108 research outputs found
Predictors of failed attendances in a multi-specialty outpatient centre using electronic databases.
- Author
- Publication venue
- BMC
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: Failure to keep outpatient medical appointments results in inefficiencies and costs. The objective of this study is to show the factors in an existing electronic database that affect failed appointments and to develop a predictive probability model to increase the effectiveness of interventions. METHODS: A retrospective study was conducted on outpatient clinic attendances at Tan Tock Seng Hospital, Singapore from 2000 to 2004. 22864 patients were randomly sampled for analysis. The outcome measure was failed outpatient appointments according to each patient's latest appointment. RESULTS: Failures comprised of 21% of all appointments and 39% when using the patients' latest appointment. Using odds ratios from the mutliple logistic regression analysis, age group (0.75 to 0.84 for groups above 40 years compared to below 20 years), race (1.48 for Malays, 1.61 for Indians compared to Chinese), days from scheduling to appointment (2.38 for more than 21 days compared to less than 7 days), previous failed appointments (1.79 for more than 60% failures and 4.38 for no previous appointments, compared with less than 20% failures), provision of cell phone number (0.10 for providing numbers compared to otherwise) and distance from hospital (1.14 for more than 14 km compared to less than 6 km) were significantly associated with failed appointments. The predicted probability model's diagnostic accuracy to predict failures is more than 80%. CONCLUSION: A few key variables have shown to adequately account for and predict failed appointments using existing electronic databases. These can be used to develop integrative technological solutions in the outpatient clinic
Bio-nanotechnology application in wastewater treatment
- Author
- A Biswas
- A Kalaiselvi
- A Pyatenko
- A Rout
- A Suganya
- AE Danks
- AG Ingale
- AG Skirtach
- AK Mittal
- AM Awwad
- AM Fayaz
- B Le Ouay
- B Sadeghi
- BB Borse
- BG Rasheed
- BN Parimi
- C Ito
- CG Kumar
- D Hebbalalu
- D Philip
- D Tilman
- D Werner
- DA Kumar
- DC Adler
- DE Carter
- EV Barmina
- F Afkhami
- F Lin
- F Pacheco-Torgal
- FE Kruis
- G González-Rubio
- G González-Rubio
- G Haferburg
- G Yashni
- G Yashni
- GG Bovi
- H Al Harbi
- H Kurita
- H Zeng
- H Zhang
- I Khan
- JD Majumdar
- JY Song
- K Anandalakshmi
- K Chaloupka
- K Lukaszkowicz
- K Punjabi
- K Saranyaadevi
- K Srinivasan
- K Ueno
- K Yamada
- KM Kumar
- KMMA El-Nour
- L Cheng
- L Christensen
- L De Sio
- M Ghaedi
- M Kim
- M Kowshik
- M Nasrollahzadeh
- M Panghal
- M Rai
- M Sorbiun
- M Wu
- MB Ningappa
- MF Lengke
- MH Gholami-Shabani
- MH Mahdieh
- MK Swamy
- MM Rahman
- MR Bindhu
- MT Moustafa
- N Ahmad
- N Bala
- N Saifuddin
- NG Semaltianos
- NI Hulkoti
- NK Sajeshkumar
- O Abdi
- P Atkinson
- P Bhattacharya
- P Kunwar
- P Marrow
- P Matteini
- P Nalawade
- P Prakash
- P Singh
- PS Pimprikar
- R Bhattacharya
- R Zamiri
- RG Palgrave
- RS Patil
- S Ahmed
- S Ahmed
- S Baek
- S Deb
- S Gupta
- S Iravani
- S Iravani
- S Link
- S Link
- S Mobasser
- S Raj
- S Scaramuzza
- S Sun
- S Suresh
- S Vivekanandhan
- SK Devatkal
- SL Logunov
- SP Dubey
- SP Kureel
- SR Bonde
- SS Kelkar
- SS Shankar
- SS Shankar
- T Kudo
- T Kumpulainen
- T Mazhar
- TS Ahmadi
- V Kathiravan
- V Kumar
- V Ravichandran
- V Thamilselvi
- VA Kumar
- VS Kumar
- Y Tachibana
- YN Slavin
- Z Fan
- Publication venue
- Springer Nature
- Publication date
- 01/01/2020
- Field of study
The nanoparticles have received high interest in the field of medicine and water purification, however, the nanomaterials produced by chemical and physical methods are considered hazardous, expensive, and leave behind harmful substances to the environment. This chapter aimed to focus on green-synthesized nanoparticles and their medical applications. Moreover, the chapter highlighted the applicability of the metallic nanoparticles (MNPs) in the inactivation of microbial cells due to their high surface and small particle size. Modifying nanomaterials produced by green-methods is safe, inexpensive, and easy. Therefore, the control and modification of nanoparticles and their properties were also discussed
Effective Rheology of Bubbles Moving in a Capillary Tube
- Author
- Abelev B
- Adam J
- Adamova D
- Adare AM
- Aggarwal MM
- Agocs AG
- Agostinelli A
- Ahammed Z
- Ahmad N
- Ahn SU
- Akindinov A
- Alaniz EC
- Aleksandrov D
- Alessandro B
- Alici A
- Alkin A
- Alme J
- Alt T
- Altini V
- Altinpinar S
- Altsybeev I
- Andrei C
- Andronic A
- Anguelov V
- Anielski J
- Anson C
- Anticic T
- Antinori F
- Antonioli P
- Aphecetche L
- Appelshauser H
- Arbor N
- Arcelli S
- Arend A
- Armesto N
- Arnaldi R
- Aronsson T
- Arsene IC
- Arslandok M
- Asryan A
- Augustinus A
- Averbeck R
- Avina EA
- Awes TC
- Aysto J
- Azmi MD
- Bach M
- Badala A
- Baek YW
- Bailhache R
- Baillie OV
- Bala R
- Balbastre GC
- Baldisseri A
- Baldit A
- Ban J
- Baral RC
- Barbera R
- Bari DD
- Barile F
- Barnafoldi GG
- Barnby LS
- Barret V
- Barros GOVD
- Barroso VC
- Bartke J
- Basile M
- Bastid N
- Bathen B
- Batigne G
- Batyunya B
- Baumann C
- Bearden IG
- Beck H
- Belikov I
- Bellini F
- Bellwied R
- Belmont-Moreno E
- Bencedi G
- Beole S
- Berceanu I
- Bercuci A
- Berdnikov Y
- Berenyi D
- Bergmann C
- Berzano D
- Betev L
- Bhasin A
- Bhati AK
- Bianchi L
- Bianchi N
- Bianchin C
- Bielcik J
- Bielcikova J
- Bjelogrlic S
- Blanco F
- Blanco F
- Blau D
- Blume C
- Boccioli M
- Bock N
- Bogdanov A
- Boggild H
- Bogolyubsky M
- Boldizsar L
- Bombara M
- Book J
- Borel H
- Borissov A
- Bornec YL
- Bose S
- Bossu F
- Botje M
- Bottger S
- Boyer B
- Braidot E
- Braun-Munzinger P
- Bregant M
- Breitner T
- Browning TA
- Broz M
- Brun R
- Bruna E
- Bruno GE
- Budnikov D
- Buesching H
- Bufalino S
- Bugaiev K
- Busch O
- Bustamante RTJ
- Buthelezi Z
- Caffarri D
- Cahuantzi MR
- Cai X
- Caines H
- Camerini P
- Carena F
- Carena W
- Carminati F
- Caro AD
- Castellanos JC
- Castro XS
- Casula EAR
- Cataldo GD
- Catanescu V
- Cavicchioli C
- Cepila J
- Cerello P
- Cervantes IM
- Chang B
- Chapeland S
- Charvet JL
- Chattopadhyay S
- Chattopadhyay S
- Chawla I
- Cherney M
- Cheshkov C
- Cheynis B
- Chiavassa E
- Chinellato DD
- Chochula P
- Chojnacki M
- Christakoglou P
- Christensen CH
- Christiansen P
- Chujo T
- Chung SU
- Cicalo C
- Cifarelli L
- Cindolo F
- Cleymans J
- Coccetti F
- Colamaria F
- Colella D
- Collaboration ALICE
- Constantin P
- Contin G
- Contreras JG
- Corchero MAD
- Cormier TM
- Corral GH
- Cortese P
- Cosentino MR
- Costa F
- Cotallo ME
- Crescio E
- Crochet P
- Cuautle E
- Cunqueiro L
- Cuveland JD
- Dainese A
- Dalsgaard HH
- Danu A
- Das D
- Das I
- Das K
- Dash A
- Dash S
- Davalos AM
- De S
- Delagrange H
- Deloff A
- Demanov V
- Denes E
- Deppman A
- Diaz AC
- Dietel T
- Divia R
- Djuvsland O
- Dobrin A
- Dobrowolski T
- Dominguez I
- Don CKK
- Donigus B
- Dordic O
- Driga O
- Dubey AK
- Ducroux L
- Dupieux P
- Elia D
- Emschermann D
- Engel H
- Erasmo GD
- Erdal HA
- Espagnon B
- Estienne M
- Esumi S
- Evans D
- Eyyubova G
- Fabris D
