628 research outputs found
New development: Directly elected mayors in Italy: creating a strong leader doesn’t mean creating strong leadership
More than 20 years after their introduction, directly elected mayors are key players in Italian urban governance. This article explains the main effects of this reform on local government systems and provides lessons for other countries considering directly elected mayors
The silicon-strip tracker of the Gamma ray Large Area Space Telescope
Abstract The Gamma ray Large Area Space Telescope (GLAST) is an astro-particle mission that will study the mostly unexplored, high energy ( 20 MeV – 1 TeV ) spectrum of photons coming from active sources in the universe. Construction of the GLAST silicon tracker, by far the largest ever built for a space mission, is now well on the way, as it is scheduled for launch by NASA in autumn 2006. We report on the basic technology adopted for the silicon detectors, particularly in connection to their use in space, on the first results of sensors testing and on the status of tracker assembly
High dose sequential chemotherapy with autologous transplantation versus dose-dense chemotherapy MegaCEOP as first line treatment in poor-prognosis diffuse large cell lymphoma: an Intergruppo Italiano Linfomi randomized trial
Background and Objectives. Poor prognosis diffuse large cell lymphoma (DLCL) responds poorly to standard chemotherapy. Randomized studies comparing high-dose chemotherapy with autologous stem-cell transplantation (ASCT) against standard chemotherapy have produced conflicting results. Dose-dense chemotherapy with granulocyte colony-stimulating factor (G-CSF) support seems to hold promise. The purpose of this multicenter, randomized trial was to compare failure-free and overall survival in patients with poor prognosis DLCL treated with high-dose sequential (HDS) chemotherapy followed by ASCT or an outpatient dose-dense chemotherapy regimen (MegaCEOP). Design and Methods. Between 1996 and 2001, 130 DLCL patients, aged <= 60 years, with intermediate-high or high-risk disease, according to the International Prognostic Index score, and/or bone marrow involvement were enrolled. Sixty were randomized to HDS chemotherapy plus high-dose mitoxantrone and melphalan with ASCT (arm A) and 66 to the MegaCEOP regimen (6-8 courses of an escalated dose of cyclophosphamide and epirubicin plus vincristine and prednisone with G-CSF every 2-weeks) (arm B); 4 patients were considered ineligible. Results. The complete remission rate was 59% in arm A and 70% in arm B (p=0.18). After a median follow-up of 78 months, the 6-year failure-free survival was 45% in arm A and 48% in arm B (hazard ratio=1.15, 95% confidence intervals =0.72-1.84, p=0.56). The 5-year overall survival was 49% in arm A and 63% in arm B (hazard ratio=1.67, 95% confidence interval=0.98-2.85, p=0.06). Two cases of secondary acute myeloid leukemia were observed after treatment in group A. Interpretations and Conclusions. HDS and ASCT as initial therapy for patients with poor-prognosis DLCL does not provide a benefit over that of outpatient dose-dense MegaCEOP chemotherapy
Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy
Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity. To define the role of Kir4.1 variants in the disorder, we sequenced KCNJ10 in a sample of affected individuals, and performed genotype-phenotype correlations. The effects of mutations on channel activity, protein trafficking, and astrocyte function were investigated in Xenopus laevis oocytes, and in human astrocytoma cell lines. An in vivo model of the disorder was also explored through generation of kcnj10a morphant zebrafish overexpressing the mutated human KCNJ10. We detected germline heterozygous KCNJ10 variants in 19/175 affected children. Epileptic spasms with dysregulated sensory processing represented the main disease phenotype. When investigated on astrocyte-like cells, the p.R18Q mutation exerted a gain-of-function effect by enhancing Kir4.1 membrane expression and current density. Similarly, the p.R348H variant led to gain of channel function through hindrance of pH-dependent current inhibition. The frequent polymorphism p.R271C seemed, instead, to have no obvious functional effects. Our results confirm that variants in KCNJ10 deserve attention in autism-epilepsy, and provide insight into the molecular mechanisms of autism and seizures. Similar to neurons, astrocyte dysfunction may result in abnormal synaptic transmission and electrical discharge, and should be regarded as a possible pharmacological target in autism-epilepsy. Supplementary information accompanies this paper in the files section.peer-reviewe
Rainfall Field Reconstruction by Opportunistic Use of the Rain-Induced Attenuation on Microwave Satellite Signals: The July 2021 Extreme Rain Event in Germany as a Case Study
This paper presents a practical application of an
opportunistic technique for the estimation of rainfall intensity
and accumulated precipitation. The proposed technique is based
upon signal strength measurements made by commercial-grade
interactive satellite terminals. By applying some processing, the
rain-induced attenuation on the microwave downlink from the
satellite is first evaluated; then the rain attenuation is eventually
mapped into a rainfall rate estimate via a tropospheric model.
