Antioxidant potential and α-glucosidase inhibitory activity of onion (Allium cepa L.) Peel and bulb extracts

Allium cepa L. is a commonly consumed vegetable that belongs to the Amaryllidaceae family and contains nutrients and antioxidants in ample amounts. In spite of the valuable food applications of onion bulb, its peel and outer fleshy layers are generally regarded as waste and exploration of their nutritional and therapeutic potential is still in progress with a very slow progression rate. The present study was designed with the purpose of doing a comparative analysis of the antioxidant potential of two parts of Allium cepa, i.g., bulb (edible part) and outer fleshy layers and dry peels (inedible part). Moreover, the inhibitory effect of the onion bulb and peel extracts on rat intestinal α-glucosidase and pancreatic α-amylase of porcine was also evaluated. The antioxidant potential of onion peel and bulb extracts were evaluated using 2,2-diphenyl- 1-picryl hydrazyl (DPPH), ferric-reducing antioxidant power assay (FRAP), 2,2’-azino-bis- 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assay, H2O2 radical scavenging activity and Fe2+ chelating activity. Total flavonoids and phenolic content of ethanolic extract of onion peel were significantly greater as compared to that of onion bulb. Ethanolic extract of onion peel also presented better antioxidant and free-radical scavenging activity as compared to the ethanolic extract of bulb, while the aqueous extract of bulb presented weakest antioxidative potential. Onion peel extract’s α-glucosidase inhibition potential was also correlated with their phenolic and flavonoid contents. The current findings presented onion peel as a possible source of antioxidative agents and phenolic compounds that might be beneficial against development of various common chronic diseases that might have an association with oxidative stress. Besides, outer dry layers and fleshy peels of onion exhibited higher phenolic content and antioxidant activities, compared to the inner bulb. The information obtained by the present study can be useful in promoting the use of vegetable parts other than the edible mesocarp for several future food applications, rather than these being wasted.Peer reviewe

Sub-Telomeric core X and Y' Elements in S.cerevisiae Suppress Extreme Variations in Gene Silencing

Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements. Subtelomeres also contain Sub-Telomeric Anti-silencing Regions (STARs). In this study we have prepared telomeres built of different combinations of core X, Y' and STARs and have analyzed them in strains lacking Histone-Acetyltransferase genes as well as in cdc6-1 and Δrif1 strains. We show that core X and Y' dramatically reduce both positive and negative variations in TPE, that are caused by these mutations. We also show that the deletion of Histone-Acetyltransferase genes reduce the silencing activity of an ACS proto-silencer, but also reduce the anti-silencing activity of a STAR. We postulate that core X and Y' act as epigenetic “cushioning” cis-elements

Production of charged pions, kaons and protons at large transverse momenta in pp and Pb-Pb collisions at sNN\sqrt{s_{NN}} = 2.76 TeV

Transverse momentum spectra of $\pi^{\pm}, K^{\pm}$ and $p(\bar{p})$ up to $p_T$ = 20 GeV/c at mid-rapidity, |y| $\le$ 0.8, in pp and Pb-Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV have been measured using the ALICE detector at the LHC. At intermediate $p_T$ (2-8 GeV/c) an enhancement of the proton-to-proton ratio, (p + \bar{p})/(\pi^+ + \pi^-\(), with respect to pp collisions is observed and the ratio reaches 0.80 in central Pb-Pb collisions. The measurement of the nuclear modification factors for \(\pi^{\pm}, K^{\pm} and $p(\bar{p})$ indicates that within the systematic and statistical uncertainties they are the same at high $p_T$ (> 10 GeV/c), suggesting that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets.publishedVersio

THE APPLICATION OF SPEED READING AT INTERMEDIATE LEVEL (A Case Study of Qualitative Research in One of Senior High School at Majalengka)

