Carreiras Jurídicas E Vida Privada: Intersecções Entre Trabalho E Família

This article focuses on five legal and judicial careers in the state of São Paulo, Brazil. It analyzes the mutual impact work and family have on women and men practicing law in the private sector and in the public sector, and in careers with more or less female participation, to examine the ways in which the boundaries between professionalism and private life are been dislocated. The aim of the research is to show how work and home overlap each other instead of being apart as supported by the hegemonic ideology of professionalism, which produces discursive boundaries between these spheres. © 2016, Universidade Estadual de Campinas UNICAMP. All Right reserved.20164624527

Performance of BOADICEA and BRCAPRO genetic models and of empirical criteria based on cancer family history for predicting BRCA mutation carrier probabilities: A retrospective study in a sample of Italian cancer genetics clinics

Abstract Purpose To evaluate in current practice the performance of BOADICEA and BRCAPRO risk models and empirical criteria based on cancer family history for the selection of individuals for BRCA genetic testing. Patients and methods The probability of BRCA mutation according to the three tools was retrospectively estimated in 918 index cases consecutively undergone BRCA testing at 15 Italian cancer genetics clinics between 2006 and 2008. Results 179 of 918 cases (19.5%) carried BRCA mutations. With the strict use of the criteria based on cancer family history 173 BRCA (21.9%) mutations would have been detected in 789 individuals. At the commonly used 10% threshold of BRCA mutation carrier probability, the genetic models showed a similar performance [PPV (38% and 37%), sensitivity (76% and 77%) and specificity (70% and 69%)]. Their strict use would have avoided around 60% of the tests but would have missed approximately 1 every 4 carriers. Conclusion Our data highlight the complexity of BRCA testing referral in routine practice and question the strict use of genetic models for BRCA risk assessment

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

The influence of diet on the morphofunctional properties of Hermetia illucens (Diptera: Stratiomyidae) larval midgut

Hermetia illucens (Diptera: Stratiomyidae) is among the most promising organisms for the bioconversion of organic waste in proteins for feed production, because the larvae are able to grow on a wide variety of organic substrates and the dry-matter of the prepupae contains a very high percentage of protein with high nutritional value. One of the potential substrates for bioconversion by H. illucens is Fruit and Vegetable Waste (FVW), which could be provided in large amounts by large-scale retail trade and wholesale markets. However, in view of a possible application of this system, it is fundamental to evaluate the biological performance and the morphological, physiological, and molecular responses of H. illucens reared on this food substrate. In the present study we compared larvae reared on a standard diet for dipteran larvae and on FVW. In particular, after evaluating the growth performances, we focused our attention on the midgut, which is responsible for nutrient digestion and absorption. The morphological changes occurring in this organ after the ingestion of the two diets were investigated by optical microscopy. Moreover, an evaluation of midgut functionality was performed. An analysis based on enzymatic histochemistry was carried out to evaluate specific differences in lipids and glycogen accumulation in midgut cells. Finally, we assessed the activity and the mRNA expression levels of enzymes involved in digestion, focusing on proteolytic and amylolytic ones. Our results demonstrate that the extraordinary feeding plasticity of this insect corresponds to an extraordinary biological, morphological, physiological and molecular plasticity, that allows larvae to perform an effective bioconversion of FVW, opening up interesting application perspectives. This work was supported by Fondazione Cariplo (Insect bioconversion: from vegetable waste to protein production for fish feed, ID 2014-0550)

Comparison of the morphofunctional properties of the larval midgut of Hermetia illucens (Diptera: Stratiomyidae) reared on different diets

Hermetia illucens (Diptera: Stratiomyidae) is among the most promising organisms for the bioconversion of organic waste in proteins for feed production, because the larvae are able to grow on a wide variety of organic substrates and the dry-matter of the prepupae contains a very high percentage of protein with high nutritional value. One of the potential substrates for bioconversion by H. illucens is Fruit and Vegetable Waste (FVW), which could be provided in large amounts by large-scale retail trade and wholesale markets. However, in view of a possible application of this system, it is fundamental to evaluate the biological performance and the morphological, physiological, and molecular responses of H. illucens reared on this food substrate. In the present study we compared larvae reared on a standard diet for dipteran larvae and on FVW. In particular, after evaluating the growth performances, we focused our attention on the midgut, which is responsible for nutrient digestion and absorption. The morphological changes occurring in this organ after the ingestion of the two diets were investigated by optical microscopy. Moreover, an evaluation of midgut functionality was performed. An analysis based on enzymatic histochemistry was carried out to evaluate specific differences in lipids and glycogen accumulation in midgut cells. Finally, we assessed the activity and the mRNA expression levels of enzymes involved in digestion, focusing on proteolytic and amylolytic ones. Our results demonstrate that the extraordinary feeding plasticity of this insect corresponds to an extraordinary biological, morphological, physiological and molecular plasticity,that allows larvae to perform an effective bioconversion of FVW, opening up interesting application perspectives. This work was supported by Fondazione Cariplo (Insect bioconversion: from vegetable waste to protein production for fish feed, ID 2014-0550)

Utilizzo di Hermetia illucens per la produzione di proteine da substrati vegetali

Il costante aumento della richiesta di proteine animali per l\u2019alimentazione e la produzione di mangimi, ha determinato un crescente interesse nei confronti degli insetti in quanto presentano un\u2019elevata efficienza di conversione dei substrati alimentari in massa corporea e possono costituire una fonte proteica con elevato valore nutrizionale. Le larve di Hermetia illucens L. (Diptera: Stratiomyidae), un dittero saprofago, sono ritenute ottimi biotrasformatori per la loro capacit\ue0 di crescere su diversi substrati in decomposizione, sia di origine animale che vegetale. Quantitativi rilevanti di frutta e verdura sono smaltiti quotidianamente dalla grande distribuzione e attualmente vengono utilizzati prevalentemente per la produzione di compost. Essi potrebbero invece rappresentare un interessante substrato per l\u2019allevamento di H. illucens al fine di produrre farine da utilizzare nell\u2019industria mangimistica. Poco \ue8 noto sullo sviluppo, le caratteristiche morfofunzionali ed il profilo proteico della farina ottenuta delle larve di H. illucens allevate su substrati vegetali. Questa mancanza di conoscenze rappresenta una forte limitazione all\u2019utilizzo di questo insetto come fonte di proteine poich\ue9 la composizione del substrato di allevamento influenza sia l\u2019efficienza di conversione che il profilo e la qualit\ue0 nutrizionale della farina. La nostra ricerca si \ue8 indirizzata alla valutazione e all\u2019ottimizzazione dell\u2019allevamento di H. illucens su frutta e verdura. Lo sviluppo e le performance di esemplari alimentati ad libitum su questo substrato sono stati confrontati con quelli di individui alimentati con una dieta standard per ditteri. A tale scopo sono state valutate le curve di crescita, i tempi di sviluppo, il tasso di mortalit\ue0 oltre che alcuni parametri dimensionali e le performance degli adulti (dimensioni e peso, sex ratio, peso e numero di uova nelle ovature). I dati ottenuti evidenziano come H. illucens sia in grado di compiere l\u2019intero ciclo di sviluppo anche quando le larve sono allevate su frutta e verdura, raggiungendo dimensioni equiparabili a quelle del gruppo controllo, seppur in tempi pi\uf9 lunghi. Inoltre gli insetti adulti dei due gruppi presentano performace analoghe. Le farine ottenute da larve allevate sui diversi substrati sono state sottoposte ad analisi centesimale per valutare eventuali variazioni nella loro composizione. Infine sono state eseguite analisi di parametri morfo-funzionali (valutazione delle caratteristiche morfologiche e ultrastrutturali dell\u2019intestino medio larvale e misurazioni dell\u2019attivit\ue0 di enzimi coinvolti nella digestione di proteine e zuccheri) al fine di individuare dei marcatori che consentano di monitorare la crescita delle larve sui due diversi substrati