Integrating weed seed loss mechanisms in regenerative agriculture for more sustainable weed management

http://dx.doi.org/10.13039/100007674 NIABhttp://dx.doi.org/10.13039/501100010761 Syngenta International A

Synthesis and characterisation of uranium(IV) complexes with tridentate NNS ligands

http://dx.doi.org/10.13039/100018992 Chemical Industry Fundhttp://dx.doi.org/10.13039/501100001659 German Research Foundatio

Ethnopharmacology and ecosystem applications of woody plant species in the Southern European Alps: a systematic review

Introduction Alpine woody plants are deeply embedded in traditional healthcare systems across the Southern European Alps, where multiple organs—including leaves, bark, fruits, buds, and flowers—are used to manage respiratory, musculoskeletal, gastrointestinal, dermatological, metabolic, cardiovascular, and urogenital disorders. This systematic review synthesizes ethnopharmacological uses, evaluates phytochemical and pharmacological evidence, and contextualizes the ecosystem functions of woody plant species native to the European Alps. Methods Following PRISMA guidelines, Web of Science, Scopus, and PubMed were systematically searched for peer-reviewed studies published up to May 2025. Data from 281 eligible sources were harmonized, covering 54 woody species (28 trees, 26 shrubs; 25 families). Extracted variables included ecological distribution, harvested organs, phytochemical classes, and experimentally validated bioactivities. Therapeutic indications were mapped using the International Classification of Primary Care (ICPC-2). Results Phytochemical profiles were predominantly characterized by phenolic acids, flavonoids, anthocyanins, tannins, terpenoids, alkaloids, and saponins. These compounds underpin convergent anti-inflammatory, antimicrobial, antioxidant, antidiabetic, vasoprotective, and cytotoxic activities demonstrated in vitro and in vivo. Beyond medicinal relevance, the same species contribute to soil stabilization, hydrological regulation, carbon sequestration, and the preservation of biocultural landscapes. However, climate-driven range shifts, land-use intensification, commercial overharvesting, and limited pharmacokinetic and toxicological data constrain both sustainability and clinical translation. Discussion High-priority taxa and critical knowledge gaps were identified. An integrated research framework is proposed, combining standardized green extraction technologies, high-resolution metabolomics, longitudinal ecological monitoring, participatory documentation of traditional knowledge, and equitable benefit-sharing mechanisms. Such integration is necessary to advance evidence-based phytotherapy while ensuring sustainable stewardship of Alpine woody ecosystems

Ras-Related Mutants Identified in Young-Onset Colorectal Cancer Display Divergent Phenotypes and Retain Their Pro-Angiogenic Effects

The Ras-related (RRAS) gene is a member of the Ras superfamily and remains largely uncharacterized compared to KRAS, NRAS, and HRAS. Its role in tumorigenesis remains poorly documented, as evidenced by its lack of canonical mutations in any cancer type. This study investigated the effects of the novel RRAS R78W and E63D mutants—identified in Filipino young-onset colorectal cancer (YO-CRC) patients—on cancer hallmarks. In silico analysis was performed to predict the effect of the mutations on RRAS structure. F-actin staining of transfected NIH3T3 cells displayed massive cytoskeletal remodeling and formation of migratory and invasive structures. RRAS R78W enhanced migration when compared to wild-type RRAS in NIH3T3 and HCT116 cells, whereas neither mutant affected invasive capacity. Both mutants did not abolish the pro-angiogenic ability of wild-type RRAS in endothelial tube formation assays. RRAS E63D conferred resistance to apoptosis in both cell lines. Both mutants had no effect on cellular proliferation in either cell line. Overexpression of both mutants did not increase Akt and Erk1/2 phosphorylation. In silico analysis further suggests that the mutations confer increased GEF-binding ability versus wild-type. Results of the study highlight the need to characterize Ras isoform- and mutation-specific phenotypic effects, which may have repercussions in CRC management.University of the Philippines System http://dx.doi.org/10.13039/501100007421Philippine Council for Health Research and Development 501100011096National Institute of Molecular Biology and Biotechnology, University of the Philippines Dilima

Dissociable dynamic effects of expectation during statistical learning

The brain is thought to optimise behaviour by generating predictions based on learned statistical regularities. Predictive processing seemingly explains expectation suppression (ES), the attenuation of neural activity in response to expected stimuli. However, the mechanisms behind ES are unclear, with conflicting evidence for alternative models. Sharpening models propose that expectations suppress neurons away from the expected stimulus, increasing the signal-to-noise ratio and boosting decoding for expected stimuli. In contrast, dampening models posit that expectations suppress neurons that are tuned to the expected stimuli, reducing overall response magnitude and decoding accuracy. The opposing process theory (OPT) suggests that both processes occur at different time points, namely that initial sharpening is followed by later dampening of the neural representations of the expected stimulus. Here we test this theory and shed light on the dynamics of expectation effects, both at single-trial level and over time. Thirty-one participants completed a statistical learning task in which a ‘leading’ image from one category predicted a ‘trailing’ image from a different category. Multivariate EEG analyses decoded stimulus information related to the trailing category. Within-trial, expectation increased decoding accuracy at early latencies and decreased it at later latencies, in line with OPT. However, across trials, stimulus expectation decreased decoding accuracy in initial trials and increased it in later trials. We theorise that these dissociable dynamics of expectation effects within and across trials support hierarchical learning mechanisms. While within-trial results support the OPT, across-trial results suggest that sharpening and dampening effects emerge at distinct stages of associative learning

Update on Alport Syndrome: The Report of the 2024 International Workshop on Alport Syndrome

http://dx.doi.org/10.13039/100012996 University of Cyprushttp://dx.doi.org/10.13039/100010661 Horizon 2020 Framework Programm

