29,800 research outputs found

    Tarjihat Ibn Uthaimin Dalam Tafsir Surah Yasin[P1-1091].

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    Penyelidikan ini mengandungi biografi menyeluruh tentang Sheikh Ibn Uthaimin. Ini diikuti oleh penerangan tentang makna Al Tarji>h{ (pendapat atau takwil yang diambil di antara pendapat- pendapat atau takwil-takwil yang terkemuka secara sepakat) dan metodologi para fundamentalis dan para pentafsir dalam bidang tersebut. This study comprised a comprehensive biography of Sheikh Ibn Uthaimin. This was followed by an explanation of the meaning of Al Tarjih (favored opinions) and methodology of fundamentalists and interpreters in the area

    Microtubule-severing enzymes: From cellular functions to molecular mechanism.

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    Microtubule-severing enzymes generate internal breaks in microtubules. They are conserved in eukaryotes from ciliates to mammals, and their function is important in diverse cellular processes ranging from cilia biogenesis to cell division, phototropism, and neurogenesis. Their mutation leads to neurodegenerative and neurodevelopmental disorders in humans. All three known microtubule-severing enzymes, katanin, spastin, and fidgetin, are members of the meiotic subfamily of AAA ATPases that also includes VPS4, which disassembles ESCRTIII polymers. Despite their conservation and importance to cell physiology, the cellular and molecular mechanisms of action of microtubule-severing enzymes are not well understood. Here we review a subset of cellular processes that require microtubule-severing enzymes as well as recent advances in understanding their structure, biophysical mechanism, and regulation

    Cryogenic Ion Trapping Systems with Surface-Electrode Traps

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    We present two simple cryogenic RF ion trap systems in which cryogenic temperatures and ultra high vacuum pressures can be reached in as little as 12 hours. The ion traps are operated either in a liquid helium bath cryostat or in a low vibration closed cycle cryostat. The fast turn around time and availability of buffer gas cooling made the systems ideal for testing surface-electrode ion traps. The vibration amplitude of the closed cycled cryostat was found to be below 106 nm. We evaluated the systems by loading surface-electrode ion traps with 88^{88}Sr+^+ ions using laser ablation, which is compatible with the cryogenic environment. Using Doppler cooling we observed small ion crystals in which optically resolved ions have a trapped lifetime over 2500 minutes.Comment: 10 pages, 13 EPS figure

    SMARANDACHE FUNCTION JOURNAL, 2-3

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    This journal is yearly published (in the Spring or Fall) in a 300-400 pages volume, and 800-1000 copies. SNJ is a referred journal: reviewed, indexed, cited, concerning any of Smarandache type functions, numbers, sequences, integer algorithms, paradoxes, Non-Euclidean geometries, etc

    Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid

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    With their essential role in inner-ear function, stereocilia of sensory hair cells demonstrate the importance of cellular actin protrusions. Actin packing in stereocilia is mediated by crosslinkers of the plastin, fascin, and espin families. While mice lacking ESPN (espin) have no vestibular or auditory function, we found that mice that either lacked PLS1 (plastin 1) or had nonfunctional FSCN2 (fascin 2) had reduced inner-ear function, with double-mutant mice most strongly affected. Targeted mass spectrometry indicated that PLS1 was the most abundant crosslinker in vestibular stereocilia, and the second-most-abundant protein overall; ESPN only accounted for ~15% of the total crosslinkers in bundles. Mouse utricle stereocilia lacking PLS1 were shorter and thinner than wild-type stereocilia. Surprisingly, while wild-type stereocilia had random liquid packing of their actin filaments, stereocilia lacking PLS1 had orderly hexagonal packing. While all three crosslinkers are required for stereocilia structure and function, PLS1 biases actin towards liquid packing, which allows stereocilia to grow to a greater diameter

    Non-Compensation of the Barrel Tile Hadron Module-0 Calorimeter

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    The detailed experimental information about the electron and pion responses, the electron energy resolution and the e/h ratio as a function of incident energy E, impact point Z and incidence angle Θ\Theta of the Module-0 of the iron-scintillator barrel hadron calorimeter with the longitudinal tile configuration is presented. The results are based on the electron and pion beams data for E = 10, 20, 60, 80, 100 and 180 GeV at η\eta = -0.25 and -0.55, which have been obtained during the test beam period in 1996. The results are compared with the existing experimental data of TILECAL 1m prototype modules, various iron-scintillator calorimeters and with some Monte Carlo calculations.Comment: 33 pages, 20 figure
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