X-ray Scattered Halo around IGR J17544-2619

X-ray photons coming from an X-ray point source not only arrive at the detector directly, but also can be strongly forward-scattered by the interstellar dust along the line of sight (LOS), leading to a detectable diffuse halo around the X-ray point source. The geometry of small angle X-ray scattering is straightforward, namely, the scattered photons travel longer paths and thus arrive later than the unscattered ones; thus the delay time of X-ray scattered halo photons can reveal information of the distances of the interstellar dust and the point source. Here we present a study of the X-ray scattered around IGR J17544-2619, which is one of the so-called supergiant fast X-ray transients. IGR J17544-2619 underwent a striking outburst when observed with Chandra on 2004 July 3, providing a near delta-function lightcurve. We find that the X-ray scattered halo around IGR J17544-2619 is produced by two interstellar dust clouds along the LOS. The one which is closer to the observer gives the X-ray scattered at larger observational angles; whereas the farther one, which is in the vicinity of the point source, explains the halo with a smaller angular size. By comparing the observational angle of the scattered halo photons with that predicted by different dust grain models, we are able to determine the normalized dust distance. With the delay times of the scattered halo photons, we can determine the point source distance, given a dust grain model. Alternatively we can discriminate between the dust grain models, given the point source distance.Comment: Accepted for publication in ApJ. 25 pages, 9 figures, 6 table

The Einstein Probe Mission

The Einstein Probe (EP) is a mission designed to monitor the sky in the soft X-ray band. It will perform systematic surveys and characterisation of high-energy transients and monitoring of variable objects at unprecedented sensitivity and monitoring cadences. It has a large instantaneous field-of-view (3,600 sq. deg.), that is realised via the lobster-eye micro-pore X-ray focusing optics. EP also carries a conventional X-ray focusing telescope with a larger effective area to perform followup observations and precise positioning of newly-discovered transients. Alerts for transient objects will be issued publicly and timely. The scientific goals of EP are concerned with discovering faint, distant or rare types of high-energy transients and variable sources. Within the confines of a modest-sized mission, EP will cover a wide range of scientific topics, from the nearby to high-redshift Universe. The Einstein Probe is a mission of the Chinese Academy of Sciences, and also an international collaborative project. This paper presents the background, scientific objectives, and the mission design including the micro-pore optics and CMOS technologies adopted, the instruments and their expected performance, and the mission profile. The development status of the project is also presented.Comment: 29 pages, 23 figures; Invited chapter for Handbook of X-ray and Gamma-ray Astrophysics (Eds. C. Bambi and A. Santangelo, Springer Singapore, expected in 2022

X-ray performance of a customized large-format scientifc CMOS detector

In recent years, the performance of Scientifc Complementary Metal Oxide Semiconductor (sCMOS) sensors has been improved signifcantly. Compared with CCD sensors, sCMOS sensors have various advantages, making them potentially better devices for optical and X-ray detection, especially in time-domain astronomy. After a series of tests of sCMOS sensors, we proposed a new dedicated high-speed, large-format X-ray detector in 2016 cooperating with Gpixel Inc. This new sCMOS sensor has a physical size of 6 cm by 6 cm, with an array of 4096 by 4096 pixels and a pixel size of 15 um. The frame rate is 20.1 fps under current condition and can be boosted to a maximum value around 100 fps. The epitaxial thickness is increased to 10 um compared to the previous sCMOS product. We show the results of its frst taped-out product in this work. The dark current of this sCMOS is lower than 10 e/pixel/s at 20C, and lower than 0.02 e/pixel/s at -30C. The Fixed Pattern Noise (FPN) and the readout noise are lower than 5 e in high-gain situation and show a small increase at low temperature. The energy resolution reaches 180.1 eV (3.1%) at 5.90 keV for single-pixel events and 212.3 eV (3.6%) for all split events. The continuous X-ray spectrum measurement shows that this sensor is able to response to X-ray photons from 500 eV to 37 keV. The excellent performance, as demonstrated from these test results, makes sCMOS sensor an ideal detector for X-ray imaging and spectroscopic application.Comment: 20 pages. published in PAS

