazione delle Tecnologie (in particolare Digitali) ai Beni Culturali. Sono riportati i risultati delle Ricerche pi\uf9 recenti nel Settore di riferimento. Sono presentate le tematiche relative alle Tecnologie dell\u27 Informazione per i Beni Culturali: sistemi multimediali, archivi, protezione dei dati, accesso ai contenuti digitali, Gallerie Virtuali. Particolare rilievo \ue8 riservato alle immagini digitali (Electronic Imaging & the Visual Arts), che riguardano le Istituzioni Culturali (Musei, Biblioteche, Palazzi - Monumenti, Siti Archeologici). La Conferenza Internazionale \ue8 articolata nelle seguenti Sessioni: Attivit\ue0 di interesse generale strategico; Nuovi Sviluppi Culturali e Scientifici e relative Applicazioni; Nuovi Sviluppi Tecnologici e Realt\ue0 Virtuale; Ecosistemi connessi all’Arte ed agli Aspetti Sociali; Musei Digitali - Gallerie Virtuali e relative Iniziative; Accesso alle Informazioni relative ai Beni Culturali. Due Workshops riguardano: l\u27Innovazione e l\u27Impresa; i Sistemi Cloud connessi alla Cultura nel contesto delle Smart Cities. In particolare sono riportati i risultati delle Ricerche pi\uf9 recenti a livello nazionale ed internazionale nel settore delle Tecnologie e dei Beni Culturali anche con dimostrazioni sperimentali delle attivit\ue0 sviluppate

Electronic Imaging & the Visual Arts. EVA 2012 Florence

The key aim of this Event is to provide a forum for the user, supplier and scientific research communities to meet and exchange experiences, ideas and plans in the wide area of Culture & Technology. Participants receive up to date news on new EC and international arts computing & telecommunications initiatives as well as on Projects in the visual arts field, in archaeology and history. Working Groups and new Projects are promoted. Scientific and technical demonstrations are presented