357 research outputs found
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Large-eddy simulation of three-dimensional dunes in a steady, unidirectional flow. Part 1. Turbulence statistics
We performed large-eddy simulations of flow over a series of three-dimensional dunes at laboratory scale (Reynolds number based on the average channel depth and streamwise velocity was 18 900) using the Lagrangian dynamic eddy-viscosity subgrid-scale model. The bedform three-dimensionality was imposed by shifting a standard two-dimensional dune shape in the streamwise direction according to a sine wave. The statistics of the flow are discussed in 10 cases with in-phase and staggered crestlines, different deformation amplitudes and wavelengths. The results are validated qualitatively against experiments. The three-dimensional separation of flow at the crestline alters the distribution of wall pressure, which in turn may cause secondary flow across the stream, which directs low-momentum fluid, near the bed, toward the lobe (the most downstream point on the crestline) and high-momentum fluid, near the top surface, toward the saddle (the most upstream point on the crestline). The mean flow is characterized by a pair of counter-rotating streamwise vortices, with core radius of the order of the flow depth. However, for wavelengths smaller than the flow depth, the secondary flow exists only near the bed and the mean flow away from the bed resembles the two-dimensional case. Staggering the crestlines alters the secondary motion; the fastest flow occurs between the lobe and the saddle planes, and two pairs of streamwise vortices appear (a strong one, centred about the lobe, and a weaker one, coming from the previous dune, centred around the saddle). The distribution of the wall stress and the focal points of separation and attachment on the bed are discussed. The sensitivity of the average reattachment length, depends on the induced secondary flow, the streamwise and spanwise components of the channel resistance (the skin friction and the form drag), and the contribution of the form drag to the total resistance are also studied. Three-dimensionality of the bed increases the drag in the channel; the form drag contributes more than in the two-dimensional case to the resistance, except for the staggered-crest case. Turbulent-kinetic energy is increased in the separated shear layer by the introduction of three-dimensionality, but its value normalized by the plane-averaged wall stress is lower than in the corresponding two-dimensional dunes. The upward flow on the stoss side and higher deceleration of flow on the lee side over the lobe plane lift and broaden the separated shear layer, respectively, affecting the turbulent kinetic energy
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Large-eddy simulation of three-dimensional dunes in a steady, unidirectional flow. Part 2. Flow structures
We performed large-eddy simulations of the flow over a series of three-dimensional (3D) dunes at laboratory scale. The bedform three-dimensionality was imposed by shifting a standard two-dimensional (2D) dune shape in the streamwise direction according to a sine wave. The turbulence statistics were discussed in Part 1 of this article (Omidyeganeh & Piomelli, J. Fluid Mech., vol. 721, 2013, pp. 454–483). Coherent flow structures and their statistics are discussed concentrating on two cases with the same crestline amplitudes and wavelengths but different crestline alignments: in-phase and staggered. The present paper shows that the induced large-scale mean streamwise vortices are the primary factor that alters the features of the instantaneous flow structures. Wall turbulence is insensitive to the crestline alignment; alternating high- and low-speed streaks appear in the internal boundary layer developing on the stoss side, whereas over the node plane (the plane normal to the spanwise direction at the node of the crestline), they are inclined towards the lobe plane (the plane normal to the spanwise direction at the most downstream point of the crestline) due to the mean spanwise pressure gradient. Spanwise vortices (rollers) generated by Kelvin–Helmholtz instability in the separated shear layer appear regularly over the lobe with much larger length scale than those over the saddle (the plane normal to the spanwise direction at the most upstream point of the crestline). Rollers over the lobe may extend to the saddle plane and affect the reattachment features; their shedding is more frequent than in 2D geometries. Vortices shed from the separated shear layer in the lobe plane undergo a three-dimensional instability while being advected downstream, and rise toward the free surface. They develop into a horseshoe shape (similar to the 2D case) and affect the whole channel depth, whereas those generated near the saddle are advected downstream and toward the bed. When the tip of such a horseshoe reaches the free surface, the ejection of flow at the surface causes ‘boils’ (upwelling events on the surface). Strong boil events are observed on the surface of the lobe planes of 3D dunes more frequently than in the saddle planes. They also appear more frequently than in the corresponding 2D geometry. The crestline alignment of the dune alters the dynamics of the flow structures, in that they appear in the lobe plane and are advected towards the saddle plane of the next dune, where they are dissipated. Boil events occur at a higher frequency in the staggered alignment, but with less intensity than in the in-phase alignment
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Large-eddy simulation of two-dimensional dunes in a steady, unidirectional flow