- Faivre J
- Falchieri D
- Falco AD
- Fantoni A
- Fasel M
- Fearick R
- Fedunov A
- Fehlker D
- Feldkamp L
- Felea D
- Feofilov G
- Ferreiro EG
- Ferretti A
- Ferretti R
- Ferroli RB
- Figiel J
- Figueredo MAS
- Filchagin S
- Filho EPDO
- Filho NC
- Finogeev D
- Fionda FM
- Fiore EM
- Floris M
- Foertsch S
- Foka P
- Fokin S
- Fragiacomo E
- Fragkiadakis M
- Frankenfeld U
- Fuchs U
- Furget C
- Gaardhoje JJ
- Gagliardi M
- Gago A
- Gallio M
- Gangadharan DR
- Ganoti P
- Garabatos C
- Garcia GM
- Garcia-Solis E
- Garishvili I
- Gerhard J
- Germain M
- Geuna C
- Gheata A
- Gheata M
- Ghidini B
- Ghosh P
- Gianotti P
- Giglio CD
- Girard MF
- Girard MR
- Giubellino P
- Gladysz-Dziadus E
- Glassel P
- Godoy DAMD
- Gomez R
- Gonzalez-Trueba LH
- Gonzalez-Zamora P
- Gorbunov S
- Goswami A
- Gotovac S
- Grabski V
- Graczykowski LK
- Grajcarek R
- Grelli A
- Grigoras A
- Grigoras C
- Grigoriev V
- Grigoryan A
- Grigoryan S
- Grinyov B
- Grion N
- Gros P
- Grosse-Oetringhaus JF
- Grossiord JY
- Grosso R
- Gruttola DD
- Guber F
- Guernane R
- Guerzoni B
- Guevara PLD
- Guilbaud M
- Gulbrandsen K
- Gunji T
- Gupta A
- Gupta R
- Gutbrod H
- Gutierrez CG
- Haaland O
- Hadjidakis C
- Haiduc M
- Haller BV
- Hamagaki H
- Hamar G
- Han BH
- Hanratty LD
- Hansen A
- Harmanova Z
- Harris JW
- Hartig M
- Hasegan D
- Hatzifotiadou D
- Hayrapetyan A
- Heckel ST
- Heide M
- Helstrup H
- Herghelegiu A
- Hernandez JFC
- Herrmann N
- Hetland KF
- Hicks B
- Hille PT
- Hippolyte B
- Horaguchi T
- Hori Y
- Hristov P
- Hrivnacova I
- Huang M
- Huber S
- Humanic TJ
- Hwang DS
- Ichou R
- Ilkaev R
- Ilkiv I
- Inaba M
- Incani E
- Innocenti GM
- Innocenti PG
- Ippolitov M
- Irfan M
- Ivan C
- Ivanov A
- Ivanov M
- Ivanov V
- Ivanytskyi O
- Jacholkowski A
- Jacobs PM
- Jancurova L
- Jang HJ
- Jangal S
- Janik MA
- Janik R
- Jayarathna PHSY
- Jena S
- Jirden L
- Jones PG
- Jung H
- Jusko A
- Kaidalov AB
- Kakoyan V
- Kalcher S
- Kalinak P
- Kalisky M
- Kalliokoski T
- Kalweit A
- Kanaki K
- Kang JH
- Kaplin V
- Karampatsos LX
- Karavichev O
- Karavicheva T
- Karpechev E
- Kazantsev A
- Kebschull U
- Keidel R
- Khan MM
- Khan P
- Khan SA
- Khanzadeev A
- Kharlov Y
- Kileng B
- Kim B
- Kim DJ
- Kim DW
- Kim JH
- Kim JS
- Kim M
- Kim S
- Kim SH
- Kim T
- Kirsch S
- Kisel I
- Kiselev S
- Kisiel A
- Klay JL
- Klein J
- Klein-Bosing C
- Kliemant M
- Kluge A
- Knichel ML
- Knospe AG
- Koch K
- Kohler MK
- Kolk NVD
- Kolojvari A
- Kondratiev V
- Kondratyeva N
- Konevskikh A
- Korneev A
- Kour R
- Kowalski M
- Kox S
- Kral J
- Kralik I
- Kramer F
- Kraus I
- Krawutschke T
- Krelina M
- Kretz M
- Krivda M
- Krizek F
- Krus M
- Kryshen E
- Krzewicki M
- Kucheriaev Y
- Kuhn C
- Kuijer PG
- Kurashvili P
- Kurepin A
- Kurepin AB
- Kuryakin A
- Kushpil S
- Kushpil V
- Kvaerno H
- Kweon MJ
- Kwon Y
- Lakomov I
- Langoy R
- Lara C
- Lara CEP
- Lardeux A
- Lazzeroni C
- Lea R
- Lee KS
- Lee SC
- Leeuwen MV
- Lefevre F
- Lehnert J
- Leistam L
- Lenhardt M
- Lenti V
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- Levai P
- Lezama EP
- Liberto SD
- Lien J
- Lietava R
- Lindal S
- Lindenstruth V
- Lippmann C
- Lisa MA
- Liu L
- Loenne PI
- Loggins VR
- Loginov V
- Lohn S
- Lohner D
- Loizides C
- Loo KK
- Lopez X
- Lovhoiden G
- Lu XG
- Luettig P
- Lunardon M
- Luo J
- Luparello G
- Luquin L
- Luzzi C
- Ma K
- Ma R
- Madagodahettige-Don DM
- Maevskaya A
- Mager M
- Mahapatra DP
- Maire A
- Majumdar AKD
- Majumdar MRD
- Mal'Kevich D
- Malaev M
- Maldonado IC
- Malinina L
- Malzacher P
- Mamonov A
- Manceau L
- Mangotra L
- Manko V
- Manso F
- Manzari V
- Mao Y
- Marchisone M
- Marco ND
- Mares J
- Margagliotti GV
- Margotti A
- Marin A
- Markert C
- Martashvili I
- Martinengo P
- Martinez MI
- Martynov Y
- Mas A
- Masciocchi S
- Masera M
- Masoni A
- Masoodi AA
- Massacrier L
- Mastromarco M
- Mastroserio A
- Matthews ZL
- Matyja A
- Mauro AD
- Mayani D
- Mayer C
- Mazer J
- Mazzoni MA
- Meddi F
- Meethaleveedu GK
- Menchaca-Rocha A
- Meres M
- Miake Y
- Milano L
- Milosevic J
- Mischke A
- Mishra AN
- Miskowiec D
- Mitu C
- Mlynarz J
- Mohanty AK
- Mohanty B
- Molina RA
- Molnar L
- Monteno M
- Montero AJR
- Montes E
- Montoya CAC
- Monzon IL
- Moon T
- Morales YC
- Morando M
- Moretto S
- Morsch A
- Muccifora V
- Mudnic E
- Muhuri S
- Muller H
- Munhoz MG
- Munoz GT
- Musa L
- Musso A
- Nandi BK
- Nania R
- Nappi E
- Nattrass C
- Naumov NP
- Navin S
- Nayak TK
- Nazarenko S
- Nazarov G
- Nedosekin A
- Nezza PD
- Nicassio M
- Nielsen BS
- Niida T
- Nikolaev S
- Nikolic V
- Nikulin S
- Nikulin V
- Nilsen BS
- Nilsson MS
- Noferini F
- Nomokonov P
- Nooren G
- Novitzky N
- Nyanin A
- Nyatha A
- Nygaard C
- Nystrand J
- Ochirov A
- Oeschler H
- Oh S
- Oh SK
- Oleniacz J
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- Orduna DC
- Ortona G
- Oskarsson A
- Ostrowski P
- Otwinowski J
- Ovrebekk G
- Oyama K
- Ozawa K
- Pachmayer Y
- Pachr M
- Padilla F
- Pagano P
- Paic G
- Painke F
- Pajares C
- Pal S
- Pal SK
- Palaha A
- Palmeri A
- Palomo LV
- Papikyan V
- Pappalardo GS
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- Pasquale SD
- Passfeld A
- Pastircak B
- Patalakha DI
- Paticchio V
- Pavlinov A
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- Pedrosa FBDS
- Peitzmann T
- Peresunko D
- Perez JM
- Perini D
- Perrino D
- Peryt W
- Pesci A
- Peskov V
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- Petracek V
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- Petris M
- Petrov P
- Petrovici M
- Petta C
- Piano S
- Piccotti A
- Pikna M
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- Pinazza O
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- Pitz N
- Piuz F
- Piyarathna DB
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- Podesta-Lerma PLM
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- Polichtchouk B
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- Porteboeuf-Houssais S
- Pospisil V
- Potukuchi B
- Prasad SK
- Preghenella R
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- Pruneau CA
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- Ricci RA
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- Riegler W
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- Rohr D
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- Schweda K
- Scioli G
- Scomparin E
- Scott PA
- Scott R
- Segato G
- Selyuzhenkov I
- Senyukov S
- Seo J
- Serci S
- Serradilla E
- Sevcenco A
- Sgura I
- Shabetai A
- Shabratova G
- Shahoyan R
- Sharma N
- Sharma S
- Shigaki K
- Shimomura M
- Shtejer K
- Sibiriak Y
- Siciliano M
- Sicking E
- Siddhanta S
- Siemiarczuk T
- Silvermyr D
- Silvestre C
- Simonetti G
- Singaraju R
- Singh R
- Singha S
- Sinha BC
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- Sitar B
- Sitta M
- Skaali TB
- Skjerdal K
- Smakal R
- Smirnov N
- Snellings RJM
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- Son H
- Song J
- Song M
- Soos C
- Soramel F
- Sputowska I
- Spyropoulou-Stassinaki M
- Srivastava BK
- Stachel J
- Stan I
- Stan I
- Stefanek G
- Stefanini G
- Steinbeck T
- Steinpreis M
- Stenlund E
- Steyn G
- Stocco D
- Stolpovskiy M
- Strabykin K
- Strmen P
- Suaide AAP
- Sugitate T
- Suire C
- Sukhorukov M
- Sultanov R
- Sumbera M
