Verschleißfreie magnetische Getriebe : Übertragung von Kräften über magnetische Felder

Elektromagnetische Felder kann man weder sehen, fühlen noch schmecken.Ohne sie wäre aber unser Alltag nicht mehr vorstellbar. Kaum ein Gerät funktioniert mehr ohne elektrischen Strom und selbst ein Großteil der zwischenmenschlichen Kommunikation findet, beispielsweise bei Handytelefonaten, mithilfe elektromagnetischer Felder statt. Bei der technischen Nutzung elektromagnetischer Felder ist es für den Entwicklungsingenieur aber ein wirkliches Hindernis, dass er sie auf direktem Wege gar nicht wahrnehmen kann. Die „Visualisierungsmöglichkeiten“ beschränkten sich bisher auf die eigene Vorstellungskraft und die Fähigkeit, komplizierte mathematische Beschreibungen zu lesen

GPS scintillation and irregularities at the front of an ionization tongue in the nightside polar ionosphere

In this paper we study a tongue of ionization (TOI) on 31 October 2011 which stretched across the polar cap from the Canadian dayside sector to Svalbard in the nightside ionosphere. The TOI front arrived over Svalbard around 1930 UT. We have investigated GPS scintillation and irregularities in relation to this TOI front. This is the first study presenting such detailed multi-instrument data of scintillation and irregularities in relation to a TOI front. Combining data from an all-sky imager, the European Incoherent Scatter Svalbard Radar, the Super Dual Auroral Radar Network Hankasalmi radar, and three GPS scintillation and total electron content (TEC) monitors in Longyearbyen and Ny-Ålesund, we observe bursts of phase scintillation and no amplitude scintillation in relation to the leading gradient of the TOI. Spectrograms of 50Hz phase measurements show highly localized and variable structuring of the TOI leading gradient, with no structuring or scintillation within the TOI or ahead of the TOI

Near real-time input to a propagation model for nowcasting of HF communications with aircraft on polar routes

There is a need for improved techniques for nowcasting and forecasting (over several hours) HF propagation at northerly latitudes to support airlines operating over the increasingly popular trans-polar routes. In this paper the assimilation of real-time measurements into a propagation model developed by the authors is described, including ionosonde measurements and Total Electron Content (TEC) measurements to define the main parameters of the ionosphere. The effects of D-region absorption in the polar cap and auroral regions are integrated with the model through satellite measurements of the flux of energetic solar protons (>1 MeV) and the X-ray flux in the 0.1-0.8 nm band, and ground-based magnetometer measurements which form the Kp and Dst indices of geomagnetic activity. The model incorporates various features (e.g. convecting patches of enhanced plasma density) of the polar ionosphere that are, in particular, responsible for off-great circle propagation and lead to propagation at times and frequencies not expected from on-great circle propagation alone. The model development is supported by the collection of HF propagation measurements over several paths within the polar cap, crossing the auroral oval, and along the mid-latitude trough

Legionella pneumophila induces human beta Defensin-3 in pulmonary cells

<p>Abstract</p> <p>Background</p> <p><it>Legionella pneumophila </it>is an important causative agent of severe pneumonia in humans. Human alveolar epithelium and macrophages are effective barriers for inhaled microorganisms and actively participate in the initiation of innate host defense. The beta defensin-3 (hBD-3), an antimicrobial peptide is an important component of the innate immune response of the human lung. Therefore we hypothesize that hBD-3 might be important for immune defense towards <it>L. pneumophila</it>.</p> <p>Methods</p> <p>We investigated the effects of <it>L. pneumophila </it>and different TLR agonists on pulmonary cells in regard to hBD-3 expression by ELISA. Furthermore, siRNA-mediated inhibition of TLRs as well as chemical inhibition of potential downstream signaling molecules was used for functional analysis.</p> <p>Results</p> <p><it>L. pneumophila </it>induced release of hBD-3 in pulmonary epithelium and alveolar macrophages. A similar response was observed when epithelial cells were treated with different TLR agonists. Inhibition of TLR2, TLR5, and TLR9 expression led to a decreased hBD-3 expression. Furthermore expression of hBD-3 was mediated through a JNK dependent activation of AP-1 (c-Jun) but appeared to be independent of NF-κB. Additionally, we demonstrate that hBD-3 elicited a strong antimicrobial effect on <it>L. pneumophila </it>replication.</p> <p>Conclusions</p> <p>Taken together, human pulmonary cells produce hBD-3 upon <it>L. pneumophila </it>infection via a TLR-JNK-AP-1-dependent pathway which may contribute to an efficient innate immune defense.</p

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

P2X7 is an intriguing ionotropic receptor for which the activation by extracellular ATP induces rapid inward cationic currents and intracellular signalling pathways associated with numerous physiological processes such as the induction of the inflammatory cascade, the survival and proliferation of cells. In contrast, long-term stimulation of P2X7 is generally associated with membrane permeabilisation and cell death. Recently, P2X7 has attracted great attention in the cancer field, and particularly in the neoplastic transformation and the progression of solid tumours. A growing number of studies were published; however they often appeared contradictory in their results and conclusions. As such, the involvement of P2X7 in the oncogenic process remains unclear so far. The present review aims to discuss the current knowledge and hypotheses on the involvement of the P2X7 receptor in the development and progression of solid tumours, and highlight the different aspects that require further clarification in order to decipher whether P2X7 could be considered as a cancer biomarker or as a target for pharmacological intervention. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers

Pattern recognition receptors in immune disorders affecting the skin.

Contains fulltext : 109004.pdf (publisher's version ) (Open Access)Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs

Familien-Register : vom 1.Januar 1809 bis Dezember 1853 /

Registry of Jewish families in Buchau, 1809-1853Contains family trees since the early 18th centuryContains family trees of Nobel Prize recipients Albert Einstein (since 1759) and Joseph Erlangerdigitize