Muhammad Salim Pajri. 14111330143. THE APPLICATION OF SPEED READING AT INTERMEDIATE LEVEL (A Case Study of Qualitative Research in One of Senior High School at Majalengka) Reading is the important things in education, because people can get knowledge and information from reading. Without reading people cannot absorb many sciences. Here, the researcher use speed reading technique as the tool of analyzing to know the learning and teaching process at intermediate level. Moreover, the aims of this research are (1). To know the teaching and learning process of speed reading. (2). To know students’ attitude towards teaching and learning speed reading. (3). To know overcome of the difficulties of speed reading. Theoretically, is regarding to the reading area, especially in the reading comprehension by using speed reading technique. Practically, the researcher will analyze of speed reading in one of Senior High School at Majalengka which has benefit for teacher to know students’ ability in school. The research finding and discussion told about the teaching and learning process of speed reading at intermediate level. There are three activities of speed reading techniques. (1) Preparation Activity: teacher begins with greetings, deliver material and prepare students by warming up to focuss in learning process. (2) Core Activity: teacher teaches all the materials of speed reading. (3) Follow-up Activity: teacher gives exercise as the activity to know students score of speed reading test. The result of the analysis shows there are 5 students’ attitude towards teaching and learning speed reading. then, the finding shows that (1). Students’ feeling towards teaching and learning using speed reading in general: students like speed reading then also comfortable. (2). Students’ feeling towards the process of teaching and learning speed reading: they get comprehension of this technique. (3). Students’ difficulties in learning using speed reading: there are unfamiliar word on athe text. (4). Students’ feeling towards their comprehension in learning using speed reading: they get purpose in speed reading learning. (5). Students’ motivation in learning using speed reading: they can read books in fast time. It was found the overcome of difficulties of speed reading technique they are the process of the teaching speed reading and response the students’ response towards it, difficulties, disadvantages and teaching using speed reading technique and the result, usefulness, critics, and suggestions of teaching using speed reading technique. From the research that has been done, it can be concluded that there is way to apply speed reading by using steps of speed reading. From this technique will increase students’ ability in reading process. It can help students to read fast and efficient time. Keywords: Reading Comprehension, Speed Reading, Intermediate Leve

The upgrade of the ALICE TPC with GEMs and continuous readout

The upgrade of the ALICE TPC will allow the experiment to cope with the high interaction rates foreseen for the forthcoming Run 3 and Run 4 at the CERN LHC. In this article, we describe the design of new readout chambers and front-end electronics, which are driven by the goals of the experiment. Gas Electron Multiplier (GEM) detectors arranged in stacks containing four GEMs each, and continuous readout electronics based on the SAMPA chip, an ALICE development, are replacing the previous elements. The construction of these new elements, together with their associated quality control procedures, is explained in detail. Finally, the readout chamber and front-end electronics cards replacement, together with the commissioning of the detector prior to installation in the experimental cavern, are presented. After a nine-year period of R&D, construction, and assembly, the upgrade of the TPC was completed in 2020.publishedVersio

The Usability of E-learning Platforms in Higher Education: A Systematic Mapping Study

The use of e-learning in higher education has increased significantly in recent years, which has led to several studies being conducted to investigate the usability of the platforms that support it. A variety of different usability evaluation methods and attributes have been used, and it has therefore become important to start reviewing this work in a systematic way to determine how the field has developed in the last 15 years. This paper describes a systematic mapping study that performed searches on five electronic libraries to identify usability issues and methods that have been used to evaluate e-learning platforms. Sixty-one papers were selected and analysed, with the majority of studies using a simple research design reliant on questionnaires. The usability attributes measured were mostly related to effectiveness, satisfaction, efficiency, and perceived ease of use. Furthermore, several research gaps have been identified and recommendations have been made for further work in the area of the usability of online learning

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

BOTANICAL COMPOSITION AND MULTIVARIATE ANALYSIS OF VEGETATION ON THE POTHOWAR PLATEAU, PAKISTAN

Volume: 1Start Page: 557End Page: 56