33 research outputs found
Campus Update: July/August 1990 v. 2, no. 6
Monthly newsletter of the BU Medical CampusNote: misnumbered v. 3, no.
Reliability and accuracy of delirium assessments among investigators at multiple international centres
Search for Na in novae supported by a novel method for measuring femtosecond nuclear lifetimes
Classical novae are thermonuclear explosions in stellar binary systems, and
important sources of Al and Na. While gamma rays from the decay
of the former radioisotope have been observed throughout the Galaxy, Na
remains untraceable. The half-life of Na (2.6 yr) would allow the
observation of its 1.275 MeV gamma-ray line from a cosmic source. However, the
prediction of such an observation requires good knowledge of the nuclear
reactions involved in the production and destruction of this nucleus. The
Na()Mg reaction remains the only source of large
uncertainty about the amount of Na ejected. Its rate is dominated by a
single resonance on the short-lived state at 7785.0(7) keV in Mg. In the
present work, a combined analysis of particle-particle correlations and
velocity-difference profiles is proposed to measure femtosecond nuclear
lifetimes. The application of this novel method to the study of the Mg
states, combining magnetic and highly-segmented tracking gamma-ray
spectrometers, places strong limits on the amount of Na produced in
novae, explains its non-observation to date in gamma rays (flux < 2.5x
ph/(cms)), and constrains its detectability with future space-borne
observatories.Comment: 18 pages, 3 figures, 1 tabl
New genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms