12 research outputs found
Action of the extracts of Pluchea sagittalis on the absorptive characteristics of the gastrointestinal tract
No full textPluchea sagittalis (Lam.) Cabrera, (quitoco or erva lucera) is commonly used to treat digestive disorders in Southern Brazil and countries of the South Cone. The crude aqueous extracts from the leaves, stalks or flowers were used in acute oral toxicity in mice and in pharmacological studies to determine the gastrointestinal transport of water, sodium, and potassium in rats. The oral administration of 5000 mg/kg of extracts examined did not produce signs of intoxication nor induce the death of any mice during the period of 14 days. The extracts from the leaves and stalk have reduced the absorption of water in the jejunum and jejunum and ileum, respectively with relation to the control. There was an absorption of sodium with the administration of these extracts, especially those from the flowers, when compared with that of the control. There was an increase in the absorption of potassium in different parts of the gastrointestinal tract in comparison to that of the control, being increased in most parts with the application of extracts from the stalks. It could be concluded that the extracts from the stalk, leaves and flowers of P. sagittalis have substances that alter the absorptive characteristics of several portions of the gastrointestinal mucosa
Ilex paraguariensis has antioxidant potential and attenuates haloperidol-induced orofacial dyskinesia and memory dysfunction in rats
No full textA surface modification of clozapine-loaded nanocapsules improves their efficacy: A study of formulation development and biological assessment
No full textNeonatal Tactile Stimulation Alters Behaviors in Heterozygous Serotonin Transporter Male Rats: Role of the Amygdala
No full textFrugivoria por aves em Nectandra megapotamica (Lauraceae) em uma área de Floresta Estacional Decidual no Rio Grande do Sul, Brasil
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The continued need for animals to advance brain research
No full textPolicymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised
Magnesium Supplementation Prevents and Reverses Experimentally Induced Movement Disturbances in Rats: Biochemical and Behavioral Parameters
No full textThe continued need for animals to advance brain research
Get PDFPolicymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised
