PENERAPAN MODEL PEMBELAJARAN PENEMUAN TERBIMBING BERBANTUAN GEOGEBRA UNTUK MENIGKATKAN KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS SISWA SMP NEGERI 1 PORSEA T.A 2020/2021

Penelitian ini bertujuan untuk mengetahui apakah penerapan model pembelajaran Penemuan Terbimbing berbantuan geogebra dapat meningkatkan kemampuan pemahaman konssep matematika siswa dikelas VIII-B SMP Negeri 1 Porsea. Jenis penelitian ini adalah penelitian tindakan kelas. Subjek penelitian ini adalah siswa kelas VIII-B SMP Negeri 1 Porsea T.P 2020/2021 yang berjumlah 21 siswa. Objek penelitian ini adalah kemampuan pemahaman konsep matematis siswa dengan menerapkan model pembelajaran Penemuan Terbimbing berbantuan geogebra pada materi koordinat kartesius. Instrumen yang dipakai tes dan pengamatan kemampuan guru. Penelitian ini terdiri dari dua siklus dan diakhir setiap siklus diberikan tes kemampuan pemahaman konsep matematis siswa. Dari penelitian yang sudah dilakukan dapat disimpulkan bahwa pemahaman konsep matematis siswa dapat meningkat dengan menerapkan model pembelajaran penemuan terbimbing berbantuan geogebra pada materi koordinat kartesius di kelas VIII-B SMP Negeri 1 Porsea

Long-term renal safety profile of ibandronate 6 mg infused over 15 minutes

In an earlier study, intravenous (i.v.) ibandronate 6 mg administered every 3-4 weeks had a similarly good renal safety profile whether infused over 15 or 60 min in women with breast cancer and bone metastases. This current study focuses on the renal safety of the extended use of ibandronate

Novel Genotyping Tools for Investigating Transmission Dynamics of Plasmodium falciparum

Background. Differentiation between gametocyte-producing Plasmodium falciparum clones depends on both high levels of stage-specific transcripts and high genetic diversity of the selected genotyping marker obtained by a high-resolution typing method. By analyzing consecutive samples of one host, the contribution of each infecting clone to transmission and the dynamics of gametocyte production in multiclone infections can be studied. Methods. We have evaluated capillary electrophoresis based differentiation of 6 length-polymorphic gametocyte genes. RNA and DNA of 25 µL whole blood from 46 individuals from Burkina Faso were simultaneously genotyped. Results. Highest discrimination power was achieved by pfs230 with 18 alleles, followed by pfg377 with 15 alleles. When assays were performed in parallel on RNA and DNA, 85.7% of all pfs230 samples and 59.5% of all pfg377 samples contained at least one matching genotype in DNA and RNA. Conclusions. The imperfect detection in both, DNA and RNA, was identified as major limitation for investigating transmission dynamics, owing primarily to the volume of blood processed and the incomplete representation of all clones in the sample tested. Abundant low-density gametocyte carriers impede clone detectability, which may be improved by analyzing larger volumes and detecting initially sequestered gametocyte clones in follow-up sample

Long-Term Outcome of Infantile Onset Pompe Disease Patients Treated with Enzyme Replacement Therapy - Data from a German-Austrian Cohort

BACKGROUND Enzyme replacement therapy (ERT) with recombinant human alglucosidase alfa (rhGAA) was approved in Europe in 2006. Nevertheless, data on the long-term outcome of infantile onset Pompe disease (IOPD) patients at school age is still limited. OBJECTIVE We analyzed in detail cardiac, respiratory, motor, and cognitive function of 15 German-speaking patients aged 7 and older who started ERT at a median age of 5 months. RESULTS Starting dose was 20 mg/kg biweekly in 12 patients, 20 mg/kg weekly in 2, and 40 mg/kg weekly in one patient. CRIM-status was positive in 13 patients (86.7%) and negative or unknown in one patient each (6.7%). Three patients (20%) received immunomodulation. Median age at last assessment was 9.1 (7.0-19.5) years. At last follow-up 1 patient (6.7%) had mild cardiac hypertrophy, 6 (42.9%) had cardiac arrhythmias, and 7 (46.7%) required assisted ventilation. Seven patients (46.7%) achieved the ability to walk independently and 5 (33.3%) were still ambulatory at last follow-up. Six patients (40%) were able to sit without support, while the remaining 4 (26.7%) were tetraplegic. Eleven patients underwent cognitive testing (Culture Fair Intelligence Test), while 4 were unable to meet the requirements for cognitive testing. Intelligence quotients (IQs) ranged from normal (IQ 117, 102, 96, 94) in 4 patients (36.4%) to mild developmental delay (IQ 81) in one patient (9.1%) to intellectual disability (IQ 69, 63, 61, 3x <55) in 6 patients (54.5%). White matter abnormalities were present in 10 out of 12 cerebral MRIs from 7 patients. CONCLUSION Substantial motor, cardiac, respiratory, and cognitive deficits are frequent in IOPD long-term survivors who started ERT before 2016. The findings of this study can be valuable as comparative data when evaluating the impact of newer treatment strategies including higher enzyme dosage, immunomodulation, modified enzymes, or early start of treatment following newborn screening

Divergent evolutionary processes associated with colonization of offshore islands

Peer reviewedPublisher PD

BELAJAR UNTUK HIDUP DENGAN PERBEDAAN BAGAIMANA CEDAR MEMBAWA ANTROPOLOGI KELUAR DARI RUANG KELAS DAN MASUK KE DUNIA

Artikel ini menjelaskan tentang proses CEDAR (Community Engaging Difference and Religion) sebuah lembaga swadaya masyarakat untuk menyebarkan ide dan praktek tentang bagaimana hidup bersama yang lain. CEDAR telah berkembang sejak awal dibentuk pada tahun 2003 dengan nama International Summer School on Religion and Public Life (ISSRPL). Namanya berubah menjadi CEDAR pada tahun 2013 dan sejak itu terus mengadakan program pelatihan di banyak negara, antara lain Inggris Raya, Bosnia, Bugaria, Israel, Amerika Serikat, Kenya dan Indonesia. Artikel ini dimulai dengan testimoni dari peserta program CEDAR yang dilakukan di berbagai negara itu selama dua minggu untuk menggambarkan perubahan yang kemudian mereka alami terutama pandangan dan sikapnya terhadap mereka yang memiliki keyakinan yang berbeda.&nbsp; Dari penagalaman program di Bosnia, Krosia dan Israel misalnya kami belajar bahwa perbedaan agama atau antara pemeluk agama dan sekuler sebagai sumber utama konflik namun juga perbedaan suku, golongan dan orientasi seksual juga merupakan sumber ketegangan, intoleransi dan saling curiga satu sama lain. Oleh karenanya, kami memasukkan berbagai faktor tersebut ke dalam program kami. Berbagi pengalaman adalah tempat terbaik untukmemahami perbedaan dibandingkan pelatihan akademis. Penekanan berbagi pengalaman berimplikasi kepada model pelatihan dimana kegiatan akademis dikurangi dan dan lebih diperbanyak kegiatan pembelajaran non akademis misalnya mengerjakan proyek bersama. Artikel ini juga menjelaskan tentang peran ahli antropologi baik dalam teori maupun iplementasinya dalam kurikulum dan kegiatan program CEDAR2003 at the time under the name of&nbsp; International Summer School on Religion and Public Life (ISSRPL). The name is changed into CEDAR in 2013 and since than have conducted summer program in many countries, such as UK, Bosnia, Bulgari, Israel, USA, Kenya and Indonesia.The article bean with testimonies from several CEDAR participants from different countries for two weeks to show their change in attitude and perception towards the others that ave different faiths. From the experience of the program in Bosnia, Kroasia and Israel for examples we learned that religious differencies or differencies between religious and seculars not always the main source of conflicts but also differencies in ethnicity, tribal groups and sexual orientation that could be the triggered for tensions, intolerance and prejudices.Therefore, we dicided to include those factors into our program. Sharing experiences is the best place to understand differences compare to academic trainings. Emphasis to sharing experiences have an implication to the reduction of academic training components and giving more times to non academic activities for instance with working together in share projects. The article also explains the role of anthropologist in theory and implementation within the CEDAR program’s curriculum and activities