- Susa T
- Szarka I
- Szostak A
- Tagridis C
- Takahashi J
- Takaki JDT
- Tauro A
- Teixido JP
- Telesca A
- Tellez AF
- Terrevoli C
- Thader J
- Thomas D
- Tieulent R
- Timmins AR
- Tlusty D
- Tobon CAM
- Toia A
- Toledo ASD
- Torii H
- Torres EL
- Toscano L
- Tosello F
- Truesdale D
- Trzaska WH
- Tsuji T
- Tumkin A
- Turrisi R
- Tveter TS
- Ulery J
- Ullaland K
- Ulrich J
- Uras A
- Urban J
- Urciuoli GM
- Usai GL
- Uysal AK
- Vajzer M
- Vala M
- Valle ZCD
- Vallero S
- Vannucci L
- Vargas A
- Vargas HL
- Varma R
- Vasileiou M
- Vasiliev A
- Vasquez MAS
- Vechernin V
- Velasquez AO
- Veldhoen M
- Venaruzzo M
- Vercellin E
- Vergara S
- Vernekohl DC
- Vernet R
- Verweij M
- Vickovic L
- Viesti G
- Vikhlyantsev O
- Vilakazi Z
- Villar EC
- Vinogradov A
- Vinogradov L
- Vinogradov Y
- Virgili T
- Viyogi YP
- Vodopyanov A
- Voloshin K
- Voloshin S
- Volpe G
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- Vulpescu B
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- Wang M
- Wang Y
- Wang Y
- Watanabe K
- Wessels JP
- Westerhoff U
- Wiechula J
- Wikne J
- Wilde M
- Wilk A
- Wilk G
- Williams MCS
- Windelband B
- Yang H
- Yang S
- Yasnopolskiy S
- Yi J
- Yin Z
- Yokoyama H
- Yoo IK
- Yoon J
- Yu W
- Yuan X
- Yushmanov I
- Zach C
- Zampolli C
- Zaporozhets S
- Zarochentsev A
- Zavada P
- Zaviyalov N
- Zbroszczyk H
- Zelnicek P
- Zetina LM
- Zgura IS
- Zhalov M
- Zhang X
- Zhou D
- Zhou F
- Zhou Y
- Zhu X
- Zichichi A
- Zimmermann A
- Zinovjev G
- Zoccarato Y
- Zynovyev M
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 16/03/2012
- Field of study
We calculate the average volumetric flux versus pressure drop of bubbles
moving in a single capillary tube with varying diameter, finding a square-root
relation from mapping the flow equations onto that of a driven overdamped
pendulum. The calculation is based on a derivation of the equation of motion of
a bubble train from considering the capillary forces and the entropy production
associated with the viscous flow. We also calculate the configurational
probability of the positions of the bubbles.Comment: 4 pages, 1 figur
Cholesterol-Lowering Drugs and Incident Open-Angle Glaucoma: A Population-Based Cohort Study
- Author
- A Corsini
- A Endo
- A Hofman
- Albert Hofman
- B McGuinness
- BE Klein
- BH Stricker
- Bruno H. Stricker
- C Ekström
- CG Owen
- CJ Vaughan
- DK De Castro
- DY Leung
- E Skenduli-Bala
- G Chodick
- G De Backer
- G McGwin
- G McGwin Jr
- GK Andrikopoulos
- HM Colhoun
- I Dielemans
- J Li
- Johannes R. Vingerling
- JS Tan
- K Sen
- K Stepien
- M Citirik
- M Iskedjian
- M Schachter
- MA Czudowska
- Michael W. Marcus
- MO Gordon
- MW Marcus
- Nomdo M. Jansonius
- P Mitchell
- Pablo Villoslada
- Paulus T. V. M. De Jong
- PJ van der Most
- R Collins
- R Van Leeuwen
- RC Wolfs
- Roger C. W. Wolfs
- Rogier P. H. M. Müskens
- S Sierra
- SM Grundy
- T Nagaoka
- T Walley
- WG Wood
- Wishal D. Ramdas
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Background: Open-angle glaucoma (OAG) is a progressive neurodegenerative disease that may lead to blindness. An elevated intraocular pressure (IOP) is its major risk factor. OAG treatment is currently exclusively directed towards the lowering of the IOP. IOP lowering does not prevent disease progression in all patients and thus other treatment modalities are needed. Earlier studies reported cholesterol-lowering drugs to have neuroprotective properties. The aim of this study was to determine the associations between the use of cholesterol-lowering drugs and incident OAG. Methodology/Principal Findings: Participants in a prospective population-based cohort study underwent ophthalmic examinations, including IOP measurements and perimetry, at baseline and follow-up. The use of statins and non-statin cholesterol-lowering drugs was monitored continuously during the study. Associations between the use of cholesterol-lowering drugs and incident OAG were analyzed with Cox regression; associations between cholesterol-lowering drugs and IOP at follow-up were analyzed with multiple linear regression. During a mean follow-up of 9.8 years, 108 of 3939 eligible participants (2.7%) developed OAG. The hazard ratio for statin use was 0.54 (95% confidence interval 0.31-0.96; P = 0.034) and for non-statin cholesterol-lowering drugs 2.07 (0.81-5.33; P = 0.13). The effect of statins was more pronounced with prolonged use (hazard ratio 0.
RNA delivery by extracellular vesicles in mammalian cells and its applications.
- Author
- A Ahadi
- A Buonfiglioli
- A Datta
- A Gori
- A Herrmann
- A Hoshino
- A Iavello
- A Khvorova
- A Longatti
- A Mondal
- A Montecalvo
- A Morales-Kastresana
- A Rustom
- A Savina
- A Varcianna
- A Wittrup
- A Yeri
- A Zomer
- AD Flynn
- AD Grabarek
- AF Saleh
- AH Van Craenenbroeck
- AJ McKenzie
- AK Rupp
- AL Blasius
- AM Leidal
- AM Marleau
- AR Soares
- AT Da Poian
- B Escudier
- B György
- B György
- B Mannerström
- B Mateescu
- B Meehan
- B Shen
- BH Sung
- BM Lehrich
- BN Hannafon
- BWM Van Balkom
- BY Nabet
- C Eliscovich
- C Escrevente
- C Geoffroy
- C Gong
- C Grange
- C Lässer
- C Ma
- C Meyer
- C Théry
- C Villarroya-Beltri
- C Williams
- C Williams
- CA Thompson
- CC Chen
- CG Liu
- CM Di Liegro
- CP Lai
- CP Lai
- D Choi
- D De Gonzalo-Calvo
- D Fanale
- D Granchi
- D Hoshino
- D Planchon
- D Shukla
- DD Yanshina
- DE Murphy
- DJ Gibbings
- DK Jeppesen
- DK Struck
- DM Jones
- DX Zhang
- E Reátegui
- E Rohde
- E Tutucci
- E van der Pol
- ED Pastuzyn
- EJ Im
- EM Guerreiro
- EN Hoen
- ENM Nolte’T Hoen
- ER Abels
- F Chen
- F De La Cuesta
- F Ghamloush
- F Gámbaro
- F Hobor
- F Kenneweg
- F Pi
- F Royo
- FJ Giles
- FM Khan
- G Haimovich
- G Van Niel
- H Goodarzi
- H Persson
- H Pollet
- H Ragelle
- H Shao
- H Sork
- H Valadi
- H Yu
- H Yuhua
- H Zhang
- H Zhang
- H Zhang
- HC Christianson
- HM van Dongen
- HW King
- I Nakase
- I Nakase
- I Nakase
- I Parolini
- I Prada
- IKH Poon
- J Ashley
- J Grove
- J Guduric-Fuchs
- J He
- J Jiang
- J Karttunen
- J Kowal
- J Liu
- J Matsuzaki
- J McKiernan
- J Schorey
- J Skog
- J Van Deun
- J Van Deun
- J Wang
- J Wang
- J Zou
- JA Tsatsaronis
- JC Akers
- JC Akers
- JD Arroyo
- JD Martin-Rufino
- JE Freedman
- JF Quinn
- JM Rimer
- JM Wahlberg
- JPK Armstrong
- JR Chevillet
- JR Edgar
- JR Schnell
- JW Clancy
- K Burgos
- K Ekström
- K Glebov
- K Hagiwara
- K Koga
- K Lee
- K Miyauchi
- K Mukherjee
- K Otake
- K Ridder
- K Yin
- KC Vickers
- KM Danielson
- KW Witwer
- L Alvarez-Erviti
- L Antoury
- L Morel
- L Pigati
- L Santangelo
- L Statello
- L Wang
- L Zhang
- LA Beninson
- LA Mulcahy
- M Alexander
- M Fabbri
- M Gimona
- M Li
- M Mathieu
- M Maugeri
- M Mendt
- M Mittelbrunn
- M Mittelbrunn
- M Miyanishi
- M Panasiuk
- M Ragusa
- M Shen
- M Tkach
- MAC Pomatto
- MC Boelens
- MC Didiot
- MD Giraldez
- ME Hung
- MF Bolukbasi
- MJ Shurtleff
- MJ Shurtleff
- ML Squadrito
- MM Temoche-Diaz
- MP Hardy
- MP Zaborowski
- MS Joerger-Messerli
- N Heath
- N Jabbari
- N Karimi
- N Kosaka
- N Sadik
- NT Chiou
- O Markov
- O Oleksiuk
- OA Kossinova
- OD Murillo
- OPB Wiklander
- OPB Wiklander
- P Gangadaran
- P Gaurivaud
- P Lönn
- P Song
- PE Mangeot
- PJ Quesenberry
- PM Godoy
- PM Godoy
- Q Liu