This methodology has been applied to a test area of 30×30 km2
around the city of Dortmund (North Rhine-Westphalia, upper
basin of Ermscher river), for the heavy rain event that devastated
western Germany in July, 2021. A rainfall map on this area is
obtained from the measurements collected by a set of satellite
terminals deployed in the region, and successfully compared with
a map obtained with a conventional weather radar
The primary cosmic ray composition between 10**15 and 10**16 eV from Extensive Air Showers electromagnetic and TeV muon data
The cosmic ray primary composition in the energy range between 10**15 and
10**16 eV, i.e., around the "knee" of the primary spectrum, has been studied
through the combined measurements of the EAS-TOP air shower array (2005 m
a.s.l., 10**5 m**2 collecting area) and the MACRO underground detector (963 m
a.s.l., 3100 m w.e. of minimum rock overburden, 920 m**2 effective area) at the
National Gran Sasso Laboratories. The used observables are the air shower size
(Ne) measured by EAS-TOP and the muon number (Nmu) recorded by MACRO. The two
detectors are separated on average by 1200 m of rock, and located at a
respective zenith angle of about 30 degrees. The energy threshold at the
surface for muons reaching the MACRO depth is approximately 1.3 TeV. Such muons
are produced in the early stages of the shower development and in a kinematic
region quite different from the one relevant for the usual Nmu-Ne studies. The
measurement leads to a primary composition becoming heavier at the knee of the
primary spectrum, the knee itself resulting from the steepening of the spectrum
of a primary light component (p, He). The result confirms the ones reported
from the observation of the low energy muons at the surface (typically in the
GeV energy range), showing that the conclusions do not depend on the production
region kinematics. Thus, the hadronic interaction model used (CORSIKA/QGSJET)
provides consistent composition results from data related to secondaries
produced in a rapidity region exceeding the central one. Such an evolution of
the composition in the knee region supports the "standard" galactic
acceleration/propagation models that imply rigidity dependent breaks of the
different components, and therefore breaks occurring at lower energies in the
spectra of the light nuclei.Comment: Submitted to Astroparticle Physic
Sunny holidays before and after melanoma diagnosis are respectively associated with lower breslow thickness and lower relapse rates in Italy
Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort. Methods: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival. Results: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment. Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007). However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after diagnosis, after multiple adjustment including education: HR=0.30 (95%CI:0.10-0.87; p=0.03) conclusions: Holidays in the sun were associated with thinner melanomas in women and reduced rates of relapse in both sexes. However, these results do not prove a direct causal effect of sun exposure on survival since other confounding factors, such as vitamin D serum levels and socio-economic status, may play a role. Other factors in sun seeking individuals may also possibly affect these results
Observation of resonances consistent with pentaquark states in decays
Observations of exotic structures in the channel, that we refer to
as pentaquark-charmonium states, in decays are
presented. The data sample corresponds to an integrated luminosity of 3/fb
acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude
analysis is performed on the three-body final-state that reproduces the
two-body mass and angular distributions. To obtain a satisfactory fit of the
structures seen in the mass spectrum, it is necessary to include two
Breit-Wigner amplitudes that each describe a resonant state. The significance
of each of these resonances is more than 9 standard deviations. One has a mass
of MeV and a width of MeV, while the second
is narrower, with a mass of MeV and a width of MeV. The preferred assignments are of opposite parity, with one
state having spin 3/2 and the other 5/2.Comment: 48 pages, 18 figures including the supplementary material, v2 after
referee's comments, now 19 figure
A high resolution, low power time-of-flight system for the space experiment AMS
The system of plastic scintillator counters for the AMS experiment is described. The main characteristics of the detector are: (a) large sensitive area (four 1.6 m2 planes) with small dead space; (b) low-power consumption (150 W for the power and the read-out electronics of 336 PMs); (c) 120 ps time resolution. ( 1999 Elsevier Science B.V. All rights reserved
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
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