4D gravity on a non-BPS bent dilatonic brane

We investigate the localization of metastable four-dimensional gravity around a bent dilatonic brane, embedded into a five-dimensional space, that exists only up to distances sufficiently small compared to a crossover scale. Far from such scale, five-dimensional effects strongly deviate the Newtonian potential. We study this effect by considering localization of massive gravity on a non-BPS bent dilatonic 3-brane solution of a five-dimensional supergravity. Our results show that the cosmological constant on the bent brane controls the size of the crossover scale. For sufficiently small positive cosmological constant, that is in accord with the present observations, the crossover scale becomes very large.Comment: 7 pages, version to appear in JCA

Spin Resolution of the Electron-Gas Correlation Energy: Positive same-spin contribution

The negative correlation energy per particle of a uniform electron gas of density parameter $r_s$ and spin polarization $\zeta$ is well known, but its spin resolution into up-down, up-up, and down-down contributions is not. Widely-used estimates are incorrect, and hamper the development of reliable density functionals and pair distribution functions. For the spin resolution, we present interpolations between high- and low-density limits that agree with available Quantum Monte Carlo data. In the low-density limit for $\zeta = 0$, we find that the same-spin correlation energy is unexpectedly positive, and we explain why. We also estimate the up and down contributions to the kinetic energy of correlation.Comment: new version, to appear in PRB Rapid Communicatio

Trasplante hepático en hemofilia A y enfermedad de von Willebrand tipo 3. Manejo perioperatorio y evolución postrasplante

Introducción: la infección por virus hepatitis C (VHC) ha sido causa de importante morbi-mortalidad en hemofilia, planteándose el trasplante hepático (TH) por cirrosis y/o carcinoma hepatocelular (CHC). Caso clínico: presentamos los casos con coagulopatías congénitas e infección por VHC sometidos a TH en nuestro centro: tres pacientes con hemofilia A y uno con enfermedad de von Willebrand (EvW) tipo 3. Evaluamos el curso de la coagulopatía, el manejo perioperatorio, el consumo de factor y componentes sanguíneos y la supervivencia postrasplante. El factor deficitario se comenzó a administrar en bolo iv directo una hora antes del inicio de la cirugía para alcanzar un nivel deseado de dicho factor de 100 UI/dl, mantenido hasta conseguir el control estable de la hemostasia. Los tres pacientes con hemofilia A curaron su coagulopatía postrasplante. El factor VIII (FVIII) fue 93 UI/dl a los once años, 59 UI/dl a los 13 meses y 109 UI/dl a los nueve meses postrasplante en cada uno de los casos. El consumo medio perioperatorio de concentrados de FVIII fue 175 UI/kg, infundido hasta 36 h postrasplante de media. El paciente con EvW tipo 3 consiguió atenuar el curso natural de su sintomatología hemorrágica sin que se detectaran niveles hemostáticos del antígeno del factor von Willebrand (FVW:Ag) postrasplante. Discusión: tras el trasplante hepático, se produce la curación de la hemofilia A y la mejoría del fenotipo hemorrágico en la EvW tipo 3. Introduction: infection with the hepatitis C virus (HCV) causes significant morbidity and mortality in patients with hemophilia. Finally, patients are considered for a liver transplantation (LT) due to cirrhosis and/or hepatocellular carcinoma (HCC). Case report: we report the cases of congenital coagulopathy and HCV infection that underwent LT in our institution. There were three patients with hemophilia A and one patient with von Willebrand disease (vWD) type 3. The coagulopathy outcome, perioperative management, factor and blood product usage and post-transplant survival were assessed. The deficient factor was initially administered in a direct bolus one hour before surgery with a target level of 100 IU/dl, which was sustained until stable hemostasis was reached. All three patients with hemophilia A were cured of their coagulopathy following transplantation. FactorVIII (FVIII) was 93 IU/dl at eleven years, 59 IU/ dl at 13 months and 109 IU/dl at nine months post-transplant, in each case.The mean perioperative usage of FVIII concentrates was 175 IU/kg; concentrates were infused for an average of 36 hours post-transplant.The natural course of the bleeding symptoms of the patient with type-3 vWD was attenuated, with no detectable hemostatic levels of von Willebrand factor antigen (vWF: Ag) after transplantation. Discussion: after transplantation, hemophilia A cure and improved bleeding phenotype of type-3 vWD reduced morbidity and mortality. However, potential graft reinfection with HCV and relapsing HCC cast a shadow over these optimum results

Supergravity brane worlds and tachyon potentials

We study massless and massive graviton modes that bind on thick branes which are supergravity domain walls solutions in $D$-dimensional supergravity theories where only the supergravity multiplet and the scalar supermultiplet are turned on. The domain walls are bulk solutions provided by tachyon potentials. Such domain walls are regarded as BPS branes of one lower dimension that are formed due to tachyon potentials on a non-BPS D-brane.Comment: RevTex4, 6 pages; version to appear in Phys. Rev.

Solvable Models of Domain Walls in N=1 Supergravity

A class of exactly solvable models of domain walls are worked out in D=4 ${\cal N}=1$ supergravity. We develop a method to embed globally supersymmetric theories with exact BPS domain wall solutions into supergravity, by introducing a gravitationally deformed superpotential. The gravitational deformation is natural in the spirit of maintaining the K\"ahler invariance. The solutions of the warp factor and the Killing spinor are also obtained. We find that three distinct behaviors of warp factors arise depending on the value of a constant term in the superpotential : exponentially decreasing in both sides of the wall, flat in one side and decreasing in the other, and increasing in one side and decreasing in the other. Only the first possibility gives the localized massless graviton zero mode. Models with multi-walls and models with runaway vacua are also discussed.Comment: 10 pages, 3 figures; Misprints in three formulas are correcte

Hospital-based proton therapy implementation during the COVID pandemic: early clinical and research experience in a European academic institution

Introduction A rapid deploy of unexpected early impact of the COVID pandemic in Spain was described in 2020. Oncology practice was revised to facilitate decision-making regarding multimodal therapy for prevalent cancer types amenable to multidisciplinary treatment in which the radiotherapy component searched more efcient options in the setting of the COVID-19 pandemic, minimizing the risks to patients whilst aiming to guarantee cancer outcomes. Methods A novel Proton Beam Therapy (PBT), Unit activity was analyzed in the period of March 2020 to March 2021. Institutional urgent, strict and mandatory clinical care standards for early diagnosis and treatment of COVID-19 infection were stablished in the hospital following national health-authorities’ recommendations. The temporary trends of patients care and research projects proposals were registered. Results 3 out of 14 members of the professional staf involved in the PBR intra-hospital process had a positive test for COVID infection. Also, 4 out of 100 patients had positive tests before initiating PBT, and 7 out of 100 developed positive tests along the weekly mandatory special checkup performed during PBT to all patients. An update of clinical performance at the PBT Unit at CUN Madrid in the initial 500 patients treated with PBT in the period from March 2020 to November 2022 registers a distribution of 131 (26%) pediatric patients, 63 (12%) head and neck cancer and central nervous system neoplasms and 123 (24%) re-irradiation indications. In November 2022, the activity reached a plateau in terms of patients under treatment and the impact of COVID pandemic became sporadic and controlled by minor medical actions. At present, the clinical data are consistent with an academic practice prospectively (NCT05151952). Research projects and scientifc production was adapted to the pandemic evolution and its infuence upon professional time availability. Seven research projects based in public funding were activated in this period and preliminary data on molecular imaging guided proton therapy in brain tumors and post-irradiation patterns of blood biomarkers are reported. Conclusions Hospital-based PBT in European academic institutions was impacted by COVID-19 pandemic, although clinical and research activities were developed and sustained. In the post-pandemic era, the benefts of online learning will shape the future of proton therapy education

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Entrapment of a Network of Domain Walls

We explore the idea of a network of defects to live inside a domain wall in models of three real scalar fields, engendering the Z_2 x Z_3 symmetry. The field that governs the Z_2 symmetry generates a domain wall, and entraps the hexagonal network formed by the three-junctions of the model of two scalar fields that describes the remaining Z_3 symmetry. If the host domain wall bends to the spherical form, in the thin wall approximation there may appear non-topological structures hosting networks that accept diverse patterns. If Z_3 is also broken, the model may generate a buckyball containing sixty junctions, a fullerene-like structure. Applications to cosmology are outlined.Comment: Revtex, 4 pages, 2 ps figures; version to appear in Phys. Rev. D, Rapid Communicatio