252 research outputs found
Feeding live Black Soldier Fly larvae (Hermetia illucens) to laying hens: effects on feed consumption, hen health, hen behaviour and egg quality
The use of insects in animal feed has the potential to reduce the demand for soybean production and reduce the deforestation and loss of natural resources. In particular, the black soldier fly (BSF, Hermetia illucens) larvae have received attention due to their ability to convert organic waste into high-value biomass. Several studies have investigated the effects of providing BSF larvae to both broilers and laying hens. However, knowledge gaps regarding hens’ voluntary intake of live larvae and the effects of larvae consumption on egg production still remain. Therefore, the aim of the present study was to determine the effects of the consumption of 4 different amounts of live BSF larvae on laying hen feed consumption, hen health and fearfulness, and egg production and quality. To this end, 40 Bovans White laying hens were housed individually and provided with 0, 10, 20% or ad libitum daily portions of live larvae from 18 to 30 wk of age. The larvae consumption and concentrate consumption, hen weight, egg production, and egg quality were monitored. Overall, differences were found between the hens given ad libitum access to larvae compared to the other treatments. Ad libitum hens, consumed 163 ± 41 g larvae/hen/day, consumed less concentrate (P = 0.03) and gained more weight (P = 0.0002) than all other treatments. They also had an overall higher consumption of protein, fat and energy (P 0.05). There was also no effect on hen behavior toward a novel object or in an open field test. This study is the first to provide different amounts of live BSF larvae, including an ad libitum portion to laying hens. The 20% diet could promote sustainability in the egg industry and be economically advantageous if BSF larvae can be bought in bulk for less than 40% of the cost of the concentrate
Neutralino-Nucleon Cross Section and Charge and Colour Breaking Constraints
We compute the neutralino-nucleon cross section in several supersymmetric
scenarios, taking into account all kind of constraints. In particular, the
constraints that the absence of dangerous charge and colour breaking minima
imposes on the parameter space are studied in detail. In addition, the most
recent experimental constraints, such as the lower bound on the Higgs mass, the
branching ratio, and the muon are considered. The
astrophysical bounds on the dark matter density are also imposed on the
theoretical computation of the relic neutralino density, assuming thermal
production. This computation is relevant for the theoretical analysis of the
direct detection of dark matter in current experiments. We consider first the
supergravity scenario with universal soft terms and GUT scale. In this scenario
the charge and colour breaking constraints turn out to be quite important, and
\tan\beta\lsim 20 is forbidden. Larger values of can also be
forbidden, depending on the value of the trilinear parameter . Finally, we
study supergravity scenarios with an intermediate scale, and also with
non-universal scalar and gaugino masses where the cross section can be very
large.Comment: Final version to appear in JHE
Constrained Supersymmetric Flipped SU(5) GUT Phenomenology
We explore the phenomenology of the minimal supersymmetric flipped SU(5) GUT
model (CFSU(5)), whose soft supersymmetry-breaking (SSB) mass parameters are
constrained to be universal at some input scale, , above the GUT scale,
. We analyze the parameter space of CFSU(5) assuming that the lightest
supersymmetric particle (LSP) provides the cosmological cold dark matter,
paying careful attention to the matching of parameters at the GUT scale. We
first display some specific examples of the evolutions of the SSB parameters
that exhibit some generic features. Specifically, we note that the relationship
between the masses of the lightest neutralino and the lighter stau is sensitive
to , as is the relationship between the neutralino mass and the masses
of the heavier Higgs bosons. For these reasons, prominent features in generic
planes such as coannihilation strips and rapid-annihilation
funnels are also sensitive to , as we illustrate for several cases with
tan(beta)=10 and 55. However, these features do not necessarily disappear at
large , unlike the case in the minimal conventional SU(5) GUT. Our
results are relatively insensitive to neutrino masses.Comment: 23 pages, 8 figures; (v2) added explanations and corrected typos,
version to appear in EPJ
Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial
