Identification of type 2 diabetes loci in 433,540 East Asian individuals

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes—NKX6-3 and ANK1—in different tissues4–6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Peer reviewe

Validation of the Survey Simulator Tool for the NEO Surveyor Mission Using NEOWISE Data

The Near-Earth Object Surveyor (NEO Surveyor) mission has a requirement to find two-thirds of the potentially hazardous asteroids larger than 140 m in size. In order to determine the mission’s expected progress toward this goal during design and testing, as well as the actual progress during the survey, a simulation tool has been developed to act as a consistent and quantifiable yardstick. We test that the survey simulation software is correctly predicting on-sky positions and thermal infrared fluxes by using it to reproduce the published measurements of asteroids from the NEOWISE mission. We then extended this work to find previously unreported detections of known near-Earth asteroids in the NEOWISE data archive, a search that resulted in 21,661 recovery detections, including 1166 objects that had no previously reported NEOWISE observations. These efforts demonstrate the reliability of the NEO Surveyor Survey Simulator tool and the perennial value of searchable image and source catalog archives for extending our knowledge of the small bodies of the solar system. © 2023. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Mid-IR plasmonics and photomodification with Ag films

The optical properties of semicontinuous silver films have been studied in the mid infrared. The film extinction spectra are shown to be well tailored by the deposition conditions and post-fabrication photomodification with both nanosecond and picosecond laser pulses at 10.6 mu m. The photomodification results in a decrease of the extinction above the laser wavelength. We find that the induced changes in the optical responses of the films are both wavelength and polarization selective. This technique allows the creation of long-pass filters for the mid-IR range in accord with the earlier theory