HYBRID DISCOURSE AND THE EMERGENCE OF CONTEXT IN BBC’S QUESTION TIME

This paper explores how hybrid discourse, instantiated in talk and interaction, can be shaped not only by a situational context (TV panel show) and cultural context (TV’s increasing democratisation of laity), but also by human volition in pursuit of recognizable and allowable goals. It does this by examining the emergence of context in light of a non-mainstream hybrid and refl exive activity. Specifically, it examines a non-normative interview format that has arisen in contemporary broadcasting through the analysis of three transcribed segments which were taken from two key episodes of the BBC’s fl agship political program: Question Time. Using a range of analytical concepts from symbolic interactionism, pragmatics, and conversational analysis, such as frames and footings, activity types, discourse types, and turn-taking, the analysis shows how institutional (political) and non-institutional (normative) practices can come together in the pursuit of individual goals and contemporary media’s goal for increasingly partisan journalism and confrontainment. Overall, the paper highlights the importance of a multidimensional approach to context, whereby meaning both emerges from and is constitutive of the forms and functions of an activity’s discourse, whilst further highlighting the role of hybridity in contemporary discourse

Modelling choice in digital writing: functional revisions and 'texture'

In this thesis, the digital writing practices of two 2nd year undergraduates are examined in terms of the functions and structures of their revision activity. Using systemic functional linguistics as an underlying framework, the project takes a first step toward to a dynamic description of written text in functional terms. To date, research into dynamic descriptions of language (i.e. the logogenesis, or unfolding of meaning in a text) has been almost entirely based upon data related to the spoken mode. Furthermore, research into revision activity has tended to ignore the functionality or meaning inherent in such revisions. The existing research has, instead, primarily focused on cognitive processes (for e.g., pause times) or which language structures, such as parts of speech, are more frequently involved in revisions that others. Ultimately, this thesis works toward providing a dynamic description of the language functions and revisions involved in revision activity in two student writers. To do this, it makes use of software called keystroke logging to record how two writers compose four academic essays on their computers. Such technology allows us to model the unfolding of a written text in much the same way as a tape recording allows researchers to model the unfolding of a speech. By examining how these writers revise text in light of academic expectations (a 'valued' configuration of field, tenor, and mode register variables present in language choices) and digital mediation (computer afforded composing practices), the thesis shows how certain language functions and structures may play a key role when it comes to shaping an academic essay. In this light, this thesis takes a first step to providing a dynamic description of what is usually analysed solely in synoptic terms, by showing how we can analyse written text as process (an evolving entity) rather than just a product (a static entity). Because of this, a new model of analysis – a combination of keystroke data and functional systemics – is proposed, which can provide an additional perspective to the already existing methods of examining writer behaviour by looking at meaning making practices in revision activity

Questioning the Sustainability of English-Medium Instruction Policy in Science Classrooms: Teachers’ and Students’ Experiences at a Hong Kong Secondary School

Teaching science through English as a medium of instruction (EMI) is a growing phenomenon around the world. In Hong Kong, this was realised on a large scale in 2010, with the implementation of a “fine-tuning” compulsory language policy. This allowed Chinese-medium schools to adopt EMI fully. Yet, despite such rapid and widespread adoption, an adequate understanding of key stakeholders’ experiences in relation to their perceptions of what constitutes effective EMI science education remains scarce. Thus, we question the sustainability of EMI programs that are driven by top-down policy. In this case study, we explore the perspectives and experiences of six EMI science teachers and thirteen of their students as their secondary school transitions from partial to full EMI. From in-depth interviews (complemented by classroom observations), findings reveal that the transition to full EMI has presented challenges that appear to hinder students’ development of scientific knowledge and the language of science in English. This directly counters the primary goal of the fine-tuning policy. Nevertheless, findings also illuminate a number of coping strategies teachers and students use to deal with their changing curricula. Overall, we offer insights into this under-researched context of transitioning EMI programs and provide recommendations for future research and practice

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

SummaryWe report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Measurement of the Jet Mass Distribution and Top Quark Mass in Hadronic Decays of Boosted Top Quarks in pp Collisions at root s=13 TeV