- Q Wang
- Q Wang
- Q Zhang
- R Bayraktar
- R Crescitelli
- R Horos
- R Kojima
- R Lucero
- R Munagala
- R Shah
- R Xu
- RA Haraszti
- RA Haraszti
- RF D’souza
- RK Tweten
- RL Maute
- S Atienzar-Aroca
- S Bala
- S Caruso
- S Chen
- S Das
- S Gerstberger
- S Kamerkar
- S Sinha
- S Srinivasan
- SA Melo
- SAA Kooijmans
- SAA Kooijmans
- SAA Kooijmans
- SAA Kooijmans
- SC Jang
- SG Antimisiaris
- SI Ohno
- SK Chakrabortty
- SM Kim
- SM Lehmann
- SN Hurwitz
- SR Baglio
- SR Baglio
- T Janas
- T Thomou
- T Tian
- TAP Driedonks
- TG Iversen
- TJ Antes
- TN Bukong
- TN Lamichhane
- V Bhaskaran
- V Ramakrishnaiah
- V Toribio
- VD Atayde
- VR Minciacchi
- W Aoi
- W Heusermann
- W Ying
- WD Gray
- WM Usman
- WP Kuo
- X Gao
- X Huang
- X Liu
- X Zhu
- X Zou
- Y Lin
- Y Long
- Y Ma
- Y Tao
- Y Teng
- Y Wang
- YY Jhan
- Z Feng
- Z Wei
- Z Wei
- ZW Luo
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2020
- Field of study
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies). Extracellular vesicles carry a variety of cargo, including RNAs, proteins, lipids and DNA, which can be taken up by other cells, both in the direct vicinity of the source cell and at distant sites in the body via biofluids, and elicit a variety of phenotypic responses. Owing to their unique biology and roles in cell-cell communication, extracellular vesicles have attracted strong interest, which is further enhanced by their potential clinical utility. Because extracellular vesicles derive their cargo from the contents of the cells that produce them, they are attractive sources of biomarkers for a variety of diseases. Furthermore, studies demonstrating phenotypic effects of specific extracellular vesicle-associated cargo on target cells have stoked interest in extracellular vesicles as therapeutic vehicles. There is particularly strong evidence that the RNA cargo of extracellular vesicles can alter recipient cell gene expression and function. During the past decade, extracellular vesicles and their RNA cargo have become better defined, but many aspects of extracellular vesicle biology remain to be elucidated. These include selective cargo loading resulting in substantial differences between the composition of extracellular vesicles and source cells; heterogeneity in extracellular vesicle size and composition; and undefined mechanisms for the uptake of extracellular vesicles into recipient cells and the fates of their cargo. Further progress in unravelling the basic mechanisms of extracellular vesicle biogenesis, transport, and cargo delivery and function is needed for successful clinical implementation. This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications
Alignment of the ALICE Inner Tracking System with cosmic-ray tracks
- Author
- Aamodt K
- Abel N
- Abeysekara U
- Adamova D
- Aggarwal M
- Agocs AG
- Ahammed Z
- Ahmad A
- Ahmad N
- Ahn SU
- Akimoto R
- Akindinov A
- Aleksandrov D
- Alessandro B
- Alici A
- Alme J
- Alt T
- Altini V
- Altinpinar S
- Andrei C
- Andronic A
- Anelli G
- Angelov V
- Anson C
- Anticic T
- Antinori F
- Antinori S
- Antipin K
- Antonczyk D
- Antonioli P
- Anzo A
- Aphecetche L
- Appelshauser H
- Arcelli S
- Arceo R
- Arend A
- Armesto N
- Arnaldi R
- Aronsson T
- Arsene IC
- Asryan A
- Augustinus A
- Averbeck R
- Avina EA
- Awes TC
- Aysto J
- Azmi MD
- Bablok S
- Bach M
- Badala A
- Baek YW
- Bagnasco S
- Bailhache R
- Baillie OV
- Bala R
- Balbastre GC
- Baldisseri A
- Baldit A
- Ban J
- Barbera R
- Barile F
- Barnafoldi GG
- Barnby L
- Barret V
- Barroso VC
- Bartke J
- Basile M
- Basmanov V
- Bastid N
- Bathen B
- Batigne G
- Batyunya B
- Baumann C
- Bearden IG
- Becker B
- Belikov I
- Bellwied R
- Belmont-Moreno E
- Belogianni A
- Benhabib L
- Beole S
- Berceanu I
- Bercuci A
- Berdermann E
- Berdnikov Y
- Betev L
- Bhasin A
- Bhati AK
- Bianchi L
- Bianchi N
- Bianchin C
- Bielcik J
- Bielcikova J
- Bilandzic A
- Bimbot L
- Biolcati E
- Blanc A
- Blanco F
- Blanco F
- Blau D
- Blume C
- Boccioli M
- Bock N
- Bogdanov A
- Boggild H
- Bogolyubsky M
- Bohm J
- Boldizsar L
- Bombara M
- Bombonati C
- Bondila M
- Borel H
- Borisov A
- Borshchov V
- Bortolin C
- Bose S
- Bosisio L
- Bossu F
- Botje M
- Bottger S
- Bourdaud G
- Boyer B
- Braun M
- Braun-Munzinger P
- Bravina L
- Bregant M
- Breitner T
- Bruckner G
- Brun R
- Bruna E
- Bruno GE
- Budnikov D
- Buesching H
- Buncic P
- Busch O
- Buthelezi Z
- Caffarri D
- Cahuantzi MR
- Cai X
- Caines H
- Camacho E
- Camerini P
- Campbell M
- Capitani GP
- Carena F
- Carena W
- Carminati F
- Caselle M
- Castellanos JC
- Catanescu V
- Cattaruzza E
- Cavicchioli C
- Cerello P
- Cervantes IM
- Chambert V
- Chang B
- Chapeland S
- Charpy A
- Charvet JL
- Chattopadhyay S
- Chattopadhyay S
- Cherney M
- Cheshkov C
- Cheynis B
- Chiavassa E
- Chiesa AM
- Chinellato DD
- Chochula P
- Choi K
- Chojnacki M
- Christakoglou P
- Christensen CH
- Christiansen P
- Chujo T
- Chuman F
- Cicalo C
- Cifarelli L
- Cindolo F
- Cleymans J
- Cobanoglu O
- Coffin JP
- Coli S
- Colla A
- Conner ES
- Constantin P
- Contin G
- Contreras GJ
- Cormier TM
- Corral GH
- Cortese P
- Cosentino MR
- Costa F
- Cotallo ME
- Crescio E
- Crochet P
- Cuautle E
- Cunqueiro L
- Cussonneau J
- D'Erasmo G
- da Silva RSD
- Dainese A
- Dalsgaard HH
- Danu A
- Das I
- Das S
- Dash A
- Dash S
- Davalos AM
- de Barros GOV
- De Caro A
- de Cataldo G
- de Cuveland J
- De Falco A
- De Gaspari M
- de Groot J
- De Gruttola D
- de Guevara PL
- de Haas AP
- De Marco N
- de Matos CT
- De Pasquale S
- De Remigis R
- de Rooij R
- de Toledo AS
- de Vaux G
- del Valle ZC
- Delagrange H
- Dellacasa G
- Deloff A
- Demanov V
- Denes E
- Deppman A
- Derkach D
- Devaux A
- Di Bari D
- Di Giglio C
- Di Liberto S
- Di Mauro A
- Di Nezza P
- Dialinas M
- Diaz AC
- Diaz L
- Diaz R
- Dietel T
- Ding H
- Divia R
- Djuvsland O
- Dobretsov V
- Dobrin A
- Dobrowolski T
- Dominguez I
- Don DMM
- Donigus B
- Dordic O
- Dubey AK
- Dubuisson J
- Ducroux L
- Dupieux P
- Elia D
- Emschermann D
- Enokizono A
- Espagnon B
- Estienne M
- Evans D
- Evrard S
- Eyyubova G
- Fabjan CW
- Fabris D
- Faivre J
- Falchieri D
- Fantoni A
- Fasel M
- Fateev O
- Fearick R
- Fedunov A
- Fehlker D
- Fekete V
- Felea D
- Fenton-Olsen B
- Feofilov G
- Ferreiro EG
- Ferretti A
- Ferretti R
- Figueredo MAS
- Filchagin S
- Fini R
- Fionda FM
- Fiore EM
- Floris M
- Fodor Z
- Foertsch S
- Foka Panagiota
- Fokin S
- Formenti F
- Fragiacomo E
- Fragkiadakis M
- Frankenfeld U
- Frolov A
- Fuchs U
- Furano F
- Furget C
- Gaardhoje JJ
- Gadrat S
- Gagliardi M
- Gago A
- Gallio M
- Gang S
- Ganoti P
- Ganti MS
- Garabatos C
- Garcia GM
- Gebelein J
- Gemme R
- Germain M
- Gheata A
- Gheata M
- Ghidini B
- Ghosh P
- Girard MF
- Giraudo G
- Giubellino P
- Gladysz-Dziadus E
- Glasow R
- Glassel P
- Glenn A
- Gomez R
- Gonzalez-Trueba LH
- Gonzalez-Zamora P
- Gorbunov S
- Gorbunov Y
- Gotovac S
- Gottschlag H
- Grabski V
- Grajcarek R
- Grelli A
- Grigoras A
- Grigoras C
- Grigoriev V
- Grigoryan A
- Grigoryan S
- Grinyov B
- Grion N
- Gros P
- Grosse-Oetringhaus JF
- Grossiord JY
- Grosso R
- Guarnaccia C
- Guber F
- Guernane R
- Guerzoni B
- Gulbrandsen K
- Gulkanyan H
- Gunji T
- Gupta A
- Gupta R
- Gustafsson HA
- Gutbrod H
- Haaland O
- Hadjidakis C
- Haiduc M
- Hamagaki H
- Hamar G
- Hamblen J
- Han BH
- Harris JW
- Hartig M
- Harutyunyan A
- Hasch D
- Hasegan D
- Hatzifotiadou D
- Hayrapetyan A
- Heide M
- Heinz M
- Helstrup H
- Herghelegiu A
- Hernandez C
- Hernandez JFC
- Herrmann N
- Hetland KF
- Hicks B
- Hiei A
- Hille PT
- Hippolyte B
- Horaguchi T
- Hori Y
- Hristov P
- Hrivnacova I
- Hu S
- Huang M
- Huber S
- Humanic TJ
- Hutter D
- Hwang DS
- Ichou R
- Ilkaev R
- Ilkiv I
- Inaba M
- Innocenti PG
- Ippolitov M
- Irfan M
- Ivan C
- Ivanov A
- Ivanov M
- Ivanov V
- Iwasaki T
- Jacholkowski A
- Jacobs P
- Jancurova L
- Jangal S
- Janik R
- Jena C
- Jena S
- Jirden L
- Jones GT
- Jones PG
- Jovanovic P
- Jung H
- Jung W
- Jusko A
- Kaidalov AB
- Kalcher S
- Kalinak P
- Kalliokoski T
- Kalweit A
- Kamal A
- Kamermans R
- Kanaki K
- Kang E
- Kang JH
- Kapitan J
- Kaplin V
- Kapusta S
- Karavichev O
- Karavicheva T
- Karpechev E
- Kazantsev A
- Kebschull U
- Keidel R
- Khan MM
- Khan SA
- Khanzadeev A
- Kharlov Y
- Kikola D
- Kileng B
- Kim DJ
- Kim DS
- Kim DW
- Kim HN
- Kim J
- Kim JH
- Kim JS
- Kim M
- Kim M
- Kim S
- Kim SH
- Kim Y
- Kirsch S
- Kisel I
- Kiselev S
- Kisiel A
- Klay JL
- Klein J
- Klein-Bosing C
- Kliemant M
- Klovning A
- Kluge A
- Kniege S
- Koch K
- Kolevatov R
- Kolojvari A
- Kondratiev V
- Kondratyeva N
- Konevskih A
- Kornas E
- Kour R
- Kowalski M
- Kox S
- Kozlov K
- Kral J
- Kralik I
- Kramer F
- Kraus I
- Kravcakova A
- Krawutschke T
- Krivda M
- Krumbhorn D
- Krus M
- Kryshen E
- Krzewicki M
- Kucheriaev Y
- Kuhn C
- Kuijer PG
- Kumar L
- Kumar N
- Kupczak R
- Kurashvili P
- Kurepin A
- Kurepin AN
- Kuryakin A
- Kushpil S
- Kushpil V
- Kutouski M
- Kvaerno H
- Kweon MJ
- Kwon Y
- La Rocca P
- Lackner F
- Lafage V
- Lal C
- Lara C
- Larsen DT
- Laurenti G
- Lazzeroni C
- Le Bornec Y
- Le Bris N
- Lee H
- Lee KS
- Lee SC
- Lefevre F
- Lehnert J
- Leistam L
- Lenhardt M
- Lenti V
- Leon H
- Lerma PLMP
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- Li X
- Li Y
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- Lindal S
- Lindenstruth V
- Lippmann C
- Lisa MA
- Listratenko O
- Liu L
- Loginov V
- Lohn S
- Lopez SR
- Lopez X
- Lopez-Ramirez R
- Lorenzo PM
- Lovhoiden G
- Lu S
- Lunardon M
- Luparello G
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- Lutz JR
- Luvisetto M
- Ma K
- Ma R
- Madagodahettige-Don DM
- Maevskaya A
- Mager M
- Mahajan A
- Mahapatra DP
- Maire A
- Majumdar AKD
- Majumdar MRD
- Makhlyueva I
- Mal'Kevich D
- Malaev M
- Malagalage KJ
- Maldonado IC
- Malek M
- Malkiewicz T
- Malzacher P
- Mamonov A
- Manceau L
- Mangotra L
- Manko V
- Manso F
- Manzari V
- Mao Y
- Mares J
- Margagliotti GV
- Margotti A
- Marin A
- Martashvili I
- Martinengo P
- Martinez MI
- Maruyama Y
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- Masera M
- Masetti M
- Masoni A
- Massacrier L
- Mastromarco M
- Mastroserio A
- Matthews ZL
- Matyja A
- Mayani D
- Mazza G
- Mazzoni MA
- Meddi F
- Menchaca-Rocha A
- Meoni M
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- Miftakhov N
- Milosevic J
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- Mischke A
- Miskowiec D
- Mitu C
- Mizoguchi K
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- Mohanty B
- Molina RA
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- Mondal MM
- Monteno M
- Montes E
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- Moretto S
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- Muccifora V
- Mudnic E
- Muhuri S
- Muller H
- Munhoz MG
- Munoz GT
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- Musa L
- Musso A
- Nandi BK
- Nania R
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- Navin S
- Nayak TK
- Nazarenko S
- Nazarov G
- Nedosekin A
- Nendaz F
- Newby J
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- Nicassio M
- Nielsen BS
- Nikolaev S
- Nikolic V
- Nikulin S
- Nikulin V
- Nilsen BS
- Nilsson MS
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- Nomokonov P
- Nooren G
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- Nyatha A
- Nygaard C
- Nyiri A
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- Oeschler H
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- Oldenburg M
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- Oppedisano C
- Orsini F
- Ortona G
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- Otterlund I
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- Palmeri A
- Palomo LV
- Panse R
- Pappalardo GS
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- Pavlinov A
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- Peyre J
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- Piccotti A
- Pikna M
- Pillot P
- Pinsky L
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- Pochybova S
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- Polozov P
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- Potukuchi B
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- Prasad SK
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- Punin A
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- Putis M
- Putschke J
- Quercigh E
- Quintana AA
- Rachevski A
- Rademakers A
- Radomski S
- Raiha TS
- Rak J
- Rakotozafindrabe A
- Ramello L
- Rammler M
- Raniwala R
- Raniwala S
- Rasanen SS
- Rashevskaya I
- Rath S
- Read KF
- Real J
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- Publication date
- 01/01/2010
- Field of study
37 pages, 15 figures, revised version, accepted by JINSTALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers each of drift, and strip detectors. The number of parameters to be determined in the spatial alignment of the 2198 sensor modules of the ITS is about 13,000. The target alignment precision is well below 10 micron in some cases (pixels). The sources of alignment information include survey measurements, and the reconstructed tracks from cosmic rays and from proton-proton collisions. The main track-based alignment method uses the Millepede global approach. An iterative local method was developed and used as well. We present the results obtained for the ITS alignment using about 10^5 charged tracks from cosmic rays that have been collected during summer 2008, with the ALICE solenoidal magnet switched off.Peer reviewe
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Da Silva LA
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- Dedey F
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- Del Basso C
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- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
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- Donoghue D
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- El Halawany M
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- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
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- El Shoura Y
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- El-Dien KS
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- El-Din RA
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- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
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- El-Shahat NS
