Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain

Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem brain samples derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort to investigate the axonal density within deep subcortical lesions. There was no significant difference between the lesional and control white matter, therefore, we conclude that there is axonal preservation within these lesions that are characterized by demyelination

The design and performance of an improved target for MICE

The linear motor driving the target for the Muon Ionisation Cooling Experiment has been redesigned to improve its reliability and performance. A new coil-winding technique is described which produces better magnetic alignment and improves heat transport out of the windings. Improved field-mapping has allowed the more precise construction to be demonstrated, and an enhanced controller exploits the full features of the hardware, enabling increased acceleration and precision. The new user interface is described and analysis of performance data to monitor friction is shown to allow quality control of bearings and a measure of the ageing of targets during use

The design, construction and performance of the MICE target

The pion-production target that serves the MICE Muon Beam consists of a titanium cylinder that is dipped into the halo of the ISIS proton beam. The design and construction of the MICE target system are described along with the quality-assurance procedures, electromagnetic drive and control systems, the readout electronics, and the data-acquisition system. The performance of the target is presented together with the particle rates delivered to the MICE Muon Beam. Finally, the beam loss in ISIS generated by the operation of the target is evaluated as a function of the particle rate, and the operating parameters of the target are derived

The learning sciences in the (Primary) Initial Teacher Education curriculum

Researchers from Bath Spa University reported on work funded by the Wellcome Trust aimed at introducing concepts from cognitive neuroscience into initial teacher education (ITE). The approach taken is framed by the Core Content Framework and Early Career Framework but goes beyond this to take a deeper look at how the newly established field of educational neuroscience is beginning to identify a wider set of key concepts for informing teacher education and development. They presented examples of developments across the Bath Spa University PGCE Primary and Early Years curriculum to explore the challenges encountered and propose ways forward. This included a look at new open-access resources developed by the team

The Learning Sciences and the Core Content Framework for Initial Teacher Training

This document is an outcome of the project 'The Learning Sciences in Initial Teacher Education' based at Bath Spa University (2019-2020) and funded by the Wellcome Trust. Our intention is to support teacher educators in responding to the 2019 Core Content Framework for Initial Teacher Training by exploring the underpinning research from the ‘Learning Sciences’

The design, construction and performance of the MICE scintillating fibre trackers

This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 ElsevierCharged-particle tracking in the international Muon Ionisation Cooling Experiment (MICE) will be performed using two solenoidal spectrometers, each instrumented with a tracking detector based on diameter scintillating fibres. The design and construction of the trackers is described along with the quality-assurance procedures, photon-detection system, readout electronics, reconstruction and simulation software and the data-acquisition system. Finally, the performance of the MICE tracker, determined using cosmic rays, is presented.This work was supported by the Science and Technology Facilities Council under grant numbers PP/E003214/1, PP/E000479/1, PP/E000509/1, PP/E000444/1, and through SLAs with STFC-supported laboratories. This work was also supportedby the Fermi National Accelerator Laboratory, which is operated by the Fermi Research Alliance, under contract No. DE-AC02-76CH03000 with the U.S. Department of Energy, and by the U.S. National Science Foundation under grants PHY-0301737,PHY-0521313, PHY-0758173 and PHY-0630052. The authors also acknowledge the support of the World Premier International Research Center Initiative (WPI Initiative), MEXT, Japan

Forward coherent ϕ\phi-meson photoproduction from deuterons near threshold

Differential cross sections and decay asymmetries for coherent $\phi$-meson photoproduction from deuterons were measured for the first time at forward angles using linearly polarized photons at $E_{\gamma}$= 1.5-2.4 GeV. This reaction offers a unique way to directly access natural-parity Pomeron dynamics and gluon exchange at low energies. The cross sections at zero degrees increase with increasing photon energy. The decay asymmetries demonstrate a complete dominance of natural-parity exchange processes, showing that isovector unnatural-parity $\pi$-meson exchange is small. Nevertheless the deduced cross sections of $\phi$-mesons from nucleons contributed by isoscalar t-channel exchange processes are not well described by the conventional Pomeron model.Comment: 14 pages, 6 figures. Final published versio

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio