An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Performance of missing transverse momentum reconstruction in proton-proton collisions at root s=13 TeV using the CMS detector

The performance of missing transverse momentum ((p) over right arrow (miss)(T)) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The results include measurements of the scale and resolution of (p) over right arrow (miss)(T), and detailed studies of events identified with anomalous (p) over right arrow (miss)(T). The performance is presented of a (p) over right arrow (miss)(T) reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed (p) over right arrow (miss)(T) with the hypothesis that it originates from resolution effects.Peer reviewe

No Efficacy of the Combination of Lopinavir/Ritonavir Plus Hydroxychloroquine Versus Standard of Care in Patients Hospitalized With COVID-19: A Non-Randomized Comparison

Objectives: No specific treatment has been approved for COVID-19. Lopinavir/ritonavir (LPV/r) and hydroxychloroquine (HCQ) have been used with poor results, and a trial showed advantages of combined antiviral therapy vs. single antivirals. The aim of the study was to assess the effectiveness of the combination of antivirals (LPV/r and HCQ) or their single use in COVID-19 hospitalized patients vs. standard of care (SoC). Methods: Patients ≥18 years with SARS-CoV-2 infection, defined as positive RT-PCR from nasal/oropharyngeal (NP/OP) swab or positive serology, admitted at L. Spallanzani Institute (Italy) were included. Primary endpoint: time to invasive ventilation/death. Secondary endpoint: time to two consecutive negative SARS-CoV-2 PCRs in NP/OP swabs. In order to control for measured confounders, a marginal Cox regression model with inverse probability weights was used. Results: A total of 590 patients were included in the analysis: 36.3% female, 64 years (IQR 51-76), and 91% with pneumonia. Cumulative probability of invasive ventilation/death at 14 days was 21.2% (95% CI 17.6, 24.7), without difference between SOC, LPV/r, hydroxychloroquine, HCQ + LPV/r, and SoC. The risk of invasive ventilation/death in the groups appeared to vary by baseline ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2). Overall cumulative probability of confirmed negative nasopharyngeal swabs at 14 days was 44.4% (95% CI 38.9, 49.9), without difference between groups. Conclusion: In this retrospective analysis, we found no difference in the rate of invasive ventilation/death or viral shedding by different strategies, as in randomized trials performed to date. Moreover, even the combination HCQ + LPV/r did not show advantages vs. SoC

L’attività dei Centri Antifumo italiani tra problematiche e aree da potenziare: i risultati di un’indagine svolta attraverso un questionario on-line

Introduzione. In Italia sono 295 i Servizi per la cessazione dal fumo di tabacco (Centri Antifumo - CA) afferenti al Servizio Sanitario Nazionale (SSN) censiti nel 2011 dall’Osservatorio Fumo, Alcol e Droga (OssFAD) dell’Istituto Superiore di Sanità. La presente indagine, condotta dall’OssFAD in collaborazione con i CA, è stata volta a rilevare alcune delle problematiche con le quali il personale dei CA si confronta per portare avanti la propria attività e le iniziative ritenute utili per migliorarla. Materiali e metodi. L’indagine è stata condotta dal 7 al 21 maggio 2012, mediante un questionario compilabile on-line composto da 5 brevi sezioni di domande con un totale di 38 items da completare. Il link al questionario on-line è stato inviato per e-mail a 322 indirizzi dei CA censiti nel 2011 dall’OssFAD. I dati raccolti sono stati elaborati statisticamente con il programma SPSS 20. Risultati. All’indagine hanno risposto 146 operatori dei CA (45,3%). Sebbene ci siano aspetti ormai consolidati dell’attività dei CA, sono ancora molte le criticità che gli operatori riscontrano nella loro attività. Le principali problematiche che influiscono in modo fondamentale/rilevante per la buona attività del centro sono le “Scarse o nulle risorse economiche” per il 60,7% del personale, “la mancanza di personale dedicato” per il 52,4% del personale; il “riconoscimento/mandato istituzionale del CA” per il 40,9% del personale. Tra le azioni ritenute più efficaci per facilitare l’accesso ai CA sono risultate la sensibilizzazione del personale sanitario (91%), in particolare dei medici di famiglia e l’inserimento delle prestazioni antitabagiche nei LEA (76,8%). Conclusioni. È auspicabile che l’attività dei CA riceva una maggiore attenzione, attraverso la dotazione di strutture, personale e finanziamenti adeguati a svolgere un importante ruolo nella tutela e promozione della salute

Measurement of electroweak production of a W boson in association with two jets in proton-proton collisions at s=\sqrt{s}= 13 TeV

A measurement is presented of electroweak (EW) production of a W boson in association with two jets in proton-proton collisions at $\sqrt{s}=$ 13 TeV. The data sample was recorded by the CMS Collaboration at the LHC and corresponds to an integrated luminosity of 35.9 fb$^{-1}$. The measurement is performed for the $\ell\nu$jj final state (with $\ell\nu$ indicating a lepton-neutrino pair, and j representing the quarks produced in the hard interaction) in a kinematic region defined by invariant mass $m_\mathrm{jj} >$ 120 GeV and transverse momenta $p_\mathrm{T j} >$ 25 GeV. The cross section of the process is measured in the electron and muon channels yielding $\sigma_\mathrm{EW}($Wjj$)=$ 6.23$\pm$0.12 (stat)$\pm$ 0.61 (syst) pb per channel, in agreement with leading-order standard model predictions. The additional hadronic activity of events in a signal-enriched region is studied, and the measurements are compared with predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. Limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are $-$2.3 $< c_{\mathrm{WWW}}/\Lambda^2 <$ 2.5 TeV$^{-2}$, $-$8.8 $< c_{\mathrm{W}}/\Lambda^2 <$ 16 TeV$^{-2}$, and $-$45 $< c_{\mathrm{B}}/\Lambda^2 <$ 46 TeV$^{-2}$. These results are combined with the CMS EW Zjj analysis, yielding the most stringent limit to date on the $c_{\mathrm{WWW}}$ coupling: $-$1.8 $< c_{\mathrm{WWW}}/\Lambda^2 <$ 2.0 TeV$^{-2}$