Actual and potential carbon sequestration in topsoils of eastern China

http://dx.doi.org/10.13039/501100022230 Deanship of Scientific Research, Princess Nourah Bint Abdulrahman Universityhttp://dx.doi.org/10.13039/501100002367 Chinese Academy of Scienceshttp://dx.doi.org/10.13039/501100019338 Distinguished Young Scholar Foundation of Hunan Provincehttp://dx.doi.org/10.13039/501100002858 China Postdoctoral Science Foundationhttp://dx.doi.org/10.13039/501100001809 National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100018647 RUDN Universit

Frequency and correlates of non-adherence in a large sample of adult patients after kidney transplantation: A cross-sectional KTx360° substudy

http://dx.doi.org/10.13039/501100018936 Universitätsklinikum Heidelber

The new S3 guideline on schizophrenia (living) 2025

Zusammenfassung Hintergrund Am 15.10.2025 erschien die neue S3-Leitlinie Schizophrenie (living). Sie wurde erstmals vollständig in das Evidence Ecosystem MAGICapp überführt und wird künftig jährlich aktualisiert. Fragestellung Diese narrative Übersichtsarbeit fasst zentrale Neuerungen der Leitlinie 2025 zusammen und erläutert deren Hintergründe. Material und Methoden Neue und überarbeitete Empfehlungen sowie Hintergrundtexte aus MAGICapp wurden extrahiert und zusammengeführt. Ergebnisse und Diskussion Die Leitlinie ist die erste Leitlinie der Deutschen Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN), die vollständig in MAGICapp integriert wurde und als Living Guideline erscheint. Zentrale Änderungen betreffen die Abschwächung der bisherigen antipsychotischen Monotherapieempfehlung, eine deutliche Erweiterung und Präzisierung des Nebenwirkungs- und Sicherheitsmonitorings sowie die Aufwertung evidenzbasierter psychotherapeutischer Verfahren, darunter u. a. das metakognitive Training und die systemische Therapie. Zudem wurden vier neue Empfehlungen verabschiedet (digitale/technikgestützte Interventionen, achtsamkeitsbasierte Verfahren, Acceptance and Commitment Therapy [ACT], traumafokussierte Therapie der posttraumatischen Belastungsstörung [PTBS]) und zwölf gestrichen. Alle Kapitel wurden umfassend überarbeitet.Abstract Background On 15 October 2025, the revised S3 guideline on schizophrenia (living) was published and transferred to the MAGICapp evidence ecosystem and will be updated annually in the future. Objective This narrative review summarizes essential innovations and explains their development. Material and methods New and revised recommendations and MAGICapp background information were extracted and summarized. Results and conclusion The guideline is now fully integrated into MAGICapp and annually updated. Key changes include a downgrading of the recommendation for antipsychotic monotherapy, a substantial expansion of guidance on adverse effect monitoring and management and a strengthened emphasis on evidence-based psychotherapeutic interventions, such as metacognitive training and systemic therapy. Additionally, 4 new recommendations (digital/technology-assisted interventions, mindfulness-based procedures, acceptance and commitment therapy [ACT], trauma-focussed therapy for post-traumatic stress disorder [PTSD]) were implemented and 12 were removed. All chapters were comprehensively revised.Zusammenfassung Hintergrund Am 15.10.2025 erschien die neue S3-Leitlinie Schizophrenie (living). Sie wurde erstmals vollständig in das Evidence Ecosystem MAGICapp überführt und wird künftig jährlich aktualisiert. Fragestellung Diese narrative Übersichtsarbeit fasst zentrale Neuerungen der Leitlinie 2025 zusammen und erläutert deren Hintergründe. Material und Methoden Neue und überarbeitete Empfehlungen sowie Hintergrundtexte aus MAGICapp wurden extrahiert und zusammengeführt. Ergebnisse und Diskussion Die Leitlinie ist die erste Leitlinie der Deutschen Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN), die vollständig in MAGICapp integriert wurde und als Living Guideline erscheint. Zentrale Änderungen betreffen die Abschwächung der bisherigen antipsychotischen Monotherapieempfehlung, eine deutliche Erweiterung und Präzisierung des Nebenwirkungs- und Sicherheitsmonitorings sowie die Aufwertung evidenzbasierter psychotherapeutischer Verfahren, darunter u. a. das metakognitive Training und die systemische Therapie. Zudem wurden vier neue Empfehlungen verabschiedet (digitale/technikgestützte Interventionen, achtsamkeitsbasierte Verfahren, Acceptance and Commitment Therapy [ACT], traumafokussierte Therapie der posttraumatischen Belastungsstörung [PTBS]) und zwölf gestrichen. Alle Kapitel wurden umfassend überarbeitet.Abstract Background On 15 October 2025, the revised S3 guideline on schizophrenia (living) was published and transferred to the MAGICapp evidence ecosystem and will be updated annually in the future. Objective This narrative review summarizes essential innovations and explains their development. Material and methods New and revised recommendations and MAGICapp background information were extracted and summarized. Results and conclusion The guideline is now fully integrated into MAGICapp and annually updated. Key changes include a downgrading of the recommendation for antipsychotic monotherapy, a substantial expansion of guidance on adverse effect monitoring and management and a strengthened emphasis on evidence-based psychotherapeutic interventions, such as metacognitive training and systemic therapy. Additionally, 4 new recommendations (digital/technology-assisted interventions, mindfulness-based procedures, acceptance and commitment therapy [ACT], trauma-focussed therapy for post-traumatic stress disorder [PTSD]) were implemented and 12 were removed. All chapters were comprehensively revised