We performed large-eddy simulations of the flow over a typical two-dimensional dune geometry at laboratory scale (the Reynolds number based on the average channel height andmean velocity is 18,900) using the Lagrangian dynamic eddy-viscosity subgrid-scale model. The results are validated by comparison with simulations and experiments in the literature. The flowseparates at the dune crest, generating a shear layer that plays a crucial role in the transport of momentum and energy, and the generation of coherent structures. The turbulent kinetic energy budgets show the importance of the turbulent transport and mean-flow advection in the bulk flow above the shear layer. In the recirculation zone and in the attached boundary layers production and dissipation are the most important terms. Large, coherent structures of various types can be observed. Spanwise vortices are generated in the separated shear layer due to the Kelvin-Helmholtz instability; as they are advected, they undergo lateral instabilities and develop into horseshoe-like structures, are tilted downward, and finally reach the surface. The ejection that occurs between the legs of the vortex creates the upwelling and downdrafting events on the free surface known as "boils." Near-wall turbulence, after the reattachment point, is affected by large streamwise Taylor-Görtler vortices generated on the concave part of the stoss side, which affect the distribution of the near-wall streaks
Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
OBJECTIVE-The effectiveness of tolerizing immunotherapeutic strategies, such as anti-CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic (NOD) mice than at peak insulitis. RelB(lo) DCs, generated in the presence of an nuclear factor-kappa B inhibitor, induce T-regulatory (Treg) cells and suppress inflammation in a model of rheumatoid arthritis. Interleukin (IL)-1 beta is overexpressed in humans and mice at risk of type 1 diabetes, dysregulates Treg cells, and accelerates diabetes in NOD mice. We investigated the relationship between IL-1 beta production and the response to RelB(lo) DCs in the prediabetic period
Understanding the role of eco-evolutionary feedbacks in host-parasite coevolution
It is widely recognised that eco-evolutionary feedbacks can have important implications for evolution. However, many models of host-parasite coevolution omit eco-evolutionary feedbacks for the sake of simplicity, typically by assuming the population sizes of both species are constant. It is often difficult to determine whether the results of these models are qualitatively robust if eco-evolutionary feedbacks are included. Here, by allowing interspecific encounter probabilities to depend on population densities without otherwise varying the structure of the models, we provide a simple method that can test whether eco-evolutionary feedbacks per se affect evolutionary outcomes. Applying this approach to explicit genetic and quantitative trait models from the literature, our framework shows that qualitative changes to the outcome can be directly attributable to eco-evolutionary feedbacks. For example, shifting the dynamics between stable monomorphism or polymorphism and cycling, as well as changing the nature of the cycles. Our approach, which can be readily applied to many different models of host-parasite coevolution, offers a straightforward method for testing whether eco-evolutionary feedbacks qualitatively change coevolutionary outcomes
Understanding delay in developmental disorders
Researchers in developmental disorders frequently refer to abilities that are in line with mental age as simply delayed. The qualifier simply might imply an existing theory of developmental delay that is well understood and uninteresting (perhaps because it is an exaggerated form of individual differences, the responsibility of other researchers). In this article, I argue that the notion of delay can be separated into descriptive and explanatory versions. The descriptive version is often used too coarsely to be helpful. Instead, we need an approach based on developmental trajectories to separate types of descriptive delay, which may then have different underlying causes. The explanatory version is poorly articulated in developmental theory. One useful way to deepen our understanding of delay is by building computational models that simulate development in large populations of individuals and explicitly implementing factors that cause variations in development. Finally, I suggest that dividing research among separate investigators of typical development, individual differences, and developmental disorders may be counterproductive if the underlying mechanisms recognize no such distinction
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Large eddy simulation of interacting barchan dunes in a steady, unidirectional flow
We have performed large-eddy simulations of turbulent flow 4 over barchan dunes in a channel with different interdune spacings in the downstream direction at Reynolds number, Re∞ ≃ 26000 (based on the free 6 stream velocity and channel height). Simulations are validated against ex-perimental data (at Re∞ = 55460); the largest interdune spacing (2.38λ, where λ is the length of the barchan model) presents similar characteristics to the isolated dune in the experiment, indicating that at this distance the sheltering effect of the upstream dune is rather weak. We examine 3D realizations of the mean and instantaneous flow to explain features of the flow field relevant to sediment transport. Barchan dunes induce two counter-rotating streamwise vortices, along each of the horns, which direct high-momentum fluid toward the symmetry plane and low-momentum fluid near the bed away from the centerline. The flow near the bed, upstream of the dune, diverges from the centerline plane, decelerates and then rises on the stoss side of the dune while accelerating; the flow close to the centerline plane separates at the crest and reattaches on the bed. Away from the centerline plane and along the horns, flow separation occurs intermittently. The flow in the separation bubble is routed towards the horns and leaves the dune at their tips. The separated flow at the crest reattaches on the bed, except on the centerline symmetry plane of the dune, where a weak saddle point of separation ap- pears at the bed. The distribution of the bed shear-stress, characteristics of the separation and reattachment regions, and instantaneous wall turbulence are discussed. Characteristics of the internal boundary layer developing on the bed after the reattachment region are studied. The interdune spacing isfound