Massless Fermions and the Instanton Dipole Liquid in Compact QED_3

We study the consequences of including parity preserving matter for the effective dual theory corresponding to compact QED_3; in particular we focus on the effect of that contribution on the confinement-deconfinement properties of the system. To that end, we compare two recent proposals when massless fermions are included, both based on an effective anomalous dual model, but having global and local Z_2 symmetries, respectively. We present a detailed analysis to show that while for large mass fermions the global Z_2 symmetry is preferred, in the massless fermion case the local Z_2 scenario turns out to be the proper one. We present a detailed discussion about how the inclusion of massless fermions in compact QED_3 leads to deconfinement, and discuss the stability of the deconfined phase by introducing a description based on an instanton dipole liquid picture.Comment: 28 page

In vitro and in vivo tetracycline-controlled myogenic conversion of NIH-3T3 cells: evidence of programmed cell death after muscle cell transplantation.

Ex vivo gene therapy of Duchenne muscular dystrophy based on autologous transplantation of genetically modified myoblasts is limited by their premature senescence. MyoD-converted fibroblasts represent an alternative source of myogenic cells. In this study the forced MyoD-dependent conversion of murine NIH-3T3 fibroblasts into myoblasts under the control of an inducible promoter silent in the presence of tetracycline was evaluated. After tetracycline withdrawal this promoter drives the transcription of MyoD in the engineered fibroblasts, inducing their myogenesis and giving rise to β-galactosidase-positive cells. MyoD-expressing fibroblasts withdrew from the cell cycle, but were unable to fuse in vitro into multinucleated myotubes. Five days following implantation of engineered fibroblasts in muscles of C57BL/10J mice we observed a sevenfold increase of β-galactosidase-positive regenerating myofibers in animals not treated with antibiotic compared with treated animals. After 1 week the number of positive fibers decreased and several apoptotic myonuclei were detected. Three weeks following implantation of MyoD-converted fibroblasts in recipient mice, no positive "blue" fiber was observed. Our results suggest that transactivation by tetracycline of MyoD may drive an in vivo myogenic conversion of NIH-3T3 fibroblasts and that, in this experimental setting, apoptosis plays a relevant role in limiting the efficacy of engineered fibroblast transplantation. This work opens the question whether apoptotic phenomena also play a general role as limiting factors of cellmediated gene therapy of inherited muscle disorders

Dyson-Schwinger Equations: Density, Temperature and Continuum Strong QCD

Continuum strong QCD is the application of models and continuum quantum field theory to the study of phenomena in hadronic physics, which includes; e.g., the spectrum of QCD bound states and their interactions; and the transition to, and properties of, a quark gluon plasma. We provide a contemporary perspective, couched primarily in terms of the Dyson-Schwinger equations but also making comparisons with other approaches and models. Our discourse provides a practitioners' guide to features of the Dyson-Schwinger equations [such as confinement and dynamical chiral symmetry breaking] and canvasses phenomenological applications to light meson and baryon properties in cold, sparse QCD. These provide the foundation for an extension to hot, dense QCD, which is probed via the introduction of the intensive thermodynamic variables: chemical potential and temperature. We describe order parameters whose evolution signals deconfinement and chiral symmetry restoration, and chronicle their use in demarcating the quark gluon plasma phase boundary and characterising the plasma's properties. Hadron traits change in an equilibrated plasma. We exemplify this and discuss putative signals of the effects. Finally, since plasma formation is not an equilibrium process, we discuss recent developments in kinetic theory and its application to describing the evolution from a relativistic heavy ion collision to an equilibrated quark gluon plasma.Comment: 103 Pages, LaTeX, epsfig. To appear in Progress in Particle and Nuclear Physics, Vol. 4

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network

Numerous transcriptional regulators of neurogenesis have been identified in the developing and adult brain, but how neurogenic fate is programmed at the epigenetic level remains poorly defined. Here, we report that the transcription factor Pax6 directly interacts with the Brg1-containing BAF complex in adult neural progenitor

Severe hepatitis B virus-negative chronic hepatitis responsive to steroids in a child with common variable hypogammaglobulinemia.

[No abstract available

Unique lifting of integer variables in minimal inequalities

This paper contributes to the theory of cutting planes for mixed integer linear programs (MILPs). Minimal valid inequalities are well understood for a relaxation of an MILP in tableau form where all the nonbasic variables are continuous; they are derived using the gauge function of maximal lattice-free convex sets. In this paper we study lifting functions for the nonbasic integer variables starting from such minimal valid inequalities. We characterize precisely when the lifted coefficient is equal to the coefficient of the corresponding continuous variable in every minimal lifting (This result first appeared in the proceedings of IPCO 2010). The answer is a nonconvex region that can be obtained as a finite union of convex polyhedra. We then establish a necessary and sufficient condition for the uniqueness of the lifting function

Evaporation of an anisotropic nanoplasma

Intense laser induced plasma dynamics in sub-micron scale helium droplets are monitored by femtosecond time-resolved X-ray coherent diffractive imaging. Anisotropic surface softening and strongly anisotropic shrinking of the plasma core are observed

Evaporation of an anisotropic nanoplasma

Intense laser induced plasma dynamics in sub-micron scale helium droplets are monitored by femtosecond time-resolved X-ray coherent diffractive imaging. Anisotropic surface softening and strongly anisotropic shrinking of the plasma core are observed