Search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at 13 TeV

Results are reported for a search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb$^{-1}$ collected at a center-of-mass energy of 13 TeV using the CMS detector. The results are interpreted in the context of models of gauge-mediated supersymmetry breaking. Production cross section limits are set on gluino and squark pair production in this framework. Gluino masses below 1.86 TeV and squark masses below 1.59 TeV are excluded at 95% confidence level

An embedding technique to determine ττ\tau\tau backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model $\tau\tau$ backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed $\mu\mu$ events and replaced with simulated tau leptons with the same kinematic properties. In this way a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at $\sqrt{s}=$ 13 TeV corresponding to an integrated luminosity of 41.5 fb$^{-1}$

Constraints on anomalous HVV couplings from the production of Higgs bosons decaying to τ\tau lepton pairs

A study is presented of anomalous HVV interactions of the Higgs boson, including its CP properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of $\tau$ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9 fb$^{-1}$. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the $\mathrm{H}\to 4\ell$ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross-section fractions and phases: the CP-violating parameter $f_{a3}\cos(\phi_{a3})=(0.00 \pm 0.27 )\times10^{-3}$ and the CP-conserving parameters $f_{a2}\cos(\phi_{a2})=(0.08^{+1.04}_{-0.21})\times10^{-3}$, $f_{\Lambda1}\cos(\phi_{\Lambda1})=(0.00^{+0.53}_{-0.09})\times10^{-3}$, and $f_{\Lambda1}^{\mathrm{Z}\gamma}\cos(\phi_{\Lambda1}^{\mathrm{Z}\gamma})=(0.0^{+1.1}_{-1.3})\times10^{-3}$. The current data set does not allow for precise constraints on CP properties in the gluon fusion process. The results are consistent with standard model expectations.A study is presented of anomalous HVV interactions of the Higgs boson, including its CP properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of τ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9  fb-1. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the H→4ℓ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross section fractions and phases: the CP-violating parameter fa3cos(ϕa3)=(0.00±0.27)×10-3 and the CP-conserving parameters fa2cos(ϕa2)=(0.08-0.21+1.04)×10-3, fΛ1cos(ϕΛ1)=(0.00-0.09+0.53)×10-3, and fΛ1Zγcos(ϕΛ1Zγ)=(0.0-1.3+1.1)×10-3. The current dataset does not allow for precise constraints on CP properties in the gluon fusion process. The results are consistent with standard model expectations.A study is presented of anomalous HVV interactions of the Higgs boson, including its $CP$ properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of $\tau$ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9 fb$^{-1}$. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the H $\to 4\ell$ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross section fractions and phases: the $CP$-violating parameter $f_{a3}\cos(\phi_{a3})$ $=$ $(0.00 \pm 0.27) \times 10^{-3}$ and the $CP$-conserving parameters $f_{a2}\cos(\phi_{a2})$ $=$ $(0.08 ^{+1.04}_{-0.21}) \times 10^{-3}$, $f_{\Lambda1}\cos(\phi_{\Lambda1})$ $=$ $(0.00 ^{+0.53}_{-0.09}) \times 10^{-3}$, and $f_{\Lambda1}^{\mathrm{Z}\gamma}\cos(\phi_{\Lambda1}^{\mathrm{Z}\gamma})$ $=$ $(0.0 ^{+1.1}_{-1.3}) \times 10^{-3}$. The current dataset does not allow for precise constraints on $CP$ properties in the gluon fusion process. The results are consistent with standard model expectations

Search for a W′ boson decaying to a vector-like quark and a top or bottom quark in the all-jets final statech

A search for a heavy W′ resonance decaying to one B or T vector-like quark and a top or bottom quark, respectively, is presented. The search uses proton-proton collision data collected in 2016 with the CMS detector at the LHC, corresponding to an integrated luminosity of 35.9 fb$^{−1}$ at $\sqrt{s}=13$ TeV. Both decay channels result in a final state with a top quark, a Higgs boson, and a b quark, each produced with significant energy. The all-hadronic decays of both the Higgs boson and the top quark are considered. The final-state jets, some of which correspond to merged decay products of a boosted top quark and a Higgs boson, are selected using jet substructure techniques, which help to suppress standard model backgrounds. A W′ boson signal would appear as a narrow peak in the invariant mass distribution of these jets. No significant deviation in data with respect to the standard model background predictions is observed. Cross section upper limits on W′ boson production in the top quark, Higgs boson, and b quark decay mode are set as a function of the W′ mass, for several vector-like quark mass hypotheses. These are the first limits for W′ boson production in this decay channel, and cover a range of 0.01 to 0.43 pb in the W′ mass range between 1.5 and 4.0 TeV

Search for W boson decays to three charged pions

For the first time, a search for the rare decay of the W boson to three charged pions has been performed. Proton-proton collision data recorded by the CMS experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 77.3 fb$^{-1}$, have been analyzed. No significant excess is observed above the background expectation. An upper limit of 1.01$\times$10$^{-6}$ is set at 95% confidence level on the branching fraction of the W boson to three charged pions. This provides a strong motivation for theoretical calculations of this branching fraction