Моделирование оптимальных геометрических параметров пьезоэлементов для полизмерительных мономорфных датчиков

Салагор А. М. Моделирование оптимальных геометрических параметров пьезоэлементов для полизмерительных мономорфных датчиков / А. М. Салагор, Е. Г. Трофименко, Л. Н. Буката // Вісник Інженерної академії України. - К.: ІАУ, 2015. - № 1. - С. 151-157.В работе исследованы зависимости основных характеристик пьезокерамики от соотношений геометрических параметров пьезоэлементов в форме бруска. Исследована схемотехническая модель мономорфного пьезокерамического преобразователя для измерения двух физических величин, проведены экспериментальные исследования. В результате анализа было установлено оптимальное соотношение геометрических параметров пьезоэлемента в виде бруска.В роботі досліджено залежності основних характеристик п'єзокераміки від співвідношень геометричних параметрів п'єзоелементів у формі бруска. Досліджено схемотехнічна модель мономорфного п'єзокерамічного перетворювача для вимірювання двох фізичних величин, проведені експериментальні дослідження. В результаті аналізу було встановлено оптимальне співвідношення геометричних параметрів п'єзоелемента у вигляді бруска

Разработка измерительных систем на базе многомерного пьезокерамического преобразователя

Коваленко А. М. Разработка измерительных систем на базе многомерного пьезокерамического преобразователя / А. М. Коваленко, Е. Г. Трофименко, Л. Н. Буката // Праці Одеського політехнічного університету. – Одеса, 2012. – Вып. 2 (39). – С. 262-267.Рассматривается повышение эффективности построения измерительных компьютеризованных систем с одним мономорфным пьезопреобразователем. Приводятся метод измерения одним мономорфным пьезоэлектрическим преобразователем более двух физических величин за счет предварительной обработки измерительной информации микропроцессором. Расположение микропроцессора на самом чувствительном элементе позволяет уменьшить влияние дестабилизирующих факторов на процесс измерения. Приведены результаты математического моделирования и экспериментального исследования.Розглядається підвищення ефективності побудови вимірювальних комп’ютеризованих систем з одним мономорфним п’єзоперетворювачем. Наводиться метод вимірювання одним мономорфним п’єзоелектричним перетворювачем більше двох фізичних величин за рахунок попередньої обробки вимірювальної інформації мікропроцесором. Розташування мікропроцесора на найчутливішому елементі дозволяє зменшити вплив дестабілізуючих факторів на процес вимірювання. Наведено результати математичного моделювання та експериментального дослідження.Increasing the efficiency of construction of measuring computerized systems with one monomorphic piezotransducer is considered. The method of measurement of more than two physical quantities with the help of one monomorphic piezotransducer by microprocessor’s pretreatment of measurement information is presented. Location of the microprocessor on the most sensitize chip allows the sensor to correct the destabilizing factors in the measurement process. The results of mathematical modeling and experimental study are presented

Метод построения полиизмерительных компьютеризованных систем на базе одного пьезокерамического преобразователя

Коваленко А. М. Метод построения полиизмерительных компьютеризованных систем на базе одного пьезокерамического преобразователя / А. М. Коваленко, Е. Г. Трофименко, Л. Н. Буката // Наукові праці ОНАЗ ім. О. С. Попова. – Одеса, 2012. – № 2. – С. 99-103.Работа посвящена повышению эффективности построения полиизмерительных компьютеризованных систем с одним мономорфным пьезопреобразователем. Предложен метод измерения нескольких физических величин одним мономорфным пьезопреобразователем за счет подачи на пьезоэлемент дополнительных электрических сигналов, количество которых равняется количеству измеряемых величин. Приведены результаты математического моделирования и экспериментального исследования.Робота присвячена підвищенню ефективності побудови полівимірювальних комп'ютеризованих систем з одним мономорфним п'єзоперетворювачем. Запропоновано метод вимірювання декількох фізичних величин одним мономорфним п'єзоперетворювачем за рахунок подачі на п'єзоелемент додаткових електричних сигналів, кількість яких дорівнює кількості вимірюваних величин. Наведено результати математичного моделювання та експериментального дослідження.The article is devoted to increasing the efficiency of construction of polymeasuring computerized systems with one monomorphic piezotransducer. Ultimately is offered the method of measurement a few physical quantities by one monomorphic piezotransducer due to the filing of a piezoelement of additional electrical signals, the number of which are equal to the number of measured quantities. In the article are given the results of mathematical modeling and experimental study

Recommendations for The Conduct of Economic Evaluations in Osteoporosis: Outcomes of An Experts’ Consensus Meeting Organized by The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) And the US Branch of The International Osteoporosis Foundation

Summary Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards. Introduction This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards. Methods A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted. Results Recommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed. Conclusion While the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.