- El-Sheemy H
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- Elashmawy M
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- Elazoul M
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- Elbatahgy A
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- Eldafrawy M
- Eldamaty L
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- Elfiky M
- Elfil M
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- Elfouly N
- Elfouly Y
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- Elgebaly A
- Elgendy AH
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- Elgheriany M
- Elhadad A
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- Elhalawany E
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- Elhelbawy MS
- Elhendawy A
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- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
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- Elkady F
- Elkelany A
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- Elkhadrawi M
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- Elshobary M
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- Elzahed N
- Elzayat I
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- Elzowawi F
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- Emile S
- Eng C
- English W
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- Espin-Basany E
- Espinoza F
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- Farrugia A
- Farrugia A
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- Fattah AA
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- Faturoti O
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- Faure A
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- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
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- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
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- Mapasse D
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- Maraie N
- Marcelo Delgado J
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- Marroquin Rodriguez DE
- Marshall DC
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- Mas R
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- Mathew SW
- Matos-Puig R
- Mattar O
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- Mendoza I
- Menegussi J
- Mensah E
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- Mentula P
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- Merlo MS
- Mesbah N
- Meshref A
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- Metwally MM
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- Mihaljevic AL
- Mihaljevic AL
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- Minguez G
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- Mircea H
- Mirghani D
- Mironescu A
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- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
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- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
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- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
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- Monteleone M
- Monteleone M
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- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
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- Moreira G
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- Morton R
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
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- Mshelbwala P
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- Nanthakumaran S
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- Narayanan R
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- Negida A
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- Nevieraite V
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- Njokanma I
- Nnajiuba H
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- Novak A
- Nowers J
- Nsengimana VJP
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- Nwabuoku E
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- Samaraweera DI
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- Tansoker I
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- Tarek D
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- Tedeschi U
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- Telfah MM
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- Ukwenya Y
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- Venskutonis D
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- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
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- Waledziak M
- Waleed H
- Walker M
- Walker N
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- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
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- Warwick AM
- Waterman A
- Watson NF
- Watson NF
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- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
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- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Definition of hemodynamic stability in blunt trauma patients: a systematic review and assessment amongst Dutch trauma team members
- Author
- A Barleben
- A Becker
- A Hagiwara
- A Salim
- A Tötterman
- AB Christmas
- AB Peitzman
- American College of Surgeons
- American College of Surgeons
- B Joseph
- BD Figler
- C Gaarder
- CG Ball
- CG Ball
- CH Vlies van der
- CM Cannon
- CY Fu
- CY Fu
- CY Fu
- D Bar-Or
- D Purvis
- D Verbeek
- DC Olthof
- DC Olthof
- DC Olthof
- E. Vandewalle
- ECTH Tan
- EJ Kuncir
- F Franco
- FA Moore
- FC Gezen
- G Pata
- G Tugnoli
- G. F. Giannakopoulos
- GA Giannopoulos
- GK Luna
- GM Wilden van der
- GM Wilden van der
- GP Victorino
- HR Guly
- IS Bhullar
- J Cook
- J DuBose
- J Morozumi
- JF Fang
- JM Gauer
- JW Meredith
- K Kawahito
- K Mitsuhide
- KC Yuan
- KJ Brasel
- KK Tan
- KK Tan
- KS Myint
- L Smithson
- L Toth
- M Bala
- M Eusanio Di
- M Katsura
- M Li
- M Mutschler
- M Mutschler
- M Shirazi
- M. Erwteman
- MJ Pommerening
- MJ Vandromme
- MY Rady
- N Yucel
- P Geisbüsch
- P Stampfl
- PI Johansson
- PP Liu
- RA Callcut
- RA Little
- RD Bland
- RH Birkhahn
- RS Friese
- S Asfar
- S Huber-Wagner
- S Matsumoto
- S. A. I. Loggers
- T Brockamp
- T Ogura
- T Suzuki
- T. W. A. Koedam
- TC Numez
- TS Misselbeck
- V Monnin
- V Vécsei
- W. P. Zuidema
- WC Lin
- Y Iqbal
- Y Kataoka
- Y Mizushima
- YC Wang
- YX Zheng
- Z Balogh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease
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- A Bonillo Perales
- A Greenough
- A Haerskjold
- A Simon
- AG Winterstein
- AM Helfrich
- B Paes
- B Resch
- B Resch
- BJ Law
- C Hampp
- CB Hall
- CB Hall
- CG Garcia
- CS Ambrose
- D Hervás
- D Makari
- D Shefali-Patel
- DF Willson
- DL Stewart
- E Bergsträsser
- E Rietveld
- EA Simões
- EA Simões
- EA Simões
- EE Wang
- G Cilla
- G Corsello
- G Doering
- G Handal
- GA Rossi
- H Nair
- H Pruikkonen
- HE Nielsen
- HO Fjaerli
- I Méndez Rubio
- I Olabarrieta
- J Figueras-Aloy
- J Figueras-Aloy
- J Figueras-Aloy
- J Forster
