4,150 research outputs found
First passage times for a tracer particle in single file diffusion and fractional Brownian motion.
We investigate the full functional form of the first passage time density (FPTD) of a tracer particle in a single-file diffusion (SFD) system whose population is: (i) homogeneous, i.e., all particles having the same diffusion constant and (ii) heterogeneous, with diffusion constants drawn from a heavy-tailed power-law distribution. In parallel, the full FPTD for fractional Brownian motion [fBm-defined by the Hurst parameter, H ∈ (0, 1)] is studied, of interest here as fBm and SFD systems belong to the same universality class. Extensive stochastic (non-Markovian) SFD and fBm simulations are performed and compared to two analytical Markovian techniques: the method of images approximation (MIA) and the Willemski-Fixman approximation (WFA). We find that the MIA cannot approximate well any temporal scale of the SFD FPTD. Our exact inversion of the Willemski-Fixman integral equation captures the long-time power-law exponent, when H ≥ 1∕3, as predicted by Molchan [Commun. Math. Phys. 205, 97 (1999)] for fBm. When H < 1∕3, which includes homogeneous SFD (H = 1∕4), and heterogeneous SFD (H < 1∕4), the WFA fails to agree with any temporal scale of the simulations and Molchan's long-time result. SFD systems are compared to their fBm counter parts; and in the homogeneous system both scaled FPTDs agree on all temporal scales including also, the result by Molchan, thus affirming that SFD and fBm dynamics belong to the same universality class. In the heterogeneous case SFD and fBm results for heterogeneity-averaged FPTDs agree in the asymptotic time limit. The non-averaged heterogeneous SFD systems display a lack of self-averaging. An exponential with a power-law argument, multiplied by a power-law pre-factor is shown to describe well the FPTD for all times for homogeneous SFD and sub-diffusive fBm systems
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a model system for antigenic variation, surviving by periodically replacing a monolayer of variant surface glycoproteins (VSG) that covers its cell surface. We compared the genome of Trypanosoma brucei with two closely related parasites Trypanosoma congolense and Trypanosoma vivax, to reveal how the variant antigen repertoire has evolved and how it might affect contemporary antigenic diversity. We reconstruct VSG diversification showing that Trypanosoma congolense uses variant antigens derived from multiple ancestral VSG lineages, whereas in Trypanosoma brucei VSG have recent origins, and ancestral gene lineages have been repeatedly co-opted to novel functions. These historical differences are reflected in fundamental differences between species in the scale and mechanism of recombination. Using phylogenetic incompatibility as a metric for genetic exchange, we show that the frequency of recombination is comparable between Trypanosoma congolense and Trypanosoma brucei but is much lower in Trypanosoma vivax. Furthermore, in showing that the C-terminal domain of Trypanosoma brucei VSG plays a crucial role in facilitating exchange, we reveal substantial species differences in the mechanism of VSG diversification. Our results demonstrate how past VSG evolution indirectly determines the ability of contemporary parasites to generate novel variant antigens through recombination and suggest that the current model for antigenic variation in Trypanosoma brucei is only one means by which these parasites maintain chronic infections
A new method to separate star forming from AGN galaxies at intermediate redshift: The submillijansky radio population in the VLA-COSMOS survey
We explore the properties of the submillijansky radio population at 20 cm by
applying a newly developed optical color-based method to separate star forming
(SF) from AGN galaxies at intermediate redshifts (z<1.3). Although optical
rest-frame colors are used, our separation method is shown to be efficient, and
not biased against dusty starburst galaxies. This classification method has
been calibrated and tested on a local radio selected optical sample. Given
accurate multi-band photometry and redshifts, it carries the potential to be
generally applicable to any galaxy sample where SF and AGN galaxies are the two
dominant populations.
