520 research outputs found
Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration
The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25
mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two
period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t
, AUC0-inf
and Cmax
values for the test and reference
products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %,
84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax
, AUC0-t
and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was
concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent
of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration
The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25
mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two
period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t
, AUC0-inf
and Cmax
values for the test and reference
products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %,
84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax
, AUC0-t
and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was
concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent
of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Study of comparative bioavailability among two formulations containing hydroxyzine hydrochloride in healthy volunteers after a single dose administration
The study was performed to compare the bioavailability of two hydroxyzine hydrochloride 25
mg tablet formulation in 16 volunteers of both sexes. The study was conducted open with randomized two
period crossover design and a two weeks wash out period. Plasma samples were obtained over a 96 h interval. Hydroxyzine concentrations were analyzed by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS). Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-t
, AUC0-inf
and Cmax
values for the test and reference
products, using logarithmic transformed data. The 90 % confidence intervals were 81.89-105.85 %,
84.61-105.30 %, and 84.04-108.66 %, respectively. Since the 90 % confidence intervals for Cmax
, AUC0-t
and AUC0-inf were within the 80-125 % interval proposed by the Food and Drug Administration, it was
concluded that the two hydroxyzine hydrochloride formulations are bioequivalent in their rate and extent
of absorption.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
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