NF-κB is a transcription factor activated in response to inflammatory, genotoxic and oxidative stress and important for driving senescence and aging. Ataxia-telangiectasia mutated (ATM) kinase, a core component of DNA damage response signaling, activates NF-κB in response to genotoxic and oxidative stress via post-translational modifications. Here we demonstrate that ATM is activated in senescent cells in culture and murine tissues from Ercc1-deficient mouse models of accelerated aging, as well as naturally aged mice. Genetic and pharmacologic inhibition of ATM reduced activation of NF-κB and markers of senescence and the senescence-associated secretory phenotype (SASP) in senescent Ercc1-/- MEFs. Ercc1-/Δ mice heterozygous for Atm have reduced NF-κB activity and cellular senescence, improved function of muscle-derived stem/progenetor cells (MDSPCs) and extended healthspan with reduced age-related pathology especially age-related bone and intervertebral disc pathologies. In addition, treatment of Ercc1-/∆ mice with the ATM inhibitor KU-55933 suppressed markers of senescence and SASP. Taken together, these results demonstrate that the ATM kinase is a major mediator of DNA damage-induced, NF-κB-mediated cellular senescence, stem cell dysfunction and aging and thus represents a therapeutic target to slow the progression of aging

Brucella abortus Choloylglycine Hydrolase Affects Cell Envelope Composition and Host Cell Internalization

Choloylglycine hydrolase (CGH, E.C. 3.5.1.24) is a conjugated bile salt hydrolase that catalyses the hydrolysis of the amide bond in conjugated bile acids. Bile salt hydrolases are expressed by gastrointestinal bacteria, and they presumably decrease the toxicity of host's conjugated bile salts. Brucella species are the causative agents of brucellosis, a disease affecting livestock and humans. CGH confers Brucella the ability to deconjugate and resist the antimicrobial action of bile salts, contributing to the establishment of a successful infection through the oral route in mice. Additionally, cgh-deletion mutant was also attenuated in intraperitoneally inoculated mice, which suggests that CGH may play a role during systemic infection other than hydrolyzing conjugated bile acids. To understand the role CGH plays in B. abortus virulence, we infected phagocytic and epithelial cells with a cgh-deletion mutant (Δcgh) and found that it is defective in the internalization process. This defect along with the increased resistance of Δcgh to the antimicrobial action of polymyxin B, prompted an analysis of the cell envelope of this mutant. Two-dimensional electrophoretic profiles of Δcgh cell envelope-associated proteins showed an altered expression of Omp2b and different members of the Omp25/31 family. These results were confirmed by Western blot analysis with monoclonal antibodies. Altogether, the results indicate that Brucella CGH not only participates in deconjugation of bile salts but also affects overall membrane composition and host cell internalization

Internet of Things for Water Sustainability

The water is a finite resource. The issue of sustainable withdrawal of freshwater is a vital concern being faced by the community. There is a strong connection between the energy, food, and water which is referred to as water-food-energy nexus. The agriculture industry and municipalities are struggling to meet the demand of water supply. This situation is particularly exacerbated in the developing countries. The projected increase in world population requires more fresh water resources. New technologies are being developed to reduce water usage in the field of agriculture (e.g., sensor guided autonomous irrigation management systems). Agricultural water withdrawal is also impacting ground and surface water resources. Although the importance of reduction in water usage cannot be overemphasized, major efforts for sustainable water are directed towards the novel technology development for cleaning and recycling. Moreover, currently, energy technologies require abundant water for energy production. Therefore, energy sustainability is inextricably linked to water sustainability. The water sustainability IoT has a strong potential to solve many challenges in water-food-energy nexus. In this chapter, the architecture of IoT for water sustainability is presented. An in-depth coverage of sensing and communication technologies and water systems is also provided

Global Boundary Stratotype Section and Point (GSSP) for the Anthropocene Series: Where and how to look for potential candidates

International audienc