In order to quantify the properties of the submillijansky radio population,
we have analyzed ~2,400 radio sources, detected at 20 cm in the VLA-COSMOS
survey. 90% of these have submillijansky flux densities. We classify the
objects into 1) star candidates, 2) quasi stellar objects, 3) AGN, 4) SF, and
5) high redshift (z>1.3) galaxies. We find, for the composition of the
submillijansky radio population, that SF galaxies are not the dominant
population at submillijansky flux levels, as previously often assumed, but that
they make up an approximately constant fraction of 30-40% in the flux density
range of ~50 microJy to 0.7 mJy. In summary, based on the entire VLA-COSMOS
radio population at 20 cm, we find that the radio population at these flux
densities is a mixture of roughly 30-40% of SF and 50-60% of AGN galaxies, with
a minor contribution (~10%) of QSOs.Comment: 26 pages, 26 figures; accepted for publication in ApJ
On the evolution of environmental and mass properties of strong lens galaxies in COSMOS
Among the 100 strong lens candidates found in the COSMOS field, 20 with
redshifts in the range [0.34,1.13], feature multiple images of background
sources. Using the multi-wavelength coverage of the field and its spectroscopic
follow-up, we characterize the evolution with redshift of the environment and
of the dark-matter (DM) fraction of the lens galaxies. We present new redshift
of the strong lens candidates. The lens environment is characterized by the
projected 10 closest galaxies around each lens and by the number of galaxies
with a projected distance less than 1Mpc at the lens galaxy redshift. In both
cases, we perform similar measurements on a control sample of twin non-lens
early type galaxies (ETGs). In addition, we identify group members and field
galaxies in the X-ray and optical catalogs of galaxy groups. From those
catalogs, we measure the external shear contribution at the lens galaxy
positions. The systems are then modeled using a SIE plus the external shear due
to the groups. We observe that the average stellar mass of lens galaxies
increases with z and that the environment of lens galaxies is compatible with
that of the twins. During the lens modeling, we notice that, when let free, the
external shear points in a direction which is the mean direction of the
external shear due to groups and of the closest galaxy to the lens. We notice
that the DM fraction of the lens galaxies within the Einstein radius decreases
as the redshift increases. Given these, we conclude that, while the environment
of lens galaxies is compatible with that of non-lens ETGS, their mass
properties evolves significantly with redshift: it is still not clear whether
this advocates in favor of a stronger lensing bias toward massive objects at
high redshift or is simply representative of the high proportion of massive and
high stellar density galaxies at high redshift.Comment: Accepted for publication in A&A. Significant modifications in the
paper but similar conclusion
Observations of the neutral gas and dust in the radio galaxy 3C305
We present MERLIN and Hubble Space Telescope (HST) observations of the
central region of the nearby radio galaxy 3C305 and use them to study the gas
and dust in this object. The MERLIN observations are of neutral hydrogen (HI)
absorption against the strong non-thermal 20cm continuum seen towards the
central 4kpc of 3C305. Our 0.2-arcsec (160 pc) resolution observations show
that the HI absorption is highly localised against the south-western
radio-emission with column densities 1.9x10^21/cm2. The absorption is broad and
red-shifted by 130 km/s relative to the systemic velocity. The HST images in
430nm, 702nm, [OIII] 500.7nm, [FeII] 1.64um and K-band polarization are
presented. Evidence is seen for coincidence of the [FeII] emission with the
knot at the end of the radio jet, suggesting the presence of shocks. We compare
the optical and radio images in order to investigate the relationship between
the dust and neutral gas. An unresolved (0.07-arcsec) nucleus is detected in H
and K and its properties are consistent with a quasar reddened by A(V)>4. We
propose that the absorption arises in a region of neutral gas and dust whose
structure is complex but is broadly consistent with an inclined disc
encircling, but not covering, the active galactic nucleus. A comparison of the
neutral gas observations and previous emission-line observations suggests that
both the neutral and ionised gas are undergoing galactic rotation towards the
observer in the north-east and away from the observer in the south-west. We
propose that the outflow giving rise to the radio emission has a component
towards the observer in the north-east and away from the observer in the
south-west.Comment: 13 pages, 11 figures, accepted by MNRA
Transformational Sexualities: Motivations of women who pay for sexual services
Previous research on client motivations to purchase sexual services in the UK has predominantly focused on the experiences of men. Women who buy sex have largely been overlooked, as it is commonly assumed that women provide, rather than purchase sexual services. In addressing this empirical absence, this article examines data gained from 50 interviews with women clients and sex workers. It examines the reasons why women decide to purchase sexual services in the UK. We argue that the increasing importance of contemporary capitalism and consumerism has shaped women’s engagement in the sex industry as clients. We show how women’s sexual agency and assertiveness as clients, inverts the female sex worker/male client binary assumed to characterize commercial sex and illustrates the overlap and convergence of male and female sexuality. Our research thus contributes to an understanding of female sexuality more broadly, as exemplifying the hallmarks of ‘transformational sexualities’ in cosmopolitanism (Plummer, 2015)
Traces of past activity in the Galactic Centre
The Milky Way centre hosts a supermassive Black Hole (BH) with a mass of
~4*10^6 M_Sun. Sgr A*, its electromagnetic counterpart, currently appears as an
extremely weak source with a luminosity L~10^-9 L_Edd. The lowest known
Eddington ratio BH. However, it was not always so; traces of "glorious" active
periods can be found in the surrounding medium. We review here our current view
of the X-ray emission from the Galactic Center (GC) and its environment, and
the expected signatures (e.g. X-ray reflection) of a past flare. We discuss the
history of Sgr A*'s past activity and its impact on the surrounding medium. The
structure of the Central Molecular Zone (CMZ) has not changed significantly
since the last active phase of Sgr A*. This relic torus provides us with the
opportunity to image the structure of an AGN torus in exquisite detail.Comment: Invited refereed review. Chapter of the book: "Cosmic ray induced
phenomenology in star forming environments" (eds. Olaf Reimer and Diego F.