IMPORTANCE Preventive interventions are needed to protect residents and staff of skilled nursing and assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, may confer rapid protection from SARS-CoV-2 infection and COVID-19. OBJECTIVE To determine the effect of bamlanivimab on the incidence of COVID-19 among residents and staff of skilled nursing and assisted living facilities. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, single-dose, phase 3 trial that enrolled residents and staff of 74 skilled nursing and assisted living facilities in the United States with at least 1 confirmed SARS-CoV-2 index case. A total of 1175 participants enrolled in the study from August 2 to November 20, 2020. Database lock was triggered on January 13, 2021, when all participants reached study day 57. INTERVENTIONS Participants were randomized to receive a single intravenous infusion of bamlanivimab, 4200mg (n = 588), or placebo (n = 587). MAIN OUTCOMES AND MEASURES The primary outcomewas incidence of COVID-19, defined as the detection of SARS-CoV-2 by reverse transcriptase–polymerase chain reaction and mild or worse disease severity within 21 days of detection, within 8 weeks of randomization. Key secondary outcomes included incidence of moderate or worse COVID-19 severity and incidence of SARS-CoV-2 infection. RESULTS The prevention population comprised a total of 966 participants (666 staff and 300 residents) who were negative at baseline for SARS-CoV-2 infection and serology (mean age, 53.0 [range, 18-104] years; 722 [74.7%] women). Bamlanivimab significantly reduced the incidence of COVID-19 in the prevention population compared with placebo (8.5%vs 15.2%; odds ratio, 0.43 [95%CI, 0.28-0.68]; P < .001; absolute risk difference, −6.6 [95%CI, −10.7 to −2.6] percentage points). Five deaths attributed to COVID-19 were reported by day 57; all occurred in the placebo group. Among 1175 participants who received study product (safety population), the rate of participants with adverse events was 20.1% in the bamlanivimab group and 18.9% in the placebo group. The most common adverse events were urinary tract infection (reported by 12 participants [2%] who received bamlanivimab and 14 [2.4%] who received placebo) and hypertension (reported by 7 participants [1.2%] who received bamlanivimab and 10 [1.7%] who received placebo). CONCLUSIONS AND RELEVANCE Among residents and staff in skilled nursing and assisted living facilities, treatment during August-November 2020 with bamlanivimab monotherapy reduced the incidence of COVID-19 infection. Further research is needed to assess preventive efficacy with current patterns of viral strains with combination monoclonal antibody therapy
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis
Psychosocial factors and cancer incidence (PSY-CA):Protocol for individual participant data meta-analyses
OBJECTIVES: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.METHODS: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).CONCLUSION: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.</p
Chargino Decays in the Complex MSSM: A Full One-Loop Analysis
We evaluate two-body decay modes of charginos in the Minimal Supersymmetric
Standard Model with complex parameters (cMSSM). Assuming heavy scalar quarks we
take into account all decay channels involving charginos, neutralinos, (scalar)
leptons, Higgs bosons and Standard Model gauge bosons. The evaluation of the
decay widths is based on a full one-loop calculation including hard and soft
QED radiation. Special attention is paid to decays involving the Lightest
Supersymmetric Particle (LSP), i.e. the lightest neutralino, or a neutral or
charged Higgs boson. The higher-order corrections of the chargino decay widths
involving the LSP can easily reach a level of about \pm 10%, while the
corrections to the decays to Higgs bosons are slightly smaller, translating
into corrections of similar size in the respective branching ratios. These
corrections are important for the correct interpretation of LSP and Higgs
production at the LHC and at a future linear e+e- collider. The results will be
implemented into the Fortran code FeynHiggs.Comment: 75 pages, 43 figures. Minor corrections; version to appear in EPJC.
arXiv admin note: substantial text overlap with arXiv:1111.728
Finite Unified Theories and the Higgs boson
All-loop Finite Unified Theories (FUTs) are very interesting N = 1
supersymmetric Grand Unified Theories (GUTs) realising an old field theory
dream, and moreover have a remarkable predictive power due to the required
reduction of couplings. Based on this theoretical framework phenomenologically
consistent FUTs have been constructed. Here we review two FUT models based on
the SU(5) gauge group, which can be seen as special, restricted and thus very
predictive versions of the MSSM. We show that from the requirement of correct
prediction of quark masses and other experimental constraints a light
Higgs-boson mass in the range M_h ~ 121 - 126 GeV is predicted, in striking
agreement with recent experimental results from ATLAS and CMS. The model
furthermore naturally predicts a relatively heavy spectrum with colored
supersymmetric particles above ~ 1.5 TeV in agreement with the non-observation
of those particles at the LHC.Comment: 13 pages, 5 figures. Proceedings devoted to the Scientific and Human
Legacy of Julius Wess, initiated by the JW2011 Workshop, August 27 - 28,
2011, Donji Milanovac, Serbi
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