Photoproduction of pion pairs from calcium nuclei

The photoproduction of πoπo and πoπ± pairs off 40Ca has been investigated with the TAPS detector using the Glasgow photon tagging spectrometer at the Mainz MAMI accelerator. Data have been taken for incident photon energies in the energy range from 200 - 820 MeV. Total cross sections have been extracted from threshold up to the maximum photon energy and invariant mass distributions of the pion pairs have been obtained for incident photon energies between 400 - 500 MeV and 500 - 550 MeV. The double πo invariant mass distributions show some relative enhancement with respect to the mixed charge channel at small invariant masses. The effects are smaller than previously observed for lead nuclei and the distributions do not significantly deviate from carbon data. The data are in good agreement with the results of recent calculations in the framework of the BUU model, with careful treatment of final state interaction effects but without an explicit in-medium modification of scalar, iso-scalar pion pairs. This means that for Ca most of the experimentally observed effect can be explained by final state interactions. Only at low incident photon energies there is still a small low mass enhancement of the double πo data over the BUU results

Hyperoctahedral Chen calculus for effective Hamiltonians

The algebraic structure of iterated integrals has been encoded by Chen. Formally, it identifies with the shuffle and Lie calculus of Lyndon, Ree and Sch\"utzenberger. It is mostly incorporated in the modern theory of free Lie algebras. Here, we tackle the problem of unraveling the algebraic structure of computations of effective Hamiltonians. This is an important subject in view of applications to chemistry, solid state physics, quantum field theory or engineering. We show, among others, that the correct framework for these computations is provided by the hyperoctahedral group algebras. We define several structures on these algebras and give various applications. For example, we show that the adiabatic evolution operator (in the time-dependent interaction representation of an effective Hamiltonian) can be written naturally as a Picard-type series and has a natural exponential expansion.Comment: Minor corrections. Some misleading notations and typos in the first version have been fixe

Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles

International audienc

Virtual Promenade: A New Serious Game for the Rehabilitation of Older Adults with Post-fall Syndrome

International audience—We introduce a novel rehabilitation tool to treat Post-Fall Syndrome (PFS) in older adults: a serious game, called Virtual Promenade, combined with a haptic chair imitating the hips movements of human walk. We report on the user-centered design of our prototype, following " living lab " principles, which was well received by our test participants. This system aims at addressing the psycho-motor consequences of older adults' falls; they are often neglected in current post-fall care practices. We first checked for feasibility and tolerability of such interventions. We then applied a living lab participatory design approach, involving health care professionals and older adults, to build the Virtual Promenade prototype. We found that patients with PFS tolerated the system well and that there were no major obstacles to feasibility. We also report that the aesthetics of the virtual environment is an important motivational factor for older adults and discuss our results in searching for the most suitable game controller for this type of patients and game. Finally, we observed that the chairs' movements improved the immersion in the game

The equation of state of ultracold Bose and Fermi gases: a few examples

We describe a powerful method for determining the equation of state of an ultracold gas from in situ images. The method provides a measurement of the local pressure of an harmonically trapped gas and we give several applications to Bose and Fermi gases. We obtain the grand-canonical equation of state of a spin-balanced Fermi gas with resonant interactions as a function of temperature. We compare our equation of state with an equation of state measured by the Tokyo group, that reveals a significant difference in the high-temperature regime. The normal phase, at low temperature, is well described by a Landau Fermi liquid model, and we observe a clear thermodynamic signature of the superfluid transition. In a second part we apply the same procedure to Bose gases. From a single image of a quasi ideal Bose gas we determine the equation of state from the classical to the condensed regime. Finally the method is applied to a Bose gas in a 3D optical lattice in the Mott insulator regime. Our equation of state directly reveals the Mott insulator behavior and is suited to investigate finite-temperature effects.Comment: 14 pages, 6 figure

Disease Severity and Progression in Progressive Supranuclear Palsy and Multiple System Atrophy: Validation of the NNIPPS – PARKINSON PLUS SCALE

BACKGROUND The Natural History and Neuroprotection in Parkinson Plus Syndromes (NNIPPS) study was a large phase III randomized placebo-controlled trial of riluzole in Progressive Supranuclear Palsy (PSP, n = 362) and Multiple System Atrophy (MSA, n = 398). To assess disease severity and progression, we constructed and validated a new clinical rating scale as an ancillary study. METHODS AND FINDINGS Patients were assessed at entry and 6-montly for up to 3 years. Evaluation of the scale's psychometric properties included reliability (n = 116), validity (n = 760), and responsiveness (n = 642). Among the 85 items of the initial scale, factor analysis revealed 83 items contributing to 15 clinically relevant dimensions, including Activity of daily Living/Mobility, Axial bradykinesia, Limb bradykinesia, Rigidity, Oculomotor, Cerebellar, Bulbar/Pseudo-bulbar, Mental, Orthostatic, Urinary, Limb dystonia, Axial dystonia, Pyramidal, Myoclonus and Tremor. All but the Pyramidal dimension demonstrated good internal consistency (Cronbach α ≥ 0.70). Inter-rater reliability was high for the total score (Intra-class coefficient = 0.94) and 9 dimensions (Intra-class coefficient = 0.80-0.93), and moderate (Intra-class coefficient = 0.54-0.77) for 6. Correlations of the total score with other clinical measures of severity were good (rho ≥ 0.70). The total score was significantly and linearly related to survival (p<0.0001). Responsiveness expressed as the Standardized Response Mean was high for the total score slope of change (SRM = 1.10), though higher in PSP (SRM = 1.25) than in MSA (SRM = 1.0), indicating a more rapid progression of PSP. The slope of change was constant with increasing disease severity demonstrating good linearity of the scale throughout disease stages. Although MSA and PSP differed quantitatively on the total score at entry and on rate of progression, the relative contribution of clinical dimensions to overall severity and progression was similar. CONCLUSIONS The NNIPPS-PPS has suitable validity, is reliable and sensitive, and therefore is appropriate for use in clinical studies with PSP or MSA. TRIAL REGISTRATION ClinicalTrials.gov NCT00211224

Conférence Nationale d'Intelligence Artificielle Année 2020

National audienc

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but do not kill all the bacilli, which can persist for years. In-depth investigation of M. tuberculosis interactions with granuloma-specific cell populations are needed to gain insight into mycobacterial persistence, and to better understand the physiopathology of the disease. We have analyzed the formation of foamy macrophages (FMs), a granuloma-specific cell population characterized by its high lipid content, and studied their interaction with the tubercle bacillus. Within our in vitro human granuloma model, M. tuberculosis long chain fatty acids, namely oxygenated mycolic acids (MA), triggered the differentiation of human monocyte-derived macrophages into FMs. In these cells, mycobacteria no longer replicated and switched to a dormant non-replicative state. Electron microscopy observation of M. tuberculosis–infected FMs showed that the mycobacteria-containing phagosomes migrate towards host cell lipid bodies (LB), a process which culminates with the engulfment of the bacillus into the lipid droplets and with the accumulation of lipids within the microbe. Altogether, our results suggest that oxygenated mycolic acids from M. tuberculosis play a crucial role in the differentiation of macrophages into FMs. These cells might constitute a reservoir used by the tubercle bacillus for long-term persistence within its human host, and could provide a relevant model for the screening of new antimicrobials against non-replicating persistent mycobacteria

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI