Dipolar versus multipolar dynamos: the influence of the background density stratification

Context: dynamo action in giant planets and rapidly rotating stars leads to a broad variety of magnetic field geometries including small scale multipolar and large scale dipole-dominated topologies. Previous dynamo models suggest that solutions become multipolar once inertia becomes influential. Being tailored for terrestrial planets, most of these models neglected the background density stratification. Aims: we investigate the influence of the density stratification on convection-driven dynamo models. Methods: three-dimensional nonlinear simulations of rapidly rotating spherical shells are employed using the anelastic approximation to incorporate density stratification. A systematic parametric study for various density stratifications and Rayleigh numbers allows to explore the dependence of the magnetic field topology on these parameters. Results: anelastic dynamo models tend to produce a broad range of magnetic field geometries that fall on two distinct branches with either strong dipole-dominated or weak multipolar fields. As long as inertia is weak, both branches can coexist but the dipolar branch vanishes once inertia becomes influential. The dipolar branch also vanishes for stronger density stratifications. The reason is the concentration of the convective columns in a narrow region close to the outer boundary equator, a configuration that favors non-axisymmetric solutions. In multipolar solutions, zonal flows can become significant and participate in the toroidal field generation. Parker dynamo waves may then play an important role close to onset of dynamo action leading to a cyclic magnetic field behavior. Conclusion: Our simulations also suggest that the fact that late M dwarfs have dipolar or multipolar magnetic fields can be explained in two ways. They may differ either by the relative influence of inertia or fall into the regime where both types of solutions coexist.Comment: 13 pages, 13 figures, 2 tables, accepted for publication in A&

Pascal's treatment of the question of grace in his works

Pascal's theology of grace, which he claimed to be the pure doctrine of St. Augustine and the orthodox teaching of the Catholic Church, has been variously labelled Augustinian, Thomist, humanist or a Jansenist heresy. In this thesis an attempt is made to determine the exact nature of that theology. Key themes and assumptions which emerge from a study of Pascal's major writings directly concerned with his theology of grace, and from the shorter works which have influenced its formulation and expression, are appraised in the light of the basic presuppositions of the Augustinian doctrine and the religious experience which is their true warrant and psychological ground. The conclusion which issues from this examination is that Pascal in fact subscribed to two conflicting sets of presuppositions, the one held at the conscious level of thought, and the other unconsciously assumed. At the conscious level he defends passionately the Augustinian doctrine of grace, reflecting a view of God and of grace based wholly upon non-rational grounds. Clearly, the fundamental Augustinian distinction between nature and grace underpins both method and matter in each of the works studied. This theology is also found to be identical, on all counts, with that of Port-Royal, Jansen, Thomas Aquinas and the orthodox teaching of the Catholic Church. The inconsistencies and irrationalities in Pascal's works on grace witness, however, to unconsciously held assumptions which directly contradict those of Augustine, and correspond rather with the assumptions held by the Jesuits. If the doctrinal disagreements between Pascal and his Jesuit opponents are transposed to the level of psychological insight, it is suggested that a view of grace can be worked out which encompasses both Augustinian and Scholastic traditions of Christian thought

Photometric observations from theoretical flip-flop models

Some active stars show a so-called flip-flop phenomenon in which the main spot activity periodically switches between two active longitudes that are 180 degrees apart. In this paper we study the flip-flop phenomenon by converting results from dynamo calculations into long-term synthetic photometric observations, which are then compared to the real stellar observations. We show that similar activity patterns as obtained from flip-flop dynamo calculations, can also be seen in the observations. The long-term light-curve behaviour seen in the synthesised data can be used for finding new stars exhibiting the flip-flop phenomenon.Comment: 5 pages, 5 figures, accepted for publication in A&