A measurement is reported of the jet mass distribution in hadronic decays of boosted top quarks produced in pp collisions at root s = 13 TeV. The data were collected with the CMS detector at the LHC and correspond to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lepton + jets channel of t (t) over bar events, where the lepton is an electron or muon. The products of the hadronic top quark decay t -> bW -> bq (q) over bar' are reconstructed as a single jet with transverse momentum larger than 400 GeV. The t (t) over bar cross section as a function of the jet mass is unfolded at the particle level and used to extract a value of the top quark mass of 172.6 +/- 2.5 GeV. A novel jet reconstruction technique is used for the first time at the LHC, which improves the precision by a factor of 3 relative to an earlier measurement. This highlights the potential of measurements using boosted top quarks, where the new technique will enable future precision measurements.Peer reviewe

Search for charged Higgs bosons decaying into a top and a bottom quark in the all-jet final state of pp collisions at root s=13 TeV

A search for charged Higgs bosons (H-+/-) decaying into a top and a bottom quark in the all-jet final state is presented. The analysis uses LHC proton-proton collision data recorded with the CMS detector in 2016 at root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No significant excess is observed above the expected background. Model-independent upper limits at 95% confidence level are set on the product of the H-+/- production cross section and branching fraction in two scenarios. For production in association with a top quark, limits of 21.3 to 0.007 pb are obtained for H-+/- masses in the range of 0.2 to 3 TeV. Combining this with a search in leptonic final states results in improved limits of 9.25 to 0.005 pb. The complementary s-channel production of an H-+/- is investigated in the mass range of 0.8 to 3 TeV and the corresponding upper limits are 4.5 to 0.023 pb. These results are interpreted using different minimal supersymmetric extensions of the standard model.Peer reviewe

Measurement of properties of B(s)(0)s -> mu(+)mu(-) decays and search for B-0 -> mu(+)mu(-) with the CMS experiment

Results are reported for the B 0s ! + branching fraction and effective lifetime and from a search for the decay B0 ! + . The analysis uses a data sample of proton-proton collisions accumulated by the CMS experiment in 2011, 2012, and 2016, with center-of-mass energies (integrated luminosities) of 7TeV (5 fb), 8TeV (20 fb), and 13TeV (36 fb). The branching fractions are determined by measuring event yields relative to B+ ! J= K+ decays (with J= ! + ), which results in the reduction of many of the systematic uncertainties. The decay B 0s ! + is observed with a significance of 5.6 standard deviations. The branching fraction is measured to be B (B 0s ! + ) = [2:9 0:7(exp) 0:2(frag)] 10, where the first uncertainty combines the experimental statistical and systematic contributions, and the second is due to the uncertainty in the ratio of the B 0s and the B+ fragmentation functions. No significant excess is observed for the decay B0 ! + , and an upper limit of B(B0 ! + ) <3:6 10 is obtained at 95% confidence level. The B 0s ! + effective lifetime is measured to be + = 1:70 +0:61 ps. These results are consistent with standard model predictions.Peer reviewe

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

Measurement of the top quark pair production cross section in dilepton final states containing one τ lepton in pp collisions at √s = 13 TeV

© 2020, The Author(s). The cross section of top quark pair production is measured in the tt¯→(ℓνℓ)(τhντ)bb¯ final state, where τh refers to the hadronic decays of the τ lepton, and ℓ is either an electron or a muon. The data sample corresponds to an integrated luminosity of 35.9 fb−1 collected in proton-proton collisions at s = 13 TeV with the CMS detector. The measured cross section is σtt ¯ = 781 ± 7 (stat) ± 62 (syst) ± 20 (lumi) pb, and the ratio of the partial width Γ(t → τντb) to the total decay width of the top quark is measured to be 0.1050 ± 0.0009 (stat) ± 0.0071 (syst). This is the first measurement of the t t ¯ production cross section in proton-proton collisions at s = 13 TeV that explicitly includes τ leptons. The ratio of the cross sections in the ℓτh and ℓℓ final states yields a value Rℓτh/ll = 0.973 ± 0.009 (stat) ± 0.066 (syst), consistent with lepton universality. [Figure not available: see fulltext.]SCOAP