- J Mauskopf
- J Papenburg
- JA Piñero Fernández
- JB Gouyon
- JG Liese
- JS Sampalis
- JS Sampalis
- K Korsten
- KA Sala
- L Bollani
- L Samson
- LG Stensballe
- M Eriksson
- M Grimaldi
- M Lanari
- M Lanari
- M Lanari
- M Sheridan-Pereira
- M Silvestri
- MA Underwood
- MN Tsolia
- MO Blanken
- NK Leidy
- O Pedersen
- O Steen Van de
- P Bala
- P Pezzotti
- PH Brubaker
- RG Gijtenbeek
- S Alan
- S Broughton
- S Joffe
- S Leader
- S Leader
- SA Deshpande
- SB Drysdale
- SD Horn
- SJ Clark
- T Heikkinen
- TG Boyce
- TP Stevens
- WP Glezen
- X Carbonell
- X Carbonell-Estrany
- X Carbonell-Estrany
- X Carbonell-Estrany
- X Carbonell-Estrany
- X Carbonell-Estrany
- Z Straňák
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Aahlin Ek
- Aamer A
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- Abbo O
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- Abd-Elrasoul Y
- Abdallah E
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- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhamed R
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- Abudeeb H
- Abuowda Y
- Abuqwaider E
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- Adebanjo A
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- Adedeji A
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- Adel A
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- Adelshone A
- Ademuyiwa A
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- Ademuyiwa Ao
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- Adenekan B
- Adeniran J
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- Adeniyi A
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- Adesanya O
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- Adesina A
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- Adeyeye A
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- Adhitama N
- Adil M
- Adisa Ao
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- Adnan Ab
- Adu-Aryee N
- Afana S
- Afandy A
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- Agarwal A
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- Agius M
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- Aguilar-Jimenez J
- Aguilera M
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- Aguilera O
- Aguilera-Arevalo Ml
- Ahlonsou G
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- Aigrain Y
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- Akoto E
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- Al Amin S
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- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
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- Al Saied G
- Al Subaie N
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- Alsaggaf M
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- Alser Oh
- Alshareef R
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- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
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- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
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- Amandito R
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- Angelieri D
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- Antezana D
- Anthoulakis C
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- Anwar Aw
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- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
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- Arachchige Lajj
- Arafa O
- Arafa S
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
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- Arnaud Ap
- Arnaud Ap
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- Arslan E
- Arsyad Hm
- Arthur T
- Arulampalam T
- Aruldas N
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- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
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- Assal A
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- Asturias S
- Asumah H
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- Atiyeh A
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- Bakr A
- Bakry Hm
- Baky Fahmy MA
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- Balalis D
- Baldacchino M
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- Balmaceda R
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- Barkolias C
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- Chambers A
- Chan E
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- Kesinger M
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- Khaled H
- Khalifah E
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- Kinandu K
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- Kiudelis M
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- Klappenbach R
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- Lilford R
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- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
- Lund J
- Lundgren Po
- Luque Gb
- Luque L
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- Lytras D
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- Má
- Mé
- Mü
- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
- Majid K
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- Major P
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- Mak T
- Mak T
- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
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- Mcdonald R
- McGarvie S
- Mcguigan A
- McIntosh K
- Mcintosh R
- Mcintyre Cj
- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
- Mealy K
- Mehdi A
- Mehrez S
- Mejia Agv
- Melo R
- Melo R
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- Mendez N
- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
- Nasr A
- Nasr M
- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
- Nawawi A
- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
- Ngayu N
- Ngwa Te
- Niazi Ak
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
- Nikoloudis N
- Niragire A
- Niranjan N
- Nirumal Mk
- Niska K
- Nita Ge
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- North As
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- Obute Rd
- Occhionorelli S
- Odeyemi B
- Odeyemi B
- Odutola O
- Ogunsua O
- Ogunyemi A
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- Oh J
- Ohene-Yeboah M
- Ojeda Rrb
- Okenabirhie O
- Olajide To
- Olaolorun A
- Olivier J
- Olori S
- Olori S
- Oludara M
- Oludara M
- Olugbemi M
- Omar Aa
- Omar Me
- Omar Mfw
- Omara S
- Omer Oa
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- Onuoha C
- Oosterkamp A
- Opoku-Agyeman R
- Oram S
- Orbegozo Pat
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- Ortega I
- Ortega-Vazquez I
- Ortiz N
- Orton P
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- Osei-Nketiah S
- Oshati O
- Oshodi O
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- Osinowo A
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- Osman O
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- Oswald D
- Otero-Dí
- Othman M
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- Oumer R
- Owen C
- Owusu F
- Owusu F
- Ozben V
- Ozkan Bb
- Ozkan Bb
- Ozkan Bb
