Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Improving statistics for hybrid segmentation of high-resolution multichannel images

High-resolution multichannel textures are difficult to characterize with simple statistics and the high level of detail makes the selection of a particular contour using classical gradient-based methods not effective. We have developed a hybrid method that combines fuzzy connectedness and Voronoi diagram classification for the segmentation of color and multichannel objects. The multi-step classification process relies on homogeneity measures derived from moment statistics and histogram information. These color features have been optimized to best combine individual channel information in the classification process. The segmentation initialization requires only a set of interior and exterior seed points, minimizing user intervention and the influence of the initialization on the overall quality of the results. The method was tested on volumes from the Visible Human and on brain multi-protocol MRI data sets. The hybrid segmentation produced robust, rapid and finely detailed contours with good visual accuracy. The addition of quantized statistics and color histogram distances as classification features improved the robustness of the method with regards to initialization when compared to our original implementation

Towards Intelligent Telerobotics: Visualization and Control of Remote Robot

Human-machine cooperative or co-robotics has been recognized as the next generation of robotics. In contrast to current systems that use limited-reasoning strategies or address problems in narrow contexts, new co-robot systems will be characterized by their flexibility, resourcefulness, varied modeling or reasoning approaches, and use of real-world data in real time, demonstrating a level of intelligence and adaptability seen in humans and animals. The research I focused is in the two sub-field of co-robotics: teleoperation and telepresence. We firstly explore the ways of teleoperation using mixed reality techniques. I proposed a new type of display: hybrid-reality display (HRD) system, which utilizes commodity projection device to project captured video frame onto 3D replica of the actual target surface. It provides a direct alignment between the frame of reference for the human subject and that of the displayed image. The advantage of this approach lies in the fact that no wearing device needed for the users, providing minimal intrusiveness and accommodating users eyes during focusing. The field-of-view is also significantly increased. From a user-centered design standpoint, the HRD is motivated by teleoperation accidents, incidents, and user research in military reconnaissance etc. Teleoperation in these environments is compromised by the Keyhole Effect, which results from the limited field of view of reference. The technique contribution of the proposed HRD system is the multi-system calibration which mainly involves motion sensor, projector, cameras and robotic arm. Due to the purpose of the system, the accuracy of calibration should also be restricted within millimeter level. The followed up research of HRD is focused on high accuracy 3D reconstruction of the replica via commodity devices for better alignment of video frame. Conventional 3D scanner lacks either depth resolution or be very expensive. We proposed a structured light scanning based 3D sensing system with accuracy within 1 millimeter while robust to global illumination and surface reflection. Extensive user study prove the performance of our proposed algorithm. In order to compensate the unsynchronization between the local station and remote station due to latency introduced during data sensing and communication, 1-step-ahead predictive control algorithm is presented. The latency between human control and robot movement can be formulated as a linear equation group with a smooth coefficient ranging from 0 to 1. This predictive control algorithm can be further formulated by optimizing a cost function. We then explore the aspect of telepresence. Many hardware designs have been developed to allow a camera to be placed optically directly behind the screen. The purpose of such setups is to enable two-way video teleconferencing that maintains eye-contact. However, the image from the see-through camera usually exhibits a number of imaging artifacts such as low signal to noise ratio, incorrect color balance, and lost of details. Thus we develop a novel image enhancement framework that utilizes an auxiliary color+depth camera that is mounted on the side of the screen. By fusing the information from both cameras, we are able to significantly improve the quality of the see-through image. Experimental results have demonstrated that our fusion method compares favorably against traditional image enhancement/warping methods that uses only a single image

3D exemplar-based image inpainting in electron microscopy

In electron microscopy (EM) a common problem is the non-availability of data, which causes artefacts in reconstructions. In this thesis the goal is to generate artificial data where missing in EM by using exemplar-based inpainting (EBI). We implement an accelerated 3D version tailored to applications in EM, which reduces reconstruction times from days to minutes. We develop intelligent sampling strategies to find optimal data as input for reconstruction methods. Further, we investigate approaches to reduce electron dose and acquisition time. Sparse sampling followed by inpainting is the most promising approach. As common evaluation measures may lead to misinterpretation of results in EM and falsify a subsequent analysis, we propose to use application driven metrics and demonstrate this in a segmentation task. A further application of our technique is the artificial generation of projections in tiltbased EM. EBI is used to generate missing projections, such that the full angular range is covered. Subsequent reconstructions are significantly enhanced in terms of resolution, which facilitates further analysis of samples. In conclusion, EBI proves promising when used as an additional data generation step to tackle the non-availability of data in EM, which is evaluated in selected applications. Enhancing adaptive sampling methods and refining EBI, especially considering the mutual influence, promotes higher throughput in EM using less electron dose while not lessening quality.Ein häufig vorkommendes Problem in der Elektronenmikroskopie (EM) ist die Nichtverfügbarkeit von Daten, was zu Artefakten in Rekonstruktionen führt. In dieser Arbeit ist es das Ziel fehlende Daten in der EM künstlich zu erzeugen, was durch Exemplar-basiertes Inpainting (EBI) realisiert wird. Wir implementieren eine auf EM zugeschnittene beschleunigte 3D Version, welche es ermöglicht, Rekonstruktionszeiten von Tagen auf Minuten zu reduzieren. Wir entwickeln intelligente Abtaststrategien, um optimale Datenpunkte für die Rekonstruktion zu erhalten. Ansätze zur Reduzierung von Elektronendosis und Aufnahmezeit werden untersucht. Unterabtastung gefolgt von Inpainting führt zu den besten Resultaten. Evaluationsmaße zur Beurteilung der Rekonstruktionsqualität helfen in der EM oft nicht und können zu falschen Schlüssen führen, weswegen anwendungsbasierte Metriken die bessere Wahl darstellen. Dies demonstrieren wir anhand eines Beispiels. Die künstliche Erzeugung von Projektionen in der neigungsbasierten Elektronentomographie ist eine weitere Anwendung. EBI wird verwendet um fehlende Projektionen zu generieren. Daraus resultierende Rekonstruktionen weisen eine deutlich erhöhte Auflösung auf. EBI ist ein vielversprechender Ansatz, um nicht verfügbare Daten in der EM zu generieren. Dies wird auf Basis verschiedener Anwendungen gezeigt und evaluiert. Adaptive Aufnahmestrategien und EBI können also zu einem höheren Durchsatz in der EM führen, ohne die Bildqualität merklich zu verschlechtern