Torres
A Study of Time-Dependent CP-Violating Asymmetries and Flavor Oscillations in Neutral B Decays at the Upsilon(4S)
We present a measurement of time-dependent CP-violating asymmetries in
neutral B meson decays collected with the BABAR detector at the PEP-II
asymmetric-energy B Factory at the Stanford Linear Accelerator Center. The data
sample consists of 29.7 recorded at the
resonance and 3.9 off-resonance. One of the neutral B mesons,
which are produced in pairs at the , is fully reconstructed in
the CP decay modes , , , () and , or in flavor-eigenstate
modes involving and (). The flavor of the other neutral B meson is tagged at the time of
its decay, mainly with the charge of identified leptons and kaons. The proper
time elapsed between the decays is determined by measuring the distance between
the decay vertices. A maximum-likelihood fit to this flavor eigenstate sample
finds . The value of the asymmetry amplitude is determined from
a simultaneous maximum-likelihood fit to the time-difference distribution of
the flavor-eigenstate sample and about 642 tagged decays in the
CP-eigenstate modes. We find , demonstrating that CP violation exists in the neutral B meson
system. (abridged)Comment: 58 pages, 35 figures, submitted to Physical Review
The Calibration of Monochromatic Far-Infrared Star Formation Rate Indicators
(Abridged) Spitzer data at 24, 70, and 160 micron and ground-based H-alpha
images are analyzed for a sample of 189 nearby star-forming and starburst
galaxies to investigate whether reliable star formation rate (SFR) indicators
can be defined using the monochromatic infrared dust emission centered at 70
and 160 micron. We compare recently published recipes for SFR measures using
combinations of the 24 micron and observed H-alpha luminosities with those
using 24 micron luminosity alone. From these comparisons, we derive a reference
SFR indicator for use in our analysis. Linear correlations between SFR and the
70 and 160 micron luminosity are found for L(70)>=1.4x10^{42} erg/s and
L(160)>=2x10^{42} erg/s, corresponding to SFR>=0.1-0.3 M_sun/yr. Below those
two luminosity limits, the relation between SFR and 70 micron (160 micron)
luminosity is non-linear and SFR calibrations become problematic. The
dispersion of the data around the mean trend increases for increasing
wavelength, becoming about 25% (factor ~2) larger at 70 (160) micron than at 24
micron. The increasing dispersion is likely an effect of the increasing
contribution to the infrared emission of dust heated by stellar populations not
associated with the current star formation. The non-linear relation between SFR
and the 70 and 160 micron emission at faint galaxy luminosities suggests that
the increasing transparency of the interstellar medium, decreasing effective
dust temperature, and decreasing filling factor of star forming regions across
the galaxy become important factors for decreasing luminosity. The SFR
calibrations are provided for galaxies with oxygen abundance 12+Log(O/H)>8.1.
At lower metallicity the infrared luminosity no longer reliably traces the SFR
because galaxies are less dusty and more transparent.Comment: 69 pages, 19 figures, 2 tables; accepted for publication on Ap
Telomeric expression sites are highly conserved in trypanosoma brucei
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanosoma brucei. To enhance our understanding of BES structure and function in host adaptation and immune evasion, the BES repertoire from the Lister 427 strain of T. brucei were independently tagged and sequenced. BESs are polymorphic in size and structure but reveal a surprisingly conserved architecture in the context of extensive recombination. Very small BESs do exist and many functioning BESs do not contain the full complement of expression site associated genes (ESAGs). The consequences of duplicated or missing ESAGs, including ESAG9, a newly named ESAG12, and additional variant surface glycoprotein genes (VSGs) were evaluated by functional assays after BESs were tagged with a drug-resistance gene. Phylogenetic analysis of constituent ESAG families suggests that BESs are sequence mosaics and that extensive recombination has shaped the evolution of the BES repertoire. This work opens important perspectives in understanding the molecular mechanisms of antigenic variation, a widely used strategy for immune evasion in pathogens, and telomere biology
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