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan

Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA. Large-scale independent testing will inform clinical use, but is lacking. We aim to test e-ASPECTS and e-CTA (Brainomix, Oxford UK) using CT scans obtained from a range of clinical studies.Methods: Using prospectively collected baseline CT and CTA scans from 10 national/international clinical stroke trials or registries (total >6600 patients), we will select a large clinically representative sample for testing e-ASPECTS and e-CTA compared to previously acquired independent expert human interpretation (reference standard). Our primary aims are to test agreement between software-derived and masked human expert ASPECTS, and the diagnostic accuracy of e-ASPECTS for identifying all causes of stroke symptoms using follow-up imaging and final clinical opinion as diagnostic ground truth. Our secondary aims are to test when and why e-ASPECTS is more or less accurate, or succeeds/fails to produce results, agreement between e-CTA and human expert CTA interpretation, and repeatability of e-ASPECTS/e-CTA results. All testing will be conducted on an intention-to-analyse basis. We will assess agreement between software and expert-human ratings and test the diagnostic accuracy of software. Conclusions: RITeS will provide comprehensive, robust and representative testing of e-ASPECTS and e-CTA against the current gold-standard, expert-human interpretation

The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Transferring BCI skills to successful application controls

The goal of our research is to enable various end-users to control applications by using a brain-computer interface (BCI). Since applications–like telepresence robots, wheelchairs or text entry systems–are quite demanding a good level of BCI control is needed. However, little is known on how much training is needed to achieve such a level. A second open issue is, if this can be done at rehabilitation clinics or user-centers, without BCI experts present? In this work we wanted to train BCI-naïve end-users within 10 days to successfully control such applications and present results of 23 severely motor-disabled participants

A stable and replicable neural signature of lifespan adversity in the adult brain

Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

Patients with femoral or distal forearm fracture in Germany: a prospective observational study on health care situation and outcome

BACKGROUND: Distal radius and proximal femoral fractures are typical injuries in later life, predominantly due to simple falls, but modulated by other relevant factors such as osteoporosis. Fracture incidence rates rise with age. Because of the growing proportion of elderly people in Western industrialized societies, the number of these fractures can be expected to increase further in the coming years, and with it the burden on healthcare resources. Our study therefore assessed the effects of these injuries on the health status of older people over time. The purpose of this paper is to describe the study method, clinical parameters of fracture patients during hospitalization, mortality up to one and a half years after discharge in relation to various factors such as type of fracture, and to describe changes in mobility and living situation. METHODS: Data were collected from all consecutive patients (no age limit) admitted to 423 hospitals throughout Germany with distal radius or femoral fractures (57% acute-care, femoral and forearm fractures; 43% rehabilitation, femoral fractures only) between January 2002 and September 2003. Polytrauma and coma patients were excluded. Demographic characteristics, exact fracture location, mobility and living situation, clinical and laboratory parameters were examined. Current health status was assessed in telephone interviews conducted on average 6–7 months after discharge. Where telephone contact could not be established, at least survival status (living/deceased/date of death) was determined. RESULTS: The study population consisted of 12,520 femoral fracture patients (86.8% hip fractures), average age 77.5 years, 76.5% female, and 2,031 forearm fracture patients, average age 67.6 years, 81.6% female. Women's average age was 6.6 (femoral fracture) to 10 years (forearm fracture) older than men's (p < 0.0001). Only 4.6% of femoral fracture patients experienced changes in their living situation post-discharge (53% because of the fracture event), although less than half of subjects who were able to walk without assistive devices prior to the fracture event (76.7%) could still do so at time of interview (34.9%). At time of interview, 1.5% of subjects were bed-ridden (0.2% before fracture). Forearm fracture patients reported no change in living situation at all. Of the femoral fracture patients 119 (0.95%), and of the forearm fracture patients 3 (0.15%) died during hospital stay. Post-discharge (follow-up one and a half years) 1,463 femoral fracture patients died (19.2% acute-care patients, 8.5% rehabilitation patients), but only 60 forearm fracture patients (3.0%). Ninety percent of femoral fracture deaths happened within the first year, approximately 66% within the first 6 months. More acute-care patients with a pertrochanteric fracture died within one year post-discharge (20.6%) than patients with a cervical fracture (16.1%). CONCLUSION: Mortality after proximal femoral fracture is still alarmingly high and highest after pertrochanteric fracture. Although at time of interview more than half of femoral fracture patients reported reduced mobility, most patients (96%) attempt to live at home. Since forearm fracture patients were on average 10 years younger than femoral fracture patients, forearm fractures may be a means of diagnosing an increased risk of later hip fractures