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- Pé
- Paž
- Pabla G
- Pacheco Rda
- Padmore G
- Pagano G
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- Pagnozzi J
- Pahlsson Hi
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- Palayan K
- Palkhi Eya
- Palliyil M
- Palliyil Mm
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- Palma Af
- Paludi Ma
- Paludi Ma
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- Panez Wr
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- Panteli C
- Papageorgiou D
- Papailia A
- Papandrea M
- Papaskarlatos Ia
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- Parakh J
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- Parasyris S
- Pardo G
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- Parmentier B
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- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
- Pascale G
- Pascale Mm
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- Pasquali S
- Pastora J
- Pata D
- Pata D
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata G
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- Patel V
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- Patoulias I
- Paul M
- Paul S
- Paulouski D
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- Pektaş
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- Perera J
- Perera J
- Periasammy D
- Perino M
- Peros G
- Perrotta G
- Pesenti G
- Petrikenas S
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- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pineñ
- Pinkney T
- Pinkney Td
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- Pino W
- Pitt Sk
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- Pluke K
- Poš
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- Popoola A
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- Poskus T
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- Powell A
- Pozo Dar
- Prabhudesai A
- Pranevicius R
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- Preckailaite E
- Primavesi F
- Prins M
- Proctor Vk
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
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- Pujol-Cano N
- Puma Cmh
- Punja V
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- Puttick M
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- Qumbos Aa
- Qureshi Au
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- Radkowiak D
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- Rahantasoa Fcfp
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- Rasoaherinomenjanahary F
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- Raza A
- Raza I
- Raza I
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- Razmdjou S
- Razuri C
- Razzaque J
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- Recinos G
- Recinos G
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- Redota Map
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- Renaux-Petel M
- Restrepo Im
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- Runigamugabo E
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- Saar S
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- Sabour Fa
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- Sahel S
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- Salama M
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- Sallinen V
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- Salma M
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- Salma U
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- Samaniego Cs
- Samaraweera Di
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- Schivo D
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- Schultz Jk
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- Senanayake Kj
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- Senanayake W
- Septiem Jg
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- Setiawan J
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- Shah A
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- Shaharuddin S
- Shahbaz Ar
- Shaheen A
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- Shaikh N
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- Shalaby A
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- Shamsedine Aw
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- Sigurdadottir J
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- Silvestri V
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
- Solaini L
- Soldevila-Verdeguer C
- Soley R
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- Soliman N
- Soliman Na
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- Sollazzo V
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- Souaibou Yi
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- Spence R
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- Srinivasan R
- Sriram A
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- Stefanopoulos A
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- Suarez Aab
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- Summerour V
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- Sundstrom Sm
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- Sykes M
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- Tade A
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- Tahboub H
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- Taiwo A
- Taiwo O
- Taiwo O
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- Tan Jk
- Tan Ksk
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- Tan Yk
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- Tanase A
- Tang A
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- Tani Si
- Tansoker I
- Tarek A
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- Tariq S
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- Tawfik G
- Tawfik G
- Taylor F
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- Tedeschi U
- Tedjaatmadja C
- Telfah Mm
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- Thompson B
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- Thorarinsdottir H
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- Thorell A
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- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
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- Torrance Hd
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- Torres Sg
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- Tselos A
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- Ubiali P
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- Ukwenya Y
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- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
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- Wold Tb
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- Yifieyeh A
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- Zachariades Dc
- Zadoroznas A
- Zahran D
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- Zakaria Y
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- Zalabia Mf
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- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
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