Lindane and Endosulfan Sulfate Isomers in Crassostrea virginica (Gmelin, 1791) Oyster Populations in Lagoon Systems from Central Gulf of Mexico

The aim of this study was to determine Lindane and Endosulfan Sulfate isomers in Crassostrea virginica oyster populations (Gmelin, 1791) in the Mandinga and Alvarado lagoon systems located in the central Gulf of Mexico. Samples were taken from the main oyster banks of each lagoon system, during the three representative seasons of the region, wet, dry and north winds. By means of free diving, 30 commercial size oysters (7 ± 3 cm) were collected in four oyster banks or stations of the Mandinga lagoon system, totaling 360 organisms, while in the Alvarado lagoon system there were a total of 90 oysters during the annual cycle. Concentration of lindane and endosulfan sulfate isotopes in C. virginica was performed with a gas chromatograph (Thermo Electron Model Trace GC Ultra 115V, Thermo Fisher Scientific Inc©, Monterrey, Nuevo León, México) with an Electron capture detector. Results showed that in the Alvarado Lagoon system mean concentrations of C. virginica oysters for lindane pesticide were 4.11 ± 3.83 ng⋅g-1, whereas for the Mandinga lagoon system, were 8.69 ± 5.15 ng⋅g-1. Endosulfan sulfate showed the highest average concentration in the Mandinga lagoon system with 24.68 ± 1.20 ng ⋅g-1. In addition, the endosulfan sulfate presents differences in its spatial distribution; high concentration levels in the Mandinga lagoon system whereas the lindane heterogeneity at all sampling points in both lagoons. Values of concentrations and relationships between compounds suggest recent contributions that could correspond to the excessive fluctuations of water discharged into the lagoon caused by the atypical rains of the year of sampling. It was concluded that endosulfan sulfate and lindane show concentration in all the points of sampling in both lagoons

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple-negative breast cancer patients after neoadjuvant chemotherapy

Abstract Background For primary triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC), higher pretreatment tumor-infiltrating lymphocytes (TILs) correlates with increased pathologic complete response (pCR) rates, and improved survival. We evaluated the added prognostic value of residual disease (RD) TILs to residual cancer burden (RCB) in predicting survival post-NAC. Patients and methods We combined four TNBC NAC patient cohorts who did not achieve pCR. RD TILs were investigated for associations with recurrence-free survival (RFS), and overall survival (OS) using Cox models with stromal TILs as a continuous variable (per 10% increment). The likelihood ratio test was used to evaluate added prognostic value of RD TILs. Results A total of 375 RD TNBC samples were evaluable for TILs and RCB. The median age was 50 years, with 62% receiving anthracycline/taxane chemotherapy. The RCB class after NAC was 11%, 50%, and 39% for I, II, and III, respectively. The median RD TIL level was 20% (IQR 10–40). There was a positive correlation between RD TIL levels and CD8+ T-cell density (ρ = 0.41). TIL levels were significantly lower with increasing post-NAC tumor (P = 0.005), nodal stage (P = 0.032), but did not differ by RCB class (P = 0.84). Higher RD TILs were significantly associated with improved RFS (HR: 0.86; 95% CI 0.79–0.92; P  Conclusions TIL levels in TNBC RD are significantly associated with improved RFS and OS and add further prognostic information to RCB class, particularly in RCB class II

Study of the Largest Multiwavelength Campaign of the Microquasar GRS 1915+105

We present the results from a multiwavelength campaign of GRS 1915+105 performed from 2000 April 16 to 25. This is one of the largest coordinated set of observations ever performed for this source, covering the wide energy band in radio (13.3-0.3 cm), near-infrared (J-H-K), X-rays and Gamma-rays (from 1 keV to 10 MeV). During the campaign GRS 1915+105 was predominantly in the "plateau" (or low/hard) state but sometimes showed soft X-ray oscillations: before April 20.3, rapid, quasi-periodic (~= 45 min) flare-dip cycles were observed. The radio flares observed on April 17 shows frequency- dependent peak delay, consistent with an expansion of synchrotron-emitting region starting at the transition from the hard-dip to the soft-flare states in X-rays. On the other hand, infrared flares on April 20 appear to follow (or precede) the beginning of X-ray oscillations with an inconstant time delay of ~= 5-30 min. This implies that the infrared emitting region is located far from the black hole by >~ 10E13 cm, while its size is <~ 10E12 cm constrained from the time variability. We find a good correlation between the quasi-steady flux level in the near-infrared band and in the X-ray band. From this we estimate that the reprocessing of X-rays, probably occurring in the outer parts of the accretion disk, accounts for about 20-30% of the observed K magnitude in the plateau state. The OSSE spectrum in the 0.05-10 MeV band is represented by a single power law with a photon index of 3.1 extending to ~1 MeV with no cutoff. The power-law slope above ~30 keV is found to be very similar between different states in spite of large flux variations in soft X-rays, implying that the electron energy distribution is not affected by the change of the state in the accretion disk.Comment: 31 pages, 11 figures. Accepted for publication in ApJ, vol. 571, 2002. Minor corrections. Figure 2 is revised (numbers on the top axis are corrected). References are update

The Herschel-PEP survey: evidence for downsizing in the hosts of dusty star-forming systems

By making use of Herschel-PEP observations of the COSMOS and Extended Groth Strip fields, we have estimated the dependence of the clustering properties of FIR-selected sources on their 100um fluxes. Our analysis shows a tendency for the clustering strength to decrease with limiting fluxes: r0(S100um >8 mJy)~4.3 Mpc and r0(S100um >5 mJy)~5.8 Mpc. These values convert into minimum halo masses Mmin~10^{11.6} Msun for sources brighter than 8 mJy and Mmin~10^{12.4} Msun for S100um > 5 mJy galaxies. We show such an increase of the clustering strength to be due to an intervening population of z~2 sources, which are very strongly clustered and whose relative contribution, equal to about 10% of the total counts at S100um > 2 mJy, rapidly decreases for brighter flux cuts. By removing such a contribution, we find that z <~ 1 FIR galaxies have approximately the same clustering properties, irrespective of their flux level. The above results were then used to investigate the intrinsic dependence on cosmic epoch of the clustering strength of dusty star-forming galaxies between z~0 and z~2.5. In order to remove any bias in the selection process, the adopted sample only includes galaxies observed at the same rest-frame wavelength, lambda~60 um, which have comparable luminosities and therefore star-formation rates (SFR>~100 Msun/yr). Our analysis shows that the same amount of (intense) star forming activity takes place in extremely different environments at the different cosmological epochs. For z<~1 the hosts of such star forming systems are small, Mmin~10^{11} Msun, isolated galaxies. High (z~2) redshift star formation instead seems to uniquely take place in extremely massive/cluster-like halos, Mmin~10^{13.5} Msun, which are associated with the highest peaks of the density fluctuation field at those epochs. (abridged)Comment: 12 pages, 8 figures, to appear in MNRA

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal