1,534 research outputs found
Estrategias de marketing e internacionalización de las MYPES agrícolas productoras de cereales andinos de la provincia de Jauja, Junín, 2020
La presente investigación tuvo como objetivo determinar de qué manera las
estrategias de marketing influyen en la internacionalización de las MYPES agrícolas
productoras de cereales andinos de la provincia de Jauja, 2020. La metodología tuvo
un enfoque cuantitativo, con una población de 20 directivos de cada una de las Mypes
teniendo una muestra censal de 20 directivos de cada una de las Mypes. La técnica
empleada fue la encuesta y el instrumento utilizado el cuestionario, conformado por
18 ítems por cada variable que fue debidamente validado por tres expertos, para luego
demostrar la confiabilidad mediante el Alfa de Cronbach. Los resultados obtenidos
fueron de un coeficiente ,629 con una Bilateral de ,003 < ,05 teniendo la conclusión
de que si existe relación entre las estrategias de marketing e internacionalización. La
recomendación que se le da a la asociación es que realice capacitaciones
en cómo mejorar las estrategias de cliente, producto y comunicación y distribución, de
no llevarlas a cabo y no aprovechar las dimensiones de estrategias de marketing, la
asociación corre el riesgo de seguir vendiéndolos a empresas terceras que les
compran cómodo sus productos y venden caro al exterior, reduciendo su ganancia,
esfuerzo y bienestar económico
Chemical Abundances of Seven Irregular and Three Tidal Dwarf Galaxies in the M81 Group
We have derived nebular abundances for 10 dwarf galaxies belonging to the M81
Group, including several galaxies which do not have abundances previously
reported in the literature. For each galaxy, multiple H \ii regions were
observed with GMOS-N at the Gemini Observatory in order to determine abundances
of several elements (oxygen, nitrogen, sulfur, neon, and argon). For seven
galaxies, at least one H \ii region had a detection of the temperature
sensitive [OIII] 4363 line, allowing a "direct" determination of the
oxygen abundance. No abundance gradients were detected in the targeted galaxies
and the observed oxygen abundances are typically in agreement with the well
known metallicity-luminosity relation. However, three candidate "tidal dwarf"
galaxies lie well off this relation, UGC 5336, Garland, and KDG 61. The nature
of these systems suggests that UGC 5336 and Garland are indeed recently formed
systems, whereas KDG 61 is most likely a dwarf spheroidal galaxy which lies
along the same line of sight as the M81 tidal debris field. We propose that
these H \ii regions formed from previously enriched gas which was stripped from
nearby massive galaxies (e.g., NGC 3077 and M81) during a recent tidal
interaction.Comment: 37 pages, 10 figures, accepted for publication in ApJ. Slit positions
in Table 2 have been update
Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves
peer-reviewedBackground There is a need to improve vaccination against respiratory pathogens in calves by stimulation of local immunity at the site of pathogen entry at an early stage in life. Ideally such a vaccine preparation would not be inhibited by the maternally derived antibodies. Additionally, localized immune response at the site of infection is also crucial to control infection at the site of entry of virus. The present study investigated the response to an intranasal bovine parainfluenza 3 virus (BPI3V) antigen preparation encapsulated in PLGA (poly dl-lactic-co-glycolide) nanoparticles in the presence of pre-existing anti-BPI3V antibodies in young calves and comparing it to a commercially available BPI3V respiratory vaccine.
Results
There was a significant (P < 0.05) increase in BPI3V-specific IgA in the nasal mucus of the BPI3V nanoparticle vaccine group alone. Following administration of the nanoparticle vaccine an early immune response was induced that continued to grow until the end of study and was not observed in the other treatment groups. Virus specific serum IgG response to both the nanoparticle vaccine and commercial live attenuated vaccine showed a significant (P < 0.05) rise over the period of study. However, the cell mediated immune response observed didn’t show any significant rise in any of the treatment groups.
Conclusion
Calves administered the intranasal nanoparticle vaccine induced significantly greater mucosal IgA responses, compared to the other treatment groups. This suggests an enhanced, sustained mucosal-based immunological response to the BPI3V nanoparticle vaccine in the face of pre-existing antibodies to BPI3V, which are encouraging and potentially useful characteristics of a candidate vaccine. However, ability of nanoparticle vaccine in eliciting cell mediated immune response needs further investigation. More sustained local mucosal immunity induced by nanoparticle vaccine has obvious potential if it translates into enhanced protective immunity in the face of virus outbreak
Enhanced trace element concentrations in tissues of the clam <em>Ruditapes decussatus</em> transplanted to areas influenced by human activities (Ria Formosa, Portugal)
Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice
Objectives:The development of hyperglycemia and the use of early parenteral feeding are associated with poor outcomes in critically ill patients. We therefore examined the impact of exogenous glucose administration on the integrated metabolic function of endotoxemic mice using our recently developed frequently sampled intravenous glucose tolerance test (FSIVGTT). We next extended our findings using a cecal ligation and puncture (CLP) sepsis model administered early parenteral glucose support.Methods:Male C57BL/6J mice, 8-12 weeks, were instrumented with chronic indwelling arterial and venous catheters. Endotoxemia was initiated with intra-arterial lipopolysaccharide (LPS; 1 mg/kg) in the presence of saline or glucose infusion (100 μL/hr), and an FSIVGTT was performed after five hours. In a second experiment, catheterized mice underwent CLP and the impact of early parenteral glucose administration on glucose homeostasis and mortality was assessed over 24 hrs.Measurements:And MAIN RESULTS: Administration of LPS alone did not impair metabolic function, whereas glucose administration alone induced an insulin sensitive state. In contrast, LPS and glucose combined caused marked glucose intolerance and insulin resistance and significantly impaired pancreatic insulin secretion. Similarly, CLP mice receiving parenteral glucose developed fulminant hyperglycemia within 18 hrs (all > 600 mg/dl) associated with increased systemic cytokine release and 40% mortality, whereas CLP alone (85 ± 2 mg/dL) or sham mice receiving parenteral glucose (113 ± 3 mg/dL) all survived and were not hyperglycemic. Despite profound hyperglycemia, plasma insulin in the CLP glucose-infused mice (3.7 ± 1.2 ng/ml) was not higher than sham glucose infused mice (2.1 ± 0.3 ng/ml).Conclusions:The combination of parenteral glucose support and the systemic inflammatory response in the acute phase of sepsis induces profound insulin resistance and impairs compensatory pancreatic insulin secretion, leading to the development of fulminant hyperglycemia. © 2013 Watanabe et al
Supermassive Black Holes in Galactic Nuclei: Past, Present and Future Research
This review discusses the current status of supermassive black hole research,
as seen from a purely observational standpoint. Since the early '90s, rapid
technological advances, most notably the launch of the Hubble Space Telescope,
the commissioning of the VLBA and improvements in near-infrared speckle imaging
techniques, have not only given us incontrovertible proof of the existence of
supermassive black holes, but have unveiled fundamental connections between the
mass of the central singularity and the global properties of the host galaxy.
It is thanks to these observations that we are now, for the first time, in a
position to understand the origin, evolution and cosmic relevance of these
fascinating objects.Comment: Invited Review, 114 pages. Because of space requirements, this
version contains low resolution figures. The full resolution version can be
downloaded from http://www.physics.rutgers.edu/~lff/publications.htm
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV
Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
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