Effects of habitat deterioration on the population genetics and conservation of the jaguar

Over the past century, human activities and their side effects have significantly threatened both ecosystems and resident species. Nevertheless, the genetic patterns of large felids that depend heavily on large and well-conserved continuous habitat remain poorly studied. Using the largest-ever contemporary genetic survey of wild jaguars (Panthera onca), we evaluated their genetic diversity and population structure in natural (Brazilian Amazon) and highly modified habitats (e.g. Cerrado, Caatinga) including those close to the northern (Yucatan, Mexico) and southern (Pantanal) edge of the species’ distribution range. Data from our set of microsatellites revealed a pronounced genetic structure, with four genetically differentiated geographic areas. Geographic distance was not the only factor influencing genetic differentiation through the jaguar range. Instead, we found evidence of the effects of habitat deterioration on genetic patterns: while the levels of genetic diversity in the Amazon forest, the largest continuum habitat for the species, are high and consistent with panmixia across large distances, genetic diversity near the edge of the species distribution has been reduced through population contractions. Mexican jaguar populations were highly differentiated from those in Brazil and genetically depauperated. An isolated population from the Caatinga showed the genetic effects of a recent demographic decline (within the last 20–30 years), which may reflect recent habitat degradation in the region. Our results demonstrate that the jaguar is highly sensitive to habitat fragmentation especially in human-dominated landscapes, and that in Brazil, the existing but limited genetic connectivity in the central protected areas should be maintained. These conclusions have important implications for the management of wide-ranging species with high dispersal and low population density. The restoration of ecological connectivity between populations over relatively large scales should be one of the main priorities for species conservation.Peer reviewe

COMPUESTOS BIOACTIVOS Y PROPIEDADES SALUDABLES DEL TAMARINDO (Tamarindus indica L)/ BIOACTIVE COMPOUNDS AND HEALTH PROPERTIES OF TAMARIND (Tamarindus indica L)

El tamarindo (Tamarindus Indica L.) es un fruto procedente de África, cuya producción a nivel mundial se encuentra entre 400 y 500 mil ton, mientras que México produce alrededor de 39 mil ton anuales; este fruto es reconocido en la tradición popular por sus propiedades antioxidantes, posiblemente relacionadas con la presencia de compuestos bioactivos, principalmente compuestos polifenólicos. Al fruto de tamarindo se le han brindado distintas aplicaciones, desde medicinales hasta de ingrediente en la industria alimentaria. La presente revisión tiene la finalidad de recopilar y mostrar algunos de los estudios recientes de los efectos benéficos que se han reportado para la pulpa de este fruto. En los últimos tiempos se han acumulado evidencias de que algunos compuestos polifenólicos ingeridos con la dieta habitual pueden encontrarse asociados con la fibra dietética, por lo que en este trabajo se incluye la cuantificación de los compuestos polifenólicos y la actividad antioxidante en la pulpa del fruto, además de la cuantificación de los compuestos fenólicos que se encuentran potencialmente asociados a la fibra dietética del fruto. Esta evaluación fue realizada por medio de métodos in vitro. Esta sencilla pero novedosa revisión podrá brindar información adicional a la literatura que se encuentra disponible respecto a este fruto, el cual contiene fitoquímicos con bioactividad/ ABSTRACT Tamarind (Tamarindus indica L.) is a fruit from Africa with a worldwide production between 400 and 500 thousand ton, with 39 000 ton produced in Mexico; traditionally it is recognized for its antioxidant properties, possibly related to the presence of bioactive compounds, mainly polyphenols. Tamarind fruit has been given different applications from medicinal as well as an ingredient in the food industry. The present review aims to collect and display some of the recent studies of the beneficial effects that have been reported for the pulp of this fruit. However, in recent times there has been enough evidence which show that some polyphenols ingested with the daily diet may be associated with dietary fiber, so in this review the quantification of polyphenols and antioxidant activity in the fruit pulp was included in addition to the quantification of the phenolic compounds that are potentially associated with dietary fiber of the fruit. This evaluation was performed by in vitro methods. This simple but novel information may provide additional information to the literature that is available around the fruit, which contains phytochemicals with bioactivity

Wild dogs at stake: deforestation threatens the only Amazon endemic canid, the short-eared dog (Atelocynus microtis)

The persistent high deforestation rate and fragmentation of the Amazon forests are the main threats to their biodiversity. To anticipate and mitigate these threats, it is important to understand and predict how species respond to the rapidly changing landscape. The short-eared dog Atelocynus microtis is the only Amazon-endemic canid and one of the most understudied wild dogs worldwide. We investigated short-eared dog habitat associations on two spatial scales. First, we used the largest record database ever compiled for short-eared dogs in combination with species distribution models to map species habitat suitability, estimate its distribution range and predict shifts in species distribution in response to predicted deforestation across the entire Amazon (regional scale). Second, we used systematic camera trap surveys and occupancy models to investigate how forest cover and forest fragmentation affect the space use of this species in the Southern Brazilian Amazon (local scale). Species distribution models suggested that the short-eared dog potentially occurs over an extensive and continuous area, through most of the Amazon region south of the Amazon River. However, approximately 30% of the short-eared dog's current distribution is expected to be lost or suffer sharp declines in habitat suitability by 2027 (within three generations) due to forest loss. This proportion might reach 40% of the species distribution in unprotected areas and exceed 60% in some interfluves (i.e. portions of land separated by large rivers) of the Amazon basin. Our local-scale analysis indicated that the presence of forest positively affected short-eared dog space use, while the density of forest edges had a negative effect. Beyond shedding light on the ecology of the short-eared dog and refining its distribution range, our results stress that forest loss poses a serious threat to the conservation of the species in a short time frame. Hence, we propose a re-assessment of the short-eared dog's current IUCN Red List status (Near Threatened) based on findings presented here. Our study exemplifies how data can be integrated across sources and modelling procedures to improve our knowledge of relatively understudied species

Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland

AIMS OF THE STUDY To describe patterns of systemic lupus erythematosus (SLE) care and the clinical effectiveness of belimumab plus standard of care therapy in a real-world clinical setting in Switzerland. METHODS This multicentre, observational, retrospective cohort study included adults with SLE who initiated belimumab as part of their usual care at least six months before data analysis. The primary outcome was the overall clinical response, assessed by a physician on a Physician’s Global Assessment-like scale, to six months’ treatment with belimumab. Secondary outcomes included improvement in disease activity, SLE manifestations and changes in corticosteroid use. RESULTS 53 patients (81% female) from three hospitals were included. At index (belimumab initiation), 23 patients (43%) had mild, 23 (43%) had moderate, and 7 (13%) had severe SLE. Overall improvement in disease activity in patients receiving belimumab was: ≥80% in 6 patients (11%), ≥50% in 12 (23%), ≥20% in 31 (58%), <20% in 13 (25%), and no improvement in 9 (17%). Mean Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index score decreased from 8.0 at index to 3.6 at six months post index in the 27 patients assessed. In addition, a ≥50% improvement in arthritis, fatigue, rash, low complement (C3, C4 or total haemolytic complement activity), and anti-double-stranded deoxyribonucleic acid antibody levels was experienced six months post index by 10 (38%), 3 (16%), 6 (38%), 2 (12%) and 4 (16%) patients who presented the manifestations at index respectively. At index, 41 patients (77%) received oral corticosteroids at a mean dose of 11.6 mg/day, which decreased to 5.9 mg/day at six months post index. Of the 31 patients receiving a high dose of corticosteroids (≥7.5 mg/day) at index, 18 required <7.5 mg/day and a further two discontinued corticosteroids at six months post index. CONCLUSIONS This study provides real-world insight into belimumab use in clinical practice in Switzerland. In line with findings from other countries, Swiss patients with SLE who received belimumab demonstrated clinical and serological improvements in SLE and a reduction in corticosteroid use after six months of treatment