to affect significantly the turbulent flow over the stoss side of the downstream dunes; at smaller interdune-spacings, coherent high- and low- speed streaks are shorter but stronger, and the spanwise normal Reynolds stress is larger. The turbulent kinetic energy budgets show the importance of the pressure transport and mean-flow advection in transporting energy from the overlying wake layer to the internal boundary layer over the stoss side of the closely-spaced dunes. The characteristics of the separated-shear layer are altered slightly at smaller interdune spacing; the separation bubble is smaller, the separated-shear layer is stronger, and the bed shear-stress is larger. Away from the dunes, typical wall-turbulence structures are observed, but coher- ent eddies generated in the separated-shear layer due to the Kelvin-Helmholtz instability are dominant near the dune. Coherent structures are generated more frequently at smaller interdune spacing; they move farther away from the bed, towards the free surface, and remain in between the horns. At larger interdune spacings, these coherent structures are advected in the spanwise direction with the mean streamwise vortices and can be observed outside of the dunes
Measurement of the Non-Common Vertex Error of a Double Corner Cube
ABSTRACT The Space Interferometry Mission (SIM) requires the control of the optical path of each interferometer with picometer accuracy. Laser metrology gauges are used to measure the path lengths to the fiiducial corner cubes at the siderostats. Due to the geometry of SIM a single corner cube does not have sufficient acceptance angle to work with all the gauges. Therefore SIM employs a double corner cube. Current fabrication methods are in fact not capable of producing such a double corner cube with vertices having sufficient commonality. The plan for SIM is to measure the non-commonalty of the vertices and correct for the error in orbit. SIM requires that the non-common vertex error (NCVE) of the double corner cube to be less than 6 µm. The required accuracy for the knowledge of the NCVE is less than 1 µm. This paper explains a method of measuring non-common vertices of a brassboard double corner cube with sub-micron accuracy. The results of such a measurement will be presented
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The micromorphology of glaciolacustrine varve sediments and their use for reconstructing palaeoglaciological and palaeoenvironmental change
Former glaciolacustrine systems are an important archive of palaeoglaciological, palaeoenvironmental and palaeoclimatic change. The annually laminated (varved) sediments that, under certain conditions, accumulate in former glacial lakes, offer a rare opportunity to reconstruct such changes (e.g. glacier advance and retreat cycles, glacier ablation trends, permafrost melt, nival events) at annual or even sub-annual temporal resolution. Data of this kind are desirable for their ability to guide and test numerical model simulations of glacier dynamics and palaeoclimatic change that occur over rapid time intervals, with implications for predicting future glacier response to climatic change, or the effects of weather and climate events on lake sedimentation. The most valuable records preserved in glaciolacustrine systems are continuous varved sequences formed in the distal parts of glacial lakes, where microscale lamination structures can accumulate relatively undisturbed. Technological advances, in the last few decades, have enabled improved characterisation of glaciolacustrine varve microfacies and the precise measurement of varve thickness at the micrometre scale. However, unlike in cognate fields (e.g. soil science), protocols for the robust and consistent description and interpretation of glaciolacustrine varve sediments are lacking. To fill this gap, and to provide a resource for future studies of glaciolacustrine varved sediments, this paper reviews the processes of sedimentation in glacial lake basins, and presents the defining microfacies characteristics of glacial varves using a descriptive protocol that uses consistent examination of grain size, sorting, structure, nature of contacts, development of plasmic fabrics and features such as dropgrains and intraclasts within individual laminations. These lamination types are then combined into lamination sets, whose structures can be interpreted as glaciolacustrine varves. Within this framework, we define five principal assemblages of glaciolacustrine varve microfacies which, if clearly identified in palaeoglaciolacustrine settings, enable more detailed palaeoenvironmental interpretations to be made. Finally, we discuss the utility and complexities of reconstructing the evolution of former glacial lake systems using varve microfacies and thickness datasets
Multi-mode fluctuating selection in host-parasite coevolution
Published onlineLetterThis is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Understanding fluctuating selection is important for our understanding of patterns of spatial and temporal diversity in nature. Host-parasite theory has classically assumed fluctuations either occur between highly specific genotypes (matching allele: MA) or from specialism to generalism (gene-for-gene: GFG). However, while MA can only generate one mode of fluctuating selection, we show that GFG can in fact produce both rapid 'within-range' fluctuations (among genotypes with identical levels of investment but which specialise on different subsets of the population) and slower cycling 'between ranges' (different levels of investment), emphasising that MA is a subset of GFG. Our findings closely match empirical observations, although sampling rates need to be high to detect these novel dynamics empirically. Within-range cycling is an overlooked process by which fluctuating selection can occur in nature, suggesting that fluctuating selection may be a more common and important process than previously thought in generating and maintaining diversity.This work was supported by the Natural Environment Research Council (NE/N014979/1 and NE/K014617/1)
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