Wavelet-based multiresolution data representations for scalable distributed GIS services

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2002.Includes bibliographical references (p. 155-160).Demand for providing scalable distributed GIS services has been growing greatly as the Internet continues to boom. However, currently available data representations for these services are limited by a deficiency of scalability in data formats. In this research, four types of multiresolution data representations based on wavelet theories have been put forward. The designed Wavelet Image (WImg) data format helps us to achieve dynamic zooming and panning of compressed image maps in a prototype GIS viewer. The Wavelet Digital Elevation Model (WDEM) format is developed to deal with cell-based surface data. A WDEM is better than a raster pyramid in that a WDEM provides a non-redundant multiresolution representation. The Wavelet Arc (WArc) format is developed for decomposing curves into a multiresolution format through the lifting scheme. The Wavelet Triangulated Irregular Network (WTIN) format is developed to process general terrain surfaces based on the second generation wavelet theory. By designing a strategy to resample a terrain surface at subdivision points through the modified Butterfly scheme, we achieve the result: only one wavelet coefficient needs to be stored for each point in the final representation. In contrast to this result, three wavelet coefficients need to be stored for each point in a general 3D object wavelet-based representation. Our scheme is an interpolation scheme and has much better performance than the Hat wavelet filter on a surface. Boundary filters are designed to make the representation consistent with the rectangular boundary constraint.(cont.) We use a multi-linked list and a quadtree array as the data structures for computing. A method to convert a high resolution DEM to a WTIN is also provided. These four wavelet-based representations provide consistent and efficient multiresolution formats for online GIS. This makes scalable distributed GIS services more efficient and implementable.by Jingsong Wu.Ph.D

A Panorama on Multiscale Geometric Representations, Intertwining Spatial, Directional and Frequency Selectivity

The richness of natural images makes the quest for optimal representations in image processing and computer vision challenging. The latter observation has not prevented the design of image representations, which trade off between efficiency and complexity, while achieving accurate rendering of smooth regions as well as reproducing faithful contours and textures. The most recent ones, proposed in the past decade, share an hybrid heritage highlighting the multiscale and oriented nature of edges and patterns in images. This paper presents a panorama of the aforementioned literature on decompositions in multiscale, multi-orientation bases or dictionaries. They typically exhibit redundancy to improve sparsity in the transformed domain and sometimes its invariance with respect to simple geometric deformations (translation, rotation). Oriented multiscale dictionaries extend traditional wavelet processing and may offer rotation invariance. Highly redundant dictionaries require specific algorithms to simplify the search for an efficient (sparse) representation. We also discuss the extension of multiscale geometric decompositions to non-Euclidean domains such as the sphere or arbitrary meshed surfaces. The etymology of panorama suggests an overview, based on a choice of partially overlapping "pictures". We hope that this paper will contribute to the appreciation and apprehension of a stream of current research directions in image understanding.Comment: 65 pages, 33 figures, 303 reference

Fractal image compression and the self-affinity assumption : a stochastic signal modelling perspective

Bibliography: p. 208-225.Fractal image compression is a comparatively new technique which has gained considerable attention in the popular technical press, and more recently in the research literature. The most significant advantages claimed are high reconstruction quality at low coding rates, rapid decoding, and "resolution independence" in the sense that an encoded image may be decoded at a higher resolution than the original. While many of the claims published in the popular technical press are clearly extravagant, it appears from the rapidly growing body of published research that fractal image compression is capable of performance comparable with that of other techniques enjoying the benefit of a considerably more robust theoretical foundation. . So called because of the similarities between the form of image representation and a mechanism widely used in generating deterministic fractal images, fractal compression represents an image by the parameters of a set of affine transforms on image blocks under which the image is approximately invariant. Although the conditions imposed on these transforms may be shown to be sufficient to guarantee that an approximation of the original image can be reconstructed, there is no obvious theoretical reason to expect this to represent an efficient representation for image coding purposes. The usual analogy with vector quantisation, in which each image is considered to be represented in terms of code vectors extracted from the image itself is instructive, but transforms the fundamental problem into one of understanding why this construction results in an efficient codebook. The signal property required for such a codebook to be effective, termed "self-affinity", is poorly understood. A stochastic signal model based examination of this property is the primary contribution of this dissertation. The most significant findings (subject to some important restrictions} are that "self-affinity" is not a natural consequence of common statistical assumptions but requires particular conditions which are inadequately characterised by second order statistics, and that "natural" images are only marginally "self-affine", to the extent that fractal image compression is effective, but not more so than comparable standard vector quantisation techniques