Optimizing and Fine-tuning Large Language Model for Urban Renewal

This study aims to innovatively explore adaptive applications of large language models (LLM) in urban renewal. It also aims to improve its performance and text generation quality for knowledge question-answering (QA) tasks. Based on the ChatGLM, we automatically generate QA datasets using urban renewal scientific literature corpora in a self-instruct manner and then conduct joint fine-tuning training on the model using the Prefix and LoRA fine-tuning methods to create an LLM for urban renewal. By guiding the LLM to automatically generate QA data based on prompt words and given text, it is possible to quickly obtain datasets in the urban renewal field and provide data support for the fine-tuning training of LLMs. The experimental results show that the joint fine-tuning training method proposed in this study can significantly improve the performance of LLM on the QA tasks. Compared with LoRA fine-tuning, the method improves the Bleu and Rouge metrics on the test by about 5%; compared with the model before fine-tuning, the method improves the Bleu and Rouge metrics by about 15%-20%. This study demonstrates the effectiveness and superiority of the joint fine-tuning method using Prefix and LoRA for ChatGLM in the urban renewal knowledge QA tasks. It provides a new approach for fine-tuning LLMs on urban renewal-related tasks.Comment: 11 pages, 2 figures, 2 tables, 41 reference

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2 in skin homeostasis in adult mice. Methodology/Principal Findings: To study the role of Ctip2 in adult skin homeostasis, we utilized Ctip2[superscript ep2/2] mouse model in which Ctip2 is selectively deleted in epidermal keratinocytes. Measurement of TEWL, followed by histological, immunohistochemical, and RT[subscript -q]PCR analyses revealed an important role of Ctip2 in barrier maintenance and in regulating adult skin homeostasis. We demonstrated that keratinocytic ablation of Ctip2 leads to atopic dermatitis (AD)-like skin inflammation, characterized by alopecia, pruritus and scaling, as well as extensive infiltration of immune cells including T lymphocytes, mast cells, and eosinophils. We observed increased expression of T-helper 2 (Th2)-type cytokines and chemokines in the mutant skin, as well as systemic immune responses that share similarity with human AD patients. Furthermore, we discovered that thymic stromal lymphopoietin (TSLP) expression was significantly upregulated in the mutant epidermis as early as postnatal day 1 and ChIP assay revealed that TSLP is likely a direct transcriptional target of Ctip2 in epidermal keratinocytes. Conclusions/Significance: Our data demonstrated a cell-autonomous role of Ctip2 in barrier maintenance and epidermal homeostasis in adult mice skin. We discovered a crucial non-cell autonomous role of keratinocytic Ctip2 in suppressing skin inflammatory responses by regulating the expression of Th2-type cytokines. It is likely that the epidermal hyperproliferation in the Ctip2-lacking epidermis may be secondary to the compensatory response of the adult epidermis that is defective in barrier functions. Our results establish an initiating role of epidermal TSLP in AD pathogenesis via a novel repressive regulatory mechanism enforced by Ctip2

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at root s = 13 TeV, and correspond to an integrated luminosity of 35.9 fb(-1). The spectra of total transverse hadronic energy of candidate events are examined for deviations from the standard model predictions. No statistically significant excess is observed over the expected background. The first cross section limits on new physics processes resulting in such events are set. The results are interpreted as upper limits on the rate of gluino pair production, utilizing a simplified stealth supersymmetry model. The excluded gluino masses extend up to 1.7 TeV, for a neutralino mass of 200 GeV and exceed previous mass constraints set by analyses targeting events with isolated photons.Peer reviewe

Measurement of nuclear modification factors of gamma(1S)), gamma(2S), and gamma(3S) mesons in PbPb collisions at root s(NN)=5.02 TeV

The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead-lead (PbPb) and proton-proton (pp) collisions at √sNN = 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied as functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of all three states are found to be significantly suppressed, and compatible with a sequential ordering of the suppression, RAA(ϒ(1S)) > RAA(ϒ(2S)) > RAA(ϒ(3S)). The suppression of ϒ(1S) is larger than that seen at √sNN = 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the RAA of ϒ(3S) integrated over pT, rapidity and centrality is 0.096 at 95% confidence level, which is the strongest suppression observed for a quarkonium state in heavy ion collisions to date. © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP3.Peer reviewe