Maximum common subgraph isomorphism algorithms for the matching of chemical structures

The maximum common subgraph (MCS) problem has become increasingly important in those aspects of chemoinformatics that involve the matching of 2D or 3D chemical structures. This paper provides a classification and a review of the many MCS algorithms, both exact and approximate, that have been described in the literature, and makes recommendations regarding their applicability to typical chemoinformatics tasks

Incommensurability and rationality in engineering design: the case of functional decomposition

In engineering design research different models of functional decomposition are advanced side-by-side. In this paper I explain and validate this co-existence of models in terms of the Kuhnian thesis of methodological incommensurability. I advance this analysis in terms of the thesis’ construal of (non-algorithmic) theory choice in terms of values, expanding this notion to the engineering domain. I further argue that the (by some) implicated threat of the thesis to rational theory choice has no force in the functional decomposition case: co-existence of different models of functional decomposition is rational from an instrumental point of view. My explanation covers cases in which different models are advanced as means for the same objective. Such cases cannot be explicated with the explanatory construct of variety in objectives, as advanced in other analyses of co-existing conceptualizations in engineering

Coordinating Changes in M-form and U-form Organizations

We introduce a method of modelling coordination inside an organization as a process of "attribute matching." Using this method, we compare organizational forms (U-form and M-form) in coordinating changes. In our model, organizational forms affect the information structure of an organization and thus the way to coordinate changes. Compared to the U-form, the M-form organization achieves better coordination but suffers from higher costs due to a lack of scale economies or a lack of what we call "attribute compatibility." The M-form has a distinctive advantage in carrying out experimentation which gives the organization more flexibility leading to more innovation and reform. We apply our theory to business firms, transition economies, and the organization of government (especially federalism). In the case of transition economies, our theory relates the initial conditions of organizational differences with reform strategies, especially the "big-bang" approach in Eastern Europe and the "experimental" approach in China.http://deepblue.lib.umich.edu/bitstream/2027.42/39668/3/wp284.pd

Inter-organizational learning in drifting environments - Experiences from a multi-firm software development project

This paper examines conditions under which organizations can acquire and profitably utilise knowledge generated in joint product development ventures. Past research states that such learning depends on relationships between knowledge accumulation at the level of joint venture and the evolution of knowledge structures in the wider organizational environment. An important argument of this paper is that such relationships might drift abruptly due to unforeseen events taking place during project operation, creating new challenges and opportunities for learning. Drawing upon previous research on project-based learning, the paper proposes a model of interorganizational learning aimed to help managers and researchers visualising links between drift and learning in distributed project contexts. The paper illustrates and assesses the empirical relevance of the analytical framework through a case study of a multi-firm product development project in the European software industry.

Network strategies for the new economy

In this paper we argue that the pace and scale of development in the information and communication technology industries (ICT) has had and continues to have major effects on the industry economics and competitive dynamics generally. We maintain that the size of changes in demand and supply conditions is forcing companies to make significant changes in the way they conceive and implement their strategies. We decompose the ICT industries into four levels, technology standards, supply chains, physical platforms, and consumer networks. The nature of these technologies and their cost characteristics coupled with higher degrees of knowledge specialisation is impelling companies to radical revisions of their attitudes towards cooperation and co-evolution with suppliers and customers. Where interdependencies between customers are particularly strong, we anticipate the possibility of winner-takes-all strategies. In these circumstances industry risks become very high and there will be significant consequences for competitive markets

Network industries in the new economy

In this paper we discuss two propositions: the supply and demand of knowledge, and network externalities. We outline the characteristics that distinguish knowledge- intensive industries from the general run of manufacturing and service businesses. Knowledge intensity and knowledge specialisation has developed as markets and globalisation have grown, leading to progressive incentives to outsource and for industries to deconstruct. The outcome has been more intensive competition. The paper looks at what is potentially the most powerful economic mechanism: positive feedback, alternatively known as demand-side increasing returns, network effects, or network externalities. We present alternative demand curves that incorporate positive feedback and discuss their potential economic and strategic consequences. We argue that knowledge supply and demand, and the dynamics of network externalities create new situations for our traditional industrial economy such that new types of economies of scale are emerging and "winner takes all" strategies are having more influence. This is the first of a pair of papers. A second paper will take the argument further and look at the nature of firms' strategies in the new world, arguing that technology standards, technical platforms, consumer networks, and supply chain strategies are making a significant contribution to relevant strategies within the new economy

Fastening on the F-14A for cost effective fatigue resistance

Cost effectiveness airframe considerations dictated a variable geometry wing design that requires weight optimization, maximum working stress resistance and minimum fatigue concentration factors. The extensive use of titanium structural materials employed electron beam welding methods and interference fit fastening techniques as principle mechanical joining means for economic F-14A production and reliability engineering

Lean and green – a systematic review of the state of the art literature

The move towards greener operations and products has forced companies to seek alternatives to balance efficiency gains and environmental friendliness in their operations and products. The exploration of the sequential or simultaneous deployment of lean and green initiatives is the results of this balancing action. However, the lean-green topic is relatively new, and it lacks of a clear and structured research definition. Thus, this paper’s main contribution is the offering of a systematic review of the existing literature on lean and green, aimed at providing guidance on the topic, uncovering gaps and inconsistencies in the literature, and finding new paths for research. The paper identifies and structures, through a concept map, six main research streams that comprise both conceptual and empirical research conducted within the context of various organisational functions and industrial sectors. Important issues for future research are then suggested in the form of research questions. The paper’s aim is to also contribute by stimulating scholars to further study this area in depth, which will lead to a better understanding of the compatibility and impact on organisational performance of lean and green initiatives. It also holds important implications for industrialists, who can develop a deeper and richer knowledge on lean and green to help them formulate more effective strategies for their deployment